Aberrant expression and mutation-inducing activity of AID in human lung cancer

Annals of Surgical Oncology

Volumn 18, Issue 7, 2011, Pages 2084-2092

  Shinmura, Kazuya ^a   Igarashi, Hisaki ^a   Goto, Masanori ^a   Tao, Hong ^a   Yamada, Hidetaka ^a   Matsuura, Shun ^a   Tajima, Mari ^a   Matsuda, Tomonari ^b   Yamane, Arito ^c   Funai, Kazuhito ^a   Tanahashi, Masayuki ^d   Niwa, Hiroshi ^d   Ogawa, Hiroshi ^d   Sugimura, Haruhiko ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^d SEIREI MIKATAHARA GENERAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; MESSENGER RNA; MUTANT PROTEIN; PROTEIN P53; SUPF PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CENTROSOME; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; LUNG CANCER; MOLECULAR CLONING; MUTATIONAL ANALYSIS; PRIMARY TUMOR; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; SINGLE STRAND CONFORMATION POLYMORPHISM;

ADENOCARCINOMA; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELLS, CULTURED; CYTIDINE DEAMINASE; DNA PRIMERS; FLUORESCENT ANTIBODY TECHNIQUE; GENES, SUPPRESSOR; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG; LUNG NEOPLASMS; MUTAGENICITY TESTS; MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, TRANSFER; SMALL CELL LUNG CARCINOMA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80051546278     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-011-1568-8     Document Type: Article

References (35)

1. Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature. 2008;455:1069-75.
2. Quadrelli S, Lyons G, Colt H, Chimondeguy D, Silva C. Lung cancer as a second primary malignancy: increasing prevalence and its influence on survival. Ann Surg Oncol. 2009;16:1033-8.
3. Mitsudomi T, Yatabe Y. Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer. FEBS J. 2010;277:301-8.
4. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359:1367-80.
5. Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers- a different disease. Nat Rev Cancer. 2007;7:778-90. (Pubitemid 47463669)
6. Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000;102:553-63.
7. Delker RK, Fugmann SD, Papavasiliou FN. A coming-of-age story: activation-induced cytidine deaminase turns 10. Nat Immunol. 2009;10:1147-53.
8. Liu M, Duke JL, Richter DJ, Vinuesa CG, Goodnow CC, Kleinstein SH, et al. Two levels of protection for the B cell genome during somatic hypermutation. Nature. 2008;451:841-5. (Pubitemid 351253166)
9. Yoshikawa K, Okazaki IM, Eto T, Kinoshita K, Muramatsu M, Nagaoka H, et al. AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts. Science. 2002;296: 2033-6. (Pubitemid 34627527)
10. Okazaki IM, Hiai H, Kakazu N, Yamada S, Muramatsu M, Kinoshita K, et al. Constitutive expression of AID leads to tumorigenesis. J Exp Med. 2003;197:1173-81. (Pubitemid 36570072)
11. Morisawa T, Marusawa H, Ueda Y, Iwai A, Okazaki IM, Honjo T, et al. Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression. Int J Cancer. 2008;123:2735-40.
12. Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med. 2007;13:470-6. (Pubitemid 46559833)
13. Klemm L, Duy C, Iacobucci I, Kuchen S, von Levetzow G, Feldhahn N, et al. The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 2009;16:232-45.
14. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, et al. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol. 1994;10:38-47.
15. Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, et al. Secreted form of EphA7 in lung cancer. Int J Oncol. 2010;36:635-40.
16. Shinmura K, Tao H, Nagura K, Goto M, Matsuura S, Mochizuki T, et al. Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. Lung Cancer. 2011;71:19-27.
17. Shinmura K, Bennett RA, Tarapore P, Fukasawa K. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene. 2007;26:2939-44. (Pubitemid 46701435)
18. Matsuda T, Yagi T, Kawanishi M, Matsui S, Takebe H. Molecular analysis of mutations induced by 2-chloroacetaldehyde, the ultimate carcinogenic form of vinyl chloride, in human cells using shuttle vectors. Carcinogenesis. 1995;16:2389-94.
19. Yamane A, Shinmura K, Sunaga N, Saitoh T, Yamaguchi S, Shinmura Y, et al. Suppressive activities of OGG1 and MYH proteins against G:C to T:A mutations caused by 8-hydroxyguanine but not by benzo[a]pyrene diol epoxide in human cells in vivo. Carcinogenesis. 2003;24:1031-7. (Pubitemid 36827254)
20. Yamada H, Shinmura K, Yamamura Y, Kurachi K, Nakamura T, Tsuneyoshi T, et al. Identification and characterization of a novel germline p53 mutation in a patient with glioblastoma and colon cancer. Int J Cancer. 2009;125:973-6.
21. Goto M, Shinmura K, Igarashi H, Kobayashi M, Konno H, Yamada H, et al. Altered expression of the human base excision repair gene NTH1 in gastric cancer. Carcinogenesis. 2009;30: 1345-52.
22. Shinmura K, Iwaizumi M, Igarashi H, Nagura K, Yamada H, Suzuki M, et al. Induction of centrosome amplification and chromosome instability in p53-deficient lung cancer cells exposed to benzo[a]pyrene diol epoxide (B[a]PDE). J Pathol. 2008;216:365-74.
23. Moudjou M, Bornens M. Method of centrosome isolation from cultured animal cells. In: Celis JE, editor. Cell biology: a laboratory handbook. New York: Academic Press; 1998. p. 111-9.
24. Suzuki H, Takahashi T, Kuroishi T, Suyama M, Ariyoshi Y, Takahashi T, et al. p53 mutations in non-small cell lung cancer in Japan: association between mutations and smoking. Cancer Res. 1992;52:734-6.
25. Greiner A, Tobollik S, Buettner M, Jungnickel B, Herrmann K, Kremmer E, et al. Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma. J Pathol. 2005;205:541-7. (Pubitemid 40514826)
26. Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer. 2007;7:911-24. (Pubitemid 350165854)
27. Pfeifer GP, Besaratinia A. Mutational spectra of human cancer. Hum Genet. 2009;125:493-506.
28. Dorsett Y, Robbiani DF, Jankovic M, Reina-San-Martin B, Eisenreich TR, Nussenzweig MC. A role for AID in chromosome translocations between c-myc and the IgH variable region. J Exp Med. 2007;204:2225-32. (Pubitemid 47360881)
29. Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, et al. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell. 2008;135:1028-38.
30. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448: 561-6. (Pubitemid 47206930)
31. Shinmura K, Kageyama S, Tao H, Bunai T, Suzuki M, Kamo T, et al. EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas. Lung Cancer. 2008;61:163-9.
32. Takahashi T, Sonobe M, Kobayashi M, Yoshizawa A, Menju T, Nakayama E, et al. Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene. Ann Surg Oncol. 2010;17:889-97.
33. Olivier M, Hussain SP, Caron de Fromentel C, Hainaut P, Harris CC. TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer. Lyon: IARC Sci Publ.; 2004 p. 247-70.
34. Lingle WL, Barrett SL, Negron VC, D'Assoro AB, Boeneman K, Liu W, et al. Centrosome amplification drives chromosomal instability in breast tumor development. Proc Natl Acad Sci USA. 2002;99:1978-83. (Pubitemid 34169000)
35. Ganem NJ, Godinho SA, Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature. 2009;460:278-82.