-
1
-
-
67649356581
-
dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster
-
Bauer, J.H., et al. dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster. Aging, 1(1), 2009, 38.
-
(2009)
Aging
, vol.1
, Issue.1
, pp. 38
-
-
Bauer, J.H.1
-
2
-
-
84903179483
-
The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
-
Bingol, B., et al. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature 510:7505 (2014), 370–375.
-
(2014)
Nature
, vol.510
, Issue.7505
, pp. 370-375
-
-
Bingol, B.1
-
3
-
-
45549098657
-
SirT1 regulates energy metabolism and response to caloric restriction in mice
-
Boily, G., et al. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS One, 3(3), 2008, e1759.
-
(2008)
PLoS One
, vol.3
, Issue.3
, pp. e1759
-
-
Boily, G.1
-
4
-
-
84983440665
-
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
-
Bonkowski, M.S., Sinclair, D.A., Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds. Nat. Rev. Mol. Cell Biol. 17:11 (2016), 679–690.
-
(2016)
Nat. Rev. Mol. Cell Biol.
, vol.17
, Issue.11
, pp. 679-690
-
-
Bonkowski, M.S.1
Sinclair, D.A.2
-
5
-
-
56349163764
-
Mutant huntingtin and mitochondrial dysfunction
-
Bossy-Wetzel, E., Petrilli, A., Knott, A.B., Mutant huntingtin and mitochondrial dysfunction. Trends Neurosci. 31:12 (2008), 609–616.
-
(2008)
Trends Neurosci.
, vol.31
, Issue.12
, pp. 609-616
-
-
Bossy-Wetzel, E.1
Petrilli, A.2
Knott, A.B.3
-
6
-
-
79955591489
-
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
-
Braidy, N., et al. Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One, 6(4), 2011, e19194.
-
(2011)
PLoS One
, vol.6
, Issue.4
, pp. e19194
-
-
Braidy, N.1
-
7
-
-
84874591240
-
The role of mitochondria in aging
-
Bratic, A., Larsson, N.-G., The role of mitochondria in aging. J. Clin. Investig. 123:3 (2013), 951–957.
-
(2013)
J. Clin. Investig.
, vol.123
, Issue.3
, pp. 951-957
-
-
Bratic, A.1
Larsson, N.-G.2
-
8
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Cantó, C., et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 458:7241 (2009), 1056–1060.
-
(2009)
Nature
, vol.458
, Issue.7241
, pp. 1056-1060
-
-
Cantó, C.1
-
9
-
-
84937522438
-
NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus
-
Cantó, C., Menzies, K.J., Auwerx, J., NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell metab. 22:1 (2015), 31–53.
-
(2015)
Cell metab.
, vol.22
, Issue.1
, pp. 31-53
-
-
Cantó, C.1
Menzies, K.J.2
Auwerx, J.3
-
10
-
-
0036403832
-
β-Amyloid fragment 25–35 causes mitochondrial dysfunction in primary cortical neurons
-
Casley, C., et al. β-Amyloid fragment 25–35 causes mitochondrial dysfunction in primary cortical neurons. Neurobiol. Dis. 10:3 (2002), 258–267.
-
(2002)
Neurobiol. Dis.
, vol.10
, Issue.3
, pp. 258-267
-
-
Casley, C.1
-
11
-
-
84919698910
-
RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1
-
Chen, S., et al. RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1. Mol. Cell Biol. 35:2 (2015), 406–416.
-
(2015)
Mol. Cell Biol.
, vol.35
, Issue.2
, pp. 406-416
-
-
Chen, S.1
-
12
-
-
84964533976
-
Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy
-
Chen, M., et al. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 12:4 (2016), 689–702.
-
(2016)
Autophagy
, vol.12
, Issue.4
, pp. 689-702
-
-
Chen, M.1
-
13
-
-
84871728323
-
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
-
Cheng, A., et al. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat. Commun., 3, 2012, 1250.
-
(2012)
Nat. Commun.
, vol.3
, pp. 1250
-
-
Cheng, A.1
-
14
-
-
84955371298
-
Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges
-
Cheng, A., et al. Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges. Cell metab. 23:1 (2016), 128–142.
-
(2016)
Cell metab.
, vol.23
, Issue.1
, pp. 128-142
-
-
Cheng, A.1
-
15
-
-
84957790549
-
Genomic integrity and the ageing brain
-
Chow, H.-m., Herrup, K., Genomic integrity and the ageing brain. Nat. Rev. Neurosci. 16:11 (2015), 672–684.
-
(2015)
Nat. Rev. Neurosci.
, vol.16
, Issue.11
, pp. 672-684
-
-
Chow, H.-M.1
Herrup, K.2
-
16
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
Clark, I.E., et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441:7097 (2006), 1162–1166.
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1162-1166
-
-
Clark, I.E.1
-
17
-
-
84920095272
-
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
-
Cornelissen, T., et al. The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Hum. Mol. Genet. 23:19 (2014), 5227–5242.
-
(2014)
Hum. Mol. Genet.
, vol.23
, Issue.19
, pp. 5227-5242
-
-
Cornelissen, T.1
-
18
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age
-
Corral-Debrinski, M., et al. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat. Genet. 2:4 (1992), 324–329.
-
(1992)
Nat. Genet.
, vol.2
, Issue.4
, pp. 324-329
-
-
Corral-Debrinski, M.1
-
19
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
Deng, H., et al. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 105:38 (2008), 14503–14508.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, Issue.38
, pp. 14503-14508
-
-
Deng, H.1
-
20
-
-
77956252454
-
Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming
-
Ding, W.X., et al. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. J. Biol. Chem. 285:36 (2010), 27879–27890.
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.36
, pp. 27879-27890
-
-
Ding, W.X.1
-
21
-
-
84920892842
-
USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin
-
Durcan, T.M., et al. USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin. EMBO J., 2014, e201489729.
-
(2014)
EMBO J.
, pp. e201489729
-
-
Durcan, T.M.1
-
22
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
Egan, D.F., et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331:6016 (2011), 456–461.
-
(2011)
Science
, vol.331
, Issue.6016
, pp. 456-461
-
-
Egan, D.F.1
-
23
-
-
85025581752
-
NAD+: the convergence of DNA repair and mitophagy
-
Fang, E.F., Bohr, V.A., NAD+: the convergence of DNA repair and mitophagy. Autophagy, 2016, 1–2.
-
(2016)
Autophagy
, pp. 1-2
-
-
Fang, E.F.1
Bohr, V.A.2
-
24
-
-
84900344357
-
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction
-
Fang, E.F., et al. Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. Cell 157:4 (2014), 882–896.
-
(2014)
Cell
, vol.157
, Issue.4
, pp. 882-896
-
-
Fang, E.F.1
-
25
-
-
84960194831
-
Nuclear DNA damage signalling to mitochondria in ageing
-
Fang, E.F., et al. Nuclear DNA damage signalling to mitochondria in ageing. Nat. Rev. Mol. Cell Biol. 17:5 (2016), 308–321.
-
(2016)
Nat. Rev. Mol. Cell Biol.
, vol.17
, Issue.5
, pp. 308-321
-
-
Fang, E.F.1
-
26
-
-
84992343671
-
NAD+ replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair
-
Fang, E.F., et al. NAD+ replenishment improves lifespan and healthspan in Ataxia telangiectasia models via mitophagy and DNA repair. Cell Metab. 24:4 (2016), 566–581.
-
(2016)
Cell Metab.
, vol.24
, Issue.4
, pp. 566-581
-
-
Fang, E.F.1
-
27
-
-
0036258718
-
Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
-
Fayet, G., et al. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. Neuromuscul. Disord. 12:5 (2002), 484–493.
-
(2002)
Neuromuscul. Disord.
, vol.12
, Issue.5
, pp. 484-493
-
-
Fayet, G.1
-
28
-
-
34347344990
-
Ambra1 regulates autophagy and development of the nervous system
-
Fimia, G.M., et al. Ambra1 regulates autophagy and development of the nervous system. Nature 447:7148 (2007), 1121–1125.
-
(2007)
Nature
, vol.447
, Issue.7148
, pp. 1121-1125
-
-
Fimia, G.M.1
-
29
-
-
49649097747
-
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
-
Gautier, C.A., Kitada, T., Shen, J., Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl. Acad. Sci. 105:32 (2008), 11364–11369.
-
(2008)
Proc. Natl. Acad. Sci.
, vol.105
, Issue.32
, pp. 11364-11369
-
-
Gautier, C.A.1
Kitada, T.2
Shen, J.3
-
30
-
-
84862758175
-
New insights into the molecular and cellular functions of poly (ADP-ribose) and PARPs
-
Gibson, B.A., Kraus, W.L., New insights into the molecular and cellular functions of poly (ADP-ribose) and PARPs. Nat. Rev. Mol. Cell Biol. 13:7 (2012), 411–424.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, Issue.7
, pp. 411-424
-
-
Gibson, B.A.1
Kraus, W.L.2
-
31
-
-
84893442805
-
Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
-
Gomes, A.P., et al. Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 155:7 (2013), 1624–1638.
-
(2013)
Cell
, vol.155
, Issue.7
, pp. 1624-1638
-
-
Gomes, A.P.1
-
32
-
-
0037386532
-
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
-
Greene, J.C., et al. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proc. Natl. Acad. Sci. U. S. A. 100:7 (2003), 4078–4083.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, Issue.7
, pp. 4078-4083
-
-
Greene, J.C.1
-
33
-
-
77949887506
-
Mammalian sirtuins: biological insights and disease relevance
-
Haigis, M.C., Sinclair, D.A., Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol., 5, 2010, 253.
-
(2010)
Annu. Rev. Pathol.
, vol.5
, pp. 253
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
34
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara, T., et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441:7095 (2006), 885–889.
-
(2006)
Nature
, vol.441
, Issue.7095
, pp. 885-889
-
-
Hara, T.1
-
35
-
-
84926374540
-
Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter
-
Hasson, S.A., et al. Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. ACS Chem. Biol. 10:5 (2015), 1188–1197.
-
(2015)
ACS Chem. Biol.
, vol.10
, Issue.5
, pp. 1188-1197
-
-
Hasson, S.A.1
-
36
-
-
84882754147
-
A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1
-
Hertz, N.T., et al. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell 154:4 (2013), 737–747.
-
(2013)
Cell
, vol.154
, Issue.4
, pp. 737-747
-
-
Hertz, N.T.1
-
37
-
-
84858797950
-
Sirtuins as regulators of metabolism and healthspan
-
Houtkooper, R.H., Pirinen, E., Auwerx, J., Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 13:4 (2012), 225–238.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, Issue.4
, pp. 225-238
-
-
Houtkooper, R.H.1
Pirinen, E.2
Auwerx, J.3
-
38
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz, K.T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425:6954 (2003), 191–196.
-
(2003)
Nature
, vol.425
, Issue.6954
, pp. 191-196
-
-
Howitz, K.T.1
-
39
-
-
0032453817
-
Age-associated change in mitochondrial DNA damage
-
Hudson, E., et al. Age-associated change in mitochondrial DNA damage. Free Radic. Res. 29:6 (1998), 573–579.
-
(1998)
Free Radic. Res.
, vol.29
, Issue.6
, pp. 573-579
-
-
Hudson, E.1
-
40
-
-
84942817626
-
Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease
-
Hwang, S., Disatnik, M.H., Mochly-Rosen, D., Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol. Med. 7:10 (2015), 1307–1326.
-
(2015)
EMBO Mol. Med.
, vol.7
, Issue.10
, pp. 1307-1326
-
-
Hwang, S.1
Disatnik, M.H.2
Mochly-Rosen, D.3
-
41
-
-
84904751060
-
NAD+ and sirtuins in aging and disease
-
Imai, S.-i., Guarente, L., NAD+ and sirtuins in aging and disease. Trends Cell Biol. 24:8 (2014), 464–471.
-
(2014)
Trends Cell Biol.
, vol.24
, Issue.8
, pp. 464-471
-
-
Imai, S.-I.1
Guarente, L.2
-
42
-
-
85014901935
-
It takes two to tango: NAD+ and sirtuins in aging/longevity control
-
Imai, S.-i., Guarente, L., It takes two to tango: NAD+ and sirtuins in aging/longevity control. npj Aging Mech. Dis., 2, 2016, 16017.
-
(2016)
npj Aging Mech. Dis.
, vol.2
, pp. 16017
-
-
Imai, S.-I.1
Guarente, L.2
-
43
-
-
84959335983
-
Hypoxia as a therapy for mitochondrial disease
-
Jain, I.H., et al. Hypoxia as a therapy for mitochondrial disease. Science 352:6281 (2016), 54–61.
-
(2016)
Science
, vol.352
, Issue.6281
, pp. 54-61
-
-
Jain, I.H.1
-
44
-
-
0021333746
-
Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain
-
Kameshita, I., et al. Poly (ADP-Ribose) synthetase. Separation and identification of three proteolytic fragments as the substrate-binding domain, the DNA-binding domain, and the automodification domain. J. Biol. Chem. 259:8 (1984), 4770–4776.
-
(1984)
J. Biol. Chem.
, vol.259
, Issue.8
, pp. 4770-4776
-
-
Kameshita, I.1
-
45
-
-
84858000209
-
The sirtuin SIRT6 regulates lifespan in male mice
-
Kanfi, Y., et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 483:7388 (2012), 218–221.
-
(2012)
Nature
, vol.483
, Issue.7388
, pp. 218-221
-
-
Kanfi, Y.1
-
46
-
-
85012907718
-
Mitophagy and Alzheimer's disease: cellular and molecular mechanisms
-
(in press), pii: S0166-2236(17)30005-X, PMID:28190529
-
Kerr, J.S., et al. Mitophagy and Alzheimer's disease: cellular and molecular mechanisms. Trends Neurosci., 2017, 10.1016/j.tins.2017.01.002 (in press), pii: S0166-2236(17)30005-X, PMID:28190529.
-
(2017)
Trends Neurosci.
-
-
Kerr, J.S.1
-
47
-
-
84927626719
-
PINK1-induced mitophagy promotes neuroprotection in Huntington's disease
-
Khalil, B., et al. PINK1-induced mitophagy promotes neuroprotection in Huntington's disease. Cell death Dis., 6(1), 2015, e1617.
-
(2015)
Cell death Dis.
, vol.6
, Issue.1
, pp. e1617
-
-
Khalil, B.1
-
48
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
Kitada, T., et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:6676 (1998), 605–608.
-
(1998)
Nature
, vol.392
, Issue.6676
, pp. 605-608
-
-
Kitada, T.1
-
49
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu, M., et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441:7095 (2006), 880–884.
-
(2006)
Nature
, vol.441
, Issue.7095
, pp. 880-884
-
-
Komatsu, M.1
-
50
-
-
77953627194
-
Somatic mitochondrial DNA mutations in mammalian aging
-
Larsson, N.-G., Somatic mitochondrial DNA mutations in mammalian aging. Annu. Rev. Biochem. 79 (2010), 683–706.
-
(2010)
Annu. Rev. Biochem.
, vol.79
, pp. 683-706
-
-
Larsson, N.-G.1
-
51
-
-
84939804206
-
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
-
Lazarou, M., et al. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524:7565 (2015), 309–314.
-
(2015)
Nature
, vol.524
, Issue.7565
, pp. 309-314
-
-
Lazarou, M.1
-
52
-
-
16844366524
-
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging
-
Lemasters, J.J., Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging. Rejuvenation Res. 8:1 (2005), 3–5.
-
(2005)
Rejuvenation Res.
, vol.8
, Issue.1
, pp. 3-5
-
-
Lemasters, J.J.1
-
53
-
-
84862789618
-
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
-
Liu, L., et al. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14:2 (2012), 177–185.
-
(2012)
Nat. Cell Biol.
, vol.14
, Issue.2
, pp. 177-185
-
-
Liu, L.1
-
54
-
-
84878864199
-
The hallmarks of aging
-
López-Otín, C., et al. The hallmarks of aging. Cell 153:6 (2013), 1194–1217.
-
(2013)
Cell
, vol.153
, Issue.6
, pp. 1194-1217
-
-
López-Otín, C.1
-
55
-
-
77956420489
-
Can autophagy promote longevity?
-
Madeo, F., Tavernarakis, N., Kroemer, G., Can autophagy promote longevity?. Nat. Cell Biol. 12:9 (2010), 842–846.
-
(2010)
Nat. Cell Biol.
, vol.12
, Issue.9
, pp. 842-846
-
-
Madeo, F.1
Tavernarakis, N.2
Kroemer, G.3
-
56
-
-
84864401965
-
Age-associated changes in oxidative stress and NAD+ metabolism in human tissue
-
Massudi, H., et al. Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 7(7), 2012, e42357.
-
(2012)
PLoS One
, vol.7
, Issue.7
, pp. e42357
-
-
Massudi, H.1
-
57
-
-
84897863239
-
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
-
McLelland, G.L., et al. Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J., 2014, e201385902.
-
(2014)
EMBO J.
, pp. e201385902
-
-
McLelland, G.L.1
-
58
-
-
84929903016
-
Compromised autophagy and neurodegenerative diseases
-
Menzies, F.M., Fleming, A., Rubinsztein, D.C., Compromised autophagy and neurodegenerative diseases. Nat. Rev. Neurosci. 16:6 (2015), 345–357.
-
(2015)
Nat. Rev. Neurosci.
, vol.16
, Issue.6
, pp. 345-357
-
-
Menzies, F.M.1
Fleming, A.2
Rubinsztein, D.C.3
-
59
-
-
80052511813
-
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
-
Mihaylova, M.M., Shaw, R.J., The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat. Cell Biol. 13:9 (2011), 1016–1023.
-
(2011)
Nat. Cell Biol.
, vol.13
, Issue.9
, pp. 1016-1023
-
-
Mihaylova, M.M.1
Shaw, R.J.2
-
60
-
-
85004028301
-
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice
-
Mills, K.F., et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 24:6 (2016), 795–806.
-
(2016)
Cell Metab.
, vol.24
, Issue.6
, pp. 795-806
-
-
Mills, K.F.1
-
61
-
-
84974815636
-
Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy
-
E3349-E3358
-
Moore, A.S., Holzbaur, E.L., Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy. Proc. Natl. Acad. Sci. U. S. A., 113(24), 2016 E3349-E3358.
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, Issue.24
-
-
Moore, A.S.1
Holzbaur, E.L.2
-
62
-
-
84880517634
-
The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling
-
Mouchiroud, L., et al. The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling. Cell 154:2 (2013), 430–441.
-
(2013)
Cell
, vol.154
, Issue.2
, pp. 430-441
-
-
Mouchiroud, L.1
-
63
-
-
84936132577
-
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation
-
Murakawa, T., et al. Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat. Commun., 6, 2015, 7527.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7527
-
-
Murakawa, T.1
-
64
-
-
38349023008
-
Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers
-
Neuspiel, M., et al. Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers. Curr. Biol. 18:2 (2008), 102–108.
-
(2008)
Curr. Biol.
, vol.18
, Issue.2
, pp. 102-108
-
-
Neuspiel, M.1
-
65
-
-
2442481789
-
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
-
Palacino, J.J., et al. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem. 279:18 (2004), 18614–18622.
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.18
, pp. 18614-18622
-
-
Palacino, J.J.1
-
66
-
-
84876335261
-
Mitophagy in neurodegeneration and aging
-
Palikaras, K., Tavernarakis, N., Mitophagy in neurodegeneration and aging. Front. Genet., 3, 2012, 297.
-
(2012)
Front. Genet.
, vol.3
, pp. 297
-
-
Palikaras, K.1
Tavernarakis, N.2
-
67
-
-
84930632378
-
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
-
Palikaras, K., Lionaki, E., Tavernarakis, N., Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521:7553 (2015), 525–528.
-
(2015)
Nature
, vol.521
, Issue.7553
, pp. 525-528
-
-
Palikaras, K.1
Lionaki, E.2
Tavernarakis, N.3
-
68
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
Park, J., et al. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441:7097 (2006), 1157–1161.
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1157-1161
-
-
Park, J.1
-
69
-
-
84959419408
-
Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition
-
Park, D., et al. Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition. Sci. Rep., 6, 2016.
-
(2016)
Sci. Rep.
, vol.6
-
-
Park, D.1
-
70
-
-
13844313915
-
Parkin-deficient mice are not a robust model of parkinsonism
-
Perez, F.A., Palmiter, R.D., Parkin-deficient mice are not a robust model of parkinsonism. Proc. Natl. Acad. Sci. U. S. A. 102:6 (2005), 2174–2179.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, Issue.6
, pp. 2174-2179
-
-
Perez, F.A.1
Palmiter, R.D.2
-
71
-
-
84921369563
-
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease
-
Pickrell, A.M., Youle, R.J., The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron 85:2 (2015), 257–273.
-
(2015)
Neuron
, vol.85
, Issue.2
, pp. 257-273
-
-
Pickrell, A.M.1
Youle, R.J.2
-
72
-
-
84937438976
-
Endogenous Parkin preserves dopaminergic substantia nigral neurons following mitochondrial DNA mutagenic stress
-
Pickrell, A.M., et al. Endogenous Parkin preserves dopaminergic substantia nigral neurons following mitochondrial DNA mutagenic stress. Neuron 87:2 (2015), 371–381.
-
(2015)
Neuron
, vol.87
, Issue.2
, pp. 371-381
-
-
Pickrell, A.M.1
-
73
-
-
39449088321
-
The PINK1/Parkin pathway regulates mitochondrial morphology
-
Poole, A.C., et al. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl. Acad. Sci. U. S. A. 105:5 (2008), 1638–1643.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, Issue.5
, pp. 1638-1643
-
-
Poole, A.C.1
-
74
-
-
33746824192
-
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
-
Qin, W., et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J. Biol. Chem. 281:31 (2006), 21745–21754.
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.31
, pp. 21745-21754
-
-
Qin, W.1
-
75
-
-
84875254650
-
A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation
-
Richter, U., et al. A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation. Curr. Biol. 23:6 (2013), 535–541.
-
(2013)
Curr. Biol.
, vol.23
, Issue.6
, pp. 535-541
-
-
Richter, U.1
-
76
-
-
85000919223
-
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
-
Rojansky, R., Cha, M.-Y., Chan, D.C., Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. eLife, 5, 2016, e17896.
-
(2016)
eLife
, vol.5
, pp. e17896
-
-
Rojansky, R.1
Cha, M.-Y.2
Chan, D.C.3
-
77
-
-
80052303130
-
Autophagy and aging
-
Rubinsztein, D.C., Mariño, G., Kroemer, G., Autophagy and aging. Cell 146:5 (2011), 682–695.
-
(2011)
Cell
, vol.146
, Issue.5
, pp. 682-695
-
-
Rubinsztein, D.C.1
Mariño, G.2
Kroemer, G.3
-
78
-
-
84858791998
-
Mitochondrial quality control: a matter of life and death for neurons
-
Rugarli, E.I., Langer, T., Mitochondrial quality control: a matter of life and death for neurons. EMBO J. 31:6 (2012), 1336–1349.
-
(2012)
EMBO J.
, vol.31
, Issue.6
, pp. 1336-1349
-
-
Rugarli, E.I.1
Langer, T.2
-
79
-
-
84925298301
-
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
-
Ryan, B.J., et al. Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease. Trends Biochem. Sci. 40:4 (2015), 200–210.
-
(2015)
Trends Biochem. Sci.
, vol.40
, Issue.4
, pp. 200-210
-
-
Ryan, B.J.1
-
80
-
-
84978136448
-
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
-
Ryu, D., et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22:8 (2016), 879–888.
-
(2016)
Nat. Med.
, vol.22
, Issue.8
, pp. 879-888
-
-
Ryu, D.1
-
81
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
Sandoval, H., et al. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454:7201 (2008), 232–235.
-
(2008)
Nature
, vol.454
, Issue.7201
, pp. 232-235
-
-
Sandoval, H.1
-
82
-
-
84877675508
-
A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging
-
Scheibye-Knudsen, M., et al. A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging. Aging (Albany NY) 5:3 (2013), 192–208.
-
(2013)
Aging (Albany NY)
, vol.5
, Issue.3
, pp. 192-208
-
-
Scheibye-Knudsen, M.1
-
83
-
-
84922800677
-
Protecting the mitochondrial powerhouse
-
Scheibye-Knudsen, M., et al. Protecting the mitochondrial powerhouse. Trends Cell Biol. 25:3 (2014), 158–170.
-
(2014)
Trends Cell Biol.
, vol.25
, Issue.3
, pp. 158-170
-
-
Scheibye-Knudsen, M.1
-
84
-
-
84993967427
-
Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
-
Scheibye-Knudsen, M., et al. Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. Proc. Natl. Acad. Sci. U. S. A. 113:44 (2016), 12502–12507.
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, Issue.44
, pp. 12502-12507
-
-
Scheibye-Knudsen, M.1
-
85
-
-
84937514081
-
Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans
-
Schiavi, A., et al. Iron-starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr. Biol. 25:14 (2015), 1810–1822.
-
(2015)
Curr. Biol.
, vol.25
, Issue.14
, pp. 1810-1822
-
-
Schiavi, A.1
-
86
-
-
84923376645
-
Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
-
Song, Y.M., et al. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway. Autophagy 11:1 (2015), 46–59.
-
(2015)
Autophagy
, vol.11
, Issue.1
, pp. 46-59
-
-
Song, Y.M.1
-
87
-
-
84985916502
-
Autophagy and ubiquitin-proteasome system contribute to sperm mitophagy after mammalian fertilization
-
E5261-E5270
-
Song, W.H., et al. Autophagy and ubiquitin-proteasome system contribute to sperm mitophagy after mammalian fertilization. Proc. Natl. Acad. Sci. U. S. A., 113(36), 2016 E5261-E5270.
-
(2016)
Proc. Natl. Acad. Sci. U. S. A.
, vol.113
, Issue.36
-
-
Song, W.H.1
-
88
-
-
84856221632
-
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes
-
Soubannier, V., et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr. Biol. 22:2 (2012), 135–141.
-
(2012)
Curr. Biol.
, vol.22
, Issue.2
, pp. 135-141
-
-
Soubannier, V.1
-
89
-
-
84922506220
-
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
-
Strappazzon, F., et al. AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. Cell Death Differ., 22(3), 2015, 517.
-
(2015)
Cell Death Differ.
, vol.22
, Issue.3
, pp. 517
-
-
Strappazzon, F.1
-
90
-
-
84908085343
-
A new pathway for mitochondrial quality control: mitochondrial-derived vesicles
-
Sugiura, A., et al. A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J., 2014, e201488104.
-
(2014)
EMBO J.
, pp. e201488104
-
-
Sugiura, A.1
-
91
-
-
84947802088
-
Measuring in vivo mitophagy
-
Sun, N., et al. Measuring in vivo mitophagy. Mol. Cell 60:4 (2015), 685–696.
-
(2015)
Mol. Cell
, vol.60
, Issue.4
, pp. 685-696
-
-
Sun, N.1
-
92
-
-
84959500135
-
The mitochondrial basis of aging
-
Sun, N., Youle, R.J., Finkel, T., The mitochondrial basis of aging. Mol. Cell 61:5 (2016), 654–666.
-
(2016)
Mol. Cell
, vol.61
, Issue.5
, pp. 654-666
-
-
Sun, N.1
Youle, R.J.2
Finkel, T.3
-
93
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum, H.A., Guarente, L., Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:6825 (2001), 227–230.
-
(2001)
Nature
, vol.410
, Issue.6825
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
94
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic, A., et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:6990 (2004), 417–423.
-
(2004)
Nature
, vol.429
, Issue.6990
, pp. 417-423
-
-
Trifunovic, A.1
-
95
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
Valente, E.M., et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304:5674 (2004), 1158–1160.
-
(2004)
Science
, vol.304
, Issue.5674
, pp. 1158-1160
-
-
Valente, E.M.1
-
96
-
-
79960407069
-
Parkin interacts with Ambra1 to induce mitophagy
-
Van Humbeeck, C., et al. Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31:28 (2011), 10249–10261.
-
(2011)
J. Neurosci.
, vol.31
, Issue.28
, pp. 10249-10261
-
-
Van Humbeeck, C.1
-
97
-
-
0033525773
-
Mitochondrial diseases in man and mouse
-
Wallace, D.C., Mitochondrial diseases in man and mouse. Science 283:5407 (1999), 1482–1488.
-
(1999)
Science
, vol.283
, Issue.5407
, pp. 1482-1488
-
-
Wallace, D.C.1
-
98
-
-
84875868055
-
A mitochondrial bioenergetic etiology of disease
-
Wallace, D.C., A mitochondrial bioenergetic etiology of disease. J. Clin. Investig. 123:4 (2013), 1405–1412.
-
(2013)
J. Clin. Investig.
, vol.123
, Issue.4
, pp. 1405-1412
-
-
Wallace, D.C.1
-
99
-
-
33750437278
-
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
-
Weydt, P., et al. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration. Cell metab. 4:5 (2006), 349–362.
-
(2006)
Cell metab.
, vol.4
, Issue.5
, pp. 349-362
-
-
Weydt, P.1
-
100
-
-
84957952429
-
Mitochondrial dysfunction induces senescence with a distinct secretory phenotype
-
Wiley, C.D., et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell metab. 23:2 (2016), 303–314.
-
(2016)
Cell metab.
, vol.23
, Issue.2
, pp. 303-314
-
-
Wiley, C.D.1
-
101
-
-
84899789746
-
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
-
Wu, W., et al. ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep. 15:5 (2014), 566–575.
-
(2014)
EMBO Rep.
, vol.15
, Issue.5
, pp. 566-575
-
-
Wu, W.1
-
102
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
Yang, Y., et al. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl. Acad. Sci. U. S. A. 103:28 (2006), 10793–10798.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, Issue.28
, pp. 10793-10798
-
-
Yang, Y.1
-
103
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
Yang, Y., et al. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc. Natl. Acad. Sci. U. S. A. 105:19 (2008), 7070–7075.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, Issue.19
, pp. 7070-7075
-
-
Yang, Y.1
-
104
-
-
84927917189
-
Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains
-
Ye, X., et al. Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains. Hum. Mol. Genet. 24:10 (2015), 2938–2951.
-
(2015)
Hum. Mol. Genet.
, vol.24
, Issue.10
, pp. 2938-2951
-
-
Ye, X.1
-
105
-
-
78650467974
-
Mechanisms of mitophagy
-
Youle, R.J., Narendra, D.P., Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12:1 (2011), 9–14.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, Issue.1
, pp. 9-14
-
-
Youle, R.J.1
Narendra, D.P.2
-
106
-
-
84902682891
-
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
-
Yun, J., et al. MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. Elife, 3, 2014, e01958.
-
(2014)
Elife
, vol.3
, pp. e01958
-
-
Yun, J.1
-
107
-
-
84976867195
-
Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization
-
Zhou, Q., et al. Mitochondrial endonuclease G mediates breakdown of paternal mitochondria upon fertilization. Science 353:6297 (2016), 394–399.
-
(2016)
Science
, vol.353
, Issue.6297
, pp. 394-399
-
-
Zhou, Q.1
|