TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

eLife

Volumn 5, Issue September2016, 2016, Pages

  Sulak, Michael ^a   Fong, Lindsey ^a   Mika, Katelyn ^a   Chigurupati, Sravanthi ^a   Yon, Lisa ^b   Mongan, Nigel P ^b,c   Emes, Richard D ^b,d   Lynch, Vincent J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PROTEIN P53; REPETITIVE DNA;

ANIMAL CELL; ARTICLE; BODY SIZE; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA DAMAGE; ELEPHANT; EVOLUTION; EVOLUTIONARY DEVELOPMENTAL BIOLOGY; GENE; GENE EXPRESSION; GENOME ANALYSIS; GENOMICS; NONHUMAN; PHYLOGENY; PROBOSCIDEA (MAMMALS); PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSPOSON; ANIMAL; APOPTOSIS; DNA REPAIR; GENE DOSAGE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; MOLECULAR EVOLUTION; PROTEIN SYNTHESIS; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BODY SIZE; DNA REPAIR; ELEPHANTS; EVOLUTION, MOLECULAR; GENE DOSAGE; GENE EXPRESSION PROFILING; GENES, P53; PROTEIN BIOSYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84991694144     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.11994     Document Type: Article

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