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Volumn 124, Issue 11, 2013, Pages 663-674

(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity

Author keywords

Dark chocolate; Epicatechin; Natural compound; Nutrition; Supplementation

Indexed keywords

EPICATECHIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOCYTE ENHANCER FACTOR 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; SYNAPTOPHYSIN; THROMBOSPONDIN 1; VASCULOTROPIN A;

EID: 84874684795     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120469     Document Type: Article
Times cited : (35)

References (60)
  • 1
    • 0029918029 scopus 로고    scopus 로고
    • Determinants of maximal oxygen transport and utilization
    • Wagner, P. D. (1996) Determinants of maximal oxygen transport and utilization. Annu. Rev. Physiol. 58, 21-50
    • (1996) Annu. Rev. Physiol. , vol.58 , pp. 21-50
    • Wagner, P.D.1
  • 2
    • 35648937073 scopus 로고    scopus 로고
    • Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals
    • Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., Lebrasseur, N. K., Yan, Z. and Spiegelman, B. M. (2007) Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals. J. Biol. Chem. 282, 30014-30021
    • (2007) J. Biol. Chem. , vol.282 , pp. 30014-30021
    • Handschin, C.1    Chin, S.2    Li, P.3    Liu, F.4    Maratos-Flier, E.5    Lebrasseur, N.K.6    Yan, Z.7    Spiegelman, B.M.8
  • 3
    • 70949087409 scopus 로고    scopus 로고
    • p38γ mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice
    • Pogozelski, A. R., Geng, T., Li, P., Yin, X., Lira, V. A., Zhang, M., Chi, J. T. and Yan, Z. (2009) p38γ mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS ONE 4, e7934
    • (2009) PLoS ONE , vol.4
    • Pogozelski, A.R.1    Geng, T.2    Li, P.3    Yin, X.4    Lira, V.A.5    Zhang, M.6    Chi, J.T.7    Yan, Z.8
  • 4
    • 84860912859 scopus 로고    scopus 로고
    • (-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining
    • Ḧuttemann, M., Lee, I. and Malek, M. H. (2012) (-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining. FASEB J. 26, 1413-1422
    • (2012) FASEB J , vol.26 , pp. 1413-1422
    • Ḧuttemann, M.1    Lee, I.2    Malek, M.H.3
  • 5
    • 65649095184 scopus 로고    scopus 로고
    • Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice
    • Malek, M. H. and Olfert, I. M. (2009) Global deletion of thrombospondin-1 increases cardiac and skeletal muscle capillarity and exercise capacity in mice. Exp. Physiol. 94, 749-760
    • (2009) Exp. Physiol. , vol.94 , pp. 749-760
    • Malek, M.H.1    Olfert, I.M.2
  • 6
    • 77957573764 scopus 로고    scopus 로고
    • Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis
    • Olfert, I. M., Howlett, R. A., Wagner, P. D. and Breen, E. C. (2010) Myocyte vascular endothelial growth factor is required for exercise-induced skeletal muscle angiogenesis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299, R1059-R1067
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.299
    • Olfert, I.M.1    Howlett, R.A.2    Wagner, P.D.3    Breen, E.C.4
  • 8
    • 79961092644 scopus 로고    scopus 로고
    • Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice
    • Jackson, J. R., Ryan, M. J. and Alway, S. E. (2011) Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice. J. Gerontol., Ser. A 66, 751-764
    • (2011) J. Gerontol., Ser. A , vol.66 , pp. 751-764
    • Jackson, J.R.1    Ryan, M.J.2    Alway, S.E.3
  • 9
    • 67650547953 scopus 로고    scopus 로고
    • PPARδ agonism activates fatty acid oxidation via PGC-1α but does not increase mitochondrial gene expression and function
    • Kleiner, S., Nguyen-Tran, V., Bare, O., Huang, X., Spiegelman, B. and Wu, Z. (2009) PPARδ agonism activates fatty acid oxidation via PGC-1α but does not increase mitochondrial gene expression and function. J. Biol. Chem. 284, 18624-18633
    • (2009) J. Biol. Chem. , vol.284 , pp. 18624-18633
    • Kleiner, S.1    Nguyen-Tran, V.2    Bare, O.3    Huang, X.4    Spiegelman, B.5    Wu, Z.6
  • 11
    • 0035543069 scopus 로고    scopus 로고
    • Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats
    • Baba, S., Osakabe, N., Natsume, M., Muto, Y., Takizawa, T. and Terao, J. (2001) Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats. J. Agric. Food Chem. 49, 6050-6056
    • (2001) J. Agric. Food Chem. , vol.49 , pp. 6050-6056
    • Baba, S.1    Osakabe, N.2    Natsume, M.3    Muto, Y.4    Takizawa, T.5    Terao, J.6
  • 12
    • 14844353944 scopus 로고    scopus 로고
    • Absorption, distribution, and secretion of epicatechin and quercetin in the rat
    • Abrahamse, S. L., Kloots, W. J. and van Amelsvoort, J. M. M. (2005) Absorption, distribution, and secretion of epicatechin and quercetin in the rat. Nut. Res. 25, 305-317
    • (2005) Nut. Res. , vol.25 , pp. 305-317
    • Abrahamse, S.L.1    Kloots, W.J.2    van Amelsvoort, J.M.M.3
  • 13
    • 0347768067 scopus 로고    scopus 로고
    • Artificial selection for intrinsic aerobic endurance running capacity in rats
    • Koch, L. G. and Britton, S. L. (2001) Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol. Genomics 5, 45-52
    • (2001) Physiol. Genomics , vol.5 , pp. 45-52
    • Koch, L.G.1    Britton, S.L.2
  • 17
    • 0037378417 scopus 로고    scopus 로고
    • Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance
    • Howlett, R. A., Gonzalez, N. C., Wagner, H. E., Fu, Z., Britton, S. L., Koch, L. G. and Wagner, P. D. (2003) Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. J. Appl. Physiol. 94, 1682-1688
    • (2003) J. Appl. Physiol. , vol.94 , pp. 1682-1688
    • Howlett, R.A.1    Gonzalez, N.C.2    Wagner, H.E.3    Fu, Z.4    Britton, S.L.5    Koch, L.G.6    Wagner, P.D.7
  • 18
    • 66749153274 scopus 로고    scopus 로고
    • Peripheral oxygen transport and utilization in rats following continued selective breeding for endurance running capacity
    • Howlett, R. A., Kirkton, S. D., Gonzalez, N. C., Wagner, H. E., Britton, S. L., Koch, L. G. and Wagner, P. D. (2009) Peripheral oxygen transport and utilization in rats following continued selective breeding for endurance running capacity. J. Appl. Physiol. 106, 1819-1825
    • (2009) J. Appl. Physiol. , vol.106 , pp. 1819-1825
    • Howlett, R.A.1    Kirkton, S.D.2    Gonzalez, N.C.3    Wagner, H.E.4    Britton, S.L.5    Koch, L.G.6    Wagner, P.D.7
  • 22
    • 75149162926 scopus 로고    scopus 로고
    • Detraining losses of skeletal muscle capillarization are associated with vascular endothelial growth factor protein expression in rats
    • Malek, M. H., Olfert, I. M. and Esposito, F. (2010) Detraining losses of skeletal muscle capillarization are associated with vascular endothelial growth factor protein expression in rats. Exp. Physiol. 85, 359-368
    • (2010) Exp. Physiol. , vol.85 , pp. 359-368
    • Malek, M.H.1    Olfert, I.M.2    Esposito, F.3
  • 23
    • 84867463958 scopus 로고    scopus 로고
    • Deletion of heart-type cytochrome c oxidase subunit 7A1 impairs skeletal muscle angiogenesis and oxidative phosphorylation
    • Lee, I., Ḧuttemann, M., Liu, J., Grossman, L. I. and Malek, M. H. (2012) Deletion of heart-type cytochrome c oxidase subunit 7A1 impairs skeletal muscle angiogenesis and oxidative phosphorylation. J. Physiol. 590, 5231-5243
    • (2012) J. Physiol. , vol.590 , pp. 5231-5243
    • Lee, I.1    Ḧuttemann, M.2    Liu, J.3    Grossman, L.I.4    Malek, M.H.5
  • 24
    • 84907128731 scopus 로고
    • A histochemical method for the simultaneous demonstration of capillaries and fiber type in skeletal muscle
    • Rosenblatt, J. D., Kuzon, W. M., Plyley, M. J., Pynn, B. R. and Mckee, N. H. (1987) A histochemical method for the simultaneous demonstration of capillaries and fiber type in skeletal muscle. Stain Technol. 62, 85-92
    • (1987) Stain Technol , vol.62 , pp. 85-92
    • Rosenblatt, J.D.1    Kuzon, W.M.2    Plyley, M.J.3    Pynn, B.R.4    Mckee, N.H.5
  • 25
    • 0034749816 scopus 로고    scopus 로고
    • Estimating the size of the capillary-to-fiber interface in skeletal muscle: a comparison of methods
    • Hepple, R. T. and Mathieu-Costello, O. (2001) Estimating the size of the capillary-to-fiber interface in skeletal muscle: a comparison of methods. J. Appl. Physiol. 91, 2150-2156
    • (2001) J. Appl. Physiol. , vol.91 , pp. 2150-2156
    • Hepple, R.T.1    Mathieu-Costello, O.2
  • 26
    • 0031065721 scopus 로고    scopus 로고
    • A new measurement of tissue capillarity: the capillary-to-fibre perimeter exchange index
    • Hepple, R. T. (1997) A new measurement of tissue capillarity: the capillary-to-fibre perimeter exchange index. Can. J. Appl. Physiol. 22, 11-22
    • (1997) Can. J. Appl. Physiol. , vol.22 , pp. 11-22
    • Hepple, R.T.1
  • 27
    • 66349114090 scopus 로고    scopus 로고
    • Anatomic capillarization is elevated in medial gastrocnemius muscle of mighty mini mice
    • Wong, L. E., Garland, Jr, T., Rowan, S. and Hepple, R. T. (2009) Anatomic capillarization is elevated in medial gastrocnemius muscle of mighty mini mice. J. Appl. Physiol. 106, 1660-1667
    • (2009) J. Appl. Physiol. , vol.106 , pp. 1660-1667
    • Wong, L.E.1    Garland Jr., T.2    Rowan, S.3    Hepple, R.T.4
  • 28
    • 0025681431 scopus 로고
    • Capillarity and diffusion distances in skeletal muscles in birds
    • Snyder, G. K. (1990) Capillarity and diffusion distances in skeletal muscles in birds. J. Comp. Physiol. B 160, 583-591
    • (1990) J. Comp. Physiol. B , vol.160 , pp. 583-591
    • Snyder, G.K.1
  • 32
    • 2442686758 scopus 로고    scopus 로고
    • Anatomic capillarization is maintained in relative excess of fiber oxidative capacity in some skeletal muscles of late middle-aged rats
    • Hepple, R. T. and Vogell, J. E. (2004) Anatomic capillarization is maintained in relative excess of fiber oxidative capacity in some skeletal muscles of late middle-aged rats. J. Appl. Physiol. 96, 2257-2264
    • (2004) J. Appl. Physiol. , vol.96 , pp. 2257-2264
    • Hepple, R.T.1    Vogell, J.E.2
  • 33
    • 6044260112 scopus 로고    scopus 로고
    • Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle
    • Waters, R. E., Rotevatn, S., Li, P., Annex, B. H. and Yan, Z. (2004) Voluntary running induces fiber type-specific angiogenesis in mouse skeletal muscle. Am. J. Physiol. Cell Physiol. 287, C1342-C1348
    • (2004) Am. J. Physiol. Cell Physiol. , vol.287
    • Waters, R.E.1    Rotevatn, S.2    Li, P.3    Annex, B.H.4    Yan, Z.5
  • 36
    • 79955141845 scopus 로고    scopus 로고
    • Importance of anti-angiogenic factors in the regulation of skeletal muscle angiogenesis
    • Olfert, I. M. and Birot, O. (2011) Importance of anti-angiogenic factors in the regulation of skeletal muscle angiogenesis. Microcirculation 18, 316-330
    • (2011) Microcirculation , vol.18 , pp. 316-330
    • Olfert, I.M.1    Birot, O.2
  • 37
    • 78449233806 scopus 로고    scopus 로고
    • Angio-adaptation in unloaded skeletal muscle: new insights into an early and muscle type-specific dynamic process
    • Roudier, E., Gineste, C., Wazna, A., Dehghan, K., Desplanches, D. and Birot, O. (2010) Angio-adaptation in unloaded skeletal muscle: new insights into an early and muscle type-specific dynamic process. J. Physiol. 588, 4579-4591
    • (2010) J. Physiol. , vol.588 , pp. 4579-4591
    • Roudier, E.1    Gineste, C.2    Wazna, A.3    Dehghan, K.4    Desplanches, D.5    Birot, O.6
  • 38
    • 33845601631 scopus 로고    scopus 로고
    • Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle
    • Kivela, R., Silvennoinen, M., Touvra, A. M., Lehti, T. M., Kainulainen, H. and Vihko, V. (2006) Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle. FASEB J. 20, 1570-1572
    • (2006) FASEB J , vol.20 , pp. 1570-1572
    • Kivela, R.1    Silvennoinen, M.2    Touvra, A.M.3    Lehti, T.M.4    Kainulainen, H.5    Vihko, V.6
  • 39
    • 78649879269 scopus 로고    scopus 로고
    • Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47
    • Kaur, S., Martin-Manso, G., Pendrak, M. L., Garfield, S. H., Isenberg, J. S. and Roberts, D. D. (2010) Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47. J. Biol. Chem. 285, 38923-38932
    • (2010) J. Biol. Chem. , vol.285 , pp. 38923-38932
    • Kaur, S.1    Martin-Manso, G.2    Pendrak, M.L.3    Garfield, S.H.4    Isenberg, J.S.5    Roberts, D.D.6
  • 41
    • 33748747969 scopus 로고    scopus 로고
    • CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1
    • Isenberg, J. S., Ridnour, L. A., Dimitry, J., Frazier, W. A., Wink, D. A. and Roberts, D. D. (2006) CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. J. Biol. Chem. 281, 26069-26080
    • (2006) J. Biol. Chem. , vol.281 , pp. 26069-26080
    • Isenberg, J.S.1    Ridnour, L.A.2    Dimitry, J.3    Frazier, W.A.4    Wink, D.A.5    Roberts, D.D.6
  • 43
    • 38349132563 scopus 로고    scopus 로고
    • Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling
    • Isenberg, J. S., Romeo, M. J., Yu, C., Yu, C. K., Nghiem, K., Monsale, J., Rick, M. E., Wink, D. A., Frazier, W. A. and Roberts, D. D. (2008) Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood 111, 613-623
    • (2008) Blood , vol.111 , pp. 613-623
    • Isenberg, J.S.1    Romeo, M.J.2    Yu, C.3    Yu, C.K.4    Nghiem, K.5    Monsale, J.6    Rick, M.E.7    Wink, D.A.8    Frazier, W.A.9    Roberts, D.D.10
  • 44
    • 67649784505 scopus 로고    scopus 로고
    • Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation
    • Isenberg, J. S., Shiva, S. and Gladwin, M. (2009) Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation. Nitric Oxide 21, 52-62
    • (2009) Nitric Oxide , vol.21 , pp. 52-62
    • Isenberg, J.S.1    Shiva, S.2    Gladwin, M.3
  • 47
    • 33845674997 scopus 로고    scopus 로고
    • The transcriptional coactivator PGC-1β drives the formation of oxidative type IIX fibers in skeletal muscle
    • Arany, Z., Lebrasseur, N., Morris, C., Smith, E., Yang, W., Ma, Y., Chin, S. and Spiegelman, B. M. (2007) The transcriptional coactivator PGC-1β drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 5, 35-46
    • (2007) Cell Metab , vol.5 , pp. 35-46
    • Arany, Z.1    Lebrasseur, N.2    Morris, C.3    Smith, E.4    Yang, W.5    Ma, Y.6    Chin, S.7    Spiegelman, B.M.8
  • 48
  • 49
    • 77749264581 scopus 로고    scopus 로고
    • PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
    • Geng, T., Li, P., Okutsu, M., Yin, X., Kwek, J., Zhang, M. and Yan, Z. (2010) PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle. Am. J. Physiol. Cell Physiol. 298, C572-C579
    • (2010) Am. J. Physiol. Cell Physiol. , vol.298
    • Geng, T.1    Li, P.2    Okutsu, M.3    Yin, X.4    Kwek, J.5    Zhang, M.6    Yan, Z.7
  • 50
    • 0038036024 scopus 로고    scopus 로고
    • Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
    • St-Pierre, J., Lin, J., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B. and Spiegelman, B. M. (2003) Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells. J. Biol. Chem. 278, 26597-26603
    • (2003) J. Biol. Chem. , vol.278 , pp. 26597-26603
    • St-Pierre, J.1    Lin, J.2    Krauss, S.3    Tarr, P.T.4    Yang, R.5    Newgard, C.B.6    Spiegelman, B.M.7
  • 52
    • 33744987954 scopus 로고    scopus 로고
    • Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state
    • Piccoli, C., Scrima, R., Boffoli, D. and Capitanio, N. (2006) Control by cytochrome c oxidase of the cellular oxidative phosphorylation system depends on the mitochondrial energy state. Biochem. J. 396, 573-583
    • (2006) Biochem. J. , vol.396 , pp. 573-583
    • Piccoli, C.1    Scrima, R.2    Boffoli, D.3    Capitanio, N.4
  • 53
    • 0031029962 scopus 로고    scopus 로고
    • In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells
    • Villani, G. and Attardi, G. (1997) In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc. Natl. Acad. Sci. U.S.A. 94, 1166-1171
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 1166-1171
    • Villani, G.1    Attardi, G.2
  • 54
    • 0033610865 scopus 로고    scopus 로고
    • Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types
    • Villani, G., Greco, M., Papa, S. and Attardi, G. (1998) Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J. Biol. Chem. 273, 31829-31836
    • (1998) J. Biol. Chem. , vol.273 , pp. 31829-31836
    • Villani, G.1    Greco, M.2    Papa, S.3    Attardi, G.4
  • 55
    • 84857923094 scopus 로고    scopus 로고
    • Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation
    • Ḧuttemann, M., Helling, S., Sanderson, T. H., Sinkler, C., Samavati, L., Mahapatra, G., Varughese, A., Lu, G., Liu, J., Ramzan, R. et al. (2011) Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation. Biochim. Biophys. Acta 1817, 598-609
    • (2011) Biochim. Biophys. Acta , vol.1817 , pp. 598-609
    • Ḧuttemann, M.1    Helling, S.2    Sanderson, T.H.3    Sinkler, C.4    Samavati, L.5    Mahapatra, G.6    Varughese, A.7    Lu, G.8    Liu, J.9    Ramzan, R.10
  • 57
    • 84862691088 scopus 로고    scopus 로고
    • The effectiveness and cost effectiveness of dark chocolate consumption as prevention therapy in people at high risk of cardiovascular disease: best case scenario analysis using a Markov model
    • Zomer, E., Owen, A., Magliano, D. J., Liew, D. and Reid, C. M. (2012) The effectiveness and cost effectiveness of dark chocolate consumption as prevention therapy in people at high risk of cardiovascular disease: best case scenario analysis using a Markov model. BMJ 344, e3657
    • (2012) BMJ , vol.344
    • Zomer, E.1    Owen, A.2    Magliano, D.J.3    Liew, D.4    Reid, C.M.5
  • 58
    • 51049107708 scopus 로고    scopus 로고
    • Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate
    • Grassi, D., Desideri, G., Necozione, S., Lippi, C., Casale, R., Properzi, G., Blumberg, J. B. and Ferri, C. (2008) Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J. Nutr. 138, 1671-1676
    • (2008) J. Nutr. , vol.138 , pp. 1671-1676
    • Grassi, D.1    Desideri, G.2    Necozione, S.3    Lippi, C.4    Casale, R.5    Properzi, G.6    Blumberg, J.B.7    Ferri, C.8
  • 59
    • 84861559254 scopus 로고    scopus 로고
    • Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach
    • Ellinger, S., Reusch, A., Stehle, P. and Helfrich, H. P. (2012) Epicatechin ingested via cocoa products reduces blood pressure in humans: a nonlinear regression model with a Bayesian approach. Am. J. Clin. Nutr. 95, 1365-1377
    • (2012) Am. J. Clin. Nutr. , vol.95 , pp. 1365-1377
    • Ellinger, S.1    Reusch, A.2    Stehle, P.3    Helfrich, H.P.4
  • 60
    • 84865957973 scopus 로고    scopus 로고
    • A rat model system to study complex disease risks, fitness, aging, and longevity
    • Koch, L. G., Britton, S. L. and Wisloff, U. (2012) A rat model system to study complex disease risks, fitness, aging, and longevity. Trends Cardiovasc. Med. 22, 29-34
    • (2012) Trends Cardiovasc. Med. , vol.22 , pp. 29-34
    • Koch, L.G.1    Britton, S.L.2    Wisloff, U.3


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