-
1
-
-
84946035099
-
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans
-
Abegglen, L.M., Caulin, A.F., Chan, A., Lee, K., Robinson, R., Campbell, M.S., Kiso, W.K., Schmitt, D.L., Waddell, P.J., Bhaskara, S., et al. Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. JAMA 314 (2015), 1850–1860.
-
(2015)
JAMA
, vol.314
, pp. 1850-1860
-
-
Abegglen, L.M.1
Caulin, A.F.2
Chan, A.3
Lee, K.4
Robinson, R.5
Campbell, M.S.6
Kiso, W.K.7
Schmitt, D.L.8
Waddell, P.J.9
Bhaskara, S.10
-
2
-
-
84893657457
-
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure
-
Ablain, J., Rice, K., Soilihi, H., de Reynies, A., Minucci, S., de Thé, H., Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure. Nat. Med. 20 (2014), 167–174.
-
(2014)
Nat. Med.
, vol.20
, pp. 167-174
-
-
Ablain, J.1
Rice, K.2
Soilihi, H.3
de Reynies, A.4
Minucci, S.5
de Thé, H.6
-
3
-
-
85005951100
-
The inherited p53 mutation in the Brazilian population
-
Achatz, M.I., Zambetti, G.P., The inherited p53 mutation in the Brazilian population. Cold Spring Harb. Perspect. Med., 6, 2016, 6.
-
(2016)
Cold Spring Harb. Perspect. Med.
, vol.6
, pp. 6
-
-
Achatz, M.I.1
Zambetti, G.P.2
-
4
-
-
84882837534
-
Signatures of mutational processes in human cancer
-
Alexandrov, L.B., Nik-Zainal, S., Wedge, D.C., Aparicio, S.A., Behjati, S., Biankin, A.V., Bignell, G.R., Bolli, N., Borg, A., Børresen-Dale, A.L., et al. Australian Pancreatic Cancer Genome Initiative ICGC Breast Cancer Consortium ICGC MMML-Seq Consortium, ICGC PedBrain. Signatures of mutational processes in human cancer. Nature 500 (2013), 415–421.
-
(2013)
Nature
, vol.500
, pp. 415-421
-
-
Alexandrov, L.B.1
Nik-Zainal, S.2
Wedge, D.C.3
Aparicio, S.A.4
Behjati, S.5
Biankin, A.V.6
Bignell, G.R.7
Bolli, N.8
Borg, A.9
Børresen-Dale, A.L.10
-
5
-
-
84994470617
-
Mutational signatures associated with tobacco smoking in human cancer
-
Alexandrov, L.B., Ju, Y.S., Haase, K., Van Loo, P., Martincorena, I., Nik-Zainal, S., Totoki, Y., Fujimoto, A., Nakagawa, H., Shibata, T., et al. Mutational signatures associated with tobacco smoking in human cancer. Science 354 (2016), 618–622.
-
(2016)
Science
, vol.354
, pp. 618-622
-
-
Alexandrov, L.B.1
Ju, Y.S.2
Haase, K.3
Van Loo, P.4
Martincorena, I.5
Nik-Zainal, S.6
Totoki, Y.7
Fujimoto, A.8
Nakagawa, H.9
Shibata, T.10
-
6
-
-
84937604711
-
Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
-
Alexandrova, E.M., Yallowitz, A.R., Li, D., Xu, S., Schulz, R., Proia, D.A., Lozano, G., Dobbelstein, M., Moll, U.M., Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature 523 (2015), 352–356.
-
(2015)
Nature
, vol.523
, pp. 352-356
-
-
Alexandrova, E.M.1
Yallowitz, A.R.2
Li, D.3
Xu, S.4
Schulz, R.5
Proia, D.A.6
Lozano, G.7
Dobbelstein, M.8
Moll, U.M.9
-
7
-
-
84902324667
-
Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms
-
Allen, M.A., Andrysik, Z., Dengler, V.L., Mellert, H.S., Guarnieri, A., Freeman, J.A., Sullivan, K.D., Galbraith, M.D., Luo, X., Kraus, W.L., et al. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. eLife, 3, 2014, e02200.
-
(2014)
eLife
, vol.3
, pp. e02200
-
-
Allen, M.A.1
Andrysik, Z.2
Dengler, V.L.3
Mellert, H.S.4
Guarnieri, A.5
Freeman, J.A.6
Sullivan, K.D.7
Galbraith, M.D.8
Luo, X.9
Kraus, W.L.10
-
8
-
-
84962677007
-
Results of the phase I trial of RG7112, a small-molecule MDM2 antagonist in leukemia
-
Andreeff, M., Kelly, K.R., Yee, K., Assouline, S., Strair, R., Popplewell, L., Bowen, D., Martinelli, G., Drummond, M.W., Vyas, P., et al. Results of the phase I trial of RG7112, a small-molecule MDM2 antagonist in leukemia. Clin. Cancer Res. 22 (2016), 868–876.
-
(2016)
Clin. Cancer Res.
, vol.22
, pp. 868-876
-
-
Andreeff, M.1
Kelly, K.R.2
Yee, K.3
Assouline, S.4
Strair, R.5
Popplewell, L.6
Bowen, D.7
Martinelli, G.8
Drummond, M.W.9
Vyas, P.10
-
9
-
-
85009843942
-
Novel targets and interaction partners of mutant p53 gain-of-function
-
Aschauer, L., Muller, P.A., Novel targets and interaction partners of mutant p53 gain-of-function. Biochem. Soc. Trans. 44 (2016), 460–466.
-
(2016)
Biochem. Soc. Trans.
, vol.44
, pp. 460-466
-
-
Aschauer, L.1
Muller, P.A.2
-
10
-
-
84991309720
-
The paradox of p53: what, how, and why?
-
Aylon, Y., Oren, M., The paradox of p53: what, how, and why?. Cold Spring Harb. Perspect. Med., 6, 2016, 6.
-
(2016)
Cold Spring Harb. Perspect. Med.
, vol.6
, pp. 6
-
-
Aylon, Y.1
Oren, M.2
-
11
-
-
33749334018
-
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
-
Aylon, Y., Michael, D., Shmueli, A., Yabuta, N., Nojima, H., Oren, M., A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes Dev. 20 (2006), 2687–2700.
-
(2006)
Genes Dev.
, vol.20
, pp. 2687-2700
-
-
Aylon, Y.1
Michael, D.2
Shmueli, A.3
Yabuta, N.4
Nojima, H.5
Oren, M.6
-
12
-
-
0025634118
-
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
-
Baker, S.J., Preisinger, A.C., Jessup, J.M., Paraskeva, C., Markowitz, S., Willson, J.K., Hamilton, S., Vogelstein, B., p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res. 50 (1990), 7717–7722.
-
(1990)
Cancer Res.
, vol.50
, pp. 7717-7722
-
-
Baker, S.J.1
Preisinger, A.C.2
Jessup, J.M.3
Paraskeva, C.4
Markowitz, S.5
Willson, J.K.6
Hamilton, S.7
Vogelstein, B.8
-
13
-
-
77955827519
-
The origins and evolution of the p53 family of genes
-
Belyi, V.A., Ak, P., Markert, E., Wang, H., Hu, W., Puzio-Kuter, A., Levine, A.J., The origins and evolution of the p53 family of genes. Cold Spring Harb. Perspect. Biol., 2, 2010, a001198.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
, pp. a001198
-
-
Belyi, V.A.1
Ak, P.2
Markert, E.3
Wang, H.4
Hu, W.5
Puzio-Kuter, A.6
Levine, A.J.7
-
14
-
-
84947020156
-
Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer
-
Blanden, A.R., Yu, X., Loh, S.N., Levine, A.J., Carpizo, D.R., Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer. Drug Discov. Today 20 (2015), 1391–1397.
-
(2015)
Drug Discov. Today
, vol.20
, pp. 1391-1397
-
-
Blanden, A.R.1
Yu, X.2
Loh, S.N.3
Levine, A.J.4
Carpizo, D.R.5
-
15
-
-
48749103325
-
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
-
Boeckler, F.M., Joerger, A.C., Jaggi, G., Rutherford, T.J., Veprintsev, D.B., Fersht, A.R., Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc. Natl. Acad. Sci. USA 105 (2008), 10360–10365.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10360-10365
-
-
Boeckler, F.M.1
Joerger, A.C.2
Jaggi, G.3
Rutherford, T.J.4
Veprintsev, D.B.5
Fersht, A.R.6
-
16
-
-
77949907107
-
p53-mediated hematopoietic stem and progenitor cell competition
-
Bondar, T., Medzhitov, R., p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6 (2010), 309–322.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 309-322
-
-
Bondar, T.1
Medzhitov, R.2
-
17
-
-
79955795151
-
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression
-
Brady, C.A., Jiang, D., Mello, S.S., Johnson, T.M., Jarvis, L.A., Kozak, M.M., Kenzelmann Broz, D., Basak, S., Park, E.J., McLaughlin, M.E., et al. Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145 (2011), 571–583.
-
(2011)
Cell
, vol.145
, pp. 571-583
-
-
Brady, C.A.1
Jiang, D.2
Mello, S.S.3
Johnson, T.M.4
Jarvis, L.A.5
Kozak, M.M.6
Kenzelmann Broz, D.7
Basak, S.8
Park, E.J.9
McLaughlin, M.E.10
-
18
-
-
84958152593
-
Clinical overview of MDM2/X-targeted therapies
-
Burgess, A., Chia, K.M., Haupt, S., Thomas, D., Haupt, Y., Lim, E., Clinical overview of MDM2/X-targeted therapies. Front. Oncol., 6, 2016, 7.
-
(2016)
Front. Oncol.
, vol.6
, pp. 7
-
-
Burgess, A.1
Chia, K.M.2
Haupt, S.3
Thomas, D.4
Haupt, Y.5
Lim, E.6
-
19
-
-
84883356320
-
Evidence for APOBEC3B mutagenesis in multiple human cancers
-
Burns, M.B., Temiz, N.A., Harris, R.S., Evidence for APOBEC3B mutagenesis in multiple human cancers. Nat. Genet. 45 (2013), 977–983.
-
(2013)
Nat. Genet.
, vol.45
, pp. 977-983
-
-
Burns, M.B.1
Temiz, N.A.2
Harris, R.S.3
-
20
-
-
84992465108
-
Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis
-
Candeias, M.M., Hagiwara, M., Matsuda, M., Cancer-specific mutations in p53 induce the translation of Δ160p53 promoting tumorigenesis. EMBO Rep. 17 (2016), 1542–1551.
-
(2016)
EMBO Rep.
, vol.17
, pp. 1542-1551
-
-
Candeias, M.M.1
Hagiwara, M.2
Matsuda, M.3
-
21
-
-
84863625900
-
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells
-
Ceccaldi, R., Parmar, K., Mouly, E., Delord, M., Kim, J.M., Regairaz, M., Pla, M., Vasquez, N., Zhang, Q.S., Pondarre, C., et al. Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell 11 (2012), 36–49.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 36-49
-
-
Ceccaldi, R.1
Parmar, K.2
Mouly, E.3
Delord, M.4
Kim, J.M.5
Regairaz, M.6
Pla, M.7
Vasquez, N.8
Zhang, Q.S.9
Pondarre, C.10
-
22
-
-
84964955489
-
Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status
-
Cha, Y.J., Kim, H.R., Lee, C.Y., Cho, B.C., Shim, H.S., Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status. Lung Cancer 97 (2016), 73–80.
-
(2016)
Lung Cancer
, vol.97
, pp. 73-80
-
-
Cha, Y.J.1
Kim, H.R.2
Lee, C.Y.3
Cho, B.C.4
Shim, H.S.5
-
23
-
-
34247197620
-
The transcriptional activity of HERV-I LTR is negatively regulated by its cis-elements and wild type p53 tumor suppressor protein
-
Chang, N.T., Yang, W.K., Huang, H.C., Yeh, K.W., Wu, C.W., The transcriptional activity of HERV-I LTR is negatively regulated by its cis-elements and wild type p53 tumor suppressor protein. J. Biomed. Sci. 14 (2007), 211–222.
-
(2007)
J. Biomed. Sci.
, vol.14
, pp. 211-222
-
-
Chang, N.T.1
Yang, W.K.2
Huang, H.C.3
Yeh, K.W.4
Wu, C.W.5
-
24
-
-
84992094325
-
p53 on the crossroad between regeneration and cancer
-
Charni, M., Aloni-Grinstein, R., Molchadsky, A., Rotter, V., p53 on the crossroad between regeneration and cancer. Cell Death Differ. 24 (2017), 8–14.
-
(2017)
Cell Death Differ.
, vol.24
, pp. 8-14
-
-
Charni, M.1
Aloni-Grinstein, R.2
Molchadsky, A.3
Rotter, V.4
-
25
-
-
84896740535
-
p53 in neurodegenerative diseases and brain cancers
-
Checler, F., Alves da Costa, C., p53 in neurodegenerative diseases and brain cancers. Pharmacol. Ther. 142 (2014), 99–113.
-
(2014)
Pharmacol. Ther.
, vol.142
, pp. 99-113
-
-
Checler, F.1
Alves da Costa, C.2
-
26
-
-
85014710473
-
Exploiting the p53 pathway for therapy
-
Cheok, C.F., Lane, D.P., Exploiting the p53 pathway for therapy. Cold Spring Harb. Perspect. Med., 7, 2017, 7.
-
(2017)
Cold Spring Harb. Perspect. Med.
, vol.7
, pp. 7
-
-
Cheok, C.F.1
Lane, D.P.2
-
27
-
-
84884997982
-
Emerging landscape of oncogenic signatures across human cancers
-
Ciriello, G., Miller, M.L., Aksoy, B.A., Senbabaoglu, Y., Schultz, N., Sander, C., Emerging landscape of oncogenic signatures across human cancers. Nat. Genet. 45 (2013), 1127–1133.
-
(2013)
Nat. Genet.
, vol.45
, pp. 1127-1133
-
-
Ciriello, G.1
Miller, M.L.2
Aksoy, B.A.3
Senbabaoglu, Y.4
Schultz, N.5
Sander, C.6
-
28
-
-
0027258466
-
Thymocyte apoptosis induced by p53-dependent and independent pathways
-
Clarke, A.R., Purdie, C.A., Harrison, D.J., Morris, R.G., Bird, C.C., Hooper, M.L., Wyllie, A.H., Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362 (1993), 849–852.
-
(1993)
Nature
, vol.362
, pp. 849-852
-
-
Clarke, A.R.1
Purdie, C.A.2
Harrison, D.J.3
Morris, R.G.4
Bird, C.C.5
Hooper, M.L.6
Wyllie, A.H.7
-
29
-
-
84905717306
-
Caught in the cross fire: p53 in inflammation
-
Cooks, T., Harris, C.C., Oren, M., Caught in the cross fire: p53 in inflammation. Carcinogenesis 35 (2014), 1680–1690.
-
(2014)
Carcinogenesis
, vol.35
, pp. 1680-1690
-
-
Cooks, T.1
Harris, C.C.2
Oren, M.3
-
30
-
-
84956573071
-
PDL1 Regulation by p53 via miR-34
-
Cortez, M.A., Ivan, C., Valdecanas, D., Wang, X., Peltier, H.J., Ye, Y., Araujo, L., Carbone, D.P., Shilo, K., Giri, D.K., et al. PDL1 Regulation by p53 via miR-34. J. Natl. Cancer Inst., 108, 2015, 108.
-
(2015)
J. Natl. Cancer Inst.
, vol.108
, pp. 108
-
-
Cortez, M.A.1
Ivan, C.2
Valdecanas, D.3
Wang, X.4
Peltier, H.J.5
Ye, Y.6
Araujo, L.7
Carbone, D.P.8
Shilo, K.9
Giri, D.K.10
-
31
-
-
0019898801
-
Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer
-
Crawford, L.V., Pim, D.C., Bulbrook, R.D., Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. Int. J. Cancer 30 (1982), 403–408.
-
(1982)
Int. J. Cancer
, vol.30
, pp. 403-408
-
-
Crawford, L.V.1
Pim, D.C.2
Bulbrook, R.D.3
-
32
-
-
55549088527
-
p53 family in development
-
Danilova, N., Sakamoto, K.M., Lin, S., p53 family in development. Mech. Dev. 125 (2008), 919–931.
-
(2008)
Mech. Dev.
, vol.125
, pp. 919-931
-
-
Danilova, N.1
Sakamoto, K.M.2
Lin, S.3
-
33
-
-
84934767133
-
Misfolding, aggregation, and disordered segments in c-Abl and p53 in human cancer
-
de Oliveira, G.A., Rangel, L.P., Costa, D.C., Silva, J.L., Misfolding, aggregation, and disordered segments in c-Abl and p53 in human cancer. Front. Oncol., 5, 2015, 97.
-
(2015)
Front. Oncol.
, vol.5
, pp. 97
-
-
de Oliveira, G.A.1
Rangel, L.P.2
Costa, D.C.3
Silva, J.L.4
-
34
-
-
84885653845
-
Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen
-
Dejosez, M., Ura, H., Brandt, V.L., Zwaka, T.P., Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen. Science 341 (2013), 1511–1514.
-
(2013)
Science
, vol.341
, pp. 1511-1514
-
-
Dejosez, M.1
Ura, H.2
Brandt, V.L.3
Zwaka, T.P.4
-
35
-
-
0018743916
-
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
-
DeLeo, A.B., Jay, G., Appella, E., Dubois, G.C., Law, L.W., Old, L.J., Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc. Natl. Acad. Sci. USA 76 (1979), 2420–2424.
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 2420-2424
-
-
DeLeo, A.B.1
Jay, G.2
Appella, E.3
Dubois, G.C.4
Law, L.W.5
Old, L.J.6
-
36
-
-
85016437418
-
An open-label phase I dose-finding study of APR-246 in hematological malignancies
-
Deneberg, S., Cherif, H., Lazarevic, V., Andersson, P.O., von Euler, M., Juliusson, G., Lehmann, S., An open-label phase I dose-finding study of APR-246 in hematological malignancies. Blood Cancer J., 6, 2016, e447.
-
(2016)
Blood Cancer J.
, vol.6
, pp. e447
-
-
Deneberg, S.1
Cherif, H.2
Lazarevic, V.3
Andersson, P.O.4
von Euler, M.5
Juliusson, G.6
Lehmann, S.7
-
37
-
-
84896711553
-
Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution
-
Dewhurst, S.M., McGranahan, N., Burrell, R.A., Rowan, A.J., Grönroos, E., Endesfelder, D., Joshi, T., Mouradov, D., Gibbs, P., Ward, R.L., et al. Tolerance of whole-genome doubling propagates chromosomal instability and accelerates cancer genome evolution. Cancer Discov. 4 (2014), 175–185.
-
(2014)
Cancer Discov.
, vol.4
, pp. 175-185
-
-
Dewhurst, S.M.1
McGranahan, N.2
Burrell, R.A.3
Rowan, A.J.4
Grönroos, E.5
Endesfelder, D.6
Joshi, T.7
Mouradov, D.8
Gibbs, P.9
Ward, R.L.10
-
38
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A. Jr., Butel, J.S., Bradley, A., Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992), 215–221.
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
Harvey, M.2
Slagle, B.L.3
McArthur, M.J.4
Montgomery, C.A.5
Butel, J.S.6
Bradley, A.7
-
39
-
-
84943410958
-
p53-regulated autophagy is controlled by glycolysis and determines cell fate
-
Duan, L., Perez, R.E., Davaadelger, B., Dedkova, E.N., Blatter, L.A., Maki, C.G., p53-regulated autophagy is controlled by glycolysis and determines cell fate. Oncotarget 6 (2015), 23135–23156.
-
(2015)
Oncotarget
, vol.6
, pp. 23135-23156
-
-
Duan, L.1
Perez, R.E.2
Davaadelger, B.3
Dedkova, E.N.4
Blatter, L.A.5
Maki, C.G.6
-
40
-
-
84872899284
-
FOXOs: signalling integrators for homeostasis maintenance
-
Eijkelenboom, A., Burgering, B.M., FOXOs: signalling integrators for homeostasis maintenance. Nat. Rev. Mol. Cell Biol. 14 (2013), 83–97.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 83-97
-
-
Eijkelenboom, A.1
Burgering, B.M.2
-
42
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W., Vogelstein, B., WAF1, a potential mediator of p53 tumor suppression. Cell 75 (1993), 817–825.
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
el-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
43
-
-
84867552067
-
Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial
-
Ellebaek, E., Engell-Noerregaard, L., Iversen, T.Z., Froesig, T.M., Munir, S., Hadrup, S.R., Andersen, M.H., Svane, I.M., Metastatic melanoma patients treated with dendritic cell vaccination, Interleukin-2 and metronomic cyclophosphamide: results from a phase II trial. Cancer Immunol. Immunother. 61 (2012), 1791–1804.
-
(2012)
Cancer Immunol. Immunother.
, vol.61
, pp. 1791-1804
-
-
Ellebaek, E.1
Engell-Noerregaard, L.2
Iversen, T.Z.3
Froesig, T.M.4
Munir, S.5
Hadrup, S.R.6
Andersen, M.H.7
Svane, I.M.8
-
44
-
-
84887933383
-
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors
-
Emerling, B.M., Hurov, J.B., Poulogiannis, G., Tsukazawa, K.S., Choo-Wing, R., Wulf, G.M., Bell, E.L., Shim, H.S., Lamia, K.A., Rameh, L.E., et al. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell 155 (2013), 844–857.
-
(2013)
Cell
, vol.155
, pp. 844-857
-
-
Emerling, B.M.1
Hurov, J.B.2
Poulogiannis, G.3
Tsukazawa, K.S.4
Choo-Wing, R.5
Wulf, G.M.6
Bell, E.L.7
Shim, H.S.8
Lamia, K.A.9
Rameh, L.E.10
-
45
-
-
0242329884
-
p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
-
Espinosa, J.M., Verdun, R.E., Emerson, B.M., p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol. Cell 12 (2003), 1015–1027.
-
(2003)
Mol. Cell
, vol.12
, pp. 1015-1027
-
-
Espinosa, J.M.1
Verdun, R.E.2
Emerson, B.M.3
-
46
-
-
79960162178
-
Regulation of female reproduction by p53 and its family members
-
Feng, Z., Zhang, C., Kang, H.J., Sun, Y., Wang, H., Naqvi, A., Frank, A.K., Rosenwaks, Z., Murphy, M.E., Levine, A.J., Hu, W., Regulation of female reproduction by p53 and its family members. FASEB J. 25 (2011), 2245–2255.
-
(2011)
FASEB J.
, vol.25
, pp. 2245-2255
-
-
Feng, Z.1
Zhang, C.2
Kang, H.J.3
Sun, Y.4
Wang, H.5
Naqvi, A.6
Frank, A.K.7
Rosenwaks, Z.8
Murphy, M.E.9
Levine, A.J.10
Hu, W.11
-
47
-
-
0024382760
-
The p53 proto-oncogene can act as a suppressor of transformation
-
Finlay, C.A., Hinds, P.W., Levine, A.J., The p53 proto-oncogene can act as a suppressor of transformation. Cell 57 (1989), 1083–1093.
-
(1989)
Cell
, vol.57
, pp. 1083-1093
-
-
Finlay, C.A.1
Hinds, P.W.2
Levine, A.J.3
-
48
-
-
85015056692
-
Census and evaluation of p53 target genes
-
Fischer, M., Census and evaluation of p53 target genes. Oncogene 36 (2017), 3943–3956.
-
(2017)
Oncogene
, vol.36
, pp. 3943-3956
-
-
Fischer, M.1
-
49
-
-
84862636275
-
Mutant p53: one name, many proteins
-
Freed-Pastor, W.A., Prives, C., Mutant p53: one name, many proteins. Genes Dev. 26 (2012), 1268–1286.
-
(2012)
Genes Dev.
, vol.26
, pp. 1268-1286
-
-
Freed-Pastor, W.A.1
Prives, C.2
-
50
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
Freed-Pastor, W.A., Mizuno, H., Zhao, X., Langerød, A., Moon, S.H., Rodriguez-Barrueco, R., Barsotti, A., Chicas, A., Li, W., Polotskaia, A., et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 148 (2012), 244–258.
-
(2012)
Cell
, vol.148
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerød, A.4
Moon, S.H.5
Rodriguez-Barrueco, R.6
Barsotti, A.7
Chicas, A.8
Li, W.9
Polotskaia, A.10
-
51
-
-
0037154149
-
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants
-
Friedler, A., Hansson, L.O., Veprintsev, D.B., Freund, S.M., Rippin, T.M., Nikolova, P.V., Proctor, M.R., Rüdiger, S., Fersht, A.R., A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants. Proc. Natl. Acad. Sci. USA 99 (2002), 937–942.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 937-942
-
-
Friedler, A.1
Hansson, L.O.2
Veprintsev, D.B.3
Freund, S.M.4
Rippin, T.M.5
Nikolova, P.V.6
Proctor, M.R.7
Rüdiger, S.8
Fersht, A.R.9
-
52
-
-
84925286831
-
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
-
Friedmann Angeli, J.P., Schneider, M., Proneth, B., Tyurina, Y.Y., Tyurin, V.A., Hammond, V.J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat. Cell Biol. 16 (2014), 1180–1191.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 1180-1191
-
-
Friedmann Angeli, J.P.1
Schneider, M.2
Proneth, B.3
Tyurina, Y.Y.4
Tyurin, V.A.5
Hammond, V.J.6
Herbach, N.7
Aichler, M.8
Walch, A.9
Eggenhofer, E.10
-
53
-
-
84869878282
-
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
-
Friedmann-Morvinski, D., Bushong, E.A., Ke, E., Soda, Y., Marumoto, T., Singer, O., Ellisman, M.H., Verma, I.M., Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science 338 (2012), 1080–1084.
-
(2012)
Science
, vol.338
, pp. 1080-1084
-
-
Friedmann-Morvinski, D.1
Bushong, E.A.2
Ke, E.3
Soda, Y.4
Marumoto, T.5
Singer, O.6
Ellisman, M.H.7
Verma, I.M.8
-
54
-
-
84907510557
-
Cytokinesis failure triggers hippo tumor suppressor pathway activation
-
Ganem, N.J., Cornils, H., Chiu, S.Y., O'Rourke, K.P., Arnaud, J., Yimlamai, D., Théry, M., Camargo, F.D., Pellman, D., Cytokinesis failure triggers hippo tumor suppressor pathway activation. Cell 158 (2014), 833–848.
-
(2014)
Cell
, vol.158
, pp. 833-848
-
-
Ganem, N.J.1
Cornils, H.2
Chiu, S.Y.3
O'Rourke, K.P.4
Arnaud, J.5
Yimlamai, D.6
Théry, M.7
Camargo, F.D.8
Pellman, D.9
-
55
-
-
84875740314
-
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
-
Gao, J., Aksoy, B.A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S.O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal., 6, 2013, pl1.
-
(2013)
Sci. Signal.
, vol.6
, pp. pl1
-
-
Gao, J.1
Aksoy, B.A.2
Dogrusoz, U.3
Dresdner, G.4
Gross, B.5
Sumer, S.O.6
Sun, Y.7
Jacobsen, A.8
Sinha, R.9
Larsson, E.10
-
56
-
-
84982123825
-
Ferroptosis is an autophagic cell death process
-
Gao, M., Monian, P., Pan, Q., Zhang, W., Xiang, J., Jiang, X., Ferroptosis is an autophagic cell death process. Cell Res. 26 (2016), 1021–1032.
-
(2016)
Cell Res.
, vol.26
, pp. 1021-1032
-
-
Gao, M.1
Monian, P.2
Pan, Q.3
Zhang, W.4
Xiang, J.5
Jiang, X.6
-
57
-
-
47949129564
-
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis
-
Garrison, S.P., Jeffers, J.R., Yang, C., Nilsson, J.A., Hall, M.A., Rehg, J.E., Yue, W., Yu, J., Zhang, L., Onciu, M., et al. Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol. Cell. Biol. 28 (2008), 5391–5402.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 5391-5402
-
-
Garrison, S.P.1
Jeffers, J.R.2
Yang, C.3
Nilsson, J.A.4
Hall, M.A.5
Rehg, J.E.6
Yue, W.7
Yu, J.8
Zhang, L.9
Onciu, M.10
-
58
-
-
77956405024
-
Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes
-
Gomes, N.P., Espinosa, J.M., Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle 9 (2010), 3428–3437.
-
(2010)
Cell Cycle
, vol.9
, pp. 3428-3437
-
-
Gomes, N.P.1
Espinosa, J.M.2
-
59
-
-
77952328364
-
Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding
-
Gomes, N.P., Espinosa, J.M., Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes Dev. 24 (2010), 1022–1034.
-
(2010)
Genes Dev.
, vol.24
, pp. 1022-1034
-
-
Gomes, N.P.1
Espinosa, J.M.2
-
60
-
-
77958189253
-
Pathologies associated with the p53 response
-
Gudkov, A.V., Komarova, E.A., Pathologies associated with the p53 response. Cold Spring Harb. Perspect. Biol., 2, 2010, a001180.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
, pp. a001180
-
-
Gudkov, A.V.1
Komarova, E.A.2
-
61
-
-
84938631379
-
Overcoming immunosuppression to enhance a p53MVA vaccine
-
Hardwick, N., Chung, V., Cristea, M., Ellenhorn, J.D., Diamond, D.J., Overcoming immunosuppression to enhance a p53MVA vaccine. OncoImmunology, 3, 2014, e958949.
-
(2014)
OncoImmunology
, vol.3
, pp. e958949
-
-
Hardwick, N.1
Chung, V.2
Cristea, M.3
Ellenhorn, J.D.4
Diamond, D.J.5
-
62
-
-
0027496935
-
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
-
Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K., Elledge, S.J., The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75 (1993), 805–816.
-
(1993)
Cell
, vol.75
, pp. 805-816
-
-
Harper, J.W.1
Adami, G.R.2
Wei, N.3
Keyomarsi, K.4
Elledge, S.J.5
-
63
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt, Y., Maya, R., Kazaz, A., Oren, M., Mdm2 promotes the rapid degradation of p53. Nature 387 (1997), 296–299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
64
-
-
84861308305
-
A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest
-
Hayashi, M.T., Cesare, A.J., Fitzpatrick, J.A., Lazzerini-Denchi, E., Karlseder, J., A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat. Struct. Mol. Biol. 19 (2012), 387–394.
-
(2012)
Nat. Struct. Mol. Biol.
, vol.19
, pp. 387-394
-
-
Hayashi, M.T.1
Cesare, A.J.2
Fitzpatrick, J.A.3
Lazzerini-Denchi, E.4
Karlseder, J.5
-
65
-
-
0037370309
-
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
-
Hemann, M.T., Fridman, J.S., Zilfou, J.T., Hernando, E., Paddison, P.J., Cordon-Cardo, C., Hannon, G.J., Lowe, S.W., An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat. Genet. 33 (2003), 396–400.
-
(2003)
Nat. Genet.
, vol.33
, pp. 396-400
-
-
Hemann, M.T.1
Fridman, J.S.2
Zilfou, J.T.3
Hernando, E.4
Paddison, P.J.5
Cordon-Cardo, C.6
Hannon, G.J.7
Lowe, S.W.8
-
66
-
-
3042601281
-
Suppression of tumorigenesis by the p53 target PUMA
-
Hemann, M.T., Zilfou, J.T., Zhao, Z., Burgess, D.J., Hannon, G.J., Lowe, S.W., Suppression of tumorigenesis by the p53 target PUMA. Proc. Natl. Acad. Sci. USA 101 (2004), 9333–9338.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 9333-9338
-
-
Hemann, M.T.1
Zilfou, J.T.2
Zhao, Z.3
Burgess, D.J.4
Hannon, G.J.5
Lowe, S.W.6
-
67
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda, R., Tanaka, H., Yasuda, H., Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420 (1997), 25–27.
-
(1997)
FEBS Lett.
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
68
-
-
34547620563
-
Divergent evolution of human p53 binding sites: cell cycle versus apoptosis
-
Horvath, M.M., Wang, X., Resnick, M.A., Bell, D.A., Divergent evolution of human p53 binding sites: cell cycle versus apoptosis. PLoS Genet., 3, 2007, e127.
-
(2007)
PLoS Genet.
, vol.3
, pp. e127
-
-
Horvath, M.M.1
Wang, X.2
Resnick, M.A.3
Bell, D.A.4
-
69
-
-
84926068205
-
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation
-
Houlihan, S.L., Feng, Y., The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. eLife, 3, 2014, e03297.
-
(2014)
eLife
, vol.3
, pp. e03297
-
-
Houlihan, S.L.1
Feng, Y.2
-
70
-
-
84976645701
-
Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells
-
Itahana, Y., Zhang, J., Göke, J., Vardy, L.A., Han, R., Iwamoto, K., Cukuroglu, E., Robson, P., Pouladi, M.A., Colman, A., Itahana, K., Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells. Sci. Rep., 6, 2016, 28112.
-
(2016)
Sci. Rep.
, vol.6
, pp. 28112
-
-
Itahana, Y.1
Zhang, J.2
Göke, J.3
Vardy, L.A.4
Han, R.5
Iwamoto, K.6
Cukuroglu, E.7
Robson, P.8
Pouladi, M.A.9
Colman, A.10
Itahana, K.11
-
71
-
-
0035158704
-
Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
-
Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., Jaenisch, R., Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation. Nat. Genet. 27 (2001), 31–39.
-
(2001)
Nat. Genet.
, vol.27
, pp. 31-39
-
-
Jackson-Grusby, L.1
Beard, C.2
Possemato, R.3
Tudor, M.4
Fambrough, D.5
Csankovszki, G.6
Dausman, J.7
Lee, P.8
Wilson, C.9
Lander, E.10
Jaenisch, R.11
-
72
-
-
80054736586
-
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages
-
Jiang, D., Brady, C.A., Johnson, T.M., Lee, E.Y., Park, E.J., Scott, M.P., Attardi, L.D., Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc. Natl. Acad. Sci. USA 108 (2011), 17123–17128.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 17123-17128
-
-
Jiang, D.1
Brady, C.A.2
Johnson, T.M.3
Lee, E.Y.4
Park, E.J.5
Scott, M.P.6
Attardi, L.D.7
-
73
-
-
84873678601
-
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
-
Jiang, P., Du, W., Mancuso, A., Wellen, K.E., Yang, X., Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493 (2013), 689–693.
-
(2013)
Nature
, vol.493
, pp. 689-693
-
-
Jiang, P.1
Du, W.2
Mancuso, A.3
Wellen, K.E.4
Yang, X.5
-
74
-
-
84926387317
-
Ferroptosis as a p53-mediated activity during tumour suppression
-
Jiang, L., Kon, N., Li, T., Wang, S.J., Su, T., Hibshoosh, H., Baer, R., Gu, W., Ferroptosis as a p53-mediated activity during tumour suppression. Nature 520 (2015), 57–62.
-
(2015)
Nature
, vol.520
, pp. 57-62
-
-
Jiang, L.1
Kon, N.2
Li, T.3
Wang, S.J.4
Su, T.5
Hibshoosh, H.6
Baer, R.7
Gu, W.8
-
75
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B., Craig, R.W., Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51 (1991), 6304–6311.
-
(1991)
Cancer Res.
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
Vogelstein, B.4
Craig, R.W.5
-
76
-
-
84875804444
-
Suppression of host p53 is critical for Plasmodium liver-stage infection
-
Kaushansky, A., Ye, A.S., Austin, L.S., Mikolajczak, S.A., Vaughan, A.M., Camargo, N., Metzger, P.G., Douglass, A.N., MacBeath, G., Kappe, S.H., Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Rep. 3 (2013), 630–637.
-
(2013)
Cell Rep.
, vol.3
, pp. 630-637
-
-
Kaushansky, A.1
Ye, A.S.2
Austin, L.S.3
Mikolajczak, S.A.4
Vaughan, A.M.5
Camargo, N.6
Metzger, P.G.7
Douglass, A.N.8
MacBeath, G.9
Kappe, S.H.10
-
77
-
-
84880713203
-
p53 regulates glucose metabolism by miR-34a
-
Kim, H.R., Roe, J.S., Lee, J.E., Cho, E.J., Youn, H.D., p53 regulates glucose metabolism by miR-34a. Biochem. Biophys. Res. Commun. 437 (2013), 225–231.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.437
, pp. 225-231
-
-
Kim, H.R.1
Roe, J.S.2
Lee, J.E.3
Cho, E.J.4
Youn, H.D.5
-
78
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky, V., Yon, M., Dickins, R.A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., Lowe, S.W., Senescence of activated stellate cells limits liver fibrosis. Cell 134 (2008), 657–667.
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
Hearn, S.4
Simon, J.5
Miething, C.6
Yee, H.7
Zender, L.8
Lowe, S.W.9
-
79
-
-
84934281252
-
p53 in survival, death and metabolic health: a lifeguard with a licence to kill
-
Kruiswijk, F., Labuschagne, C.F., Vousden, K.H., p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat. Rev. Mol. Cell Biol. 16 (2015), 393–405.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 393-405
-
-
Kruiswijk, F.1
Labuschagne, C.F.2
Vousden, K.H.3
-
80
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat, M.H., Jones, S.N., Vousden, K.H., Regulation of p53 stability by Mdm2. Nature 387 (1997), 299–303.
-
(1997)
Nature
, vol.387
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
81
-
-
84961912193
-
p53 regulation upon genotoxic stress: intricacies and complexities
-
Kumari, R., Kohli, S., Das, S., p53 regulation upon genotoxic stress: intricacies and complexities. Mol. Cell. Oncol., 1, 2014, e969653.
-
(2014)
Mol. Cell. Oncol.
, vol.1
, pp. e969653
-
-
Kumari, R.1
Kohli, S.2
Das, S.3
-
82
-
-
84860608697
-
Epithelial-mesenchymal transition induced by senescent fibroblasts
-
Laberge, R.M., Awad, P., Campisi, J., Desprez, P.Y., Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron. 5 (2012), 39–44.
-
(2012)
Cancer Microenviron.
, vol.5
, pp. 39-44
-
-
Laberge, R.M.1
Awad, P.2
Campisi, J.3
Desprez, P.Y.4
-
83
-
-
0027109075
-
Cancer. p53, guardian of the genome
-
Lane, D.P., Cancer. p53, guardian of the genome. Nature 358 (1992), 15–16.
-
(1992)
Nature
, vol.358
, pp. 15-16
-
-
Lane, D.P.1
-
84
-
-
0018348655
-
T antigen is bound to a host protein in SV40-transformed cells
-
Lane, D.P., Crawford, L.V., T antigen is bound to a host protein in SV40-transformed cells. Nature 278 (1979), 261–263.
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
85
-
-
77951882016
-
Mdm2 and p53 are highly conserved from placozoans to man
-
Lane, D.P., Cheok, C.F., Brown, C., Madhumalar, A., Ghadessy, F.J., Verma, C., Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle 9 (2010), 540–547.
-
(2010)
Cell Cycle
, vol.9
, pp. 540-547
-
-
Lane, D.P.1
Cheok, C.F.2
Brown, C.3
Madhumalar, A.4
Ghadessy, F.J.5
Verma, C.6
-
86
-
-
77953141743
-
The Mdm2 and p53 genes are conserved in the Arachnids
-
Lane, D.P., Cheok, C.F., Brown, C.J., Madhumalar, A., Ghadessy, F.J., Verma, C., The Mdm2 and p53 genes are conserved in the Arachnids. Cell Cycle 9 (2010), 748–754.
-
(2010)
Cell Cycle
, vol.9
, pp. 748-754
-
-
Lane, D.P.1
Cheok, C.F.2
Brown, C.J.3
Madhumalar, A.4
Ghadessy, F.J.5
Verma, C.6
-
87
-
-
84055199760
-
Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish
-
Lane, D.P., Madhumalar, A., Lee, A.P., Tay, B.H., Verma, C., Brenner, S., Venkatesh, B., Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish. Cell Cycle 10 (2011), 4272–4279.
-
(2011)
Cell Cycle
, vol.10
, pp. 4272-4279
-
-
Lane, D.P.1
Madhumalar, A.2
Lee, A.P.3
Tay, B.H.4
Verma, C.5
Brenner, S.6
Venkatesh, B.7
-
88
-
-
0031931414
-
Characterization of the p53-dependent postmitotic checkpoint following spindle disruption
-
Lanni, J.S., Jacks, T., Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol. Cell. Biol. 18 (1998), 1055–1064.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1055-1064
-
-
Lanni, J.S.1
Jacks, T.2
-
89
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko, O., Prives, C., Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006), 951–961.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
90
-
-
85009724479
-
Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months
-
Leijen, S., van Geel, R.M., Sonke, G.S., de Jong, D., Rosenberg, E.H., Marchetti, S., Pluim, D., van Werkhoven, E., Rose, S., Lee, M.A., et al. Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With TP53-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months. J. Clin. Oncol. 34 (2016), 4354–4361.
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. 4354-4361
-
-
Leijen, S.1
van Geel, R.M.2
Sonke, G.S.3
de Jong, D.4
Rosenberg, E.H.5
Marchetti, S.6
Pluim, D.7
van Werkhoven, E.8
Rose, S.9
Lee, M.A.10
-
91
-
-
84871999134
-
p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs
-
Leonova, K.I., Brodsky, L., Lipchick, B., Pal, M., Novototskaya, L., Chenchik, A.A., Sen, G.C., Komarova, E.A., Gudkov, A.V., p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. Proc. Natl. Acad. Sci. USA 110 (2013), E89–E98.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. E89-E98
-
-
Leonova, K.I.1
Brodsky, L.2
Lipchick, B.3
Pal, M.4
Novototskaya, L.5
Chenchik, A.A.6
Sen, G.C.7
Komarova, E.A.8
Gudkov, A.V.9
-
92
-
-
84969545612
-
P53 and the defenses against genome instability caused by transposons and repetitive elements
-
Levine, A.J., Ting, D.T., Greenbaum, B.D., P53 and the defenses against genome instability caused by transposons and repetitive elements. BioEssays 38 (2016), 508–513.
-
(2016)
BioEssays
, vol.38
, pp. 508-513
-
-
Levine, A.J.1
Ting, D.T.2
Greenbaum, B.D.3
-
93
-
-
85016552990
-
Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response
-
Li, H., Wang, S., Chen, Y., Lǚ, K., Yin, B., Li, S., He, J., Li, C., Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response. Sci. Rep., 7, 2017, 45821.
-
(2017)
Sci. Rep.
, vol.7
, pp. 45821
-
-
Li, H.1
Wang, S.2
Chen, Y.3
Lǚ, K.4
Yin, B.5
Li, S.6
He, J.7
Li, C.8
-
94
-
-
0018760324
-
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer, D.I., Levine, A.J., Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 17 (1979), 43–52.
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.1
Levine, A.J.2
-
95
-
-
0346455759
-
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
-
Liu, G., Parant, J.M., Lang, G., Chau, P., Chavez-Reyes, A., El-Naggar, A.K., Multani, A., Chang, S., Lozano, G., Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat. Genet. 36 (2004), 63–68.
-
(2004)
Nat. Genet.
, vol.36
, pp. 63-68
-
-
Liu, G.1
Parant, J.M.2
Lang, G.3
Chau, P.4
Chavez-Reyes, A.5
El-Naggar, A.K.6
Multani, A.7
Chang, S.8
Lozano, G.9
-
96
-
-
58049216794
-
p53 regulates hematopoietic stem cell quiescence
-
Liu, Y., Elf, S.E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J.M., Deblasio, A., Menendez, S., et al. p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell 4 (2009), 37–48.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 37-48
-
-
Liu, Y.1
Elf, S.E.2
Miyata, Y.3
Sashida, G.4
Liu, Y.5
Huang, G.6
Di Giandomenico, S.7
Lee, J.M.8
Deblasio, A.9
Menendez, S.10
-
97
-
-
84928788044
-
TP53 loss creates therapeutic vulnerability in colorectal cancer
-
Liu, Y., Zhang, X., Han, C., Wan, G., Huang, X., Ivan, C., Jiang, D., Rodriguez-Aguayo, C., Lopez-Berestein, G., Rao, P.H., et al. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature 520 (2015), 697–701.
-
(2015)
Nature
, vol.520
, pp. 697-701
-
-
Liu, Y.1
Zhang, X.2
Han, C.3
Wan, G.4
Huang, X.5
Ivan, C.6
Jiang, D.7
Rodriguez-Aguayo, C.8
Lopez-Berestein, G.9
Rao, P.H.10
-
98
-
-
84962219514
-
Deletions linked to TP53 loss drive cancer through p53-independent mechanisms
-
Liu, Y., Chen, C., Xu, Z., Scuoppo, C., Rillahan, C.D., Gao, J., Spitzer, B., Bosbach, B., Kastenhuber, E.R., Baslan, T., et al. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature 531 (2016), 471–475.
-
(2016)
Nature
, vol.531
, pp. 471-475
-
-
Liu, Y.1
Chen, C.2
Xu, Z.3
Scuoppo, C.4
Rillahan, C.D.5
Gao, J.6
Spitzer, B.7
Bosbach, B.8
Kastenhuber, E.R.9
Baslan, T.10
-
99
-
-
0026801062
-
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
-
Livingstone, L.R., White, A., Sprouse, J., Livanos, E., Jacks, T., Tlsty, T.D., Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70 (1992), 923–935.
-
(1992)
Cell
, vol.70
, pp. 923-935
-
-
Livingstone, L.R.1
White, A.2
Sprouse, J.3
Livanos, E.4
Jacks, T.5
Tlsty, T.D.6
-
100
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., Jacks, T., p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362 (1993), 847–849.
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
101
-
-
0028323294
-
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
-
Lowe, S.W., Jacks, T., Housman, D.E., Ruley, H.E., Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc. Natl. Acad. Sci. USA 91 (1994), 2026–2030.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2026-2030
-
-
Lowe, S.W.1
Jacks, T.2
Housman, D.E.3
Ruley, H.E.4
-
102
-
-
84876291823
-
Non-cell-autonomous tumor suppression by p53
-
Lujambio, A., Akkari, L., Simon, J., Grace, D., Tschaharganeh, D.F., Bolden, J.E., Zhao, Z., Thapar, V., Joyce, J.A., Krizhanovsky, V., Lowe, S.W., Non-cell-autonomous tumor suppression by p53. Cell 153 (2013), 449–460.
-
(2013)
Cell
, vol.153
, pp. 449-460
-
-
Lujambio, A.1
Akkari, L.2
Simon, J.3
Grace, D.4
Tschaharganeh, D.F.5
Bolden, J.E.6
Zhao, Z.7
Thapar, V.8
Joyce, J.A.9
Krizhanovsky, V.10
Lowe, S.W.11
-
103
-
-
84859726248
-
Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
-
Ma, C.X., Cai, S., Li, S., Ryan, C.E., Guo, Z., Schaiff, W.T., Lin, L., Hoog, J., Goiffon, R.J., Prat, A., et al. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. J. Clin. Invest. 122 (2012), 1541–1552.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1541-1552
-
-
Ma, C.X.1
Cai, S.2
Li, S.3
Ryan, C.E.4
Guo, Z.5
Schaiff, W.T.6
Lin, L.7
Hoog, J.8
Goiffon, R.J.9
Prat, A.10
-
104
-
-
84950240143
-
Chromothripsis and kataegis induced by telomere crisis
-
Maciejowski, J., Li, Y., Bosco, N., Campbell, P.J., de Lange, T., Chromothripsis and kataegis induced by telomere crisis. Cell 163 (2015), 1641–1654.
-
(2015)
Cell
, vol.163
, pp. 1641-1654
-
-
Maciejowski, J.1
Li, Y.2
Bosco, N.3
Campbell, P.J.4
de Lange, T.5
-
105
-
-
84879577081
-
p53 integrates host defense and cell fate during bacterial pneumonia
-
Madenspacher, J.H., Azzam, K.M., Gowdy, K.M., Malcolm, K.C., Nick, J.A., Dixon, D., Aloor, J.J., Draper, D.W., Guardiola, J.J., Shatz, M., et al. p53 integrates host defense and cell fate during bacterial pneumonia. J. Exp. Med. 210 (2013), 891–904.
-
(2013)
J. Exp. Med.
, vol.210
, pp. 891-904
-
-
Madenspacher, J.H.1
Azzam, K.M.2
Gowdy, K.M.3
Malcolm, K.C.4
Nick, J.A.5
Dixon, D.6
Aloor, J.J.7
Draper, D.W.8
Guardiola, J.J.9
Shatz, M.10
-
106
-
-
0025633582
-
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
-
Malkin, D., Li, F.P., Strong, L.C., Fraumeni, J.F. Jr., Nelson, C.E., Kim, D.H., Kassel, J., Gryka, M.A., Bischoff, F.Z., Tainsky, M.A., et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250 (1990), 1233–1238.
-
(1990)
Science
, vol.250
, pp. 1233-1238
-
-
Malkin, D.1
Li, F.P.2
Strong, L.C.3
Fraumeni, J.F.4
Nelson, C.E.5
Kim, D.H.6
Kassel, J.7
Gryka, M.A.8
Bischoff, F.Z.9
Tainsky, M.A.10
-
107
-
-
33845611951
-
Modeling the therapeutic efficacy of p53 restoration in tumors
-
Martins, C.P., Brown-Swigart, L., Evan, G.I., Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127 (2006), 1323–1334.
-
(2006)
Cell
, vol.127
, pp. 1323-1334
-
-
Martins, C.P.1
Brown-Swigart, L.2
Evan, G.I.3
-
108
-
-
85012110528
-
Clonal heterogeneity and tumor evolution: past, present, and the future
-
McGranahan, N., Swanton, C., Clonal heterogeneity and tumor evolution: past, present, and the future. Cell 168 (2017), 613–628.
-
(2017)
Cell
, vol.168
, pp. 613-628
-
-
McGranahan, N.1
Swanton, C.2
-
109
-
-
77958481889
-
p53: guardian of reprogramming
-
Menendez, S., Camus, S., Izpisua Belmonte, J.C., p53: guardian of reprogramming. Cell Cycle 9 (2010), 3887–3891.
-
(2010)
Cell Cycle
, vol.9
, pp. 3887-3891
-
-
Menendez, S.1
Camus, S.2
Izpisua Belmonte, J.C.3
-
110
-
-
85020467098
-
The cytidine deaminase APOBEC3 family is subject to transcriptional regulation by p53
-
Menendez, D., Nguyen, T.A., Snipe, J., Resnick, M.A., The cytidine deaminase APOBEC3 family is subject to transcriptional regulation by p53. Mol. Cancer Res. 15 (2017), 735–743.
-
(2017)
Mol. Cancer Res.
, vol.15
, pp. 735-743
-
-
Menendez, D.1
Nguyen, T.A.2
Snipe, J.3
Resnick, M.A.4
-
111
-
-
85019220581
-
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
-
Merkle, F.T., Ghosh, S., Kamitaki, N., Mitchell, J., Avior, Y., Mello, C., Kashin, S., Mekhoubad, S., Ilic, D., Charlton, M., et al. Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations. Nature 545 (2017), 229–233.
-
(2017)
Nature
, vol.545
, pp. 229-233
-
-
Merkle, F.T.1
Ghosh, S.2
Kamitaki, N.3
Mitchell, J.4
Avior, Y.5
Mello, C.6
Kashin, S.7
Mekhoubad, S.8
Ilic, D.9
Charlton, M.10
-
112
-
-
84859103002
-
Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells
-
Messina, R.L., Sanfilippo, M., Vella, V., Pandini, G., Vigneri, P., Nicolosi, M.L., Gianì, F., Vigneri, R., Frasca, F., Reactivation of p53 mutants by prima-1 [corrected] in thyroid cancer cells. Int. J. Cancer 130 (2012), 2259–2270.
-
(2012)
Int. J. Cancer
, vol.130
, pp. 2259-2270
-
-
Messina, R.L.1
Sanfilippo, M.2
Vella, V.3
Pandini, G.4
Vigneri, P.5
Nicolosi, M.L.6
Gianì, F.7
Vigneri, R.8
Frasca, F.9
-
113
-
-
0028335717
-
Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
-
Miyashita, T., Krajewski, S., Krajewska, M., Wang, H.G., Lin, H.K., Liebermann, D.A., Hoffman, B., Reed, J.C., Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9 (1994), 1799–1805.
-
(1994)
Oncogene
, vol.9
, pp. 1799-1805
-
-
Miyashita, T.1
Krajewski, S.2
Krajewska, M.3
Wang, H.G.4
Lin, H.K.5
Liebermann, D.A.6
Hoffman, B.7
Reed, J.C.8
-
114
-
-
78651100119
-
Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
-
Mizuno, H., Spike, B.T., Wahl, G.M., Levine, A.J., Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures. Proc. Natl. Acad. Sci. USA 107 (2010), 22745–22750.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 22745-22750
-
-
Mizuno, H.1
Spike, B.T.2
Wahl, G.M.3
Levine, A.J.4
-
115
-
-
75149175733
-
Regulation of the p53 transcriptional response by structurally diverse core promoters
-
Morachis, J.M., Murawsky, C.M., Emerson, B.M., Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev. 24 (2010), 135–147.
-
(2010)
Genes Dev.
, vol.24
, pp. 135-147
-
-
Morachis, J.M.1
Murawsky, C.M.2
Emerson, B.M.3
-
116
-
-
84862999019
-
Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy
-
Morandell, S., Yaffe, M.B., Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy. Prog. Mol. Biol. Transl. Sci. 110 (2012), 289–314.
-
(2012)
Prog. Mol. Biol. Transl. Sci.
, vol.110
, pp. 289-314
-
-
Morandell, S.1
Yaffe, M.B.2
-
117
-
-
85009250505
-
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer
-
Mu, P., Zhang, Z., Benelli, M., Karthaus, W.R., Hoover, E., Chen, C.C., Wongvipat, J., Ku, S.Y., Gao, D., Cao, Z., et al. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science 355 (2017), 84–88.
-
(2017)
Science
, vol.355
, pp. 84-88
-
-
Mu, P.1
Zhang, Z.2
Benelli, M.3
Karthaus, W.R.4
Hoover, E.5
Chen, C.C.6
Wongvipat, J.7
Ku, S.Y.8
Gao, D.9
Cao, Z.10
-
118
-
-
84896098750
-
Mutant p53 in cancer: new functions and therapeutic opportunities
-
Muller, P.A., Vousden, K.H., Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell 25 (2014), 304–317.
-
(2014)
Cancer Cell
, vol.25
, pp. 304-317
-
-
Muller, P.A.1
Vousden, K.H.2
-
119
-
-
84874786083
-
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
-
Muller, P.A., Trinidad, A.G., Timpson, P., Morton, J.P., Zanivan, S., van den Berghe, P.V., Nixon, C., Karim, S.A., Caswell, P.T., Noll, J.E., et al. Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion. Oncogene 32 (2013), 1252–1265.
-
(2013)
Oncogene
, vol.32
, pp. 1252-1265
-
-
Muller, P.A.1
Trinidad, A.G.2
Timpson, P.3
Morton, J.P.4
Zanivan, S.5
van den Berghe, P.V.6
Nixon, C.7
Karim, S.A.8
Caswell, P.T.9
Noll, J.E.10
-
120
-
-
1242272932
-
The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine
-
Nieto, M., Samper, E., Fraga, M.F., González de Buitrago, G., Esteller, M., Serrano, M., The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine. Oncogene 23 (2004), 735–743.
-
(2004)
Oncogene
, vol.23
, pp. 735-743
-
-
Nieto, M.1
Samper, E.2
Fraga, M.F.3
González de Buitrago, G.4
Esteller, M.5
Serrano, M.6
-
121
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive, K.P., Tuveson, D.A., Ruhe, Z.C., Yin, B., Willis, N.A., Bronson, R.T., Crowley, D., Jacks, T., Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119 (2004), 847–860.
-
(2004)
Cell
, vol.119
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
Yin, B.4
Willis, N.A.5
Bronson, R.T.6
Crowley, D.7
Jacks, T.8
-
122
-
-
77955363995
-
TP53 mutations in human cancers: origins, consequences, and clinical use
-
Olivier, M., Hollstein, M., Hainaut, P., TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harb. Perspect. Biol., 2, 2010, a001008.
-
(2010)
Cold Spring Harb. Perspect. Biol.
, vol.2
, pp. a001008
-
-
Olivier, M.1
Hollstein, M.2
Hainaut, P.3
-
123
-
-
85000460046
-
Emerging non-canonical functions and regulation by p53: p53 and stemness
-
Olivos, D.J., Mayo, L.D., Emerging non-canonical functions and regulation by p53: p53 and stemness. Int. J. Mol. Sci., 17, 2016, 17.
-
(2016)
Int. J. Mol. Sci.
, vol.17
, pp. 17
-
-
Olivos, D.J.1
Mayo, L.D.2
-
124
-
-
85026624819
-
p53 maintains baseline expression of multiple tumor suppressor genes
-
Pappas, K., Xu, J., Zairis, S., Resnick-Silverman, L., Abate, F., Steinbach, N., Ozturk, S., Saal, L.H., Su, T., Cheung, P., et al. p53 maintains baseline expression of multiple tumor suppressor genes. Mol. Cancer Res. 15 (2017), 1051–1062.
-
(2017)
Mol. Cancer Res.
, vol.15
, pp. 1051-1062
-
-
Pappas, K.1
Xu, J.2
Zairis, S.3
Resnick-Silverman, L.4
Abate, F.5
Steinbach, N.6
Ozturk, S.7
Saal, L.H.8
Su, T.9
Cheung, P.10
-
125
-
-
84954480179
-
Targeting oncogenic mutant p53 for cancer therapy
-
Parrales, A., Iwakuma, T., Targeting oncogenic mutant p53 for cancer therapy. Front. Oncol., 5, 2015, 288.
-
(2015)
Front. Oncol.
, vol.5
, pp. 288
-
-
Parrales, A.1
Iwakuma, T.2
-
126
-
-
73649143160
-
A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages
-
Pearson, B.J., Sánchez Alvarado, A., A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development 137 (2010), 213–221.
-
(2010)
Development
, vol.137
, pp. 213-221
-
-
Pearson, B.J.1
Sánchez Alvarado, A.2
-
127
-
-
84933501783
-
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells
-
Pfister, N.T., Fomin, V., Regunath, K., Zhou, J.Y., Zhou, W., Silwal-Pandit, L., Freed-Pastor, W.A., Laptenko, O., Neo, S.P., Bargonetti, J., et al. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 29 (2015), 1298–1315.
-
(2015)
Genes Dev.
, vol.29
, pp. 1298-1315
-
-
Pfister, N.T.1
Fomin, V.2
Regunath, K.3
Zhou, J.Y.4
Zhou, W.5
Silwal-Pandit, L.6
Freed-Pastor, W.A.7
Laptenko, O.8
Neo, S.P.9
Bargonetti, J.10
-
128
-
-
0032549704
-
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
-
Pomerantz, J., Schreiber-Agus, N., Liégeois, N.J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.W., et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92 (1998), 713–723.
-
(1998)
Cell
, vol.92
, pp. 713-723
-
-
Pomerantz, J.1
Schreiber-Agus, N.2
Liégeois, N.J.3
Silverman, A.4
Alland, L.5
Chin, L.6
Potes, J.7
Chen, K.8
Orlow, I.9
Lee, H.W.10
-
129
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle, D.E., Zindy, F., Ashmun, R.A., Sherr, C.J., Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83 (1995), 993–1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
130
-
-
84862907577
-
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
-
Rausch, T., Jones, D.T., Zapatka, M., Stütz, A.M., Zichner, T., Weischenfeldt, J., Jäger, N., Remke, M., Shih, D., Northcott, P.A., et al. Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. Cell 148 (2012), 59–71.
-
(2012)
Cell
, vol.148
, pp. 59-71
-
-
Rausch, T.1
Jones, D.T.2
Zapatka, M.3
Stütz, A.M.4
Zichner, T.5
Weischenfeldt, J.6
Jäger, N.7
Remke, M.8
Shih, D.9
Northcott, P.A.10
-
131
-
-
85014075894
-
The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
-
Ritschka, B., Storer, M., Mas, A., Heinzmann, F., Ortells, M.C., Morton, J.P., Sansom, O.J., Zender, L., Keyes, W.M., The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration. Genes Dev. 31 (2017), 172–183.
-
(2017)
Genes Dev.
, vol.31
, pp. 172-183
-
-
Ritschka, B.1
Storer, M.2
Mas, A.3
Heinzmann, F.4
Ortells, M.C.5
Morton, J.P.6
Sansom, O.J.7
Zender, L.8
Keyes, W.M.9
-
132
-
-
0029978501
-
p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge
-
Roth, J., Dittmer, D., Rea, D., Tartaglia, J., Paoletti, E., Levine, A.J., p53 as a target for cancer vaccines: recombinant canarypox virus vectors expressing p53 protect mice against lethal tumor cell challenge. Proc. Natl. Acad. Sci. USA 93 (1996), 4781–4786.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4781-4786
-
-
Roth, J.1
Dittmer, D.2
Rea, D.3
Tartaglia, J.4
Paoletti, E.5
Levine, A.J.6
-
133
-
-
80055079998
-
The cooperating mutation or “second hit” determines the immunologic visibility toward MYC-induced murine lymphomas
-
Schuster, C., Berger, A., Hoelzl, M.A., Putz, E.M., Frenzel, A., Simma, O., Moritz, N., Hoelbl, A., Kovacic, B., Freissmuth, M., et al. The cooperating mutation or “second hit” determines the immunologic visibility toward MYC-induced murine lymphomas. Blood 118 (2011), 4635–4645.
-
(2011)
Blood
, vol.118
, pp. 4635-4645
-
-
Schuster, C.1
Berger, A.2
Hoelzl, M.A.3
Putz, E.M.4
Frenzel, A.5
Simma, O.6
Moritz, N.7
Hoelbl, A.8
Kovacic, B.9
Freissmuth, M.10
-
134
-
-
79958733630
-
Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition
-
Schvartzman, J.M., Duijf, P.H., Sotillo, R., Coker, C., Benezra, R., Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition. Cancer Cell 19 (2011), 701–714.
-
(2011)
Cancer Cell
, vol.19
, pp. 701-714
-
-
Schvartzman, J.M.1
Duijf, P.H.2
Sotillo, R.3
Coker, C.4
Benezra, R.5
-
135
-
-
84905967017
-
p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state
-
Senturk, S., Yao, Z., Camiolo, M., Stiles, B., Rathod, T., Walsh, A.M., Nemajerova, A., Lazzara, M.J., Altorki, N.K., Krainer, A., et al. p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state. Proc. Natl. Acad. Sci. USA 111 (2014), E3287–E3296.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E3287-E3296
-
-
Senturk, S.1
Yao, Z.2
Camiolo, M.3
Stiles, B.4
Rathod, T.5
Walsh, A.M.6
Nemajerova, A.7
Lazzara, M.J.8
Altorki, N.K.9
Krainer, A.10
-
136
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D., Lowe, S.W., Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 (1997), 593–602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
137
-
-
84865145772
-
The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells
-
Shatz, M., Menendez, D., Resnick, M.A., The human TLR innate immune gene family is differentially influenced by DNA stress and p53 status in cancer cells. Cancer Res. 72 (2012), 3948–3957.
-
(2012)
Cancer Res.
, vol.72
, pp. 3948-3957
-
-
Shatz, M.1
Menendez, D.2
Resnick, M.A.3
-
138
-
-
0026054961
-
A role for both RB and p53 in the regulation of human cellular senescence
-
Shay, J.W., Pereira-Smith, O.M., Wright, W.E., A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196 (1991), 33–39.
-
(1991)
Exp. Cell Res.
, vol.196
, pp. 33-39
-
-
Shay, J.W.1
Pereira-Smith, O.M.2
Wright, W.E.3
-
139
-
-
0030667702
-
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
-
Shieh, S.Y., Ikeda, M., Taya, Y., Prives, C., DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91 (1997), 325–334.
-
(1997)
Cell
, vol.91
, pp. 325-334
-
-
Shieh, S.Y.1
Ikeda, M.2
Taya, Y.3
Prives, C.4
-
140
-
-
80051546278
-
Aberrant expression and mutation-inducing activity of AID in human lung cancer
-
Shinmura, K., Igarashi, H., Goto, M., Tao, H., Yamada, H., Matsuura, S., Tajima, M., Matsuda, T., Yamane, A., Funai, K., et al. Aberrant expression and mutation-inducing activity of AID in human lung cancer. Ann. Surg. Oncol. 18 (2011), 2084–2092.
-
(2011)
Ann. Surg. Oncol.
, vol.18
, pp. 2084-2092
-
-
Shinmura, K.1
Igarashi, H.2
Goto, M.3
Tao, H.4
Yamada, H.5
Matsuura, S.6
Tajima, M.7
Matsuda, T.8
Yamane, A.9
Funai, K.10
-
141
-
-
84994669286
-
TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
-
Shirole, N.H., Pal, D., Kastenhuber, E.R., Senturk, S., Boroda, J., Pisterzi, P., Miller, M., Munoz, G., Anderluh, M., Ladanyi, M., et al. TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions. eLife, 5, 2016, 5.
-
(2016)
eLife
, vol.5
, pp. 5
-
-
Shirole, N.H.1
Pal, D.2
Kastenhuber, E.R.3
Senturk, S.4
Boroda, J.5
Pisterzi, P.6
Miller, M.7
Munoz, G.8
Anderluh, M.9
Ladanyi, M.10
-
142
-
-
84919771811
-
Tumor suppressor p53 alters host cell metabolism to limit Chlamydia trachomatis infection
-
Siegl, C., Prusty, B.K., Karunakaran, K., Wischhusen, J., Rudel, T., Tumor suppressor p53 alters host cell metabolism to limit Chlamydia trachomatis infection. Cell Rep. 9 (2014), 918–929.
-
(2014)
Cell Rep.
, vol.9
, pp. 918-929
-
-
Siegl, C.1
Prusty, B.K.2
Karunakaran, K.3
Wischhusen, J.4
Rudel, T.5
-
143
-
-
84957910884
-
A designed inhibitor of p53 aggregation rescues p53 tumor suppression in ovarian carcinomas
-
Soragni, A., Janzen, D.M., Johnson, L.M., Lindgren, A.G., Thai-Quynh Nguyen, A., Tiourin, E., Soriaga, A.B., Lu, J., Jiang, L., Faull, K.F., et al. A designed inhibitor of p53 aggregation rescues p53 tumor suppression in ovarian carcinomas. Cancer Cell 29 (2016), 90–103.
-
(2016)
Cancer Cell
, vol.29
, pp. 90-103
-
-
Soragni, A.1
Janzen, D.M.2
Johnson, L.M.3
Lindgren, A.G.4
Thai-Quynh Nguyen, A.5
Tiourin, E.6
Soriaga, A.B.7
Lu, J.8
Jiang, L.9
Faull, K.F.10
-
144
-
-
85020860390
-
p53 prohibits propagation of chromosome segregation errors that produce structural aneuploidies
-
Soto, M., Raaijmakers, J.A., Bakker, B., Spierings, D.C.J., Lansdorp, P.M., Foijer, F., Medema, R.H., p53 prohibits propagation of chromosome segregation errors that produce structural aneuploidies. Cell Rep. 19 (2017), 2423–2431.
-
(2017)
Cell Rep.
, vol.19
, pp. 2423-2431
-
-
Soto, M.1
Raaijmakers, J.A.2
Bakker, B.3
Spierings, D.C.J.4
Lansdorp, P.M.5
Foijer, F.6
Medema, R.H.7
-
145
-
-
33751009381
-
Regulation of AIF expression by p53
-
Stambolsky, P., Weisz, L., Shats, I., Klein, Y., Goldfinger, N., Oren, M., Rotter, V., Regulation of AIF expression by p53. Cell Death Differ. 13 (2006), 2140–2149.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 2140-2149
-
-
Stambolsky, P.1
Weisz, L.2
Shats, I.3
Klein, Y.4
Goldfinger, N.5
Oren, M.6
Rotter, V.7
-
146
-
-
84937904208
-
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
-
Steensma, D.P., Bejar, R., Jaiswal, S., Lindsley, R.C., Sekeres, M.A., Hasserjian, R.P., Ebert, B.L., Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. Blood 126 (2015), 9–16.
-
(2015)
Blood
, vol.126
, pp. 9-16
-
-
Steensma, D.P.1
Bejar, R.2
Jaiswal, S.3
Lindsley, R.C.4
Sekeres, M.A.5
Hasserjian, R.P.6
Ebert, B.L.7
-
147
-
-
85018242019
-
p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM
-
Stewart-Ornstein, J., Lahav, G., p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci. Signal., 10, 2017, 10.
-
(2017)
Sci. Signal.
, vol.10
, pp. 10
-
-
Stewart-Ornstein, J.1
Lahav, G.2
-
148
-
-
84924386478
-
Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation
-
Su, D., Wang, X., Campbell, M.R., Song, L., Safi, A., Crawford, G.E., Bell, D.A., Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation. PLoS Genet., 11, 2015, e1004885.
-
(2015)
PLoS Genet.
, vol.11
, pp. e1004885
-
-
Su, D.1
Wang, X.2
Campbell, M.R.3
Song, L.4
Safi, A.5
Crawford, G.E.6
Bell, D.A.7
-
149
-
-
84991694144
-
TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants
-
Sulak, M., Fong, L., Mika, K., Chigurupati, S., Yon, L., Mongan, N.P., Emes, R.D., Lynch, V.J., TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5, 2016, 10.7554/eLife.11994.
-
(2016)
eLife
, vol.5
-
-
Sulak, M.1
Fong, L.2
Mika, K.3
Chigurupati, S.4
Yon, L.5
Mongan, N.P.6
Emes, R.D.7
Lynch, V.J.8
-
150
-
-
84857342600
-
The p53 circuit board
-
Sullivan, K.D., Gallant-Behm, C.L., Henry, R.E., Fraikin, J.L., Espinosa, J.M., The p53 circuit board. Biochim. Biophys. Acta 1825 (2012), 229–244.
-
(2012)
Biochim. Biophys. Acta
, vol.1825
, pp. 229-244
-
-
Sullivan, K.D.1
Gallant-Behm, C.L.2
Henry, R.E.3
Fraikin, J.L.4
Espinosa, J.M.5
-
151
-
-
84921853118
-
ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels
-
Sullivan, K.D., Palaniappan, V.V., Espinosa, J.M., ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle 14 (2015), 56–63.
-
(2015)
Cell Cycle
, vol.14
, pp. 56-63
-
-
Sullivan, K.D.1
Palaniappan, V.V.2
Espinosa, J.M.3
-
152
-
-
62649112876
-
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
-
Sur, S., Pagliarini, R., Bunz, F., Rago, C., Diaz, L.A. Jr., Kinzler, K.W., Vogelstein, B., Papadopoulos, N., A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proc. Natl. Acad. Sci. USA 106 (2009), 3964–3969.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 3964-3969
-
-
Sur, S.1
Pagliarini, R.2
Bunz, F.3
Rago, C.4
Diaz, L.A.5
Kinzler, K.W.6
Vogelstein, B.7
Papadopoulos, N.8
-
153
-
-
79951689086
-
Identification of aneuploidy-selective antiproliferation compounds
-
Tang, Y.C., Williams, B.R., Siegel, J.J., Amon, A., Identification of aneuploidy-selective antiproliferation compounds. Cell 144 (2011), 499–512.
-
(2011)
Cell
, vol.144
, pp. 499-512
-
-
Tang, Y.C.1
Williams, B.R.2
Siegel, J.J.3
Amon, A.4
-
154
-
-
84898043853
-
Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels
-
Thorburn, J., Andrysik, Z., Staskiewicz, L., Gump, J., Maycotte, P., Oberst, A., Green, D.R., Espinosa, J.M., Thorburn, A., Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels. Cell Rep. 7 (2014), 45–52.
-
(2014)
Cell Rep.
, vol.7
, pp. 45-52
-
-
Thorburn, J.1
Andrysik, Z.2
Staskiewicz, L.3
Gump, J.4
Maycotte, P.5
Oberst, A.6
Green, D.R.7
Espinosa, J.M.8
Thorburn, A.9
-
155
-
-
79551642322
-
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers
-
Ting, D.T., Lipson, D., Paul, S., Brannigan, B.W., Akhavanfard, S., Coffman, E.J., Contino, G., Deshpande, V., Iafrate, A.J., Letovsky, S., et al. Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers. Science 331 (2011), 593–596.
-
(2011)
Science
, vol.331
, pp. 593-596
-
-
Ting, D.T.1
Lipson, D.2
Paul, S.3
Brannigan, B.W.4
Akhavanfard, S.5
Coffman, E.J.6
Contino, G.7
Deshpande, V.8
Iafrate, A.J.9
Letovsky, S.10
-
156
-
-
84970946060
-
The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells
-
Tosoni, D., Zecchini, S., Coazzoli, M., Colaluca, I., Mazzarol, G., Rubio, A., Caccia, M., Villa, E., Zilian, O., Di Fiore, P.P., Pece, S., The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells. J. Cell Biol. 211 (2015), 845–862.
-
(2015)
J. Cell Biol.
, vol.211
, pp. 845-862
-
-
Tosoni, D.1
Zecchini, S.2
Coazzoli, M.3
Colaluca, I.4
Mazzarol, G.5
Rubio, A.6
Caccia, M.7
Villa, E.8
Zilian, O.9
Di Fiore, P.P.10
Pece, S.11
-
157
-
-
85021223361
-
p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity
-
Tovy, A., Spiro, A., McCarthy, R., Shipony, Z., Aylon, Y., Allton, K., Ainbinder, E., Furth, N., Tanay, A., Barton, M., Oren, M., p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 31 (2017), 959–972.
-
(2017)
Genes Dev.
, vol.31
, pp. 959-972
-
-
Tovy, A.1
Spiro, A.2
McCarthy, R.3
Shipony, Z.4
Aylon, Y.5
Allton, K.6
Ainbinder, E.7
Furth, N.8
Tanay, A.9
Barton, M.10
Oren, M.11
-
158
-
-
84905377981
-
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer
-
Tschaharganeh, D.F., Xue, W., Calvisi, D.F., Evert, M., Michurina, T.V., Dow, L.E., Banito, A., Katz, S.F., Kastenhuber, E.R., Weissmueller, S., et al. p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell 158 (2014), 579–592.
-
(2014)
Cell
, vol.158
, pp. 579-592
-
-
Tschaharganeh, D.F.1
Xue, W.2
Calvisi, D.F.3
Evert, M.4
Michurina, T.V.5
Dow, L.E.6
Banito, A.7
Katz, S.F.8
Kastenhuber, E.R.9
Weissmueller, S.10
-
159
-
-
84975230962
-
Coordinated tumor suppression by chromosome 8p
-
Tschaharganeh, D.F., Bosbach, B., Lowe, S.W., Coordinated tumor suppression by chromosome 8p. Cancer Cell 29 (2016), 617–619.
-
(2016)
Cancer Cell
, vol.29
, pp. 617-619
-
-
Tschaharganeh, D.F.1
Bosbach, B.2
Lowe, S.W.3
-
160
-
-
84905900534
-
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
-
Tubio, J.M.C., Li, Y., Ju, Y.S., Martincorena, I., Cooke, S.L., Tojo, M., Gundem, G., Pipinikas, C.P., Zamora, J., Raine, K., et al. ICGC Breast Cancer Group ICGC Bone Cancer Group, ICGC Prostate Cancer Group. Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. Science, 345, 2014, 1251343.
-
(2014)
Science
, vol.345
, pp. 1251343
-
-
Tubio, J.M.C.1
Li, Y.2
Ju, Y.S.3
Martincorena, I.4
Cooke, S.L.5
Tojo, M.6
Gundem, G.7
Pipinikas, C.P.8
Zamora, J.9
Raine, K.10
-
161
-
-
84878546043
-
p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa
-
Valente, L.J., Gray, D.H., Michalak, E.M., Pinon-Hofbauer, J., Egle, A., Scott, C.L., Janic, A., Strasser, A., p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa. Cell Rep. 3 (2013), 1339–1345.
-
(2013)
Cell Rep.
, vol.3
, pp. 1339-1345
-
-
Valente, L.J.1
Gray, D.H.2
Michalak, E.M.3
Pinon-Hofbauer, J.4
Egle, A.5
Scott, C.L.6
Janic, A.7
Strasser, A.8
-
162
-
-
0036093592
-
Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine
-
van der Burg, S.H., Menon, A.G., Redeker, A., Bonnet, M.C., Drijfhout, J.W., Tollenaar, R.A., van de Velde, C.J., Moingeon, P., Kuppen, P.J., Offringa, R., Melief, C.J., Induction of p53-specific immune responses in colorectal cancer patients receiving a recombinant ALVAC-p53 candidate vaccine. Clin. Cancer Res. 8 (2002), 1019–1027.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1019-1027
-
-
van der Burg, S.H.1
Menon, A.G.2
Redeker, A.3
Bonnet, M.C.4
Drijfhout, J.W.5
Tollenaar, R.A.6
van de Velde, C.J.7
Moingeon, P.8
Kuppen, P.J.9
Offringa, R.10
Melief, C.J.11
-
163
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev, L.T., Vu, B.T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004), 844–848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
-
164
-
-
84925538910
-
IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo
-
Venkatanarayan, A., Raulji, P., Norton, W., Chakravarti, D., Coarfa, C., Su, X., Sandur, S.K., Ramirez, M.S., Lee, J., Kingsley, C.V., et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature 517 (2015), 626–630.
-
(2015)
Nature
, vol.517
, pp. 626-630
-
-
Venkatanarayan, A.1
Raulji, P.2
Norton, W.3
Chakravarti, D.4
Coarfa, C.5
Su, X.6
Sandur, S.K.7
Ramirez, M.S.8
Lee, J.9
Kingsley, C.V.10
-
165
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura, A., Kirsch, D.G., McLaughlin, M.E., Tuveson, D.A., Grimm, J., Lintault, L., Newman, J., Reczek, E.E., Weissleder, R., Jacks, T., Restoration of p53 function leads to tumour regression in vivo. Nature 445 (2007), 661–665.
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
166
-
-
77950531729
-
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
-
Vitale, I., Senovilla, L., Jemaà, M., Michaud, M., Galluzzi, L., Kepp, O., Nanty, L., Criollo, A., Rello-Varona, S., Manic, G., et al. Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos. EMBO J. 29 (2010), 1272–1284.
-
(2010)
EMBO J.
, vol.29
, pp. 1272-1284
-
-
Vitale, I.1
Senovilla, L.2
Jemaà, M.3
Michaud, M.4
Galluzzi, L.5
Kepp, O.6
Nanty, L.7
Criollo, A.8
Rello-Varona, S.9
Manic, G.10
-
167
-
-
84871935248
-
Centrosomes, chromosome instability (CIN) and aneuploidy
-
Vitre, B.D., Cleveland, D.W., Centrosomes, chromosome instability (CIN) and aneuploidy. Curr. Opin. Cell Biol. 24 (2012), 809–815.
-
(2012)
Curr. Opin. Cell Biol.
, vol.24
, pp. 809-815
-
-
Vitre, B.D.1
Cleveland, D.W.2
-
168
-
-
79952234403
-
Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
-
Wang, Y., Suh, Y.A., Fuller, M.Y., Jackson, J.G., Xiong, S., Terzian, T., Quintás-Cardama, A., Bankson, J.A., El-Naggar, A.K., Lozano, G., Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J. Clin. Invest. 121 (2011), 893–904.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 893-904
-
-
Wang, Y.1
Suh, Y.A.2
Fuller, M.Y.3
Jackson, J.G.4
Xiong, S.5
Terzian, T.6
Quintás-Cardama, A.7
Bankson, J.A.8
El-Naggar, A.K.9
Lozano, G.10
-
169
-
-
84874962987
-
Increased oxidative metabolism in the Li-Fraumeni syndrome
-
Wang, P.Y., Ma, W., Park, J.Y., Celi, F.S., Arena, R., Choi, J.W., Ali, Q.A., Tripodi, D.J., Zhuang, J., Lago, C.U., et al. Increased oxidative metabolism in the Li-Fraumeni syndrome. N. Engl. J. Med. 368 (2013), 1027–1032.
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 1027-1032
-
-
Wang, P.Y.1
Ma, W.2
Park, J.Y.3
Celi, F.S.4
Arena, R.5
Choi, J.W.6
Ali, Q.A.7
Tripodi, D.J.8
Zhuang, J.9
Lago, C.U.10
-
170
-
-
85007227714
-
The p53 family coordinates Wnt and nodal inputs in mesendodermal differentiation of embryonic stem cells
-
Wang, Q., Zou, Y., Nowotschin, S., Kim, S.Y., Li, Q.V., Soh, C.L., Su, J., Zhang, C., Shu, W., Xi, Q., et al. The p53 family coordinates Wnt and nodal inputs in mesendodermal differentiation of embryonic stem cells. Cell Stem Cell 20 (2017), 70–86.
-
(2017)
Cell Stem Cell
, vol.20
, pp. 70-86
-
-
Wang, Q.1
Zou, Y.2
Nowotschin, S.3
Kim, S.Y.4
Li, Q.V.5
Soh, C.L.6
Su, J.7
Zhang, C.8
Shu, W.9
Xi, Q.10
-
171
-
-
84898614449
-
Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling
-
Weissmueller, S., Manchado, E., Saborowski, M., Morris, J.P. 4th, Wagenblast, E., Davis, C.A., Moon, S.H., Pfister, N.T., Tschaharganeh, D.F., Kitzing, T., et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Cell 157 (2014), 382–394.
-
(2014)
Cell
, vol.157
, pp. 382-394
-
-
Weissmueller, S.1
Manchado, E.2
Saborowski, M.3
Morris, J.P.4
Wagenblast, E.5
Davis, C.A.6
Moon, S.H.7
Pfister, N.T.8
Tschaharganeh, D.F.9
Kitzing, T.10
-
172
-
-
84996615311
-
TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes
-
Welch, J.S., Petti, A.A., Miller, C.A., Fronick, C.C., O'Laughlin, M., Fulton, R.S., Wilson, R.K., Baty, J.D., Duncavage, E.J., Tandon, B., et al. TP53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes. N. Engl. J. Med. 375 (2016), 2023–2036.
-
(2016)
N. Engl. J. Med.
, vol.375
, pp. 2023-2036
-
-
Welch, J.S.1
Petti, A.A.2
Miller, C.A.3
Fronick, C.C.4
O'Laughlin, M.5
Fulton, R.S.6
Wilson, R.K.7
Baty, J.D.8
Duncavage, E.J.9
Tandon, B.10
-
173
-
-
84964956080
-
p53 in the DNA-damage-repair process
-
Williams, A.B., Schumacher, B., p53 in the DNA-damage-repair process. Cold Spring Harb. Perspect. Med., 6, 2016, 6.
-
(2016)
Cold Spring Harb. Perspect. Med.
, vol.6
, pp. 6
-
-
Williams, A.B.1
Schumacher, B.2
-
174
-
-
84925518008
-
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
-
Wong, T.N., Ramsingh, G., Young, A.L., Miller, C.A., Touma, W., Welch, J.S., Lamprecht, T.L., Shen, D., Hundal, J., Fulton, R.S., et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature 518 (2015), 552–555.
-
(2015)
Nature
, vol.518
, pp. 552-555
-
-
Wong, T.N.1
Ramsingh, G.2
Young, A.L.3
Miller, C.A.4
Touma, W.5
Welch, J.S.6
Lamprecht, T.L.7
Shen, D.8
Hundal, J.9
Fulton, R.S.10
-
175
-
-
84898723119
-
p53 activity is selectively licensed in the Drosophila stem cell compartment
-
Wylie, A., Lu, W.J., D'Brot, A., Buszczak, M., Abrams, J.M., p53 activity is selectively licensed in the Drosophila stem cell compartment. eLife, 3, 2014, e01530.
-
(2014)
eLife
, vol.3
, pp. e01530
-
-
Wylie, A.1
Lu, W.J.2
D'Brot, A.3
Buszczak, M.4
Abrams, J.M.5
-
176
-
-
84953426050
-
p53 genes function to restrain mobile elements
-
Wylie, A., Jones, A.E., D'Brot, A., Lu, W.J., Kurtz, P., Moran, J.V., Rakheja, D., Chen, K.S., Hammer, R.E., Comerford, S.A., et al. p53 genes function to restrain mobile elements. Genes Dev. 30 (2016), 64–77.
-
(2016)
Genes Dev.
, vol.30
, pp. 64-77
-
-
Wylie, A.1
Jones, A.E.2
D'Brot, A.3
Lu, W.J.4
Kurtz, P.5
Moran, J.V.6
Rakheja, D.7
Chen, K.S.8
Hammer, R.E.9
Comerford, S.A.10
-
177
-
-
84930003179
-
Age-related mutations associated with clonal hematopoietic expansion and malignancies
-
Xie, M., Lu, C., Wang, J., McLellan, M.D., Johnson, K.J., Wendl, M.C., McMichael, J.F., Schmidt, H.K., Yellapantula, V., Miller, C.A., et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20 (2014), 1472–1478.
-
(2014)
Nat. Med.
, vol.20
, pp. 1472-1478
-
-
Xie, M.1
Lu, C.2
Wang, J.3
McLellan, M.D.4
Johnson, K.J.5
Wendl, M.C.6
McMichael, J.F.7
Schmidt, H.K.8
Yellapantula, V.9
Miller, C.A.10
-
178
-
-
84902671592
-
Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations
-
Xu, J., Qian, J., Hu, Y., Wang, J., Zhou, X., Chen, H., Fang, J.Y., Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations. Sci. Rep., 4, 2014, 4223.
-
(2014)
Sci. Rep.
, vol.4
, pp. 4223
-
-
Xu, J.1
Qian, J.2
Hu, Y.3
Wang, J.4
Zhou, X.5
Chen, H.6
Fang, J.Y.7
-
179
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue, W., Zender, L., Miething, C., Dickins, R.A., Hernando, E., Krizhanovsky, V., Cordon-Cardo, C., Lowe, S.W., Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445 (2007), 656–660.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
Cordon-Cardo, C.7
Lowe, S.W.8
-
180
-
-
0026801977
-
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
-
Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L.C., Wahl, G.M., Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70 (1992), 937–948.
-
(1992)
Cell
, vol.70
, pp. 937-948
-
-
Yin, Y.1
Tainsky, M.A.2
Bischoff, F.Z.3
Strong, L.C.4
Wahl, G.M.5
-
181
-
-
0025784539
-
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
-
Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A., Oren, M., Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352 (1991), 345–347.
-
(1991)
Nature
, vol.352
, pp. 345-347
-
-
Yonish-Rouach, E.1
Resnitzky, D.2
Lotem, J.3
Sachs, L.4
Kimchi, A.5
Oren, M.6
-
182
-
-
64349123107
-
Autophagy mediates the mitotic senescence transition
-
Young, A.R., Narita, M., Ferreira, M., Kirschner, K., Sadaie, M., Darot, J.F., Tavaré, S., Arakawa, S., Shimizu, S., Watt, F.M., Narita, M., Autophagy mediates the mitotic senescence transition. Genes Dev. 23 (2009), 798–803.
-
(2009)
Genes Dev.
, vol.23
, pp. 798-803
-
-
Young, A.R.1
Narita, M.2
Ferreira, M.3
Kirschner, K.4
Sadaie, M.5
Darot, J.F.6
Tavaré, S.7
Arakawa, S.8
Shimizu, S.9
Watt, F.M.10
Narita, M.11
-
183
-
-
84861368058
-
Allele-specific p53 mutant reactivation
-
Yu, X., Vazquez, A., Levine, A.J., Carpizo, D.R., Allele-specific p53 mutant reactivation. Cancer Cell 21 (2012), 614–625.
-
(2012)
Cancer Cell
, vol.21
, pp. 614-625
-
-
Yu, X.1
Vazquez, A.2
Levine, A.J.3
Carpizo, D.R.4
-
184
-
-
84886399680
-
Regulation of p53 is critical for vertebrate limb regeneration
-
Yun, M.H., Gates, P.B., Brockes, J.P., Regulation of p53 is critical for vertebrate limb regeneration. Proc. Natl. Acad. Sci. USA 110 (2013), 17392–17397.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 17392-17397
-
-
Yun, M.H.1
Gates, P.B.2
Brockes, J.P.3
-
185
-
-
84873081589
-
Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial
-
Zeestraten, E.C., Speetjens, F.M., Welters, M.J., Saadatmand, S., Stynenbosch, L.F., Jongen, R., Kapiteijn, E., Gelderblom, H., Nijman, H.W., Valentijn, A.R., et al. Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial. Int. J. Cancer 132 (2013), 1581–1591.
-
(2013)
Int. J. Cancer
, vol.132
, pp. 1581-1591
-
-
Zeestraten, E.C.1
Speetjens, F.M.2
Welters, M.J.3
Saadatmand, S.4
Stynenbosch, L.F.5
Jongen, R.6
Kapiteijn, E.7
Gelderblom, H.8
Nijman, H.W.9
Valentijn, A.R.10
-
186
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang, Y., Xiong, Y., Yarbrough, W.G., ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92 (1998), 725–734.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
187
-
-
84890695935
-
Tumour-associated mutant p53 drives the Warburg effect
-
Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A.J., et al. Tumour-associated mutant p53 drives the Warburg effect. Nat. Commun., 4, 2013, 2935.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2935
-
-
Zhang, C.1
Liu, J.2
Liang, Y.3
Wu, R.4
Zhao, Y.5
Hong, X.6
Lin, M.7
Yu, H.8
Liu, L.9
Levine, A.J.10
-
188
-
-
77954464666
-
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
-
Zhao, Z., Zuber, J., Diaz-Flores, E., Lintault, L., Kogan, S.C., Shannon, K., Lowe, S.W., p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes Dev 24 (2010), 1389–1402.
-
(2010)
Genes Dev
, vol.24
, pp. 1389-1402
-
-
Zhao, Z.1
Zuber, J.2
Diaz-Flores, E.3
Lintault, L.4
Kogan, S.C.5
Shannon, K.6
Lowe, S.W.7
-
189
-
-
84941220446
-
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
-
Zhu, J., Sammons, M.A., Donahue, G., Dou, Z., Vedadi, M., Getlik, M., Barsyte-Lovejoy, D., Al-awar, R., Katona, B.W., Shilatifard, A., et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature 525 (2015), 206–211.
-
(2015)
Nature
, vol.525
, pp. 206-211
-
-
Zhu, J.1
Sammons, M.A.2
Donahue, G.3
Dou, Z.4
Vedadi, M.5
Getlik, M.6
Barsyte-Lovejoy, D.7
Al-awar, R.8
Katona, B.W.9
Shilatifard, A.10
|