Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

Nature

Volumn 518, Issue 7540, 2015, Pages 552-555

  Wong, Terrence N ^a   Ramsingh, Giridharan ^b   Young, Andrew L ^c   Miller, Christopher A ^a   Touma, Waseem ^a,d   Welch, John S ^a   Lamprecht, Tamara L ^e   Shen, Dong ^a   Hundal, Jasreet ^a   Fulton, Robert S ^a   Heath, Sharon ^c   Baty, Jack D ^a,d   Klco, Jeffery M ^a,c,d   Ding, Li ^a,d   Mardis, Elaine R ^a,d   Westervelt, Peter ^a,d   Dipersio, John F ^a,d   Walter, Matthew J ^a,d   Graubert, Timothy A ^a,d   Ley, Timothy J ^a,d   Druley, Todd E ^c   Link, Daniel C ^a,d   Wilson, Richard K ^a,c,d   more..

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d USA   (United States)

^e ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ETHYLNITROSOUREA;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; AGED; ANIMAL TISSUE; ARTICLE; BONE MARROW; CANCER PATIENT; CANCER PROGNOSIS; CANCER RESISTANCE; CLONAL EVOLUTION; CONTROLLED STUDY; DNA DAMAGE; DRUG INDUCED CANCER; FEMALE; GENE DISRUPTION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME ANALYSIS; HEMATOPOIETIC STEM CELL; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN TISSUE; LEUKEMOGENESIS; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOUSE; MUTATION RATE; MUTATOR GENE; MYELODYSPLASTIC SYNDROME; NONHUMAN; NORMAL HUMAN; PATIENT HISTORY OF CHEMOTHERAPY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RADIATION INDUCED NEOPLASM; SINGLE NUCLEOTIDE POLYMORPHISM; STEM CELL EXPANSION; THERAPY RELATED ACUTE MYELOID LEUKAEMIA; THERAPY RELATED MYELODYSPLASTIC SYNDROME; TP53 GENE; TUMOR GENE; WILD TYPE; ALLELE; ANIMAL; BIOLOGICAL MODEL; CELL CLONE; CELL LINEAGE; CELL PROLIFERATION; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; METABOLISM; MOLECULAR EVOLUTION; MUTATION; PATHOLOGY; TUMOR SUPPRESSOR GENE;

ALLELES; ANIMALS; CELL LINEAGE; CELL PROLIFERATION; CLONE CELLS; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; ETHYLNITROSOUREA; EVOLUTION, MOLECULAR; GENES, P53; HEMATOPOIETIC STEM CELLS; HETEROZYGOTE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MODELS, GENETIC; MUTATION;

EID: 84925518008     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13968     Document Type: Article

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