Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway

Pharmacological Research

Volumn 105, Issue , 2016, Pages 1-12

  Bai, Ting ^a,b   Yang, Yong ^a   Yao, You Li ^a   Sun, Peng ^a   Lian, Li Hua ^a   Wu, Yan Ling ^a   Nan, Ji Xing ^a  

^a YANBIAN UNIVERSITY   (China)

^b UNIVERSITY OF JINAN   (China)

Author keywords

Alcoholic liver injury; AMPK; Betulin; LKB1; SIRT1

Indexed keywords

ALCOHOL; ALPHA SMOOTH MUSCLE ACTIN; AMINOTRANSFERASE; BETULIN; COLLAGEN TYPE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE LKB1; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; TRITERPENE;

ALCOHOL LIVER CIRRHOSIS; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STELLATE CELL; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BIRCH; C57BL MOUSE; CELL LINE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; LIVER; LIVER DISEASES, ALCOHOLIC; METABOLISM; PATHOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BETULA; CELL LINE; CELL SURVIVAL; ETHANOL; HUMANS; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRITERPENES;

EID: 84955466128     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.12.022     Document Type: Article

References (41)

1. A.D. Clouston, J.R. Jonsson, and E.E. Powell Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others Clin. Liver Dis. 11 2007 173 189
2. R.M. Carr, and J. Correnti Insulin resistance in clinical and experimental alcoholic liver disease Ann. N. Y. Acad. Sci. 2015
3. R. Raghow, C. Yellaturu, X. Deng, E.A. Park, and M.B. Elam SREBPs: the crossroads of physiological and pathological lipid homeostasis Trends Endocrinol. Metab.: TEM 19 2008 65 73
4. A.C. Calkin, and P. Tontonoz Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR Nat. Rev. Mol. Cell Biol. 13 2012 213 224
5. H.Y. Quan, Y. Kim do, S.J. Kim, H.K. Jo, G.W. Kim, and S.H. Chung Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK-mTOR-SREBP signaling pathway Biochem. Pharmacol. 85 2013 1330 1340
6. M.S. Seo, J.H. Kim, H.J. Kim, K.C. Chang, and S.W. Park Honokiol activates the LKB1-AMPK signaling pathway and attenuates the lipid accumulation in hepatocytes Toxicol. Appl. Pharmacol. 284 2015 113 124
7. X. Liu, J. Lian, C.H. Hu, and C. Deng Betahistine co-treatment ameliorates dyslipidemia induced by chronic olanzapine treatment in rats through modulation of hepatic AMPKalpha-SREBP-1 and PPARalpha-dependent pathways Pharmacol. Res. 100 2015 36 46
8. P.T. Pfluger, D. Herranz, S. Velasco-Miguel, M. Serrano, and M.H. Tschop Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U. S. A. 105 2008 9793 9798
9. Y. Wu, X. Liu, Q. Zhou, C. Huang, X. Meng, F. Xu, and J. Li Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion Toxicol. Appl. Pharmacol. 289 2015 163 176
10. X.Z. Huang, D. Wen, M. Zhang, Q. Xie, L. Ma, Y. Guan, Y. Ren, J. Chen, and C.M. Hao Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-beta/Smad3 pathway J. Cell. Biochem. 115 2014 996 1005
11. W. He, Y. Wang, M.Z. Zhang, L. You, L.S. Davis, H. Fan, H.C. Yang, A.B. Fogo, R. Zent, R.C. Harris, M.D. Breyer, and C.M. Hao Sirt1 activation protects the mouse renal medulla from oxidative injury J. Clin. Invest. 120 2010 1056 1068
12. X. Zhai, K. Yan, J. Fan, M. Niu, Q. Zhou, Y. Zhou, and H. Chen The beta-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis Br. J. Pharmacol. 169 2013 197 212
13. N.C. Henderson, and J.P. Iredale Liver fibrosis: cellular mechanisms of progression and resolution Clin. Sci. (Lond.) 112 2007 265 280
14. M. Adachi, and D.A. Brenner High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase Hepatology 47 2008 677 685
15. I.D. Bori, H.Y. Hung, K. Qian, C.H. Chen, S.L. Morris-Natschke, and K.H. Lee Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry Tetrahedron Lett. 53 2012 1987 1989
16. A. Szuster-Ciesielska, K. Plewka, J. Daniluk, and M. Kandefer-Szerszen Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-alpha TGF-beta) production and by influencing intracellular signaling Toxicology 280 2011 152 163
17. Y. Wan, S. Jiang, L.H. Lian, T. Bai, P.H. Cui, X.T. Sun, X.J. Jin, Y.L. Wu, and J.X. Nan Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro Int. Immunopharmacol. 17 2013 184 190
18. L. Xu, A.Y. Hui, E. Albanis, M.J. Arthur, S.M. O'Byrne, W.S. Blaner, P. Mukherjee, S.L. Friedman, and F.J. Eng Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Gut 54 2005 142 151
19. A. Bertola, S. Mathews, S.H. Ki, H. Wang, and B. Gao Mouse model of chronic and binge ethanol feeding (the NIAAA model) Nat. Protoc. 8 2013 627 637
20. T. Bai, Y. Yang, Y.L. Wu, S. Jiang, J.J. Lee, L.H. Lian, and J.X. Nan Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice Int. Immunopharmacol. 19 2014 351 357
21. J. Ma, H. Shi, C. Mi, H.L. Li, J.J. Lee, and X. Jin Malloapelta B suppresses LPS-induced NF-kappaB activation and NF-kappaB-regulated target gene products Int. Immunopharmacol. 24 2015 147 152
22. T. Bai, L.H. Lian, Y.L. Wu, Y. Wan, and J.X. Nan Thymoquinone attenuates liver fibrosis via PI3 K and TLR4 signaling pathways in activated hepatic stellate cells Int. Immunopharmacol. 15 2013 275 281
23. Y. Li, S. Xu, M.M. Mihaylova, B. Zheng, X. Hou, B. Jiang, O. Park, Z. Luo, E. Lefai, J.Y. Shyy, B. Gao, M. Wierzbicki, T.J. Verbeuren, R.J. Shaw, R.A. Cohen, and M. Zang AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice Cell Metab. 13 2011 376 388
24. M. You, X. Liang, J.M. Ajmo, and G.C. Ness Involvement of mammalian sirtuin 1 in the action of ethanol in the liver: American journal of physiology Gastrointest. Liver Physiol. 294 2008 G892 898
25. M. You, A. Jogasuria, C. Taylor, and J. Wu Sirtuin 1 signaling and alcoholic fatty liver disease Hepatobiliary Surg. Nutr. 4 2015 88 100
26. C. Canto, Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Milne, P.J. Elliott, P. Puigserver, and J. Auwerx AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature 458 2009 1056 1060
27. H.S. Zhang, and M.R. Wu SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase Virus Res. 146 2009 51 57
28. S. Elhanati, Y. Kanfi, A. Varvak, A. Roichman, I. Carmel-Gross, S. Barth, G. Gibor, and H.Y. Cohen Multiple regulatory layers of SREBP1/2 by SIRT6 Cell Rep. 4 2013 905 912
29. Y.D. Kim, K.M. Lee, S.L. Hwang, H.W. Chang, K.J. Kim, R.A. Harris, H.S. Choi, W.S. Choi, S.E. Lee, and C.S. Park Inhibition of cereblon by fenofibrate ameliorates alcoholic liver disease by enhancing AMPK Biochim. Biophys. Acta 1852 2015 2662 2670
30. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M.F. Hirshman, L.J. Goodyear, and D.E. Moller Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest. 108 2001 1167 1174
31. J. Li, Y. Pan, M. Kan, X. Xiao, Y. Wang, F. Guan, X. Zhang, and L. Chen Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinase Life Sci. 98 2014 24 30
32. S.A. Hawley, J. Boudeau, J.L. Reid, K.J. Mustard, L. Udd, T.P. Makela, D.R. Alessi, and D.G. Hardie Complexes between the LKB1 tumor suppressor STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade J. Biol. 2 2003 28
33. D.J. Branvold, D.R. Allred, D.J. Beckstead, H.J. Kim, N. Fillmore, B.M. Condon, J.D. Brown, S.N. Sudweeks, D.M. Thomson, and W.W. Winder Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1alpha in rat muscle (1985) J. Appl. Physiol. 105 2008 1218 1227
34. F. Yang, J. Li, J. Zhu, D. Wang, S. Chen, and X. Bai Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-kappaB signaling pathway in H22 tumor-bearing mice Eur. J. Pharmacol. 754 2015 105 114
35. T.K. Sin, A.P. Yu, B.Y. Yung, S.P. Yip, L.W. Chan, C.S. Wong, M. Ying, J.A. Rudd, and P.M. Siu Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart J. Physiol. 592 2014 2535 2548
36. P. Simic, E.O. Williams, E.L. Bell, J.J. Gong, M. Bonkowski, and L. Guarente SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis Cell Rep. 3 2013 1175 1186
37. D. Warburton, W. Shi, and B. Xu TGF-beta-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development? Am. J. Physiol. Lung Cell. Mol. Physiol. 304 2013 L83 L85
38. X. Jin, M. Chen, L. Yi, H. Chang, T. Zhang, L. Wang, W. Ma, X. Peng, Y. Zhou, and M. Mi Delphinidin-3-glucoside protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway Mol. Nutr. Food Res. 58 2014 1941 1951
39. H. Yin, M. Hu, X. Liang, J.M. Ajmo, X. Li, R. Bataller, G. Odena, S.M. Stevens Jr., and M. You Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver Gastroenterology 146 2014 801 811
40. J.M. Ajmo, X. Liang, C.Q. Rogers, B. Pennock, and M. You Resveratrol alleviates alcoholic fatty liver in mice: American journal of physiology Gastrointest. Liver Physiol. 295 2008 G833 842
41. Z. Shen, X. Liang, C.Q. Rogers, D. Rideout, and M. You Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice Am. J. Physiol. Gastrointest. Liver Physiol. 298 2010 G364 G374