-
1
-
-
77950965840
-
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
-
Ahmed A.A., Etemadmoghadam D., Temple J., Lynch A.G., Riad M., Sharma R., Stewart C., Fereday S., Caldas C., Defazio A., et al. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary. J. Pathol. 2010, 221:49-56.
-
(2010)
J. Pathol.
, vol.221
, pp. 49-56
-
-
Ahmed, A.A.1
Etemadmoghadam, D.2
Temple, J.3
Lynch, A.G.4
Riad, M.5
Sharma, R.6
Stewart, C.7
Fereday, S.8
Caldas, C.9
Defazio, A.10
-
2
-
-
33645721632
-
Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins
-
Anderson L., Hunter C.L. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol. Cell Proteomics 2006, 5:573-588.
-
(2006)
Mol. Cell Proteomics
, vol.5
, pp. 573-588
-
-
Anderson, L.1
Hunter, C.L.2
-
4
-
-
0031447171
-
Thermodynamic stability of wild-type and mutant p53 core domain
-
Bullock A.N., Henckel J., DeDecker B.S., Johnson C.M., Nikolova P.V., Proctor M.R., Lane D.P., Fersht A.R. Thermodynamic stability of wild-type and mutant p53 core domain. Proc. Natl. Acad. Sci. USA 1997, 94:14338-14342.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 14338-14342
-
-
Bullock, A.N.1
Henckel, J.2
DeDecker, B.S.3
Johnson, C.M.4
Nikolova, P.V.5
Proctor, M.R.6
Lane, D.P.7
Fersht, A.R.8
-
5
-
-
0036128899
-
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
-
Bykov V.J.N., Issaeva N., Shilov A., Hultcrantz M., Pugacheva E., Chumakov P., Bergman J., Wiman K.G., Selivanova G. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nat. Med. 2002, 8:282-288.
-
(2002)
Nat. Med.
, vol.8
, pp. 282-288
-
-
Bykov, V.J.N.1
Issaeva, N.2
Shilov, A.3
Hultcrantz, M.4
Pugacheva, E.5
Chumakov, P.6
Bergman, J.7
Wiman, K.G.8
Selivanova, G.9
-
6
-
-
79959838081
-
Integrated genomic analyses of ovarian carcinoma
-
Cancer Genome Atlas Research Network Integrated genomic analyses of ovarian carcinoma. Nature 2011, 474:609-615.
-
(2011)
Nature
, vol.474
, pp. 609-615
-
-
-
7
-
-
0033754993
-
P73 gene expression in ovarian cancer tissues and cell lines
-
Chen C.L., Ip S.M., Cheng D., Wong L.C., Ngan H.Y. P73 gene expression in ovarian cancer tissues and cell lines. Clin. Cancer Res. 2000, 6:3910-3915.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3910-3915
-
-
Chen, C.L.1
Ip, S.M.2
Cheng, D.3
Wong, L.C.4
Ngan, H.Y.5
-
8
-
-
84858374665
-
The amyloid state of proteins in human diseases
-
Eisenberg D., Jucker M. The amyloid state of proteins in human diseases. Cell 2012, 148:1188-1203.
-
(2012)
Cell
, vol.148
, pp. 1188-1203
-
-
Eisenberg, D.1
Jucker, M.2
-
9
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
Freed-Pastor W.A., Mizuno H., Zhao X., Langerød A., Moon S.-H., Rodriguez-Barrueco R., Barsotti A., Chicas A., Li W., Polotskaia A., et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 2012, 148:244-258.
-
(2012)
Cell
, vol.148
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerød, A.4
Moon, S.-H.5
Rodriguez-Barrueco, R.6
Barsotti, A.7
Chicas, A.8
Li, W.9
Polotskaia, A.10
-
10
-
-
22444439952
-
Polyarginine as a multifunctional fusion tag
-
Fuchs S.M., Raines R.T. Polyarginine as a multifunctional fusion tag. Protein Sci. 2005, 14:1538-1544.
-
(2005)
Protein Sci.
, vol.14
, pp. 1538-1544
-
-
Fuchs, S.M.1
Raines, R.T.2
-
11
-
-
84907462407
-
Investigating the intrinsic aggregation potential of evolutionarily conserved segments in p53
-
Ghosh S., Ghosh D., Ranganathan S., Anoop A., P S.K., Jha N.N., Padinhateeri R., Maji S.K. Investigating the intrinsic aggregation potential of evolutionarily conserved segments in p53. Biochemistry 2014, 53:5995-6010.
-
(2014)
Biochemistry
, vol.53
, pp. 5995-6010
-
-
Ghosh, S.1
Ghosh, D.2
Ranganathan, S.3
Anoop, A.P.S.K.4
Jha, N.N.5
Padinhateeri, R.6
Maji, S.K.7
-
12
-
-
77649240855
-
Identifying the amylome, proteins capable of forming amyloid-like fibrils
-
Goldschmidt L., Teng P.K., Riek R., Eisenberg D. Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc. Natl. Acad. Sci. USA 2010, 107:3487-3492.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 3487-3492
-
-
Goldschmidt, L.1
Teng, P.K.2
Riek, R.3
Eisenberg, D.4
-
13
-
-
84863987464
-
Inhibition of amyloid formation
-
Härd T., Lendel C. Inhibition of amyloid formation. J. Mol. Biol. 2012, 421:441-465.
-
(2012)
J. Mol. Biol.
, vol.421
, pp. 441-465
-
-
Härd, T.1
Lendel, C.2
-
14
-
-
12544258226
-
Alendronate inhibits intraperitoneal dissemination in in vivo ovarian cancer model
-
Hashimoto K., Morishige K., Sawada K., Tahara M., Kawagishi R., Ikebuchi Y., Sakata M., Tasaka K., Murata Y. Alendronate inhibits intraperitoneal dissemination in in vivo ovarian cancer model. Cancer Res. 2005, 65:540-545.
-
(2005)
Cancer Res.
, vol.65
, pp. 540-545
-
-
Hashimoto, K.1
Morishige, K.2
Sawada, K.3
Tahara, M.4
Kawagishi, R.5
Ikebuchi, Y.6
Sakata, M.7
Tasaka, K.8
Murata, Y.9
-
15
-
-
0345255605
-
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
-
Issaeva N., Friedler A., Bozko P., Wiman K.G., Fersht A.R., Selivanova G. Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide. Proc. Natl. Acad. Sci. USA 2003, 100:13303-13307.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 13303-13307
-
-
Issaeva, N.1
Friedler, A.2
Bozko, P.3
Wiman, K.G.4
Fersht, A.R.5
Selivanova, G.6
-
16
-
-
84938491857
-
An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer
-
Janzen D.M., Tiourin E., Salehi J.A., Paik D.Y., Lu J., Pellegrini M., Memarzadeh S. An apoptosis-enhancing drug overcomes platinum resistance in a tumour-initiating subpopulation of ovarian cancer. Nat. Commun. 2015, 6:7956.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7956
-
-
Janzen, D.M.1
Tiourin, E.2
Salehi, J.A.3
Paik, D.Y.4
Lu, J.5
Pellegrini, M.6
Memarzadeh, S.7
-
17
-
-
47649096991
-
Structural biology of the tumor suppressor p53
-
Joerger A.C., Fersht A.R. Structural biology of the tumor suppressor p53. Annu. Rev. Biochem. 2008, 77:557-582.
-
(2008)
Annu. Rev. Biochem.
, vol.77
, pp. 557-582
-
-
Joerger, A.C.1
Fersht, A.R.2
-
18
-
-
84895779578
-
Drugging the p53 pathway: understanding the route to clinical efficacy
-
Khoo K.H., Verma C.S., Lane D.P. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat. Rev. Drug Discov. 2014, 13:217-236.
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 217-236
-
-
Khoo, K.H.1
Verma, C.S.2
Lane, D.P.3
-
19
-
-
60949112148
-
Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay
-
Knight L.A., Kurbacher C.M., Glaysher S., Fernando A., Reichelt R., Dexel S., Reinhold U., Cree I.A. Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay. BMC Cancer 2009, 9:38.
-
(2009)
BMC Cancer
, vol.9
, pp. 38
-
-
Knight, L.A.1
Kurbacher, C.M.2
Glaysher, S.3
Fernando, A.4
Reichelt, R.5
Dexel, S.6
Reinhold, U.7
Cree, I.A.8
-
20
-
-
84934281252
-
P53 in survival, death and metabolic health: a lifeguard with a licence to kill
-
Kruiswijk F., Labuschagne C.F., Vousden K.H. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat. Rev. Mol. Cell Biol. 2015, 16:393-405.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 393-405
-
-
Kruiswijk, F.1
Labuschagne, C.F.2
Vousden, K.H.3
-
21
-
-
41349100528
-
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications
-
Kurman R.J., Shih I.-M. Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications. Int. J. Gynecol. Pathol. 2008, 27:151-160.
-
(2008)
Int. J. Gynecol. Pathol.
, vol.27
, pp. 151-160
-
-
Kurman, R.J.1
Shih, I.-M.2
-
22
-
-
0018348655
-
T antigen is bound to a host protein in SY40-transformed cells
-
Lane D.P., Crawford L.V. T antigen is bound to a host protein in SY40-transformed cells. Nature 1979, 278:261-263.
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
23
-
-
84872490673
-
Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity
-
Lasagna-Reeves C.A., Clos A.L., Castillo-Carranza D., Sengupta U., Guerrero-Muñoz M., Kelly B., Wagner R., Kayed R. Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity. Biochem. Biophys. Res. Commun. 2013, 430:963-968.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.430
, pp. 963-968
-
-
Lasagna-Reeves, C.A.1
Clos, A.L.2
Castillo-Carranza, D.3
Sengupta, U.4
Guerrero-Muñoz, M.5
Kelly, B.6
Wagner, R.7
Kayed, R.8
-
24
-
-
78650905964
-
ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules
-
Leaver-Fay A., Tyka M., Lewis S.M., Lange O.F., Thompson J., Jacak R., Kaufman K., Renfrew P.D., Smith C.A., Sheffler W., et al. ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods Enzymol. 2011, 487:545-574.
-
(2011)
Methods Enzymol.
, vol.487
, pp. 545-574
-
-
Leaver-Fay, A.1
Tyka, M.2
Lewis, S.M.3
Lange, O.F.4
Thompson, J.5
Jacak, R.6
Kaufman, K.7
Renfrew, P.D.8
Smith, C.A.9
Sheffler, W.10
-
25
-
-
84867615093
-
Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer
-
Lehmann S., Bykov V.J.N., Ali D., Andrén O., Cherif H., Tidefelt U., Uggla B., Yachnin J., Juliusson G., Moshfegh A., et al. Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. J. Clin. Oncol. 2012, 30:3633-3639.
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 3633-3639
-
-
Lehmann, S.1
Bykov, V.J.N.2
Ali, D.3
Andrén, O.4
Cherif, H.5
Tidefelt, U.6
Uggla, B.7
Yachnin, J.8
Juliusson, G.9
Moshfegh, A.10
-
26
-
-
1942509342
-
Mutation and expression of the TP53 gene in early stage epithelial ovarian carcinoma
-
Leitao M.M., Soslow R.A., Baergen R.N., Olvera N., Arroyo C., Boyd J. Mutation and expression of the TP53 gene in early stage epithelial ovarian carcinoma. Gynecol. Oncol. 2004, 93:301-306.
-
(2004)
Gynecol. Oncol.
, vol.93
, pp. 301-306
-
-
Leitao, M.M.1
Soslow, R.A.2
Baergen, R.N.3
Olvera, N.4
Arroyo, C.5
Boyd, J.6
-
27
-
-
41549112390
-
Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids
-
L'Espérance S., Bachvarova M., Tetu B., Mes-Masson A.-M., Bachvarov D. Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids. BMC Genomics 2008, 9:99.
-
(2008)
BMC Genomics
, vol.9
, pp. 99
-
-
L'Espérance, S.1
Bachvarova, M.2
Tetu, B.3
Mes-Masson, A.-M.4
Bachvarov, D.5
-
28
-
-
70349442548
-
The first 30 years of p53: growing ever more complex
-
Levine A.J., Oren M. The first 30 years of p53: growing ever more complex. Nat. Rev. Cancer 2009, 9:749-758.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 749-758
-
-
Levine, A.J.1
Oren, M.2
-
29
-
-
78650251684
-
Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors
-
Levy C.B., Stumbo A.C., Ano Bom A.P.D., Portari E.A., Cordeiro Y., Carneiro Y., Silva J.L., De Moura-Gallo C.V. Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors. Int. J. Biochem. Cell Biol. 2011, 43:60-64.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 60-64
-
-
Levy, C.B.1
Stumbo, A.C.2
Ano Bom, A.P.D.3
Portari, E.A.4
Cordeiro, Y.5
Carneiro, Y.6
Silva, J.L.7
De Moura-Gallo, C.V.8
-
30
-
-
0018760324
-
Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer D.I.H., Levine A.J. Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 1979, 17:43-52.
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.H.1
Levine, A.J.2
-
31
-
-
84880234835
-
Small molecule induced reactivation of mutant p53 in cancer cells
-
Liu X., Wilcken R., Joerger A.C., Chuckowree I.S., Amin J., Spencer J., Fersht A.R. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res. 2013, 41:6034-6044.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 6034-6044
-
-
Liu, X.1
Wilcken, R.2
Joerger, A.C.3
Chuckowree, I.S.4
Amin, J.5
Spencer, J.6
Fersht, A.R.7
-
32
-
-
77951182123
-
Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance
-
Martirosyan A., Clendening J.W., Goard C.A., Penn L.Z. Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance. BMC Cancer 2010, 10:103.
-
(2010)
BMC Cancer
, vol.10
, pp. 103
-
-
Martirosyan, A.1
Clendening, J.W.2
Goard, C.A.3
Penn, L.Z.4
-
33
-
-
84887254206
-
Ovarian cancer, version 2.2013
-
Morgan R.J., Alvarez R.D., Armstrong D.K., Burger R.A., Chen L., Copeland L., Crispens M.A., Gershenson D.M., Gray H.J., Hakam A., et al. Ovarian cancer, version 2.2013. J. Natl. Compr. Canc Netw. 2013, 11:1199-1209.
-
(2013)
J. Natl. Compr. Canc Netw.
, vol.11
, pp. 1199-1209
-
-
Morgan, R.J.1
Alvarez, R.D.2
Armstrong, D.K.3
Burger, R.A.4
Chen, L.5
Copeland, L.6
Crispens, M.A.7
Gershenson, D.M.8
Gray, H.J.9
Hakam, A.10
-
35
-
-
18344380440
-
Ovarian cancer metastasis: integrating insights from disparate model organisms
-
Naora H., Montell D.J. Ovarian cancer metastasis: integrating insights from disparate model organisms. Nat. Rev. Cancer 2005, 5:355-366.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 355-366
-
-
Naora, H.1
Montell, D.J.2
-
36
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database
-
Petitjean A., Mathe E., Kato S., Ishioka C., Tavtigian S.V., Hainaut P., Olivier M. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum. Mutat. 2007, 28:622-629.
-
(2007)
Hum. Mutat.
, vol.28
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
Ishioka, C.4
Tavtigian, S.V.5
Hainaut, P.6
Olivier, M.7
-
37
-
-
84869238813
-
Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells
-
Rieber M., Strasberg-Rieber M. Hypoxia, Mn-SOD and H(2)O(2) regulate p53 reactivation and PRIMA-1 toxicity irrespective of p53 status in human breast cancer cells. Biochem. Pharmacol. 2012, 84:1563-1570.
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 1563-1570
-
-
Rieber, M.1
Strasberg-Rieber, M.2
-
38
-
-
80052989887
-
P73 in cancer
-
Rufini A., Agostini M., Grespi F., Tomasini R., Sayan B.S., Niklison-Chirou M.V., Conforti F., Velletri T., Mastino A., Mak T.W., et al. p73 in cancer. Genes Cancer 2011, 2:491-502.
-
(2011)
Genes Cancer
, vol.2
, pp. 491-502
-
-
Rufini, A.1
Agostini, M.2
Grespi, F.3
Tomasini, R.4
Sayan, B.S.5
Niklison-Chirou, M.V.6
Conforti, F.7
Velletri, T.8
Mastino, A.9
Mak, T.W.10
-
39
-
-
34249290108
-
Atomic structures of amyloid cross-beta spines reveal varied steric zippers
-
Sawaya M.R., Sambashivan S., Nelson R., Ivanova M.I., Sievers S.A., Apostol M.I., Thompson M.J., Balbirnie M., Wiltzius J.J.W., McFarlane H.T., et al. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature 2007, 447:453-457.
-
(2007)
Nature
, vol.447
, pp. 453-457
-
-
Sawaya, M.R.1
Sambashivan, S.2
Nelson, R.3
Ivanova, M.I.4
Sievers, S.A.5
Apostol, M.I.6
Thompson, M.J.7
Balbirnie, M.8
Wiltzius, J.J.W.9
McFarlane, H.T.10
-
40
-
-
0347511893
-
The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin
-
Seidman J.D., Horkayne-Szakaly I., Haiba M., Boice C.R., Kurman R.J., Ronnett B.M. The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin. Int. J. Gynecol. Pathol. 2004, 23:41-44.
-
(2004)
Int. J. Gynecol. Pathol.
, vol.23
, pp. 41-44
-
-
Seidman, J.D.1
Horkayne-Szakaly, I.2
Haiba, M.3
Boice, C.R.4
Kurman, R.J.5
Ronnett, B.M.6
-
41
-
-
0345256652
-
Cisplatin: mode of cytotoxic action and molecular basis of resistance
-
Siddik Z.H. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003, 22:7265-7279.
-
(2003)
Oncogene
, vol.22
, pp. 7265-7279
-
-
Siddik, Z.H.1
-
42
-
-
84892805731
-
Cancer statistics, 2014
-
Siegel R., Ma J., Zou Z., Jemal A. Cancer statistics, 2014. CA Cancer J. Clin. 2014, 64:9-29.
-
(2014)
CA Cancer J. Clin.
, vol.64
, pp. 9-29
-
-
Siegel, R.1
Ma, J.2
Zou, Z.3
Jemal, A.4
-
43
-
-
79960065022
-
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
-
Sievers S.A., Karanicolas J., Chang H.W., Zhao A., Jiang L., Zirafi O., Stevens J.T., Münch J., Baker D., Eisenberg D. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature 2011, 475:96-100.
-
(2011)
Nature
, vol.475
, pp. 96-100
-
-
Sievers, S.A.1
Karanicolas, J.2
Chang, H.W.3
Zhao, A.4
Jiang, L.5
Zirafi, O.6
Stevens, J.T.7
Münch, J.8
Baker, D.9
Eisenberg, D.10
-
44
-
-
84901243647
-
Prion-like aggregation of mutant p53 in cancer
-
Silva J.L., Gallo C.V.D.M., Costa D.C.F., Rangel L.P. Prion-like aggregation of mutant p53 in cancer. Trends Biochem. Sci. 2014, 39:260-267.
-
(2014)
Trends Biochem. Sci.
, vol.39
, pp. 260-267
-
-
Silva, J.L.1
Gallo, C.V.D.M.2
Costa, D.C.F.3
Rangel, L.P.4
-
45
-
-
84865578822
-
P53 inactivation upregulates p73 expression through E2F-1 mediated transcription
-
Tophkhane C., Yang S.-H., Jiang Y., Ma Z., Subramaniam D., Anant S., Yogosawa S., Sakai T., Liu W.-G., Edgerton S., et al. p53 inactivation upregulates p73 expression through E2F-1 mediated transcription. PLoS One 2012, 7:e43564.
-
(2012)
PLoS One
, vol.7
, pp. e43564
-
-
Tophkhane, C.1
Yang, S.-H.2
Jiang, Y.3
Ma, Z.4
Subramaniam, D.5
Anant, S.6
Yogosawa, S.7
Sakai, T.8
Liu, W.-G.9
Edgerton, S.10
-
46
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
-
Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., Kong N., Kammlott U., Lukacs C., Klein C., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004, 303:844-848.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
-
47
-
-
80053168788
-
Rethinking ovarian cancer: recommendations for improving outcomes
-
Vaughan S., Coward J.I., Bast R.C., Berchuck A., Berek J.S., Brenton J.D., Coukos G., Crum C.C., Drapkin R., Etemadmoghadam D., et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nat. Rev. Cancer 2011, 11:719-725.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 719-725
-
-
Vaughan, S.1
Coward, J.I.2
Bast, R.C.3
Berchuck, A.4
Berek, J.S.5
Brenton, J.D.6
Coukos, G.7
Crum, C.C.8
Drapkin, R.9
Etemadmoghadam, D.10
-
48
-
-
84868359914
-
Allele specific gain-of-function activity of p53 mutants in lung cancer cells
-
Vaughan C.A., Frum R., Pearsall I., Singh S., Windle B., Yeudall A., Deb S.P., Deb S. Allele specific gain-of-function activity of p53 mutants in lung cancer cells. Biochem. Biophys. Res. Commun. 2012, 428:6-10.
-
(2012)
Biochem. Biophys. Res. Commun.
, vol.428
, pp. 6-10
-
-
Vaughan, C.A.1
Frum, R.2
Pearsall, I.3
Singh, S.4
Windle, B.5
Yeudall, A.6
Deb, S.P.7
Deb, S.8
-
49
-
-
57049114832
-
The genetics of the p53 pathway, apoptosis and cancer therapy
-
Vazquez A., Bond E.E., Levine A.J., Bond G.L. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat. Rev. Drug Discov. 2008, 7:979-987.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 979-987
-
-
Vazquez, A.1
Bond, E.E.2
Levine, A.J.3
Bond, G.L.4
-
50
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A., Kirsch D.G., McLaughlin M.E., Tuveson D.A., Grimm J., Lintault L., Newman J., Reczek E.E., Weissleder R., Jacks T. Restoration of p53 function leads to tumour regression in vivo. Nature 2007, 445:661-665.
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
51
-
-
0037161921
-
DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest
-
Vossio S., Palescandolo E., Pediconi N., Moretti F., Balsano C., Levrero M., Costanzo A. DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. Oncogene 2002, 21:3796-3803.
-
(2002)
Oncogene
, vol.21
, pp. 3796-3803
-
-
Vossio, S.1
Palescandolo, E.2
Pediconi, N.3
Moretti, F.4
Balsano, C.5
Levrero, M.6
Costanzo, A.7
-
53
-
-
84865293745
-
First-order rate-determining aggregation mechanism of p53 and its implications
-
Wang G., Fersht A.R. First-order rate-determining aggregation mechanism of p53 and its implications. Proc. Natl. Acad. Sci. USA 2012, 109:13590-13595.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 13590-13595
-
-
Wang, G.1
Fersht, A.R.2
-
54
-
-
84865281347
-
Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition
-
Wilcken R., Wang G., Boeckler F.M., Fersht A.R. Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition. Proc. Natl. Acad. Sci. USA 2012, 109:13584-13589.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 13584-13589
-
-
Wilcken, R.1
Wang, G.2
Boeckler, F.M.3
Fersht, A.R.4
-
55
-
-
79955054710
-
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
-
Xu J., Reumers J., Couceiro J.R., De Smet F., Gallardo R., Rudyak S., Cornelis A., Rozenski J., Zwolinska A., Marine J.-C., et al. Gain of function of mutant p53 by coaggregation with multiple tumor suppressors. Nat. Chem. Biol. 2011, 7:285-295.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 285-295
-
-
Xu, J.1
Reumers, J.2
Couceiro, J.R.3
De Smet, F.4
Gallardo, R.5
Rudyak, S.6
Cornelis, A.7
Rozenski, J.8
Zwolinska, A.9
Marine, J.-C.10
-
56
-
-
84861368058
-
Allele specific p53 mutant reactivation
-
Yu X., Vazquez A., Levine A.J., Carpizo D.R. Allele specific p53 mutant reactivation. Cancer Cell 2012, 21:614-625.
-
(2012)
Cancer Cell
, vol.21
, pp. 614-625
-
-
Yu, X.1
Vazquez, A.2
Levine, A.J.3
Carpizo, D.R.4
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