Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

EMBO Reports

Volumn 16, Issue 8, 2015, Pages 939-954

  Kazlauskaite, Agne ^a   Martínez Torres, R Julio ^a   Wilkie, Scott ^a   Kumar, Atul ^a   Peltier, Julien ^a   Gonzalez, Alba ^a   Johnson, Clare ^a   Zhang, Jinwei ^a   Hope, Anthony G ^a   Peggie, Mark ^a   Trost, Matthias ^a   Van Aalten, Daan M F ^a   Alessi, Dario R ^a   Prescott, Alan R ^a   Knebel, Axel ^a   Walden, Helen ^a   Muqit, Miratul M K ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Parkin; Parkinson's disease; phosphorylation; PINK1; ubiquitin

Indexed keywords

HISTIDINE; LYSINE; MITOCHONDRIAL PROTEIN; PARKIN; PROTEIN KINASE PTEN INDUCED KINASE 1; SERINE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; PROTEIN BINDING; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STOICHIOMETRY; GENETICS; HEK293 CELL LINE; MASS SPECTROMETRY; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; UBIQUITINATION;

HEK293 CELLS; HUMANS; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; SERINE; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84938742614     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201540352     Document Type: Article

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