Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by rapamycin

Journal of Neuroscience

Volumn 35, Issue 37, 2015, Pages 12833-12844

  Siddiqui, Almas ^a   Bhaumik, Dipa ^a   Chinta, Shankar J ^a   Rane, Anand ^a   Rajagopalan, Subramanian ^a   Lieu, Christopher A ^a   Lithgow, Gordon J ^a   Andersen, Julie K ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Autophagy; Mitochondria; Parkin; Parkinson s; PGC1 ; TFEB

Indexed keywords

ALPHA SYNUCLEIN; CATHEPSIN D; MITOCHONDRIAL PROTEIN; PARKIN; PARKIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEINASE K; RAPAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PPARGC1A PROTEIN, MOUSE; REPRESSOR PROTEIN; TCFEB PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE; ZNF746 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; GENE MUTATION; IMAGE ANALYSIS; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL VOLUME; MITOPHAGY; MOUSE; NONHUMAN; OPEN FIELD BEHAVIOR; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; STEREOLOGY; UPREGULATION; WESTERN BLOTTING; ANIMAL; CROSS BREEDING; CYTOLOGY; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; GENETICS; HUMAN; LYSOSOME; METABOLISM; MITOCHONDRION; PHYSIOLOGY; POINT MUTATION; RAT; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CROSSES, GENETIC; DOPAMINERGIC NEURONS; ELECTRON TRANSPORT COMPLEX I; EXPLORATORY BEHAVIOR; HUMANS; LYSOSOMES; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; MITOCHONDRIA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; POINT MUTATION; RATS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 84941795152     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0109-15.2015     Document Type: Article

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