SOX2 promotes lineage plasticity and antiandrogen resistance in TP53-and RB1-deficient prostate cancer

Science

Volumn 355, Issue 6320, 2017, Pages

  Mu, Ping ^a   Zhang, Zeda ^a   Benelli, Matteo ^b   Karthaus, Wouter R ^a   Hoover, Elizabeth ^a   Chen, Chi Chao ^a,c   Wongvipat, John ^a   Ku, Sheng Yu ^d   Gao, Dong ^a   Cao, Zhen ^a,c   Shah, Neel ^a   Adams, Elizabeth J ^a   Abida, Wassim ^a   Watson, Philip A ^a   Prandi, Davide ^b   Huang, Chun Hao ^a,c   De Stanchina, Elisa ^a   Lowe, Scott W ^a,c,e   Ellis, Leigh ^d   Beltran, Himisha ^f,g   Rubin, Mark A ^f,g   Goodrich, David W ^d   Demichelis, Francesca ^b,f   Sawyers, Charles L ^a,e   more..

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF TRENTO   (Italy)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CYTOKERATIN 18; CYTOKERATIN 8; DOXYCYCLINE; ENZALUTAMIDE; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA PROTEIN 1; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; ANTIANDROGEN; PHENYLTHIOHYDANTOIN; RB1 PROTEIN, HUMAN; RETINOBLASTOMA BINDING PROTEIN; SOX2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX; UBIQUITIN PROTEIN LIGASE;

ANDROGEN; CANCER; CELLS AND CELL COMPONENTS; DISEASE RESISTANCE; DRUG; GENE EXPRESSION; GENETIC ANALYSIS; LABORATORY METHOD; PHENOTYPIC PLASTICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANDROGEN THERAPY; ARTICLE; CANCER RESISTANCE; CASTRATION RESISTANT PROSTATE CANCER; CELL LINEAGE; CELL PLASTICITY; CELL SURVIVAL; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; GENE AMPLIFICATION; GENE LOCUS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; META ANALYSIS (TOPIC); MOUSE; NEUROENDOCRINE TUMOR; NONHUMAN; PHENOTYPE; PRIMARY TUMOR; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE EPITHELIUM CELL; PROTEIN EXPRESSION; RNA SEQUENCE; TUMOR XENOGRAFT; UPREGULATION; ANALOGS AND DERIVATIVES; GENETICS; MALE; METABOLISM; PATHOLOGY; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

ANDROGEN ANTAGONISTS; CELL LINE, TUMOR; CELL LINEAGE; CELL PLASTICITY; HUMANS; MALE; PHENYLTHIOHYDANTOIN; PROSTATIC NEOPLASMS; RETINOBLASTOMA BINDING PROTEINS; SOXB1 TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 85009250505     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah4307     Document Type: Article

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