PINK1 deficiency in b-cells increases basal insulin secretion and improves glucose tolerance in mice

Open Biology

Volumn 4, Issue MAY, 2014, Pages

  Deas, Emma ^a   Piipari, Kaisa ^b   Machhada, Asif ^c   Li, Abi ^a   Gutierrez Del Arroyo, Ana ^d   Withers, Dominic J ^b   Wood, Nicholas W ^a   Abramov, Andrey Y ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Diabetes; Insulin; Parkinsons disease; PINK1; cells

Indexed keywords

MUS;

CALCIUM; GLUCOSE; INSULIN; PROTEIN KINASE; PTEN INDUCED PUTATIVE KINASE; PTEN-INDUCED PUTATIVE KINASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; CELL CULTURE; CYTOLOGY; DIABETES MELLITUS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; GLUCOSE TOLERANCE TEST; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MOUSE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PARKINSON DISEASE; PATHOLOGY; PINK1; RNA INTERFERENCE; SECRETION (PROCESS); Β-CELLS;

DIABETES; INSULIN; PARKINSON'S DISEASE; PINK1; Β-CELLS;

ANIMALS; CALCIUM; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84900993015     PISSN: None     EISSN: 20462441     Source Type: Journal    
DOI: 10.1098/rsob.140051     Document Type: Article

References (38)

1. Nolan CJ, Damm P, Prentki M. 2011 Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 378, 169-181. (doi:10.1016/S0140-6736(11)60614-4
2. Saini V. 2010 Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J. Diabetes 1, 68-75. (doi:10.4239/wjd.v1.i3.68
3. Defronzo RA. 2009 Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 58, 773-795. (doi:10.2337/db09-9028
4. Leturque A, Brot-Laroche E, Le Gall M. 2009 GLUT2 mutations, translocation, and receptor function in diet sugar managing. Am. J. Physiol. Endocrinol. Metab. 296, E985-E992. (doi:10.1152/ajpendo. 00004.2009
5. Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P. 2003 Hierarchy of the beta-cell signals controlling insulin secretion. Eur. J. Clin. Invest. 33, 742-750. (doi:10.1046/j.1365-2362.2003.01207.x (Pubitemid 37082859)
6. Deas E, Plun-Favreau H, Wood NW. 2009 PINK1 function in health and disease. EMBO Mol. Med. 1, 152-165. (doi:10.1002/emmm.200900024
7. Valente EM et al. 2004 Hereditary early-onset Parkinsons disease caused by mutations in PINK1. Science 304, 1158-1160. (doi:10.1126/science. 1096284 (Pubitemid 38661852)
8. Gandhi S et al. 2009 PINK1-associated Parkinsons disease is caused by neuronal vulnerability to calcium-induced cell death. Mol. Cell 33, 627-638. (doi:10.1016/j.molcel.2009.02.013
9. Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. 2009 Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinsons disease by disturbing calcium flux. J. Neurochem. 108, 1561-1574. (doi:10.1111/j. 1471-4159.2009.05932.x
10. Yao Z, Gandhi S, Burchell VS, Plun-Favreau H, Wood NW, Abramov AY. 2011 Cell metabolism affects selective vulnerability in PINK1-associated Parkinsons disease. J. Cell Sci. 124, 4194-4202. (doi:10.1242/jcs.088260
11. Scheele C et al. 2007 Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration FASEB J. 21, 3653-3665. (doi:10.1096/fj.07-8520com (Pubitemid 350075153)
12. Qu Y, Sun L, Yang Z, Han R. 2011 Variation in the PTEN-induced putative kinase 1 gene associated with the increase risk of type 2 diabetes in northern Chinese. J. Genet. 90, 125-128. (doi:10.1007/s12041-011-0020-y
13. Bao W, Hu FB, Rong S, Rong Y, Bowers K, Schisterman EF, Liu L, Zhang C. 2013 Predicting risk of type 2 diabetes mellitus with genetic risk models on the basis of established genome-wide association markers: a systematic review. Am. J. Epidemiol. 178, 1197-1207. (doi:10.1093/aje/kwt123
14. Wood-Kaczmar A et al. 2008 PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 3, e2455. (doi:10.1371/journal.pone.0002455
15. Exner N et al. 2007 Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27, 12413-12418. (doi:10.1523/JNEUROSCI.0719-07.2007 (Pubitemid 350085485)
16. Pieczenik SR, Neustadt J. 2007 Mitochondrial dysfunction and molecular pathways of disease. Exp. Mol. Pathol. 83, 84-92. (doi:10.1016/j.yexmp.2006. 09.008 (Pubitemid 46842959)
17. Wiederkehr A, Wollheim CB. 2006 Minireview: implication of mitochondria in insulin secretion and action. Endocrinology 147, 2643-2649. (doi:10. 1210/en.2006-0057 (Pubitemid 43764598)
18. Abramov AY, Canevari L, Duchen MR. 2004 b-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase. J. Neurosci. 24, 565-575. (doi:10.1523/JNEUROSCI.4042-03.2004 (Pubitemid 38112390)
19. Ibanez P, Lesage S, Lohmann E, Thobois S, De Michele G, Borg M, Agid Y, Durr A, Brice A. 2006 Mutational analysis of the PINK1 gene in earlyonset parkinsonism in Europe and North Africa. Brain 129, 686-694. (doi:10.1093/brain/awl005 (Pubitemid 43278230)
20. Pilsl A, Winklhofer KF. 2011 Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinsons disease. Acta Neuropathol. 123, 173-188. (doi:10.1007/s00401-011-0902-3
21. Vives-Bauza C, Przedborski S. 2011 Mitophagy: the latest problem for Parkinsons disease. Trends Mol. Med. 17, 158-165. (doi:10.1016/j.molmed.2010. 11.002
22. Kandror KV, Pilch PF. 1996 Compartmentalization of protein traffic in insulin-sensitive cells. Am. J. Physiol. 271, E1-E14.
23. Taylor BL, Liu FF, Sander M. 2013 Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells. Cell Rep. 4, 1262-1275. (doi:10.1016/j. celrep.2013.08.010
24. Gu C et al. 2010 Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab. 11, 298-310. (doi:10.1016/j.cmet.2010. 03.006
25. Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy JY, Zhu Y, Sladek FM. 2009 Down-regulation of hepatic HNF4a gene expression during hyperinsulinemia via SREBPs. Mol. Endocrinol. 23, 434-443. (doi:10.1210/me.2007-0531
26. Sandyk R. 1993 The relationship between diabetes mellitus and Parkinsons disease. Int. J. Neurosci. 69, 125-130. (doi:10.3109/00207459309003322
27. Sun Y, Chang YH, Chen HF, Su YH, Su HF, Li CY. 2012 Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications. Diabetes Care 35, 1047-1049. (doi:10.2337/dc11-1511
28. Morris JK et al. 2011 Insulin resistance impairs nigrostriatal dopamine function. Exp. Neurol. 231, 171-180. (doi:10.1016/j.expneurol.2011. 06.005
29. Figlewicz DP, Brot MD, McCall AL, Szot P. 1996 Diabetes causes differential changes in CNS noradrenergic and dopaminergic neurons in the rat: a molecular study. Brain Res. 736, 54-60. (doi:10. 1016/0006-8993(96)00727-5 (Pubitemid 26356462)
30. Wada A, Yokoo H, Yanagita T, Kobayashi H. 2005 New twist on neuronal insulin receptor signaling in health, disease, and therapeutics. J. Pharmacol. Sci. 99, 128-143. (doi:10.1254/jphs.CRJ05006X (Pubitemid 41524451)
31. Konner AC et al. 2011 Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Cell Metab. 13, 720-728. (doi:10. 1016/j.cmet.2011.03.021
32. Craft S, Watson GS. 2004 Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol. 3, 169-178. (doi:10. 1016/S1474-4422(04)00681-7 (Pubitemid 38229951)
33. Cereda E, Barichella M, Cassani E, Caccialanza R, Pezzoli G. 2012 Clinical features of Parkinson disease when onset of diabetes came first: a case-control study. Neurology 78, 1507-1511. (doi:10.1212/WNL.0b013e3182553cc9
34. Luo S, Liang Y, Cincotta AH. 1999 Intracerebroventricular administration of bromocriptine ameliorates the insulin-resistant/glucose-intolerant state in hamsters. Neuroendocrinology 69, 160-166. (doi:10.1159/000054415 (Pubitemid 29134491)
35. Smith JL, Ju JS, Saha BM, Racette BA, Fisher JS. 2004 Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle. J. Appl. Physiol. 97, 2339-2346. (doi:10. 1152/japplphysiol.01219.2003 (Pubitemid 39552475)
36. Zheng B et al. 2010 PGC-1a, a potential therapeutic target for early intervention in Parkinsons disease. Sci. Transl. Med. 2, 52ra73. (doi:10.1126/scitranslmod.3001059
37. Li DS, Yuan YH, Tu HJ, Liang QL, Dai LJ. 2009 A protocol for islet isolation from mouse pancreas. Nat. Protoc. 4, 1649-1652. (doi:10.1038/nprot. 2009.150
38. Cantley J, Choudhury AI, Asare-Anane H, Selman C, Lingard S, Heffron H, Herrera P, Persaud SJ, Withers DJ. 2007 Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice. Diabetologica 50, 1248-1256. (doi:10.1007/s00125-007-0637-9) (Pubitemid 46701548)