Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

Nature

Volumn 545, Issue 7653, 2017, Pages 229-233

  Merkle, Florian T ^a,b,c,d,h,i   Ghosh, Sulagna ^a,b,c,d   Kamitaki, Nolan ^c,e   Mitchell, Jana ^a,b,c,d   Avior, Yishai ^f   Mello, Curtis ^c,e   Kashin, Seva ^c,e   Mekhoubad, Shila ^a,b,d,h   Ilic, Dusko ^g   Charlton, Maura ^a,b,c,d   Saphier, Genevieve ^a,c,d   Handsaker, Robert E ^c,e   Genovese, Giulio ^c,e   Bar, Shiran ^f   Benvenisty, Nissim ^f   McCarroll, Steven A ^c,e   Eggan, Kevin ^a,b,c,d  

^a Harvard University   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^g KING'S COLLEGE LONDON   (United Kingdom)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

ⁱ BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; PROTEIN P53; DNA;

CELLS AND CELL COMPONENTS; GENETIC ANALYSIS; GENOME; HETEROZYGOSITY; MUTATION; RNA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DATA MINING; DNA BINDING; DNA BINDING MOTIF; EXOME; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN EMBRYONIC STEM CELL; MALIGNANT NEOPLASM; MISSENSE MUTATION; POINT MUTATION; PRIORITY JOURNAL; RNA SEQUENCE; STEM CELL EXPANSION; ALLELE; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CHEMISTRY; CYTOLOGY; DNA MUTATIONAL ANALYSIS; DOMINANT GENE; GENETIC SELECTION; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MOSAICISM; MUTATION; NEOPLASM; PROTEIN DOMAIN; TUMOR SUPPRESSOR GENE;

ALLELES; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; DNA; DNA MUTATIONAL ANALYSIS; EXOME; GENES, DOMINANT; GENES, P53; HUMAN EMBRYONIC STEM CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LOSS OF HETEROZYGOSITY; MOSAICISM; MUTATION; NEOPLASMS; PROTEIN DOMAINS; SELECTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85019220581     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature22312     Document Type: Article

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