Regulation of p53 is critical for vertebrate limb regeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 43, 2013, Pages 17392-17397

  Yun, Maximina H ^a   Gates, Phillip B ^a   Brockes, Jeremy P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Carcinogenesis; Chondrogenesis; Myogenesis; P73

Indexed keywords

DELTA NP73 PROTEIN; PROTEIN P53; PROTEIN P73; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLASTEMA; CELL CYCLE REGULATION; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CELL FATE; CELL REDIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; LIMB REGENERATION; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SALAMANDER; UPREGULATION; VERTEBRATE;

CARCINOGENESIS; CHONDROGENESIS; MYOGENESIS; P73;

AMBYSTOMA MEXICANUM; ANIMALS; BLOTTING, WESTERN; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DNA-BINDING PROTEINS; EXTREMITIES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; LUCIFERASES; MICROSCOPY, FLUORESCENCE; MUSCLE FIBERS, SKELETAL; NUCLEAR PROTEINS; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS; VERTEBRATES;

EID: 84886399680     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1310519110     Document Type: Article

References (53)

1. Brockes JP, Kumar A (2008) Comparative aspects of animal regeneration. Annu Rev Cell Dev Biol 24:525-549.
2. Brockes JP, Kumar A (2002) Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nat Rev Mol Cell Biol 3(8):566-574.
3. Kragl M, et al. (2009) Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460(7251):60-65.
4. Stewart R, et al. (2013) Comparative RNA-seq analysis in the unsequenced axolotl: The oncogene burst highlights early gene expression in the blastema. PLOS Comput Biol 9(3):e1002936.
5. Hay ED, Fischman DA (1961) Origin of the blastema in regenerating limbs of the newt Triturus viridescens. An autoradiographic study using tritiated thymidine to follow cell proliferation and migration. Dev Biol 3:26-59.
6. Kumar A, Velloso CP, Imokawa Y, Brockes JP (2000) Plasticity of retrovirus-labelled myotubes in the newt limb regeneration blastema. Dev Biol 218(2):125-136.
7. Lo DC, Allen F, Brockes JP (1993) Reversal of muscle differentiation during urodele limb regeneration. Proc Natl Acad Sci USA 90(15):7230-7234.
8. Steen TP (1968) Stability of chondrocyte differentiation and contribution of muscle to cartilage during limb regeneration in the axolotl (Siredon mexicanum). J Exp Zool 167(1):49-78.
9. Jopling C, et al. (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464(7288):606-609.
10. Knopf F, et al. (2011) Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell 20(5):713-724.
11. Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM (2010) Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell 7(2):198-213.
12. Vousden KH (2000) p53: Death star. Cell 103(5):691-694.
13. Hong H, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460(7259):1132-1135.
14. Kawamura T, et al. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460(7259):1140-1144.
15. Li H, et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460(7259):1136-1139.
16. Utikal J, et al. (2009) Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460(7259):1145-1148.
17. Zhao Y, et al. (2008) Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell 3(5):475-479.
18. Molchadsky A, Rivlin N, Brosh R, Rotter V, Sarig R (2010) p53 is balancing development, differentiation and de-differentiation to assure cancer prevention. Carcinogenesis 31(9):1501-1508.
19. Villiard E, et al. (2007) Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC Evol Biol 7:180.
20. Oren M (1999) Regulation of the p53 tumor suppressor protein. J Biol Chem 274(51): 36031-36034.
21. Riley T, Sontag E, Chen P, Levine A (2008) Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol 9(5):402-412.
22. Komarov PG, et al. (1999) A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285(5434):1733-1737.
23. Vassilev LT, et al. (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303(5659):844-848.
24. Tanaka EM, Gann AA, Gates PB, Brockes JP (1997) Newt myotubes reenter the cell cycle by phosphorylation of the retinoblastoma protein. J Cell Biol 136(1):155-165.
25. Walsh K, Perlman H (1997) Cell cycle exit upon myogenic differentiation. Curr Opin Genet Dev 7(5):597-602.
26. Brandt T, Petrovich M, Joerger AC, Veprintsev DB (2009) Conservation of DNA-binding specificity and oligomerisation properties within the p53 family. BMC Genomics 10:628.
27. Lu X (2010) Tied up in loops: Positive and negative autoregulation of p53. Cold Spring Harb Perspect Biol 2(5):a000984.
28. Cam H, et al. (2006) p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell 10(4):281-293.
29. Pozniak CD, et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289(5477):304-306.
30. Stiewe T, Theseling CC, Pützer BM (2002) Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: Implications for tumorigenesis. J Biol Chem 277(16):14177-14185.
31. Stiewe T, Zimmermann S, Frilling A, Esche H, Pützer BM (2002) Transactivationdeficient DeltaTA-p73 acts as an oncogene. Cancer Res 62(13):3598-3602.
32. Das B, et al. (2012) HIF-2α suppresses p53 to enhance the stemness and regenerative potential of human embryonic stem cells. Stem Cells 30(8):1685-1695.
33. Sasai N, Yakura R, Kamiya D, Nakazawa Y, Sasai Y (2008) Ectodermal factor restricts mesoderm differentiation by inhibiting p53. Cell 133(5):878-890.
34. Lee DF, et al. (2012) Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell 11(2):179-194.
35. Odelberg SJ (2004) Unraveling the molecular basis for regenerative cellular plasticity. PLoS Biol 2(8):E232.
36. Tao W, Levine AJ (1999) P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci USA 96(12):6937-6941.
37. Weber JD, Taylor LJ, Roussel MF, Sherr CJ, Bar-Sagi D (1999) Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol 1(1):20-26.
38. Bedelbaeva K, et al. (2010) Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc Natl Acad Sci USA 107(13):5845-5850.
39. Bensaad K, Rouillard D, Soussi T (2001) Regulation of the cell cycle by p53 after DNA damage in an amphibian cell line. Oncogene 20(29):3766-3775.
40. Pearson BJ, Sánchez Alvarado A (2010) A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development 137(2):213-221.
41. Brockes JP, Kumar A, Velloso CP (2001) Regeneration as an evolutionary variable. J Anat 199(Pt 1-2):3-11.
42. Tanaka EM, Reddien PW (2011) The cellular basis for animal regeneration. Dev Cell 21(1):172-185.
43. Donehower LA, et al. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356(6366):215-221.
44. White JD, Rachel C, Vermeulen R, Davies M, Grounds MD (2002) The role of p53 in vivo during skeletal muscle post-natal development and regeneration: Studies in p53 knockout mice. Int J Dev Biol 46(4):577-582.
45. Stiewe T (2007) The p53 family in differentiation and tumorigenesis. Nat Rev Cancer 7(3):165-168.
46. Wallingford JB, Seufert DW, Virta VC, Vize PD (1997) p53 activity is essential for normal development in Xenopus. Curr Biol 7(10):747-757.
47. Cerone MA, et al. (2000) p53 is involved in the differentiation but not in the differentiation-associated apoptosis of myoblasts. Cell Death Differ 7(5):506-508.
48. Soddu S, et al. (1996) Interference with p53 protein inhibits hematopoietic and muscle differentiation. J Cell Biol 134(1):193-204.
49. Mazzaro G, Bossi G, Coen S, Sacchi A, Soddu S (1999) The role of wild-type p53 in the differentiation of primary hemopoietic and muscle cells. Oncogene 18(42):5831-5835.
50. Porrello A, et al. (2000) p53 regulates myogenesis by triggering the differentiation activity of pRb. J Cell Biol 151(6):1295-1304.
51. Hirai H, et al. (2010) Post-mitotic role of nucleostemin as a promoter of skeletal muscle cell differentiation. Biochem Biophys Res Commun 391(1):299-304.
52. Lin Y, Cheng Z, Yang Z, Zheng J, Lin T (2012) DNp73 improves generation efficiency of human induced pluripotent stem cells. BMC Cell Biol 13:9.
53. Kim D, Song J, Jin EJ (2010) MicroRNA-221 regulates chondrogenic differentiation through promoting proteosomal degradation of slug by targeting Mdm2. J Biol Chem 285(35):26900-26907.