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Volumn 107, Issue 52, 2010, Pages 22745-22750

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53;

EID: 78651100119     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017001108     Document Type: Article
Times cited : (132)

References (37)
  • 2
  • 3
    • 34648821257 scopus 로고    scopus 로고
    • Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis
    • Stingl J, Caldas C (2007) Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer 7:791-799.
    • (2007) Nat Rev Cancer , vol.7 , pp. 791-799
    • Stingl, J.1    Caldas, C.2
  • 4
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: Mirage or reality? Nat Med 15:1010-1012.
    • (2009) Nat Med , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 5
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 6
    • 34249863603 scopus 로고    scopus 로고
    • Strategies and new developments in the generation of patient-specific pluripotent stem cells
    • Yamanaka S (2007) Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1:39-49.
    • (2007) Cell Stem Cell , vol.1 , pp. 39-49
    • Yamanaka, S.1
  • 7
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1
  • 8
    • 70349093119 scopus 로고    scopus 로고
    • Senescence impairs successful reprogramming to pluripotent stem cells
    • Banito A, et al. (2009) Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev 23:2134-2139.
    • (2009) Genes Dev , vol.23 , pp. 2134-2139
    • Banito, A.1
  • 9
    • 69349100455 scopus 로고    scopus 로고
    • Linking the p53 tumour suppressor pathway to somatic cell reprogramming
    • Kawamura T, et al. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460:1140-1144.
    • (2009) Nature , vol.460 , pp. 1140-1144
    • Kawamura, T.1
  • 10
    • 69349094006 scopus 로고    scopus 로고
    • A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    • Marión RM, et al. (2009) A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460:1149-1153.
    • (2009) Nature , vol.460 , pp. 1149-1153
    • Marión, R.M.1
  • 11
    • 71449109765 scopus 로고    scopus 로고
    • Direct cell reprogramming is a stochastic process amenable to acceleration
    • Hanna J, et al. (2009) Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 462:595-601.
    • (2009) Nature , vol.462 , pp. 595-601
    • Hanna, J.1
  • 12
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460:1132-1135.
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1
  • 13
    • 69349103956 scopus 로고    scopus 로고
    • The Ink4/Arf locus is a barrier for iPS cell reprogramming
    • Li H, et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460:1136-1139.
    • (2009) Nature , vol.460 , pp. 1136-1139
    • Li, H.1
  • 14
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 40:499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1
  • 15
    • 70350222208 scopus 로고    scopus 로고
    • An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma
    • Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG (2009) An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res 15:6386-6390.
    • (2009) Clin Cancer Res , vol.15 , pp. 6386-6390
    • Hassan, K.A.1    Chen, G.2    Kalemkerian, G.P.3    Wicha, M.S.4    Beer, D.G.5
  • 16
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34:267-273.
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1
  • 17
    • 34147113900 scopus 로고    scopus 로고
    • A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas
    • Assou S, et al. (2007) A meta-analysis of human embryonic stem cells transcriptome integrated into a web-based expression atlas. Stem Cells 25:961-973.
    • (2007) Stem Cells , vol.25 , pp. 961-973
    • Assou, S.1
  • 18
    • 26444546442 scopus 로고    scopus 로고
    • An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
    • Miller LD, et al. (2005) An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci USA 102:13550-13555.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13550-13555
    • Miller, L.D.1
  • 19
    • 34250760957 scopus 로고    scopus 로고
    • TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
    • Langerød A, et al. (2007) TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer. Breast Cancer Res 9:R30.
    • (2007) Breast Cancer Res , vol.9
    • Langerød, A.1
  • 20
    • 67649965344 scopus 로고    scopus 로고
    • Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis
    • Tomida S, et al. (2009) Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J Clin Oncol 27:2793-2799.
    • (2009) J Clin Oncol , vol.27 , pp. 2793-2799
    • Tomida, S.1
  • 21
    • 18544385947 scopus 로고    scopus 로고
    • Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23
    • Li J, et al. (2002) Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat Genet 31:133-134.
    • (2002) Nat Genet , vol.31 , pp. 133-134
    • Li, J.1
  • 22
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by Polycomb in human embryonic stem cells
    • Lee TI, et al. (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125:301-313.
    • (2006) Cell , vol.125 , pp. 301-313
    • Lee, T.I.1
  • 23
    • 76249102530 scopus 로고    scopus 로고
    • A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells
    • Lee KH, et al. (2010) A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells. Proc Natl Acad Sci USA 107:69-74.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 69-74
    • Lee, K.H.1
  • 24
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sørlie T, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10869-10874
    • Sørlie, T.1
  • 25
    • 53149133527 scopus 로고    scopus 로고
    • Refinement of breast cancer classification by molecular characterization of histological special types
    • Weigelt B, et al. (2008) Refinement of breast cancer classification by molecular characterization of histological special types. J Pathol 216:141-150.
    • (2008) J Pathol , vol.216 , pp. 141-150
    • Weigelt, B.1
  • 26
    • 0033531767 scopus 로고    scopus 로고
    • p53 mutation as a genetic trait of typical medullary breast carcinoma
    • de Cremoux P, et al. (1999) p53 mutation as a genetic trait of typical medullary breast carcinoma. J Natl Cancer Inst 91:641-643.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 641-643
    • De Cremoux, P.1
  • 27
    • 27744461881 scopus 로고    scopus 로고
    • Metaplastic breast carcinoma with squamous differentiation: Molecular and clinical analysis of six cases
    • Kochhar R, Howard EM, Umbreit JN, Lau SK (2005) Metaplastic breast carcinoma with squamous differentiation: Molecular and clinical analysis of six cases. Breast J 11:367-369.
    • (2005) Breast J , vol.11 , pp. 367-369
    • Kochhar, R.1    Howard, E.M.2    Umbreit, J.N.3    Lau, S.K.4
  • 28
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy BT, et al. (2009) Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 69:4116-4124.
    • (2009) Cancer Res , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1
  • 29
    • 69349098834 scopus 로고    scopus 로고
    • Stem cells: The promises and perils of p53
    • Krizhanovsky V, Lowe SW (2009) Stem cells: The promises and perils of p53. Nature 460:1085-1086.
    • (2009) Nature , vol.460 , pp. 1085-1086
    • Krizhanovsky, V.1    Lowe, S.W.2
  • 31
    • 75649149550 scopus 로고    scopus 로고
    • Histological and molecular types of breast cancer: Is there a unifying taxonomy?
    • Weigelt B, Reis-Filho JS (2009) Histological and molecular types of breast cancer: Is there a unifying taxonomy? Nat Rev Clin Oncol 6:718-730.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 718-730
    • Weigelt, B.1    Reis-Filho, J.S.2
  • 32
    • 33847339743 scopus 로고    scopus 로고
    • A mouse model of basal-like breast carcinoma with metaplastic elements
    • McCarthy A, et al. (2007) A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol 211:389-398.
    • (2007) J Pathol , vol.211 , pp. 389-398
    • McCarthy, A.1
  • 33
    • 77749237125 scopus 로고    scopus 로고
    • Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice
    • Yan H, et al. (2010) Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice. Am J Pathol 176:1421-1432.
    • (2010) Am J Pathol , vol.176 , pp. 1421-1432
    • Yan, H.1
  • 34
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
    • Kim J, et al. (2010) A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 143:313-324.
    • (2010) Cell , vol.143 , pp. 313-324
    • Kim, J.1
  • 35
    • 77953482819 scopus 로고    scopus 로고
    • The p53 response element and transcriptional repression
    • Wang B, Xiao Z, Ko HL, Ren EC (2010) The p53 response element and transcriptional repression. Cell Cycle 9:870-879.
    • (2010) Cell Cycle , vol.9 , pp. 870-879
    • Wang, B.1    Xiao, Z.2    Ko, H.L.3    Ren, E.C.4
  • 36
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 37
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3


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