Tolerance of whole- genome doubling propagates chromosomal instability and accelerates cancer genome evolution

Cancer Discovery

Volumn 4, Issue 2, 2014, Pages 175-185

  Dewhurst, Sally M ^a   McGranahan, Nicholas ^a,b   Burrell, Rebecca A ^a   Rowan, Andrew J ^a   Grönroos, Eva ^a   Endesfelder, David ^d   Joshi, Tejal ^e   Mouradov, Dmitri ^f,g   Gibbs, Peter ^f,g   Ward, Robyn L ^h   Hawkins, Nicholas J ⁱ   Szallasi, Zoltan ^e,j   Sieber, Oliver M ^f,g   Swanton, Charles ^a,c  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF APPLIED SCIENCES KOBLENZ   (Germany)

^e TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^f WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h UNIVERSITY OF NEW SOUTH WALES   (Australia)

ⁱ UNIVERSITY OF NEW SOUTH WALES   (Australia)

^j HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME NUMBER; CHROMOSOME SEGREGATION; COLORECTAL CANCER; CONTROLLED STUDY; COPY NUMBER VARIATION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE IN SITU HYBRIDIZATION; GENE FREQUENCY; GENETIC PARAMETERS; GENOME DOUBLING; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MICROSATELLITE INSTABILITY; PLOIDY; SCORING SYSTEM; TETRAPLOIDY; VALIDATION PROCESS;

CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; DNA COPY NUMBER VARIATIONS; HUMANS; NEOPLASMS; PHENOTYPE; PLOIDIES; POLYPLOIDY; PROGNOSIS;

EID: 84896711553     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-13-0285     Document Type: Article

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