Mechanism of oxidative stress in neurodegeneration

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Gandhi, Sonia ^a   Abramov, Andrey Y ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; DISEASE CONTROL; FREE RADICALS; OXIDATIVE STRESS; OXYGEN;

ANTIOXIDANT SYSTEMS; BIOLOGICAL TISSUES; CLINICAL STUDY; CLINICAL TREATMENTS; DAMAGING EFFECTS; DISEASE MODELS; NEURODEGENERATION; REACTIVE OXYGEN SPECIES;

NEURODEGENERATIVE DISEASES;

ALPHA TOCOPHEROL; AMINE OXIDASE (FLAVIN CONTAINING); ASCORBIC ACID; CATALASE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; NITRIC OXIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; SUPEROXIDE DISMUTASE; UBIDECARENONE; XANTHINE OXIDASE;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANTIOXIDANT ACTIVITY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUNTINGTON CHOREA; LIPID PEROXIDATION; NERVE DEGENERATION; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PARKINSON DISEASE; REVIEW; VITAMIN SUPPLEMENTATION;

EID: 84862297475     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/428010     Document Type: Review

References (102)

1. Lin M. T., Beal M. F., Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 2006 443 7113 787 795 (Pubitemid 44622683)
2. Halliwell B., Oxidative stress and neurodegeneration: where are we now? Journal of Neurochemistry 2006 97 6 1634 1658 (Pubitemid 43873658)
3. Ahdab-Barmada M., Moossy J., Nemoto E. M., Lin M. R., Hyperoxia produces neuronal necrosis in the rat Journal of Neuropathology and Experimental Neurology 1986 45 3 233 246 (Pubitemid 16061965)
4. Davydov B. I., Drobyshev V. I., Ushakov I. B., Fyodorov V. P., Morphological analysis of animal brain reactions to short-term hyperoxia Kosmicheskaya Biologiya i Aviakosmicheskaya Meditsina 1988 22 2 56 62
5. Drge W., Free radicals in the physiological control of cell function Physiological Reviews 2002 82 1 47 95
6. Lovell M. A., Ehmann W. D., Butler S. M., Markesbery W. R., Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease Neurology 1995 45 8 1594 1601
7. Hensley K., Butterfield D. A., Hall N., Cole P., Subramaniam R., Mark R., Mattson M. P., Markesbery W. R., Harris M. E., Aksenov M., Aksenova M., Wu J. F., Carney J. M., Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide Annals of the New York Academy of Sciences 1996 786 120 134 (Pubitemid 26273159)
8. Hensley K., Hall N., Subramaniam R., Cole P., Harris M., Aksenov M., Aksenova M., Gabbita S. P., Wu J. F., Carney J. M., Lovell M., Markesbery W. R., Butterfield D. A., Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation Journal of Neurochemistry 1995 65 5 2146 2156
9. Mecocci P., Cherubini A., Polidori M. C., Cecchetti R., Chionne F., Senin U., Oxidative stress and dementia: new perspectives in AD pathogenesis Aging 1997 9 4 51 52
10. Mecocci P., Polidori M. C., Ingegni T., Cherubini A., Chionne F., Cecchetti R., Senin U., Oxidative damage to DNA in lymphocytes from AD patients Neurology 1998 51 4 1014 1017 (Pubitemid 28473393)
11. Pratic D., Evidence of oxidative stress in Alzheimer's disease brain and antioxidant therapy: lights and shadows Annals of the New York Academy of Sciences 2008 1147 70 78
12. Dalfo E. P., Portero-Otin M. M. P., Ayala V. P., Martinez A., Pamplona R. M., Ferrer I. M., Evidence of oxidative stress in the neocortex in incidental lewy body disease Journal of Neuropathology Experimental Neurology 2005 64 816 830 (Pubitemid 41285815)
13. Beal M. F., Oxidatively modified proteins in aging and disease Free Radical Biology and Medicine 2002 32 9 797 803 (Pubitemid 34439250)
14. Brown G. C., Borutaite V., Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols Biochimica et Biophysica Acta 2004 1658 1-2 44 49 (Pubitemid 39013232)
15. Seet R. C. S., Lee C. Y. J., Lim E. C. H., Tan J. J. H., Quek A. M. L., Chong W. L., Looi W. F., Huang S. H., Wang H., Chan Y. H., Halliwell B., Oxidative damage in Parkinson disease: measurement using accurate biomarkers Free Radical Biology and Medicine 2010 48 4 560 566
16. Bender A., Krishnan K. J., Morris C. M., Taylor G. A., Reeve A. K., Perry R. H., Jaros E., Hersheson J. S., Betts J., Klopstock T., Taylor R. W., Turnbull D. M., High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease Nature Genetics 2006 38 5 515 517
17. Schapira A. H., Mitochondria in the aetiology and pathogenesis of Parkinson's disease The Lancet Neurology 2008 7 1 97 109 (Pubitemid 350251942)
18. Lotharius J., O'Malley K. L., The Parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation: a novel mechanism of toxicity Journal of Biological Chemistry 2000 275 49 38581 38588 (Pubitemid 32009186)
19. Smith T. S., Bennett J. P., Mitochondrial toxins in models of neurodegenerative diseases. I: in vivo brain hydroxyl radical production during sytemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions Brain Research 1997 765 2 183 188 (Pubitemid 27397613)
20. Gonzlez-Polo R. A., Soler G., Rodrguezmartn A., Morn J. M., Fuentes J. M., Protection against MPP+ neurotoxicity in cerebellar granule cells by antioxidants Cell Biology International 2004 28 5 373 380 (Pubitemid 38748927)
21. Andrews Z. B., Horvath B., Barnstable C. J., Elseworth J., Yang L., Beal M. F., Roth R. H., Matthews R. T., Horvath T. L., Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease Journal of Neuroscience 2005 25 1 184 191 (Pubitemid 40110779)
22. Lev N., Ickowicz D., Melamed E., Offen D., Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection NeuroToxicology 2008 29 3 397 405
23. Li H. M., Niki T., Taira T., Iguchi-Ariga S. M. M., Ariga H., Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress Free Radical Research 2005 39 10 1091 1099 (Pubitemid 41358563)
24. Gandhi S., Wood-Kaczmar A., Yao Z., Plun-Favreau H., Deas E., Klupsch K., Downward J., Latchman D. S., Tabrizi S. J., Wood N. W., Duchen M. R., Abramov A. Y., PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death Molecular Cell 2009 33 5 627 638
25. Piccoli C., Sardanelli A., Scrima R., Ripoli M., Quarato G., D'Aprile A., Bellomo F., Scacco S., De Michele G., Filla A., Iuso A., Boffoli D., Capitanio N., Papa S., Mitochondrial respiratory dysfunction in familiar Parkinsonism associated with PINK1 mutation Neurochemical Research 2008 33 12 2565 2574
26. Wood-Kaczmar A., Gandhi S., Yao Z., Abramov A. S. Y., Miljan E. A., Keen G., Stanyer L., Hargreaves I., Klupsch K., Deas E., Downward J., Mansfield L., Jat P., Taylor J., Heales S., Duchen M. R., Latchman D., Tabrizi S. J., Wood N. W., PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons PLoS ONE 2008 3 6
27. Crompton M., Barksby E., Johnson N., Capano M., Mitochondrial intermembrane junctional complexes and their involvement in cell death Biochimie 2002 84 2-3 143 152
28. Giorgio V., Soriano M. E., Basso E., Bisetto E., Lippe G., Forte M. A., Bernardi P., Cyclophilin D in mitochondrial pathophysiology Biochimica et Biophysica Acta 2010 1797 6-7 1113 1118
29. Cleren C., Starkov A. A., Calingasan N. Y., Lorenzo B. J., Chen J., Beal M. F., Promethazine protects against 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity Neurobiology of Disease 2005 20 3 701 708 (Pubitemid 41619346)
30. Geisler S., Holmstrm K. M., Skujat D., Fiesel F. C., Rothfuss O. C., Kahle P. J., Springer W., PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 Nature Cell Biology 2010 12 2 119 131
31. Narendra D. P., Jin S. M., Tanaka A., Suen D. F., Gautier C. A., Shen J., Cookson M. R., Youle R. J., PINK1 is selectively stabilized on impaired mitochondria to activate Parkin PLoS Biology 2010 8 1
32. Vives-Bauza C., Zhou C., Huang Y., Cui M., De Vries R. L. A., Kim J., May J., Tocilescu M. A., Liu W., Ko H. S., Magrané J., Moore D. J., Dawson V. L., Grailhe R., Dawson T. M., Li C., Tieu K., Przedborski S., PINK1-dependent recruitment of Parkin to mitochondria in mitophagy Proceedings of the National Academy of Sciences of the United States of America 2010 107 1 378 383
33. Devi L., Raghavendran V., Prabhu B. M., Avadhani N. G., Anandatheerthavarada H. K., Mitochondrial import and accumulation of -synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain Journal of Biological Chemistry 2008 283 14 9089 9100
34. Martin L. J., Pan Y., Price A. C., Sterling W., Copeland N. G., Jenkins N. A., Price D. L., Lee M. K., Parkinson's disease -synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death Journal of Neuroscience 2006 26 1 41 50 (Pubitemid 43089519)
35. Esteves A. R., Arduno D. M., Swerdlow R. H., Oliveira C. R., Cardoso S. M., Oxidative stress involvement in -synuclein oligomerization in Parkinson's disease cybrids Antioxidants and Redox Signaling 2009 11 3 439 448
36. Kamp F., Exner N., Lutz A. K., Wender N., Hegermann J., Brunner B., Nuscher B., Bartels T., Giese A., Beyer K., Eimer S., Winklhofer K. F., Haass C., Inhibition of mitochondrial fusion by -synuclein is rescued by PINK1, Parkin and DJ-1 EMBO Journal 2010 29 20 3571 3589
37. Du H., Guo L., Yan S., Sosunov A. A., McKhann G. M., Yan S. S., Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model Proceedings of the National Academy of Sciences of the United States of America 2010 107 43 18670 18675
38. Caspersen C., Wang N., Yao J., Sosunov A., Chen X., Lustbader J. W., Xu H. W., Stern D., McKhann G., Yan S. D., Mitochondrial A : a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease The FASEB Journal 2005 19 14 2040 2041 (Pubitemid 41759758)
39. Abramov A. Y., Canevari L., Duchen M. R., Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity Journal of Neuroscience 2003 23 12 5088 5095 (Pubitemid 36793236)
40. Abramov A. Y., Canevari L., Duchen M. R., Calcium signals induced by amyloid peptide and their consequences in neurons and astrocytes in culture Biochimica et Biophysica Acta 2004 1742 1-3 81 87 (Pubitemid 39601768)
41. Parks J. K., Smith T. S., Trimmer P. A., Bennett J. P., Davis Parker W., Neurotoxic A peptides increase oxidative stress in vivo through NMDA-receptor and nitric-oxide-synthase mechanisms, and inhibit complex IV activity and induce a mitochondrial permeability transition in vitro Journal of Neurochemistry 2001 76 4 1050 1056 (Pubitemid 32167378)
42. Shevtzova E. F., Kireeva E. G., Bachurin S. O., Effect of -amyloid peptide fragment 25-35 on nonselective permeability of mitochondria Bulletin of Experimental Biology and Medicine 2001 132 6 1173 1176 (Pubitemid 34575488)
43. Abramov A. Y., Canevari L., Duchen M. R., Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase Journal of Neuroscience 2004 24 2 565 575 (Pubitemid 38112390)
44. Abramov A. Y., Duchen M. R., The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides Philosophical Transactions of the Royal Society B 2005 360 1464 2309 2314 (Pubitemid 46682150)
45. Abramov A. Y., Fraley C., Diao C. T., Winkfein R., Colicos M. A., Duchen M. R., French R. J., Pavlov E., Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death Proceedings of the National Academy of Sciences of the United States of America 2007 104 46 18091 18096 (Pubitemid 350210825)
46. Du H., Guo L., Zhang W., Rydzewska M., Yan S., Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model Neurobiology of Aging 2011 32 3 398 406
47. Wang X., Su B., Siedlak S. L., Moreira P. I., Fujioka H., Wang Y., Casadesus G., Zhu X., Amyloid- overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins Proceedings of the National Academy of Sciences of the United States of America 2008 105 49 19318 19323
48. Shimohama S., Tanino H., Kawakami N., Okamura N., Kodama H., Yamaguchi T., Hayakawa T., Nunomura A., Chiba S., Perry G., Smith M. A., Fujimoto S., Activation of NADPH oxidase in Alzheimer's disease brains Biochemical and Biophysical Research Communications 2000 273 1 5 9 (Pubitemid 30426853)
49. De La Monte S. M., Wands J. R., Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease Journal of Alzheimer's Disease 2006 9 2 167 181 (Pubitemid 44088244)
50. Park L., Anrather J., Zhou P., Frys K., Pitstick R., Younkin S., Carlson G. A., Iadecola C., NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid peptide Journal of Neuroscience 2005 25 7 1769 1777 (Pubitemid 40279282)
51. Park L., Zhou P., Pitstick R., Capone C., Anrather J., Norris E. H., Younkin L., Younkin S., Carlson G., McEwen B. S., Iadecola C., Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein Proceedings of the National Academy of Sciences of the United States of America 2008 105 4 1347 1352 (Pubitemid 351397056)
52. Della Bianca V., Dusi S., Bianchini E., Dal Pr I., Rossi F., -amyloid activates the O 2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease Journal of Biological Chemistry 1999 274 22 15493 15499
53. Wilkinson B., Koenigsknecht-Talboo J., Grommes C., Lee C. Y. D., Landreth G., Fibrillar -amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia Journal of Biological Chemistry 2006 281 30 20842 20850 (Pubitemid 44115425)
54. DeCoursey T. E., Morgan D., Cherny V. V., The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels Nature 2003 422 6931 531 534 (Pubitemid 36433649)
55. Milton R. H., Abeti R., Averaimo S., DeBiasi S., Vitellaro L., Jiang L., Curmi P. M. G., Breit S. N., Duchen M. R., Mazzanti M., CLIC1 function is required for -amyloid-induced generation of reactive oxygen species by microglia Journal of Neuroscience 2008 28 45 11488 11499
56. Abramov Y. A., Kasymov V. A., Zinchenko V. P., Beta-amyloid activates synthesis of nitric oxide in hyppocampal astrocytes and causes death of neurons Biologicheskie Membrany 2008 25 1 11 17 (Pubitemid 351374018)
57. Brown G. C., Mechanisms of inflammatory neurodegeneration: INOS and NADPH oxidase Biochemical Society Transactions 2007 35 5 1119 1121 (Pubitemid 350206442)
58. Ionov M., Burchell V., Klajnert B., Bryszewska M., Abramov A. Y., Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity Neuroscience 2011 180 229 237
59. Reiter R., Tang L., Garcia J. J., Muoz-Hoyos A., Pharmacological actions of melatonin in oxygen radical pathophysiology Life Sciences 1997 60 25 2255 2271
60. Hicks J. B., Lai Y., Sheng W., Yang X., Zhu D., Sun G. Y., Lee J. C. M., Amyloid- peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2 Biochimica et Biophysica Acta 2008 1778 11 2512 2519
61. Hashimoto Y., Niikura T., Yuko I. T. O., Kita Y., Terashita K., Nishimoto I., Neurotoxic mechanisms by Alzheimer's disease-linked N141l mutant presenilin 2 Journal of Pharmacology and Experimental Therapeutics 2002 300 3 736 745 (Pubitemid 34164974)
62. Hashimoto Y., Tsukamoto E., Niikura T., Yamagishi Y., Ishizaka M., Aiso S., Takashima A., Nishimoto I., Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: study of 27 different presenilin 1 mutants Journal of Neuroscience Research 2004 75 3 417 428 (Pubitemid 38173478)
63. Shelat P. B., Chalimoniuk M., Wang J. H., Strosznajder J. B., Lee J. C., Sun A. Y., Simonyi A., Sun G. Y., Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons Journal of Neurochemistry 2008 106 1 45 55 (Pubitemid 351840199)
64. Gao H. M., Liu B., Hong J. S., Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons Journal of Neuroscience 2003 23 15 6181 6187 (Pubitemid 36875618)
65. Wu D. C., Teismann P., Tieu K., Vila M., Jackson-Lewis V., Ischiropoulos H., Przedborski S., NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2003 100 10 6145 6150 (Pubitemid 36576945)
66. Anantharam V., Kaul S., Song C., Kanthasamy A., Kanthasamy A. G., Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells NeuroToxicology 2007 28 5 988 997 (Pubitemid 47519806)
67. Abe Y., Hashimoto Y., Tomita Y., Terashita K., Aiso S., Tajima H., Niikura T., Matsuoka M., Nishimoto I., Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant Journal of Neuroscience Research 2004 77 4 583 595 (Pubitemid 39007010)
68. Kaminsky Y. G., Kosenko E. A., Effects of amyloid-beta peptides on hydrogen peroxide-metabolizing enzymes in rat brain in vivo Free Radical Research 2008 42 6 564 573 (Pubitemid 351935149)
69. Obata T., Kubota S., Yamanaka Y., Allopurinol suppresses para-nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical generation in rat striatum Neuroscience Letters 2001 306 1-2 9 12 (Pubitemid 32524285)
70. Wang X., Michaelis E. K., Selective neuronal vulnerability to oxidative stress in the brain Frontiers in Aging Neuroscience 2010 2 12
71. Mller T., Motor complications, levodopa metabolism and progression of Parkinson's disease Expert Opinion on Drug Metabolism and Toxicology 2011 7 7 847 855
72. Mller T., Muhlack S., Cysteinyl-glycine reduction as marker for levodopa-induced oxidative stress in Parkinson's disease patients Movement Disorders 2011 26 3 543 546
73. Vaarmann A., Gandhi S., Abramov A. Y., Dopamine induces Ca 2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase Journal of Biological Chemistry 2010 285 32 25018 25023
74. Surmeier D. J., Guzman J. N., Sanchez-Padilla J., Goldberg J. A., The origins of oxidant stress in parkinson's disease and therapeutic strategies Antioxidants and Redox Signaling 2011 14 7 1289 1301
75. Conte V., Uryu K., Fujimoto S., Yao Y., Rokach J., Longhi L., Trojanowski J. Q., Lee V. M. Y., McIntosh T. K., Pratic D., Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury Journal of Neurochemistry 2004 90 3 758 764 (Pubitemid 38989408)
76. Sung S., Yao Y., Uryu K., Yang H., Lee V. M., Trojanowski J. Q., Pratic D., Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease. The FASEB Journal 2004 18 2 323 325
77. Du H., Yan S. S., Mitochondrial permeability transition pore in Alzheimer's disease: cyclophilin D and amyloid beta Biochimica et Biophysica Acta 2010 1802 1 198 204
78. Dumont M., Lin M. T., Beal M. F., Mitochondria and antioxidant targeted therapeutic strategies for Alzheimer's disease Journal of Alzheimer's Disease 2010 20 2 S633 S643
79. Burchell V. S., Gandhi S., Deas E., Wood N. W., Abramov A. Y., Plun-Favreau H., Targeting mitochondrial dysfunction in neurodegenerative disease: part II Expert Opinion on Therapeutic Targets 2010 14 5 497 511
80. Mller T., New small molecules for the treatment of Parkinson's disease Expert Opinion on Investigational Drugs 2010 19 9 1077 1086
81. Weber C. A., Ernst M. E., Antioxidants, supplements, and Parkinson's disease Annals of Pharmacotherapy 2006 40 5 935 938 (Pubitemid 43765012)
82. Babior B. M., Kipnes R. S., Curnutte J. T., Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent Journal of Clinical Investigation 1973 52 3 741 744
83. Babior B. M., NADPH oxidase Current Opinion in Immunology 2004 16 1 42 47 (Pubitemid 38198116)
84. Colton C. A., Gilbert D. L., Production of superoxide anions by a CNS macrophage, the microglia FEBS Letters 1987 223 2 284 288
85. Abramov A. Y., Jacobson J., Wientjes F., Hothersall J., Canevari L., Duchen M. R., Expression and modulation of an NADPH oxidase in mammalian astrocytes Journal of Neuroscience 2005 25 40 9176 9184 (Pubitemid 41500826)
86. Noh K. M., Koh J. Y., Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. The Journal of Neuroscience 2000 20 23 RC111
87. Brown D. I., Griendling K. K., Nox proteins in signal transduction Free Radical Biology and Medicine 2009 47 9 1239 1253
88. Harrison R., Structure and function of xanthine oxidoreductase: where are we now? Free Radical Biology and Medicine 2002 33 6 774 797 (Pubitemid 35232313)
89. Granger D. N., Hollwarth M. E., Parks D. A., Ischemia-reperfusion injury: role of oxygen-derived free radicals Acta Physiologica Scandinavica 1986 126 548 47 63 (Pubitemid 16090298)
90. Andreyev A. Y., Kushnareva Y. E., Starkov A. A., Mitochondrial metabolism of reactive oxygen species Biochemistry 2005 70 2 200 214 (Pubitemid 40512329)
91. Jensen P. K., Antimycin-insensitive oxidation of succinate and reduced nicotinamide-adenine dinucleotide in electron-transport particles I. pH dependency and hydrogen peroxide formation Biochimica et Biophysica Acta 1966 122 2 157 166
92. Loschen G., Flohé L., Chance B., Respiratory chain linked H 2 O 2 production in pigeon heart mitochondria FEBS Letters 1971 18 2 261 264
93. Tretter L., Adam-Vizi V., Generation of reactive oxygen species in the reaction catalyzed by -ketoglutarate dehydrogenase Journal of Neuroscience 2004 24 36 7771 7778 (Pubitemid 39215680)
94. Abramov A. Y., Scorziello A., Duchen M. R., Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation Journal of Neuroscience 2007 27 5 1129 1138 (Pubitemid 46203321)
95. Mehta S. L., Li P. A., Neuroprotective role of mitochondrial uncoupling protein 2 in cerebral stroke Journal of Cerebral Blood Flow and Metabolism 2009 29 6 1069 1078
96. Huang G., Chen Y., Lu H., Cao X., Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon- and retinoic acid-induced cancer cell death Cell Death and Differentiation 2007 14 2 327 337 (Pubitemid 46092235)
97. Iuso A., Scacco S., Piccoli C., Bellomo F., Petruzzella V., Trentadue R., Minuto M., Ripoli M., Capitanio N., Zeviani M., Papa S., Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I Journal of Biological Chemistry 2006 281 15 10374 10380 (Pubitemid 43864576)
98. Abramov A. Y., Smulders-Srinivasan T. K., Kirby D. M., Acin-Perez R., Enriquez J. A., Lightowlers R. N., Duchen M. R., Turnbull D. M., Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations Brain 2010 133 3 797 807
99. Edmondson D. E., Binda C., Wang J., Upadhyay A. K., Mattevi A., Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases Biochemistry 2009 48 20 4220 4230
100. Miao L., Clair D. K. S., Regulation of superoxide dismutase genes: implications in disease Free Radical Biology and Medicine 2009 47 4 344 356
101. Margis R., Dunand C., Teixeira F. K., Margis-Pinheiro M., Glutathione peroxidase familyan evolutionary overview FEBS Journal 2008 275 15 3959 3970 (Pubitemid 351990959)
102. Dringen R., Hirrlinger J., Glutathione pathways in the brain Biological Chemistry 2003 384 4 505 516 (Pubitemid 36609167)