메뉴 건너뛰기




Volumn 2014, Issue 3, 2014, Pages

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN G1; GROWTH DIFFERENTIATION FACTOR 15; MICRORNA 34A; NUTLIN 3; PROTEIN MDM2; PROTEIN P53;

EID: 84902324667     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02200.001     Document Type: Article
Times cited : (176)

References (52)
  • 1
    • 77958471357 scopus 로고    scopus 로고
    • Differential expression analysis for sequence count data
    • doi: 10.1186/gb-2010-11-10-r106
    • Anders S, Huber W. 2010. Differential expression analysis for sequence count data. Genome Biology 11:R106. doi: 10.1186/gb-2010-11-10-r106.
    • (2010) Genome Biology , vol.11
    • Anders, S.1    Huber, W.2
  • 2
    • 84878538147 scopus 로고    scopus 로고
    • A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation
    • doi: 10.1016/j.celrep.2013.04.014
    • Andrysik A, Kim J, Tan AC, Espinosa JM. 2013. A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation. Cell Reports 3:1-9. doi: 10.1016/j.celrep.2013.04.014.
    • (2013) Cell Reports , vol.3 , pp. 1-9
    • Andrysik, A.1    Kim, J.2    Tan, A.C.3    Espinosa, J.M.4
  • 4
    • 84875520533 scopus 로고    scopus 로고
    • Mdm2 and MdmX as regulators of gene expression
    • doi: 10.1177/1947601912455331
    • Biderman L, Manley JL, Prives C. 2012. Mdm2 and MdmX as regulators of gene expression. Genes & cancer 3:264-273. doi: 10.1177/1947601912455331.
    • (2012) Genes & cancer , vol.3 , pp. 264-273
    • Biderman, L.1    Manley, J.L.2    Prives, C.3
  • 6
    • 0029802591 scopus 로고    scopus 로고
    • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
    • doi: 10.1101/gad.10.19.2438
    • Chen X, Ko LJ, Jayaraman L, Prives C. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes & Development 10:2438-2451. doi: 10.1101/gad.10.19.2438.
    • (1996) Genes & Development , vol.10 , pp. 2438-2451
    • Chen, X.1    Ko, L.J.2    Jayaraman, L.3    Prives, C.4
  • 7
    • 0032511990 scopus 로고    scopus 로고
    • Characterization of a new intrabody directed against the N-terminal region of human p53
    • doi: 10.1038/sj.onc.1202190
    • Cohen PA, Mani JC, Lane DP. 1998. Characterization of a new intrabody directed against the N-terminal region of human p53. Oncogene 17:2445-2456. doi: 10.1038/sj.onc.1202190.
    • (1998) Oncogene , vol.17 , pp. 2445-2456
    • Cohen, P.A.1    Mani, J.C.2    Lane, D.P.3
  • 8
    • 57849109058 scopus 로고    scopus 로고
    • Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
    • doi: 10.1126/science.1162228
    • Core LJ, Waterfall JJ, Lis JT. 2008. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322:1845-1848. doi: 10.1126/science.1162228.
    • (2008) Science , vol.322 , pp. 1845-1848
    • Core, L.J.1    Waterfall, J.J.2    Lis, J.T.3
  • 9
    • 34548049032 scopus 로고    scopus 로고
    • Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation
    • doi: 10.1016/j.cell.2007.06.013
    • Das S, Raj L, Zhao B, Kimura Y, Bernstein A, Aaronson SA, Lee SW. 2007. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 130:624-637. doi: 10.1016/j.cell.2007.06.013.
    • (2007) Cell , vol.130 , pp. 624-637
    • Das, S.1    Raj, L.2    Zhao, B.3    Kimura, Y.4    Bernstein, A.5    Aaronson, S.A.6    Lee, S.W.7
  • 11
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • doi: 10.1016/S1097-2765(01)00283-0
    • Espinosa JM, Emerson BM. 2001. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Molecular Cell 8:57-69. doi: 10.1016/S1097-2765(01)00283-0.
    • (2001) Molecular Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 12
    • 0242329884 scopus 로고    scopus 로고
    • p53 functions through stress-and promoter-specific recruitment of transcription initiation components before and after DNA damage
    • doi: 10.1016/S1097-2765(03)00359-9
    • Espinosa JM, Verdun RE, Emerson BM. 2003. p53 functions through stress-and promoter-specific recruitment of transcription initiation components before and after DNA damage. Molecular Cell 12:1015-1027. doi: 10.1016/S1097-2765(03)00359-9.
    • (2003) Molecular Cell , vol.12 , pp. 1015-1027
    • Espinosa, J.M.1    Verdun, R.E.2    Emerson, B.M.3
  • 14
    • 33644787084 scopus 로고    scopus 로고
    • Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program
    • doi: 10.1101/gad.1398206
    • Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. 2006. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes & Development 20:601-612. doi: 10.1101/gad.1398206.
    • (2006) Genes & Development , vol.20 , pp. 601-612
    • Gomes, N.P.1    Bjerke, G.2    Llorente, B.3    Szostek, S.A.4    Emerson, B.M.5    Espinosa, J.M.6
  • 15
    • 79955836460 scopus 로고    scopus 로고
    • A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells
    • doi: 10.1016/j.cell.2011.03.042
    • Hah N, Danko CG, Core L, Waterfall JJ, Siepel A, Lis JT, Kraus WL. 2011. A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells. Cell 145:622-634. doi: 10.1016/j.cell.2011.03.042.
    • (2011) Cell , vol.145 , pp. 622-634
    • Hah, N.1    Danko, C.G.2    Core, L.3    Waterfall, J.J.4    Siepel, A.5    Lis, J.T.6    Kraus, W.L.7
  • 16
    • 67649648237 scopus 로고    scopus 로고
    • Control of inducible gene expression by signal-dependent transcriptional elongation
    • doi: 10.1016/j.cell.2009.05.047
    • Hargreaves DC, Horng T, Medzhitov R. 2009. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell 138:129-145. doi: 10.1016/j.cell.2009.05.047.
    • (2009) Cell , vol.138 , pp. 129-145
    • Hargreaves, D.C.1    Horng, T.2    Medzhitov, R.3
  • 17
    • 84857997208 scopus 로고    scopus 로고
    • A DR4:TBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX
    • doi: 10.1038/emboj.2011.498
    • Henry RE, Andrysik Z, Paris R, Galbraith MD, Espinosa JM. 2012. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. The EMBO Journal 31:1266-1278. doi: 10.1038/emboj.2011.498.
    • (2012) The EMBO Journal , vol.31 , pp. 1266-1278
    • Henry, R.E.1    Andrysik, Z.2    Paris, R.3    Galbraith, M.D.4    Espinosa, J.M.5
  • 19
    • 84891926803 scopus 로고    scopus 로고
    • RNA-mediated gene activation
    • doi: 10.4161/epi.26942
    • Jiao AL, Slack FJ. 2013. RNA-mediated gene activation. Epigenetics 9:27-36. doi: 10.4161/epi.26942.
    • (2013) Epigenetics , vol.9 , pp. 27-36
    • Jiao, A.L.1    Slack, F.J.2
  • 21
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • doi: 10.1038/387299a0
    • Kubbutat MH, Jones SN, Vousden KH. 1997. Regulation of p53 stability by Mdm2. Nature 387:299-303. doi: 10.1038/387299a0.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 23
    • 33646807491 scopus 로고    scopus 로고
    • Transcriptional regulation by p53: One protein, many possibilities
    • doi: 10.1038/sj.cdd.4401916
    • Laptenko O, Prives C. 2006. Transcriptional regulation by p53: one protein, many possibilities. Cell Death and Differentiation 13:951-961. doi: 10.1038/sj.cdd.4401916.
    • (2006) Cell Death and Differentiation , vol.13 , pp. 951-961
    • Laptenko, O.1    Prives, C.2
  • 24
    • 84862777719 scopus 로고    scopus 로고
    • Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells
    • doi: 10.1016/j.molcel.2012.01.020
    • Li M, He Y, Dubois W, Wu X, Shi J, Huang J. 2012. Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells. Molecular Cell 46:30-42. doi: 10.1016/j.molcel.2012.01.020.
    • (2012) Molecular Cell , vol.46 , pp. 30-42
    • Li, M.1    He, Y.2    Dubois, W.3    Wu, X.4    Shi, J.5    Huang, J.6
  • 27
    • 84883474258 scopus 로고    scopus 로고
    • Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells
    • doi: 10.1093/nar/gkt504
    • Menendez D, Nguyen TA, Freudenberg JM, Mathew VJ, Anderson CW, Jothi R, Resnick MA. 2013. Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. Nucleic Acids Research 41:7286-7301. doi: 10.1093/nar/gkt504.
    • (2013) Nucleic Acids Research , vol.41 , pp. 7286-7301
    • Menendez, D.1    Nguyen, T.A.2    Freudenberg, J.M.3    Mathew, V.J.4    Anderson, C.W.5    Jothi, R.6    Resnick, M.A.7
  • 28
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • doi: 10.1016/0092-8674(92)90644-R
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. 1992. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69:1237-1245. doi: 10.1016/0092-8674(92)90644-R.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 29
    • 75149175733 scopus 로고    scopus 로고
    • Regulation of the p53 transcriptional response by structurally diverse core promoters
    • doi: 10.1101/gad.1856710
    • Morachis JM, Murawsky CM, Emerson BM. 2010. Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes & Development 24:135-147. doi: 10.1101/gad.1856710.
    • (2010) Genes & Development , vol.24 , pp. 135-147
    • Morachis, J.M.1    Murawsky, C.M.2    Emerson, B.M.3
  • 31
    • 33745194153 scopus 로고    scopus 로고
    • Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription
    • doi: 10.1074/jbc.M601388200
    • Ohkubo S, Tanaka T, Taya Y, Kitazato K, Prives C. 2006. Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. The Journal of Biological Chemistry 281:16943-16950. doi: 10.1074/jbc.M601388200.
    • (2006) The Journal of Biological Chemistry , vol.281 , pp. 16943-16950
    • Ohkubo, S.1    Tanaka, T.2    Taya, Y.3    Kitazato, K.4    Prives, C.5
  • 32
  • 33
    • 0027964904 scopus 로고
    • Immunochemical analysis of the interaction of p53 with MDM2;-fine mapping of the MDM2 binding site on p53 using synthetic peptides
    • Picksley SM, Vojtesek B, Sparks A, Lane DP. 1994. Immunochemical analysis of the interaction of p53 with MDM2;-fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 9:2523-2529.
    • (1994) Oncogene , vol.9 , pp. 2523-2529
    • Picksley, S.M.1    Vojtesek, B.2    Sparks, A.3    Lane, D.P.4
  • 42
    • 0035028599 scopus 로고    scopus 로고
    • Kinetics of p53 binding to promoter sites in vivo
    • doi: 10.1128/MCB.21.10.3375-3386.2001
    • Szak ST, Mays D, Pietenpol JA. 2001. Kinetics of p53 binding to promoter sites in vivo. Molecular and Cellular Biology 21:3375-3386. doi: 10.1128/MCB.21.10.3375-3386.2001.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 3375-3386
    • Szak, S.T.1    Mays, D.2    Pietenpol, J.A.3
  • 43
    • 0032582812 scopus 로고    scopus 로고
    • Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53
    • doi: 10.1074/jbc.273.44.29156
    • Tang HY, Zhao K, Pizzolato JF, Fonarev M, Langer JC, Manfredi JJ. 1998. Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53. The Journal of Biological Chemistry 273:29156-29163. doi: 10.1074/jbc.273.44.29156.
    • (1998) The Journal of Biological Chemistry , vol.273 , pp. 29156-29163
    • Tang, H.Y.1    Zhao, K.2    Pizzolato, J.F.3    Fonarev, M.4    Langer, J.C.5    Manfredi, J.J.6
  • 44
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: A dual mechanism
    • doi: 10.1101/gad.11.15.1974
    • Thut CJ, Goodrich JA, Tjian R. 1997. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes & Development 11:1974-1986. doi: 10.1101/gad.11.15.1974.
    • (1997) Genes & Development , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 47
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • doi: 10.1016/j.cell.2009.04.037
    • Vousden KH, Prives C. 2009. Blinded by the light: the growing complexity of p53. Cell 137:413-431. doi: 10.1016/j.cell.2009.04.037.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 48
    • 84903362301 scopus 로고    scopus 로고
    • Mapping the p53 transcriptome universe using p53 natural polymorphs
    • doi: 10.1038/cdd.2013.132
    • Wang B, Niu D, Lam TH, Xiao Z, Ren EC. 2013. Mapping the p53 transcriptome universe using p53 natural polymorphs. Cell Death and Differentiation 21:521-532. doi: 10.1038/cdd.2013.132.
    • (2013) Cell Death and Differentiation , vol.21 , pp. 521-532
    • Wang, B.1    Niu, D.2    Lam, T.H.3    Xiao, Z.4    Ren, E.C.5
  • 50
    • 33645751553 scopus 로고    scopus 로고
    • Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription
    • doi: 10.1158/0008-5472.CAN-05-1381
    • White DE, Talbott KE, Arva NC, Bargonetti J. 2006. Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription. Cancer Research 66:3463-3470. doi: 10.1158/0008-5472.CAN-05-1381.
    • (2006) Cancer Research , vol.66 , pp. 3463-3470
    • White, D.E.1    Talbott, K.E.2    Arva, N.C.3    Bargonetti, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.