Mitophagy Transcriptome: Mechanistic Insights into Polyphenol-Mediated Mitophagy

Oxidative Medicine and Cellular Longevity

Volumn 2017, Issue , 2017, Pages

  Tan, Sijie ^a   Wong, Esther ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PHYSIOLOGY;

CELLULAR FUNCTION; CELLULAR PROTECTION; DIETARY INTAKES; FUNCTIONAL CONNECTION; MITOCHONDRIAL STRESS; REGULATORY MECHANISM; TRANSCRIPTOMES; UP-REGULATION;

MITOCHONDRIA;

MEMBRANE PROTEIN; PARKIN; POLYPHENOL; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTOME;

DIETARY INTAKE; HUMAN; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MITOPHAGY; PHAGOSOME; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; GENETICS; METABOLISM;

AGING; DISEASES; TOXICITY;

HUMANS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; POLYPHENOLS; TRANSCRIPTOME;

EID: 85021702696     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2017/9028435     Document Type: Review

References (133)

1. D. D. Newmeyer and S. Ferguson-Miller, "Mitochondria: releasing power for life and unleashing the machineries of death," Cell, vol. 112, no. 4, pp. 481-490, 2003.
2. A. Y. Seo, A. M. Joseph, D. Dutta, J. C. Hwang, J. P. Aris, and C. Leeuwenburgh, "New insights into the role of mitochondria in aging: mitochondrial dynamics and more," Journal of Cell Science, vol. 123, Part 15, pp. 2533-2542, 2010.
3. D. K. Woo and G. S. Shadel, "Mitochodrial stress signals. Revise an old aging theory," Cell, vol. 144, no. 1, pp. 11-12, 2011.
4. D. F. Dai, Y. A. Chiao, D. J. Marcinek, H. H. Szeto, and P. S. Rabinovitch, "Mitochondrial oxidative stress in aging and healthspan," Longevity & Healthspan, vol. 3, no. 1, p. 6, 2014.
5. A. Bratic and N. G. Larsson, "The role of mitochondria in aging," The Journal of Clinical Investigation, vol. 123, no. 3, pp. 951-957, 2013.
6. C. F. Bento, M. Renna, G. Ghislat et al., "Mammalian autophagy: how does it work?" Annual Review of Biochemistry, vol. 85, pp. 685-713, 2016.
7. L. Liu, K. Sakakibara, Q. Chen, and K. Okamoto, "Receptormediated mitophagy in yeast and mammalian systems," Cell Research, vol. 24, no. 7, pp. 787-795, 2014.
8. J. J. Lemasters, "Variants of mitochondrial autophagy:types 1 and 2 mitophagy and micromitophagy (type 3)," Redox Biology, vol. 2, pp. 749-754, 2014.
9. E. M. Fivenson, S. Lautrup, N. Sun et al., "Mitophagy in neurodegeneration and aging," Neurochemistry International, 2017, In press.
10. N. Sun, R. J. Youle, and T. Finkel, "The mitochondrial basis of aging," Molecular Cell, vol. 61, no. 5, pp. 654-666, 2016.
11. C. Correia-Meio, F. D. Marques, R. Anderson et al., "Mitochondria are required for pro-ageing features of the senescent phenotype," The EMBO Journal, vol. 35, no. 7, pp. 724-742, 2016.
12. M. C. Lo, C. I. Lu, M. H. Chen, C. D. Chen, H. M. Lee, and S. H. Kao, "Gycoxidative stress-induced mitophagy modulates mitochondrial fates," Annals of the New York Academy of Sciences, vol. 1201, no. 1, pp. 1-7, 2010.
13. A. Siddiqui, D. Bhaumik, S. J. Chinta et al., "Mitochondrial quality control via the PGC1alpha-TFEB signaling pathway is compromised by Parkin Q311X mutation but independently restored by rapamycin," The Journal of Neuroscience, vol. 35, no. 37, pp. 12833-12844, 2015.
14. A. Schiavi, S. Maglioni, K. Palikaras et al., "Iron-starvationinduced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans," Current Biology, vol. 25, no. 14, pp. 1810-1822, 2015.
15. D. Ryu, D. Ryu, L. Mouchiroud et al., "Urolithin a induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents," Nature Medicine, vol. 22, no. 8, pp. 879-888, 2016.
16. K. F. Mills, K. F. Mills, S. Yoshida et al., "Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice," Cell Metabolism, vol. 24, no. 6, pp. 795-806, 2016.
17. M. S. Bonkowski and D. A. Sinclair, "Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds," Nature Reviews. Molecular Cell Biology, vol. 17, no. 11, pp. 679-690, 2016.
18. D. Ivankovic, D. Ivankovic, K. Y. Chau, A. H. Schapira, and M. E. Gegg, "Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy," Journal of Neurochemistry, vol. 136, no. 2, pp. 388-402, 2016.
19. N. Raben and R. Puertollano, "TFEB and TFE3: linking lysosomes to cellular adaptation to stress," Annual Review of Cell and Developmental Biology, vol. 32, pp. 255-278, 2016.
20. X. Zhang, X. Zhang, X. Cheng et al., "MCOLN1 is a ROS sensor in lysosomes that regulates autophagy," Nature Communications, vol. 7, p. 12109, 2016.
21. E. F. Fang, M. Scheibye-Knudsen, K. F. Chua, M. P. Mattson, D. L. Croteau, and V. A. Bohr, "Nuclear DNA damage signalling to mitochondria in ageing," Nature Reviews. Molecular Cell Biology, vol. 17, no. 5, pp. 308-321, 2016.
22. E. F. Fang, E. F. Fang, H. Kassahun et al., "NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair," Cell Metabolism, vol. 24, no. 4, pp. 566-581, 2016.
23. L. R. Lapierre, L. R. Lapierre, C. Kumsta, M. Sandri, A. Ballabio, and M. Hansen, "Transcriptional and epigenetic regulation of autophagy in aging," Autophagy, vol. 11, no. 6, pp. 867-880, 2015.
24. K. Pallauf, N. Duckstein, and G. Rimbach, "A literature review of flavonoids and lifespan in model organisms," The Proceedings of the Nutrition Society, vol. 76, no. 2, pp. 145-162, 2016.
25. K. Pallauf and G. Rimbach, "Autophagy, polyphenols and healthy ageing," Ageing Research Reviews, vol. 12, no. 1, pp. 237-252, 2013.
26. G. Testa, G. Testa, F. Biasi, G. Poli, and E. Chiarpotto, "Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity," Current Pharmaceutical Design, vol. 20, no. 18, pp. 2950-2977, 2014.
27. S. Das, S. Das, G. Mitrovsky, H. R. Vasanthi, and D. K. Das, "Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN," Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 345105, p. 13, 2014.
28. X. Yu, X. Yu, Y. Xu et al., "Quercetin attenuates chronic ethanol-induced hepatic mitochondrial damage through enhanced mitophagy," Nutrients, vol. 8, no. 1, p. 27, 2016.
29. L. Yang, X. Wang, and X. Yang, "Possible antioxidant mechanism of melanoidins extract from Shanxi aged vinegar in mitophagy-dependent and mitophagy-independent pathways," Journal of Agricultural and Food Chemistry, vol. 62, no. 34, pp. 8616-8622, 2014.
30. J. Zhang, J. Zhang, J. Wang et al., "Curcumin targets the TFEB-lysosome pathway for induction of autophagy," Oncotarget, vol. 7, no. 46, pp. 75659-75671, 2016.
31. U. Cagin and J. A. Enriquez, "The complex crosstalk between mitochondria and the nucleus: what goes in between?" The International Journal of Biochemistry & Cell Biology, vol. 63, pp. 10-15, 2015.
32. C. Cherry, B. Thompson, N. Saptarshi, J. Wu, and J. Hoh, "2016: a "Mitochondria" odyssey," Trends in Molecular Medicine, vol. 22, no. 5, pp. 391-403, 2016.
33. P. M. Quiros, A. Mottis, and J. Auwerx, "Mitonuclear communication in homeostasis and stress," Nature Reviews. Molecular Cell Biology, vol. 17, no. 4, pp. 213-226, 2016.
34. D. H. Margineantu and D. M. Hockenbery, "Mitochondrial functions in stem cells," Current Opinion in Genetics & Development, vol. 38, pp. 110-117, 2016.
35. J. A. Menendez and J. Joven, "Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer," Advances in Experimental Medicine and Biology, vol. 824, pp. 117-140, 2014.
36. C. M. Haynes and D. Ron, "The mitochondrial UPR - protecting organelle protein homeostasis," Journal of Cell Science, vol. 123, Part 22, pp. 3849-3855, 2010.
37. V. Jovaisaite, L. Mouchiroud, and J. Auwerx, "The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease," The Journal of Experimental Biology, vol. 217, Part 1, pp. 137-143, 2014.
38. M. W. Pellegrino, A. M. Nargund, and C. M. Haynes, "Signaling the mitochondrial unfolded protein response," Biochimica et Biophysica Acta, vol. 1833, no. 2, pp. 410-416, 2013.
39. K. Palikaras, E. Lionaki, and N. Tavernarakis, "Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans," Nature, vol. 521, no. 7553, pp. 525-528, 2015.
40. K. Palikaras, E. Lionaki, and N. Tavernarakis, "Coupling mitogenesis and mitophagy for longevity," Autophagy, vol. 11, no. 8, pp. 1428-1430, 2015.
41. K. Palikaras and N. Tavernarakis, "Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis," Experimental Gerontology, vol. 56, pp. 182-188, 2014.
42. H. B. Suliman and C. A. Piantadosi, "Mitochondrial quality control as a therapeutic target," Pharmacological Reviews, vol. 68, no. 1, pp. 20-48, 2016.
43. G. Juhasz, "A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17," The Journal of Cell Biology, vol. 214, no. 3, pp. 241-243, 2016.
44. G. Ashrafi and T. L. Schwarz, "The pathways of mitophagy for quality control and clearance of mitochondria," Cell Death and Differentiation, vol. 20, no. 1, pp. 31-42, 2013.
45. C. H. Davis, K. Y. Kim, E. A. Bushong et al., "Transcellular degradation of axonal mitochondria," Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 26, pp. 9633-9638, 2014.
46. C. H. Davis and N. Marsh-Armstrong, "Discovery and implications of transcellular mitophagy," Autophagy, vol. 10, no. 12, pp. 2383-2384, 2014.
47. K. Palikaras, E. Lionaki, and N. Tavernarakis, "Mitophagy: in sickness and in health," Molecular & Cellular Oncology, vol. 3, no. 1, article e1056332, 2016.
48. E. Lionaki, E. Lionaki, M. Markaki, K. Palikaras, and N. Tavernarakis, "Mitochondria, autophagy and age-associated neurodegenerative diseases: new insights into a complex interplay," Biochimica et Biophysica Acta, vol. 1847, no. 11, pp. 1412-1423, 2015.
49. I. G. Onyango, S. M. Khan, and J. P. Bennett Jr., "Mitochondria in the pathophysiology of Alzheimer's and Parkinson's diseases," Frontiers in bioscience (Landmark edition), vol. 22, pp. 854-872, 2017.
50. S. H. Lee, S. H. Lee, J. Du et al., "Inducing mitophagy in diabetic platelets protects against severe oxidative stress," EMBO Molecular Medicine, vol. 8, no. 7, pp. 779-795, 2016.
51. Y. Feng, Y. Feng, D. He, Z. Yao, and D. J. Klionsky, "The machinery of macroautophagy," Cell Research, vol. 24, no. 1, pp. 24-41, 2014.
52. N. Mizushima, T. Yoshimori, and Y. Ohsumi, "The role of Atg proteins in autophagosome formation," Annual Review of Cell and Developmental Biology, vol. 27, pp. 107-132, 2011.
53. T. Hara, T. Hara, K. Nakamura et al., "Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice," Nature, vol. 441, no. 7095, pp. 885-889, 2006.
54. M. Komatsu, M. Komatsu, S. Waguri et al., "Loss of autophagy in the central nervous system causes neurodegeneration in mice," Nature, vol. 441, no. 7095, pp. 880-884, 2006.
55. A. Takamura, A. Takamura, M. Komatsu et al., "Autophagydeficient mice develop multiple liver tumors," Genes & Development, vol. 25, no. 8, pp. 795-800, 2011.
56. A. Kuma, A. Kuma, M. Hatano, M. Matsui, and A. Yamamoto, "The role of autophagy during the early neonatal starvation period," Nature, vol. 432, no. 7020, pp. 1032-1036, 2004.
57. A. Stolz, A. Ernst, and I. Dikic, "Cargo recognition and trafficking in selective autophagy," Nature Cell Biology, vol. 16, no. 6, pp. 495-501, 2014.
58. H. M. Ni, J. A. Williams, and W. X. Ding, "Mitochondrial dynamics and mitochondrial quality control," Redox Biology, vol. 4, pp. 6-13, 2015.
59. E. Smirnova, E. Smirnova, L. Griparic, D. L. Shurland, and A. M. Van Der Bliek, "Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells," Molecular Biology of the Cell, vol. 12, no. 8, pp. 2245-2256, 2001.
60. H. Chen, S. A. Detmer, A. J. Ewald, E. E. Griffin, S. E. Fraser, and D. C. Chan, "Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development," The Journal of Cell Biology, vol. 160, no. 2, pp. 189-200, 2003.
61. M. E. Gegg, J. M. Cooper, K. Y. Chau, M. Rojo, A. H. Schapira, and J. W. Taanman, "Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy," Human Molecular Genetics, vol. 19, no. 24, pp. 4861-4870, 2010.
62. E. Deas, H. Plun-Favreau, S. Gandhi et al., "PINK1 cleavage at position A103 by the mitochondrial protease PARL," Human Molecular Genetics, vol. 20, no. 5, pp. 867-879, 2011.
63. A. W. Greene, K. Grenier, M. A. Aguileta et al., "Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment," EMBO Reports, vol. 13, no. 4, pp. 378-385, 2012.
64. C. Meissner, H. Lorenz, A. Weihofen, D. J. Selkoe, and M. K. Lemberg, "The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking," Journal of Neurochemistry, vol. 117, no. 5, pp. 856-867, 2011.
65. S. M. Jin, M. Lazarou, C. Wang, L. A. Kane, D. P. Narendra, and R. J. Youle, "Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL," The Journal of Cell Biology, vol. 191, no. 5, pp. 933-942, 2010.
66. M. Lazarou, S. M. Jin, L. A. Kane, and R. J. Youle, "Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin," Developmental Cell, vol. 22, no. 2, pp. 320-333, 2012.
67. T. R. Caulfield, F. C. Fiesel, E. L. Moussaud-Lamodière, D. F. Dourado, S. C. Flores, and W. Springer, "Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin," PLoS Computational Biology, vol. 10, no. 11, article e1003935, 2014.
68. A. Kazlauskaite, V. Kelly, C. Johnson et al., "Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity," Open Biology, vol. 4, no. 3, p. 130213, 2014.
69. A. Kazlauskaite, C. Kondapalli, R. Gourlay et al., "Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65," The Biochemical Journal, vol. 460, no. 1, pp. 127-139, 2014.
70. A. Kazlauskaite, R. J. Martínez - Torres, S. Wilkie et al., "Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation," EMBO Reports, vol. 16, no. 8, pp. 939-954, 2015.
71. S. Michiorri, V. Gelmetti, E. Giarda et al., "The Parkinsonassociated protein PINK1 interacts with Beclin1 and promotes autophagy," Cell Death and Differentiation, vol. 17, no. 6, pp. 962-974, 2010.
72. C. Van Humbeeck, T. Cornelissen, H. Hofkens et al., "Parkin interacts with Ambra1 to induce mitophagy," The Journal of Neuroscience, vol. 31, no. 28, pp. 10249-10261, 2011.
73. F. Strappazzon, F. Nazio, M. Corrado et al., "AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1," Cell Death and Differentiation, vol. 22, no. 3, pp. 419-432, 2015.
74. C. T. Chu, J. Ji, R. K. Dagda et al., "Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells," Nature Cell Biology, vol. 15, no. 10, pp. 1197-1205, 2013.
75. V. E. Kagan, V. E. Kagan, J. Jiang et al., "NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy," Cell Death and Differentiation, vol. 23, no. 7, pp. 1140-1151, 2016.
76. R. D. Sentelle, C. E. Senkal, W. Jiang et al., "Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy," Nature Chemical Biology, vol. 8, no. 10, pp. 831-838, 2012.
77. J. Fullgrabe, D. J. Klionsky, and B. Joseph, "The return of the nucleus: transcriptional and epigenetic control of autophagy," Nature Reviews. Molecular Cell Biology, vol. 15, no. 1, pp. 65-74, 2014.
78. A. E. Webb and A. Brunet, "FOXO transcription factors: key regulators of cellular quality control," Trends in Biochemical Sciences, vol. 39, no. 4, pp. 159-169, 2014.
79. L. R. Lapierre, C. D. De Magalhaes Filho, M. Q. PR et al., "The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans," Nature Communications, vol. 4, article 2267, pp. 1-8, 2013.
80. C. T. Murphy, C. T. Murphy, M. C. SA et al., "Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans," Nature, vol. 424, no. 6946, pp. 277-283, 2003.
81. A. M. Sanchez, R. B. Candau, and H. Bernardi, "FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis," Cellular and Molecular Life Sciences, vol. 71, no. 9, pp. 1657-1671, 2014.
82. E. L. Greer, P. R. Oskoui, M. R. Banko et al., "The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor," The Journal of Biological Chemistry, vol. 282, no. 41, pp. 30107-30119, 2007.
83. E. L. Greer, D. Dowlatshahi, M. R. Banko et al., "An AMPKFOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans," Current Biology, vol. 17, no. 19, pp. 1646-1656, 2007.
84. A. Brunet, L. B. Sweeney, J. F. Sturgill et al., "Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase," Science, vol. 303, no. 5666, pp. 2011-2015, 2004.
85. C. Mammucari, C. Mammucari, G. Milan et al., "FoxO3 controls autophagy in skeletal muscle in vivo," Cell Metabolism, vol. 6, no. 6, pp. 458-471, 2007.
86. C. Mammucari, S. Schiaffino, and M. Sandri, "Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle," Autophagy, vol. 4, no. 4, pp. 524-526, 2008.
87. J. Zhao, J. J. Brault, A. Schild et al., "FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells," Cell Metabolism, vol. 6, no. 6, pp. 472-483, 2007.
88. L. Papa and D. Germain, "SirT3 regulates the mitochondrial unfolded protein response," Molecular and Cellular Biology, vol. 34, no. 4, pp. 699-710, 2014.
89. W. Yu, B. Gao, N. Li et al., "Sirt3 deficiency exacerbates diabetic cardiac dysfunction: role of Foxo3A-Parkin-mediated mitophagy," Biochimica et Biophysica Acta, 2016, In press.
90. M. Sardiello, M. Sardiello, M. Palmieri et al., "A gene network regulating lysosomal biogenesis and function," Science, vol. 325, no. 5939, pp. 473-477, 2009.
91. M. Palmieri, M. Palmieri, S. Impey et al., "Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways," Human Molecular Genetics, vol. 20, no. 19, pp. 3852-3866, 2011.
92. M. Sardiello, "Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases," Annals of the New York Academy of Sciences, vol. 1371, no. 1, pp. 3-14, 2016.
93. Y. Sancak, L. Bar-Peled, R. Zoncu, A. L. Markhard, S. Nada, and D. M. Sabatini, "Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids," Cell, vol. 141, no. 2, pp. 290-303, 2010.
94. R. Zoncu, L. Bar-Peled, A. Efeyan, S. Wang, Y. Sancak, and D. M. Sabatini, "mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase," Science, vol. 334, no. 6056, pp. 678-683, 2011.
95. A. Roczniak-Ferguson, C. S. Petit, F. Froehlich et al., "The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis," Science Signaling, vol. 5, no. 228, p. ra42, 2012.
96. C. Settembre, C. Di Malta, V. A. Polito et al., "TFEB links autophagy to lysosomal biogenesis," Science, vol. 332, no. 6036, pp. 1429-1433, 2011.
97. D. L. Medina, S. Di Paola, I. Peluso et al., "Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB," Nature Cell Biology, vol. 17, no. 3, pp. 288-299, 2015.
98. C. L. Nezich, C. Wang, A. I. Fogel, and R. J. Youle, "MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5," The Journal of Cell Biology, vol. 210, no. 3, pp. 435-450, 2015.
99. Y. Lee, D. A. Stevens, S. U. Kang et al., "PINK1 primes Parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival," Cell Reports, vol. 18, no. 4, pp. 918-932, 2017.
100. J. B. Harborne, "Role of secondary metabolites in chemical defence mechanisms in plants," Ciba Foundation Symposium, vol. 154, pp. 126-134, 1990, discussion 135-9.
101. C. Sandoval-Acuna, J. Ferreira, and H. Speisky, "Polyphenols and mitochondria: an update on their increasingly emerging ROS-scavenging independent actions," Archives of Biochemistry and Biophysics, vol. 559, pp. 75-90, 2014.
102. D. Valenti, L. de Bari, D. de Rasmo et al., "The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model," Biochimica et Biophysica Acta, vol. 1862, no. 6, pp. 1093-1104, 2016.
103. Y. Mizuguchi, H. Hatakeyama, K. Sueoka, M. Tanaka, and Y. I. Goto, "Low dose resveratrol ameliorates mitochondrial respiratory dysfunction and enhances cellular reprogramming," Mitochondrion, 2017.
104. G. Jayanthy, V. Roshana Devi, K. Ilango, and S. P. Subramanian, "Rosmarinic acid mediates mitochondrial biogenesis in insulin resistant skeletal muscle through activation of AMPK," Journal of Cellular Biochemistry, vol. 118, no. 7, pp. 1839-1848, 2017.
105. M. Huttemann, I. Lee, and M. H. Malek, "(-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining," The FASEB Journal, vol. 26, no. 4, pp. 1413-1422, 2012.
106. M. Huttemann, I. Lee, G. A. Perkins, S. L. Britton, L. G. Koch, and M. H. Malek, "(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity," Clinical Science (London, England), vol. 124, no. 11, pp. 663-674, 2013.
107. I. Lee, M. Hüttemann, A. Kruger, A. Bollig-Fischer, and M. H. Malek, "(-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice," Frontiers in Pharmacology, vol. 6, article 43, pp. 1-10, 2015.
108. A. Moreno-Ulloa, A. Cid, I. Rubio-Gayosso, G. Ceballos, F. Villarreal, and I. Ramirez-Sanchez, "Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins," Bioorganic & Medicinal Chemistry Letters, vol. 23, no. 15, pp. 4441-4446, 2013.
109. A. Moreno-Ulloa, L. Nogueira, A. Rodriguez et al., "Recovery of indicators of mitochondrial biogenesis, oxidative stress, and aging with (-)-epicatechin in senile mice," The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences, vol. 70, no. 11, pp. 1370-1378, 2015.
110. L. Nogueira, I. Ramirez - Sanchez, G. A. Perkins et al., "(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle," The Journal of Physiology, vol. 589, Part 18, pp. 4615-4631, 2011.
111. I. Ramirez-Sanchez, L. Nogueira, A. Moreno et al., "Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: additive effects with exercise," Journal of Cardiovascular Pharmacology, vol. 60, no. 5, pp. 429-438, 2012.
112. I. Ramirez-Sanchez, A. Rodríguez, A. Moreno-Ulloa, G. Ceballos, and F. Villarreal, "(-)-Epicatechin-induced recovery of mitochondria from simulated diabetes: potential role of endothelial nitric oxide synthase," Diabetes & Vascular Disease Research, vol. 13, no. 3, pp. 201-210, 2016.
113. K. G. Yamazaki, A. Y. Andreyev, P. Ortiz-Vilchis et al., "Intravenous (-)-epicatechin reduces myocardial ischemic injury by protecting mitochondrial function," International Journal of Cardiology, vol. 175, no. 2, pp. 297-306, 2014.
114. H. Yamamoto, K. Morino, L. Mengistu et al., "Amla enhances mitochondrial spare respiratory capacity by increasing mitochondrial biogenesis and antioxidant systems in a murine skeletal muscle cell line," Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 1735841, p. 11, 2016.
115. Y. Mei, Y. Zhang, K. Yamamoto, W. Xie, T. W. Mak, and H. You, "FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation," Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 13, pp. 5153-5158, 2009.
116. M. Song, G. Gong, Y. Burelle et al., "Interdependence of Parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts," Circulation Research, vol. 117, no. 4, pp. 346-351, 2015.
117. Y. Tang, C. Gao, M. Xing et al., "Quercetin prevents ethanolinduced dyslipidemia and mitochondrial oxidative damage," Food and Chemical Toxicology, vol. 50, no. 5, pp. 1194-1200, 2012.
118. T. Bai, Y. Yang, Y. L. Yao et al., "Betulin alleviated ethanolinduced alcoholic liver injury via SIRT1/AMPK signaling pathway," Pharmacological Research, vol. 105, pp. 1-12, 2016.
119. X. Jin, M. Chen, L. Yi et al., "Delphinidin-3-glucoside protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway," Molecular Nutrition & Food Research, vol. 58, no. 10, pp. 1941-1951, 2014.
120. I. H. Lee, L. Cao, R. Mostoslavsky et al., "A role for the NADdependent deacetylase Sirt1 in the regulation of autophagy," Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 9, pp. 3374-3379, 2008.
121. J. X. Song, Y. R. Sun, I. Peluso et al., "A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition," Autophagy, vol. 12, no. 8, pp. 1372-1389, 2016.
122. M. Wirth, J. Joachim, and S. A. Tooze, "Autophagosome formation-the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage," Seminars in Cancer Biology, vol. 23, no. 5, pp. 301-309, 2013.
123. X. Ma, H. Liu, J. T. Murphy et al., "Regulation of the transcription factor EB-PGC1alpha axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress," Molecular and Cellular Biology, vol. 35, no. 6, pp. 956-976, 2015.
124. J. S. Kim, T. Nitta, D. Mohuczy et al., "Impaired autophagy: a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes," Hepatology, vol. 47, no. 5, pp. 1725-1736, 2008.
125. T. Finkel, "Signal transduction by mitochondrial oxidants," The Journal of Biological Chemistry, vol. 287, no. 7, pp. 4434-4440, 2012.
126. T. Finkel, "Signal transduction by reactive oxygen species," The Journal of Cell Biology, vol. 194, no. 1, pp. 7-15, 2011.
127. Y. Wang and S. Hekimi, "Mitochondrial dysfunction and longevity in animals: untangling the knot," Science, vol. 350, no. 6265, pp. 1204-1207, 2015.
128. G. S. Shadel and T. L. Horvath, "Mitochondrial ROS signaling in organismal homeostasis," Cell, vol. 163, no. 3, pp. 560-569, 2015.
129. J. Yun and T. Finkel, "Mitohormesis," Cell Metabolism, vol. 19, no. 5, pp. 757-766, 2014.
130. B. Halliwell, "Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?" Archives of Biochemistry and Biophysics, vol. 476, no. 2, pp. 107-112, 2008.
131. F. Pietrocola, G. Mariño, D. Lissa et al., "Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins," Cell Cycle, vol. 11, no. 20, pp. 3851-3860, 2012.
132. J. A. Lim, L. Li, O. Kakhlon, R. Myerowitz, and N. Raben, "Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease," Autophagy, vol. 11, no. 2, pp. 385-402, 2015.
133. J. Demers-Lamarche, G. Guillebaud, M. Tlili et al., "Loss of mitochondrial function impairs lysosomes," The Journal of Biological Chemistry, vol. 291, no. 19, pp. 10263-10276, 2016.