Stimulatory effects of the flavanol (-)-epicatechin on cardiac angiogenesis: Additive effects with exercise

Journal of Cardiovascular Pharmacology

Volumn 60, Issue 5, 2012, Pages 429-438

  Ramirez Sanchez, Israel ^a,b   Nogueira, Leonardo ^a   Moreno, Aldo ^a,b   Murphy, Ann ^c   Taub, Pam ^a   Perkins, Guy ^c   Ceballos, Guillermo M ^a,b   Hogan, Michael ^a   Malek, Moh ^d   Villarreal, Francisco ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

angiogenesis; flavonoids; ischemia; myocardium

Indexed keywords

CD31 ANTIGEN; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPICATECHIN; GELATINASE A; GELATINASE B; STEROID RECEPTOR COACTIVATOR 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; CARDIAC ANGIOGENESIS; CONTROLLED STUDY; EXERCISE; HEART MUSCLE CAPILLARY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ZYMOGRAPHY;

ADMINISTRATION, ORAL; ANGIOGENESIS INDUCING AGENTS; ANIMALS; BLOTTING, WESTERN; CAPILLARIES; CARDIOTONIC AGENTS; CATECHIN; CORONARY VESSELS; CYCLIC GMP; EXERCISE TEST; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; PHYSICAL CONDITIONING, ANIMAL;

EID: 84870063237     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318269ae0d     Document Type: Article

References (33)

1. Buitrago-Lopez A, et al. Chocolate consumption and cardiometabolic disorders: systematic review and meta-analysis. BMJ. 2011;343:D4488.
2. Mostofsky E, et al. Chocolate intake and incidence of heart failure: a population-based prospective study of middle-aged and elderly women. Circ Heart Fail. 2010;3:612-616.
3. Fisher ND, Hollenberg NK. Flavanols for cardiovascular health: the science behind the sweetness. J Hypertens. 2005;23:1453-1459. (Pubitemid 41104812)
4. Corti R, et al. Cocoa and cardiovascular health. Circulation. 2009;119:1433-1441.
5. McCullough ML, et al. Hypertension, the Kuna, and the epidemiology of flavanols. J Cardiovasc Pharmacol. 2006;47(suppl 2):S103-S109; Discussion: 119-121. (Pubitemid 44620199)
6. Heiss C, et al. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010;56:218-224.
7. Ottaviani JI, et al. The stereochemical configuration of flavanols influences the level and metabolism of flavanols in humans and their biological activity in vivo. Free Radic Biol Med. 2011;50:237-244.
8. Schroeter H, et al. (-)-Epicatechin mediates beneficial effects of flavanolrich cocoa on vascular function in humans. Proc Natl Acad Sci U S A. 2006;103:1024-1029. (Pubitemid 43212215)
9. Yamazaki KG, et al. Short-and long-term effects of (-)-epicatechin on myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2008;295:H761-H767.
10. Yamazaki KG, et al. Effects of (-)-epicatechin on myocardial infarct size and left ventricular remodeling after permanent coronary occlusion. J Am Coll Cardiol. 2010;55:2869-2876.
11. Jones SP, Bolli R, The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol. 2006;40:16-23. (Pubitemid 43012113)
12. Ramirez-Sanchez I, et al. (-)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension. 2010;55:1398-1405.
13. Ramirez-Sanchez I, et al. (-)-Epicatechin induces calcium and translocation independent eNOS activation in arterial endothelial cells. Am J Physiol Cell Physiol. 2011;300:C880-C887.
14. Bloor CM. Angiogenesis during exercise and training. Angiogenesis. 2005;8:263-271. (Pubitemid 41759151)
15. Fukuda S, et al. Resveratrol ameliorates myocardial damage by inducing vascular endothelial growth factor-angiogenesis and tyrosine kinase receptor Flk-1. Cell Biochem Biophys. 2006;44:43-49. (Pubitemid 43099570)
16. Nogueira L, et al. (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle. J Physiol. 2011;589:4615-4631.
17. Ramirez-Sanchez I, Mendoza-Lorenzo P, Zentella-Dehesa A, et al. Caveolae and non-caveolae lipid raft microdomains of human umbilical vein endothelial cells contain utrophin-associated protein complexes. Biochimie 2012;94:1884-1890.
18. Ismail JA, et al. Immunohistologic labeling of murine endothelium. Cardiovasc Pathol. 2003;12:82-90. (Pubitemid 36398209)
19. Zachary I, Morgan RD. Therapeutic angiogenesis for cardiovascular disease: biological context, challenges, prospects. Heart. 2011;97:181-189.
20. Banquet S, et al. Arteriogenic therapy by intramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure. Circulation. 2011;124:1059-1069.
21. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev. 1992;72:369-417.
22. Gigante B, et al. Placenta growth factor is not required for exerciseinduced angiogenesis. Angiogenesis. 2004;7:277-284.
23. White FC, et al. Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart. J Appl Physiol. 1998;85:1160-1168. (Pubitemid 28413299)
24. Leosco D, et al. Exercise promotes angiogenesis and improves betaadrenergic receptor signalling in the post-ischaemic failing rat heart. Cardiovasc Res. 2008;78:385-394. (Pubitemid 351556096)
25. Wagner PD. Determinants of maximal oxygen transport and utilization. Annu Rev Physiol. 1996;58:21-50. (Pubitemid 26106712)
26. Morbidelli L, et al. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol. 1996;270(1 Pt 2):H411-H415.
27. Ziche MJ, et al. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J Clin Invest. 1994;94:2036-2044.
28. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669-676. (Pubitemid 36749215)
29. Lamalice L, Le Boeu F, Huot J. Endothelial cell migration during angiogenesis. Circ Res. 2007;100:782-794. (Pubitemid 46555683)
30. Kaga S, et al. Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. J Mol Cell Cardiol. 2005;39:813-822. (Pubitemid 41464418)
31. Elewa HF, et al. Diverse effects of statins on angiogenesis: new therapeutic avenues. Pharmacotherapy. 2010;30:169-176.
32. Jaquet K, et al. Erythropoietin and VEGF exhibit equal angiogenic potential. Microvasc Res. 2002;64:326-333.
33. Najjar SS, et al. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA. 2011;305:1863-1872.