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Volumn 12, Issue 1, 2013, Pages 237-252

Autophagy, polyphenols and healthy ageing

Author keywords

A ; AD; Ageing; AMP; AMPK; APP; Atg; ATP; Autophagy; AV; Bcl 2; Bcl xl; Caloric restriction; CMA; CR; DAPK; Diet; EGCG; Erk; FoxO; HD; HMGB1; Hsc70; Htt; JNK1; LAMP; LC3; M TOR; MAPK; MEK; MTORC1; NAD; Neurodegenerative diseases; NFkappaB; Nrf2; PCD; PD; PE; PI3K; PINK1; PMN; Polyphenols; PS 1; PTEN; Raptor; ROS; SAMP8; SQSTM1 (=p62); TOR; TSC; Ulk1; Vps

Indexed keywords

CATECHIN; CURCUMIN; EPIGALLOCATECHIN GALLATE; GENISTEIN; GREEN TEA EXTRACT; POLYPHENOL; QUERCETIN; RESVERATROL; SILIBININ;

EID: 84867385981     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2012.03.008     Document Type: Review
Times cited : (145)

References (187)
  • 1
    • 77649208936 scopus 로고    scopus 로고
    • Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice
    • Abraham J., Johnson R.W. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Research 2009, 12:445-453.
    • (2009) Rejuvenation Research , vol.12 , pp. 445-453
    • Abraham, J.1    Johnson, R.W.2
  • 2
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • Alavez S., Vantipalli M.C., Zucker D.J., Klang I.M., Lithgow G.J. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature 2011, 472:226-229.
    • (2011) Nature , vol.472 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3    Klang, I.M.4    Lithgow, G.J.5
  • 4
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways
    • Aoki H., Takada Y., Kondo S., Sawaya R., Aggarwal B.B., Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Molecular Pharmacology 2007, 72:29-39.
    • (2007) Molecular Pharmacology , vol.72 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3    Sawaya, R.4    Aggarwal, B.B.5    Kondo, Y.6
  • 7
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: back to the future
    • Bertram L., Lill C.M., Tanzi R.E. The genetics of Alzheimer disease: back to the future. Neuron 2010, 68:270-281.
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 11
    • 34250901592 scopus 로고    scopus 로고
    • Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent, Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the
    • Boocock D.J., Faust G.E., Patel K.R., Schinas A.M., Brown V.A., Ducharme M.P., Booth T.D., Crowell J.A., Perloff M., Gescher A.J., Steward W.P., Brenner D.E. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent, Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the. American Society of Preventive Oncology 2007, 16:1246-1252.
    • (2007) American Society of Preventive Oncology , vol.16 , pp. 1246-1252
    • Boocock, D.J.1    Faust, G.E.2    Patel, K.R.3    Schinas, A.M.4    Brown, V.A.5    Ducharme, M.P.6    Booth, T.D.7    Crowell, J.A.8    Perloff, M.9    Gescher, A.J.10    Steward, W.P.11    Brenner, D.E.12
  • 12
    • 77249179774 scopus 로고    scopus 로고
    • How accurate are cancer cell lines?
    • Borrell B. How accurate are cancer cell lines?. Nature 2010, 463:858.
    • (2010) Nature , vol.463 , pp. 858
    • Borrell, B.1
  • 15
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
    • Caccamo A., Majumder S., Richardson A., Strong R., Oddo S. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. The Journal of Biological Chemistry 2010, 285:13107-13120.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 17
    • 79954437554 scopus 로고    scopus 로고
    • Inhibition and disaggregation of alpha-synuclein oligomers by natural polyphenolic compounds
    • Caruana M., Hogen T., Levin J., Hillmer A., Giese A., Vassallo N. Inhibition and disaggregation of alpha-synuclein oligomers by natural polyphenolic compounds. FEBS Letters 2011, 585:1113-1120.
    • (2011) FEBS Letters , vol.585 , pp. 1113-1120
    • Caruana, M.1    Hogen, T.2    Levin, J.3    Hillmer, A.4    Giese, A.5    Vassallo, N.6
  • 18
    • 51449085299 scopus 로고    scopus 로고
    • The role of autophagy in mammalian development: cell makeover rather than cell death
    • Cecconi F., Levine B. The role of autophagy in mammalian development: cell makeover rather than cell death. Developmental Cell 2008, 15:344-357.
    • (2008) Developmental Cell , vol.15 , pp. 344-357
    • Cecconi, F.1    Levine, B.2
  • 19
    • 79960308079 scopus 로고    scopus 로고
    • Autophagy deregulation in neurodegenerative diseases-recent advances and future perspectives
    • Cheung Z.H., Ip N.Y. Autophagy deregulation in neurodegenerative diseases-recent advances and future perspectives. Journal of Neurochemistry 2011, 118:317-325.
    • (2011) Journal of Neurochemistry , vol.118 , pp. 317-325
    • Cheung, Z.H.1    Ip, N.Y.2
  • 23
    • 77956834462 scopus 로고    scopus 로고
    • Autophagy: a potential link between obesity and insulin resistance
    • Codogno P., Meijer A.J. Autophagy: a potential link between obesity and insulin resistance. Cell Metabolism 2010, 11:449-451.
    • (2010) Cell Metabolism , vol.11 , pp. 449-451
    • Codogno, P.1    Meijer, A.J.2
  • 26
    • 34548279788 scopus 로고    scopus 로고
    • Molecular understanding and modern application of traditional medicines: triumphs and trials
    • Corson T.W., Crews C.M. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell 2007, 130:769-774.
    • (2007) Cell , vol.130 , pp. 769-774
    • Corson, T.W.1    Crews, C.M.2
  • 27
    • 56349168452 scopus 로고    scopus 로고
    • Autophagy and aging: keeping that old broom working
    • Cuervo A.M. Autophagy and aging: keeping that old broom working. Trends in Genetics: TIG 2008, 24:604-612.
    • (2008) Trends in Genetics: TIG , vol.24 , pp. 604-612
    • Cuervo, A.M.1
  • 29
    • 0034613294 scopus 로고    scopus 로고
    • Age-related decline in chaperone-mediated autophagy
    • Cuervo A.M., Dice J.F. Age-related decline in chaperone-mediated autophagy. The Journal of Biological Chemistry 2000, 275:31505-31513.
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 31505-31513
    • Cuervo, A.M.1    Dice, J.F.2
  • 30
    • 0028848119 scopus 로고
    • Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation
    • Cuervo A.M., Knecht E., Terlecky S.R., Dice J.F. Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation. The American Journal of Physiology 1995, 269:C1200-C1208.
    • (1995) The American Journal of Physiology , vol.269
    • Cuervo, A.M.1    Knecht, E.2    Terlecky, S.R.3    Dice, J.F.4
  • 32
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo A.M., Stefanis L., Fredenburg R., Lansbury P.T., Sulzer D. Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305:1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 33
    • 27844433156 scopus 로고    scopus 로고
    • Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate
    • Dashwood W.M., Carter O., Al-Fageeh M., Li Q., Dashwood R.H. Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate. Mutation Research 2005, 591:161-172.
    • (2005) Mutation Research , vol.591 , pp. 161-172
    • Dashwood, W.M.1    Carter, O.2    Al-Fageeh, M.3    Li, Q.4    Dashwood, R.H.5
  • 35
    • 77049229661 scopus 로고
    • Tissue fractionation studies, 6. Intracellular distribution patterns of enzymes in rat-liver tissue
    • De Duve C., Pressman B.C., Gianetto R., Wattiaux R., Appelmans F. Tissue fractionation studies, 6. Intracellular distribution patterns of enzymes in rat-liver tissue. The Biochemical Journal 1955, 60:604-617.
    • (1955) The Biochemical Journal , vol.60 , pp. 604-617
    • De Duve, C.1    Pressman, B.C.2    Gianetto, R.3    Wattiaux, R.4    Appelmans, F.5
  • 37
    • 40249119157 scopus 로고    scopus 로고
    • Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death
    • Delmulle L., Vanden Berghe T., Keukeleire D.D., Vandenabeele P. Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death. Phytotherapy Research: PTR 2008, 22:197-203.
    • (2008) Phytotherapy Research: PTR , vol.22 , pp. 197-203
    • Delmulle, L.1    Vanden Berghe, T.2    Keukeleire, D.D.3    Vandenabeele, P.4
  • 38
    • 79951910694 scopus 로고    scopus 로고
    • Autophagy in immunity and cell-autonomous defense against intracellular microbes
    • Deretic V. Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunological Reviews 2011, 240:92-104.
    • (2011) Immunological Reviews , vol.240 , pp. 92-104
    • Deretic, V.1
  • 39
    • 40949114175 scopus 로고    scopus 로고
    • Preventive effect of (-)epigallocatechin-gallate (EGCG) on lysosomal enzymes in heart and subcellular fractions in isoproterenol-induced myocardial infarcted Wistar rats
    • Devika P.T., Prince P.S. Preventive effect of (-)epigallocatechin-gallate (EGCG) on lysosomal enzymes in heart and subcellular fractions in isoproterenol-induced myocardial infarcted Wistar rats. Chemico-Biological Interactions 2008, 172:245-252.
    • (2008) Chemico-Biological Interactions , vol.172 , pp. 245-252
    • Devika, P.T.1    Prince, P.S.2
  • 44
    • 77953526775 scopus 로고    scopus 로고
    • Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway
    • Duan W., Jin X., Li Q., Tashiro S., Onodera S., Ikejima T. Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. Journal of Pharmacological Sciences 2010, 113:48-56.
    • (2010) Journal of Pharmacological Sciences , vol.113 , pp. 48-56
    • Duan, W.1    Jin, X.2    Li, Q.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 45
    • 80053942110 scopus 로고    scopus 로고
    • Which sources of flavonoids: complex diets or dietary supplements?
    • Egert S., Rimbach G. Which sources of flavonoids: complex diets or dietary supplements?. Advances in Nutrition 2011, 2:8-14.
    • (2011) Advances in Nutrition , vol.2 , pp. 8-14
    • Egert, S.1    Rimbach, G.2
  • 47
    • 84859148429 scopus 로고    scopus 로고
    • Alpha-synuclein fate: proteasome or autophagy?
    • Engelender S. alpha-synuclein fate: proteasome or autophagy?. Autophagy 2012, 8.
    • (2012) Autophagy , pp. 8
    • Engelender, S.1
  • 48
    • 26844531363 scopus 로고    scopus 로고
    • Maturation of autophagic vacuoles in mammalian cells
    • Eskelinen E.L. Maturation of autophagic vacuoles in mammalian cells. Autophagy 2005, 1:1-10.
    • (2005) Autophagy , vol.1 , pp. 1-10
    • Eskelinen, E.L.1
  • 49
    • 0036751978 scopus 로고    scopus 로고
    • A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes
    • Esposito E., Rotilio D., Di Matteo V., Di Giulio C., Cacchio M., Algeri S. A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiology of Aging 2002, 23:719-735.
    • (2002) Neurobiology of Aging , vol.23 , pp. 719-735
    • Esposito, E.1    Rotilio, D.2    Di Matteo, V.3    Di Giulio, C.4    Cacchio, M.5    Algeri, S.6
  • 50
    • 80555144324 scopus 로고    scopus 로고
    • Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells
    • Fan S., Li L., Chen S., Yu Y., Qi M., Tashiro S., Onodera S., Ikejima T. Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells. Free Radical Research 2011, 45:1307-1324.
    • (2011) Free Radical Research , vol.45 , pp. 1307-1324
    • Fan, S.1    Li, L.2    Chen, S.3    Yu, Y.4    Qi, M.5    Tashiro, S.6    Onodera, S.7    Ikejima, T.8
  • 51
    • 0141639855 scopus 로고    scopus 로고
    • Antioxidant activity of tea polyphenols in vivo: evidence from animal studies
    • Frei B., Higdon J.V. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. The Journal of Nutrition 2003, 133:3275S-3284S.
    • (2003) The Journal of Nutrition , vol.133
    • Frei, B.1    Higdon, J.V.2
  • 52
    • 65749114284 scopus 로고    scopus 로고
    • Macroautophagy in immunity and tolerance
    • Gannage M., Munz C. Macroautophagy in immunity and tolerance. Traffic 2009, 10:615-620.
    • (2009) Traffic , vol.10 , pp. 615-620
    • Gannage, M.1    Munz, C.2
  • 54
    • 0028957045 scopus 로고
    • Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid
    • Gordon P.B., Holen I., Seglen P.O. Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. The Journal of Biological Chemistry 1995, 270:5830-5838.
    • (1995) The Journal of Biological Chemistry , vol.270 , pp. 5830-5838
    • Gordon, P.B.1    Holen, I.2    Seglen, P.O.3
  • 56
    • 79959354999 scopus 로고    scopus 로고
    • Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    • Green D.R., Galluzzi L., Kroemer G. Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science 2011, 333:1109-1112.
    • (2011) Science , vol.333 , pp. 1109-1112
    • Green, D.R.1    Galluzzi, L.2    Kroemer, G.3
  • 58
    • 77952475396 scopus 로고    scopus 로고
    • Dietary polyphenols, inflammation, and cancer
    • Guo W., Kong E., Meydani M. Dietary polyphenols, inflammation, and cancer. Nutrition and Cancer 2009, 61:807-810.
    • (2009) Nutrition and Cancer , vol.61 , pp. 807-810
    • Guo, W.1    Kong, E.2    Meydani, M.3
  • 61
    • 73549106551 scopus 로고    scopus 로고
    • Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway
    • Hamaguchi T., Ono K., Murase A., Yamada M. Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. The American Journal of Pathology 2009, 175:2557-2565.
    • (2009) The American Journal of Pathology , vol.175 , pp. 2557-2565
    • Hamaguchi, T.1    Ono, K.2    Murase, A.3    Yamada, M.4
  • 62
  • 63
    • 77049308856 scopus 로고
    • Aging: a theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 1956, 11:298-300.
    • (1956) Journal of Gerontology , vol.11 , pp. 298-300
    • Harman, D.1
  • 67
    • 33646793360 scopus 로고    scopus 로고
    • Accumulation of altered proteins and ageing: causes and effects
    • Hipkiss A.R. Accumulation of altered proteins and ageing: causes and effects. Experimental Gerontology 2006, 41:464-473.
    • (2006) Experimental Gerontology , vol.41 , pp. 464-473
    • Hipkiss, A.R.1
  • 70
    • 0026029402 scopus 로고
    • Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis
    • Huang M.T., Lysz T., Ferraro T., Abidi T.F., Laskin J.D., Conney A.H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Research 1991, 51:813-819.
    • (1991) Cancer Research , vol.51 , pp. 813-819
    • Huang, M.T.1    Lysz, T.2    Ferraro, T.3    Abidi, T.F.4    Laskin, J.D.5    Conney, A.H.6
  • 71
    • 0023790908 scopus 로고
    • Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate
    • Huang M.T., Smart R.C., Wong C.Q., Conney A.H. Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Research 1988, 48:5941-5946.
    • (1988) Cancer Research , vol.48 , pp. 5941-5946
    • Huang, M.T.1    Smart, R.C.2    Wong, C.Q.3    Conney, A.H.4
  • 74
    • 35848937781 scopus 로고    scopus 로고
    • Autophagy is required for dietary restriction-mediated life span extension in C. elegans
    • Jia K., Levine B. Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 2007, 3:597-599.
    • (2007) Autophagy , vol.3 , pp. 597-599
    • Jia, K.1    Levine, B.2
  • 75
    • 0029757364 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines
    • Jiang M.C., Yang-Yen H.F., Yen J.J., Lin J.K. Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutrition and Cancer 1996, 26:111-120.
    • (1996) Nutrition and Cancer , vol.26 , pp. 111-120
    • Jiang, M.C.1    Yang-Yen, H.F.2    Yen, J.J.3    Lin, J.K.4
  • 77
    • 4444370179 scopus 로고    scopus 로고
    • How does parkin ligate ubiquitin to Parkinson's disease?
    • Kahle P.J., Haass C. How does parkin ligate ubiquitin to Parkinson's disease?. EMBO Reports 2004, 5:681-685.
    • (2004) EMBO Reports , vol.5 , pp. 681-685
    • Kahle, P.J.1    Haass, C.2
  • 78
    • 57749121573 scopus 로고    scopus 로고
    • Mitophagy in yeast occurs through a selective mechanism
    • Kanki T., Klionsky D.J. Mitophagy in yeast occurs through a selective mechanism. The Journal of Biological Chemistry 2008, 283:32386-32393.
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 32386-32393
    • Kanki, T.1    Klionsky, D.J.2
  • 81
    • 82955187812 scopus 로고    scopus 로고
    • Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells
    • Kauntz H., Bousserouel S., Gosse F., Raul F. Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis: An International Journal on Programmed Cell Death 2011, 16:1042-1053.
    • (2011) Apoptosis: An International Journal on Programmed Cell Death , vol.16 , pp. 1042-1053
    • Kauntz, H.1    Bousserouel, S.2    Gosse, F.3    Raul, F.4
  • 84
    • 84857627775 scopus 로고    scopus 로고
    • Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity
    • Klappan A.K., Hones S., Mylonas I., Bruning A. Proteasome inhibition by quercetin triggers macroautophagy and blocks mTOR activity. Histochemistry and Cell Biology 2012, 137:25-36.
    • (2012) Histochemistry and Cell Biology , vol.137 , pp. 25-36
    • Klappan, A.K.1    Hones, S.2    Mylonas, I.3    Bruning, A.4
  • 86
    • 77950506157 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy in health and disease
    • Kon M., Cuervo A.M. Chaperone-mediated autophagy in health and disease. FEBS Letters 2010, 584:1399-1404.
    • (2010) FEBS Letters , vol.584 , pp. 1399-1404
    • Kon, M.1    Cuervo, A.M.2
  • 87
    • 60549093730 scopus 로고    scopus 로고
    • Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
    • Korolchuk V.I., Mansilla A., Menzies F.M., Rubinsztein D.C. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Molecular Cell 2009, 33:517-527.
    • (2009) Molecular Cell , vol.33 , pp. 517-527
    • Korolchuk, V.I.1    Mansilla, A.2    Menzies, F.M.3    Rubinsztein, D.C.4
  • 88
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiological Reviews 2007, 87:99-163.
    • (2007) Physiological Reviews , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 91
    • 0347626109 scopus 로고    scopus 로고
    • Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins
    • Leone M., Zhai D., Sareth S., Kitada S., Reed J.C., Pellecchia M. Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. Cancer Research 2003, 63:8118-8121.
    • (2003) Cancer Research , vol.63 , pp. 8118-8121
    • Leone, M.1    Zhai, D.2    Sareth, S.3    Kitada, S.4    Reed, J.C.5    Pellecchia, M.6
  • 92
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 95
    • 71449091240 scopus 로고    scopus 로고
    • Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin
    • Liu H.Y., Han J., Cao S.Y., Hong T., Zhuo D., Shi J., Liu Z., Cao W. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. The Journal of Biological Chemistry 2009, 284:31484-31492.
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 31484-31492
    • Liu, H.Y.1    Han, J.2    Cao, S.Y.3    Hong, T.4    Zhuo, D.5    Shi, J.6    Liu, Z.7    Cao, W.8
  • 96
    • 70450285045 scopus 로고    scopus 로고
    • Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model
    • Long J., Gao H., Sun L., Liu J., Zhao-Wilson X. Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Research 2009, 12:321-331.
    • (2009) Rejuvenation Research , vol.12 , pp. 321-331
    • Long, J.1    Gao, H.2    Sun, L.3    Liu, J.4    Zhao-Wilson, X.5
  • 98
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L., Chen Z., Erdjument-Bromage H., Tempst P., Pandolfi P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121:179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 99
    • 79956324801 scopus 로고    scopus 로고
    • Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice
    • Ma Q., Qiang J., Gu P., Wang Y., Geng Y., Wang M. Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice. Experimental Gerontology 2011, 46:533-541.
    • (2011) Experimental Gerontology , vol.46 , pp. 533-541
    • Ma, Q.1    Qiang, J.2    Gu, P.3    Wang, Y.4    Geng, Y.5    Wang, M.6
  • 100
    • 80053243942 scopus 로고    scopus 로고
    • Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
    • Majumder S., Richardson A., Strong R., Oddo S. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS ONE 2011, 6:e25416.
    • (2011) PLoS ONE , vol.6
    • Majumder, S.1    Richardson, A.2    Strong, R.3    Oddo, S.4
  • 101
    • 78751487371 scopus 로고    scopus 로고
    • Curcumin and Alzheimer disease: this marriage is not to be performed
    • (author reply p. le4)
    • Mancuso C., Siciliano R., Barone E. Curcumin and Alzheimer disease: this marriage is not to be performed. The Journal of Biological Chemistry 2011, 286:le3. (author reply p. le4).
    • (2011) The Journal of Biological Chemistry , vol.286
    • Mancuso, C.1    Siciliano, R.2    Barone, E.3
  • 104
    • 0028890119 scopus 로고
    • Apoptosis and cancer: the failure of controls on cell death and cell survival
    • Martin S.J., Green D.R. Apoptosis and cancer: the failure of controls on cell death and cell survival. Critical Reviews in Oncology/Hematology 1995, 18:137-153.
    • (1995) Critical Reviews in Oncology/Hematology , vol.18 , pp. 137-153
    • Martin, S.J.1    Green, D.R.2
  • 107
    • 14644390872 scopus 로고    scopus 로고
    • Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
    • Mattson M.P., Wan R. Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. The Journal of Nutritional Biochemistry 2005, 16:129-137.
    • (2005) The Journal of Nutritional Biochemistry , vol.16 , pp. 129-137
    • Mattson, M.P.1    Wan, R.2
  • 108
    • 77955708390 scopus 로고    scopus 로고
    • Overview of macroautophagy regulation in mammalian cells
    • Mehrpour M., Esclatine A., Beau I., Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Research 2010, 20:748-762.
    • (2010) Cell Research , vol.20 , pp. 748-762
    • Mehrpour, M.1    Esclatine, A.2    Beau, I.3    Codogno, P.4
  • 109
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Melendez A., Talloczy Z., Seaman M., Eskelinen E.L., Hall D.H., Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003, 301:1387-1391.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 110
    • 14944370013 scopus 로고    scopus 로고
    • Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro
    • Mertens-Talcott S.U., Bomser J.A., Romero C., Talcott S.T., Percival S.S. Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. The Journal of Nutrition 2005, 135:609-614.
    • (2005) The Journal of Nutrition , vol.135 , pp. 609-614
    • Mertens-Talcott, S.U.1    Bomser, J.A.2    Romero, C.3    Talcott, S.T.4    Percival, S.S.5
  • 111
    • 12844268624 scopus 로고    scopus 로고
    • Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells
    • Mertens-Talcott S.U., Percival S.S. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Letters 2005, 218:141-151.
    • (2005) Cancer Letters , vol.218 , pp. 141-151
    • Mertens-Talcott, S.U.1    Percival, S.S.2
  • 112
    • 0027992226 scopus 로고
    • Scavenging of reactive oxygen species by silibinin dihemisuccinate
    • Mira L., Silva M., Manso C.F. Scavenging of reactive oxygen species by silibinin dihemisuccinate. Biochemical Pharmacology 1994, 48:753-759.
    • (1994) Biochemical Pharmacology , vol.48 , pp. 753-759
    • Mira, L.1    Silva, M.2    Manso, C.F.3
  • 113
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 114
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N., Yoshimori T., Levine B. Methods in mammalian autophagy research. Cell 2010, 140:313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 121
    • 2442623486 scopus 로고    scopus 로고
    • The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells
    • Nguyen T.T., Tran E., Nguyen T.H., Do P.T., Huynh T.H., Huynh H. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 2004, 25:647-659.
    • (2004) Carcinogenesis , vol.25 , pp. 647-659
    • Nguyen, T.T.1    Tran, E.2    Nguyen, T.H.3    Do, P.T.4    Huynh, T.H.5    Huynh, H.6
  • 122
  • 124
    • 79955969705 scopus 로고    scopus 로고
    • Autophagy failure in Alzheimer's disease-locating the primary defect
    • Nixon R.A., Yang D.S. Autophagy failure in Alzheimer's disease-locating the primary defect. Neurobiology of Disease 2011, 43:38-45.
    • (2011) Neurobiology of Disease , vol.43 , pp. 38-45
    • Nixon, R.A.1    Yang, D.S.2
  • 125
    • 0034672063 scopus 로고    scopus 로고
    • Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
    • Ogier-Denis E., Pattingre S., El Benna J., Codogno P. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. The Journal of Biological Chemistry 2000, 275:39090-39095.
    • (2000) The Journal of Biological Chemistry , vol.275 , pp. 39090-39095
    • Ogier-Denis, E.1    Pattingre, S.2    El Benna, J.3    Codogno, P.4
  • 131
    • 0038269032 scopus 로고    scopus 로고
    • Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
    • Pattingre S., Bauvy C., Codogno P. Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. The Journal of Biological Chemistry 2003, 278:16667-16674.
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 16667-16674
    • Pattingre, S.1    Bauvy, C.2    Codogno, P.3
  • 134
    • 34447092454 scopus 로고    scopus 로고
    • Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells
    • Psahoulia F.H., Moumtzi S., Roberts M.L., Sasazuki T., Shirasawa S., Pintzas A. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis 2007, 28:1021-1031.
    • (2007) Carcinogenesis , vol.28 , pp. 1021-1031
    • Psahoulia, F.H.1    Moumtzi, S.2    Roberts, M.L.3    Sasazuki, T.4    Shirasawa, S.5    Pintzas, A.6
  • 138
    • 80053199541 scopus 로고    scopus 로고
    • Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors
    • Roy S.K., Chen Q., Fu J., Shankar S., Srivastava R.K. Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors. PLoS ONE 2011, 6:e25166.
    • (2011) PLoS ONE , vol.6
    • Roy, S.K.1    Chen, Q.2    Fu, J.3    Shankar, S.4    Srivastava, R.K.5
  • 141
    • 41549135942 scopus 로고    scopus 로고
    • FoxO transcription factors in the maintenance of cellular homeostasis during aging
    • Salih D.A., Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Current Opinion in Cell Biology 2008, 20:126-136.
    • (2008) Current Opinion in Cell Biology , vol.20 , pp. 126-136
    • Salih, D.A.1    Brunet, A.2
  • 142
    • 40549139768 scopus 로고    scopus 로고
    • An updated systematic review with meta-analysis for the clinical evidence of silymarin
    • Saller R., Brignoli R., Melzer J., Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed 2008, 15:9-20.
    • (2008) Forsch Komplementmed , vol.15 , pp. 9-20
    • Saller, R.1    Brignoli, R.2    Melzer, J.3    Meier, R.4
  • 144
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • Scalbert A., Williamson G. Dietary intake and bioavailability of polyphenols. The Journal of Nutrition 2000, 130:2073S-2085S.
    • (2000) The Journal of Nutrition , vol.130
    • Scalbert, A.1    Williamson, G.2
  • 145
    • 47249094223 scopus 로고    scopus 로고
    • Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
    • Scarlatti F., Maffei R., Beau I., Codogno P., Ghidoni R. Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death and Differentiation 2008, 15:1318-1329.
    • (2008) Cell Death and Differentiation , vol.15 , pp. 1318-1329
    • Scarlatti, F.1    Maffei, R.2    Beau, I.3    Codogno, P.4    Ghidoni, R.5
  • 147
    • 0017075410 scopus 로고
    • Antioxidant activity of curcumin and related compounds
    • Sharma O.P. Antioxidant activity of curcumin and related compounds. Biochemical Pharmacology 1976, 25:1811-1812.
    • (1976) Biochemical Pharmacology , vol.25 , pp. 1811-1812
    • Sharma, O.P.1
  • 149
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A., Cumming R.C., Brech A., Isakson P., Schubert D.R., Finley K.D. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008, 4:176-184.
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 150
    • 34548227773 scopus 로고    scopus 로고
    • From exotic spice to modern drug?
    • Singh S. From exotic spice to modern drug?. Cell 2007, 130:765-768.
    • (2007) Cell , vol.130 , pp. 765-768
    • Singh, S.1
  • 152
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal R.S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science 1996, 273:59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 153
    • 77955498539 scopus 로고    scopus 로고
    • Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
    • Spencer J.P. Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. The Proceedings of the Nutrition Society 2010, 69:244-260.
    • (2010) The Proceedings of the Nutrition Society , vol.69 , pp. 244-260
    • Spencer, J.P.1
  • 154
    • 84860389354 scopus 로고    scopus 로고
    • Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
    • Strasser A., Cory S., Adams J.M. Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. The EMBO Journal 2011, 30:3667-3683.
    • (2011) The EMBO Journal , vol.30 , pp. 3667-3683
    • Strasser, A.1    Cory, S.2    Adams, J.M.3
  • 156
    • 75349112375 scopus 로고    scopus 로고
    • Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging
    • Terman A., Kurz T., Navratil M., Arriaga E.A., Brunk U.T. Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxidants & Redox Signaling 2010, 12:503-535.
    • (2010) Antioxidants & Redox Signaling , vol.12 , pp. 503-535
    • Terman, A.1    Kurz, T.2    Navratil, M.3    Arriaga, E.A.4    Brunk, U.T.5
  • 157
    • 80053606380 scopus 로고    scopus 로고
    • Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings
    • Trepanowski J.F., Canale R.E., Marshall K.E., Kabir M.M., Bloomer R.J. Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings. Nutrition Journal 2011, 10:107.
    • (2011) Nutrition Journal , vol.10 , pp. 107
    • Trepanowski, J.F.1    Canale, R.E.2    Marshall, K.E.3    Kabir, M.M.4    Bloomer, R.J.5
  • 158
    • 0037069290 scopus 로고    scopus 로고
    • Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study
    • Truelsen T., Thudium D., Gronbaek M. Amount and type of alcohol and risk of dementia: the Copenhagen City Heart Study. Neurology 2002, 59:1313-1319.
    • (2002) Neurology , vol.59 , pp. 1313-1319
    • Truelsen, T.1    Thudium, D.2    Gronbaek, M.3
  • 159
    • 79955161193 scopus 로고    scopus 로고
    • Mitochondria: Sovereign of inflammation?
    • Tschopp J. Mitochondria: Sovereign of inflammation?. European Journal of Immunology 2011, 41:1196-1202.
    • (2011) European Journal of Immunology , vol.41 , pp. 1196-1202
    • Tschopp, J.1
  • 162
    • 77954197767 scopus 로고    scopus 로고
    • Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae
    • van der Vaart A., Griffith J., Reggiori F. Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae. Molecular Biology of the Cell 2010, 21:2270-2284.
    • (2010) Molecular Biology of the Cell , vol.21 , pp. 2270-2284
    • van der Vaart, A.1    Griffith, J.2    Reggiori, F.3
  • 163
    • 77956634425 scopus 로고    scopus 로고
    • Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management
    • Vargas A.J., Burd R. Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management. Nutrition Reviews 2010, 68:418-428.
    • (2010) Nutrition Reviews , vol.68 , pp. 418-428
    • Vargas, A.J.1    Burd, R.2
  • 167
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T., Xilouri M., Vekrellis K., Stefanis L. Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. The Journal of Biological Chemistry 2008, 283:23542-23556.
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 170
    • 80052380331 scopus 로고    scopus 로고
    • Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling
    • Wang K., Liu R., Li J., Mao J., Lei Y., Wu J., Zeng J., Zhang T., Wu H., Chen L., Huang C., Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy 2011, 7:966-978.
    • (2011) Autophagy , vol.7 , pp. 966-978
    • Wang, K.1    Liu, R.2    Li, J.3    Mao, J.4    Lei, Y.5    Wu, J.6    Zeng, J.7    Zhang, T.8    Wu, H.9    Chen, L.10    Huang, C.11    Wei, Y.12
  • 171
    • 0020044308 scopus 로고
    • Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence
    • Weindruch R., Walford R.L. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science 1982, 215:1415-1418.
    • (1982) Science , vol.215 , pp. 1415-1418
    • Weindruch, R.1    Walford, R.L.2
  • 173
    • 79953653114 scopus 로고    scopus 로고
    • The Parkinson disease protein alpha-synuclein inhibits autophagy
    • Winslow A.R., Rubinsztein D.C. The Parkinson disease protein alpha-synuclein inhibits autophagy. Autophagy 2011, 7:429-431.
    • (2011) Autophagy , vol.7 , pp. 429-431
    • Winslow, A.R.1    Rubinsztein, D.C.2
  • 176
    • 80155194987 scopus 로고    scopus 로고
    • Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells
    • Wu J.C., Lai C.S., Badmaev V., Nagabhushanam K., Ho C.T., Pan M.H. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. Molecular Nutrition & Food Research 2011, 55:1646-1654.
    • (2011) Molecular Nutrition & Food Research , vol.55 , pp. 1646-1654
    • Wu, J.C.1    Lai, C.S.2    Badmaev, V.3    Nagabhushanam, K.4    Ho, C.T.5    Pan, M.H.6
  • 177
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 178
    • 0031593675 scopus 로고    scopus 로고
    • Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
    • Yamamoto A., Tagawa Y., Yoshimori T., Moriyama Y., Masaki R., Tashiro Y. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Structure and Function 1998, 23:33-42.
    • (1998) Cell Structure and Function , vol.23 , pp. 33-42
    • Yamamoto, A.1    Tagawa, Y.2    Yoshimori, T.3    Moriyama, Y.4    Masaki, R.5    Tashiro, Y.6
  • 180
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L., Li P., Fu S., Calay E.S., Hotamisligil G.S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metabolism 2010, 11:467-478.
    • (2010) Cell Metabolism , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 181
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: core molecular machinery and signaling regulation
    • Yang Z., Klionsky D.J. Mammalian autophagy: core molecular machinery and signaling regulation. Current Opinion in Cell Biology 2010, 22:124-131.
    • (2010) Current Opinion in Cell Biology , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 185
    • 67650270918 scopus 로고    scopus 로고
    • Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
    • Zalckvar E., Berissi H., Eisenstein M., Kimchi A. Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy 2009, 5:720-722.
    • (2009) Autophagy , vol.5 , pp. 720-722
    • Zalckvar, E.1    Berissi, H.2    Eisenstein, M.3    Kimchi, A.4
  • 186
    • 77956498654 scopus 로고    scopus 로고
    • Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein
    • Zhang C., Browne A., Child D., Tanzi R.E. Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein. The Journal of Biological Chemistry 2010, 285:28472-28480.
    • (2010) The Journal of Biological Chemistry , vol.285 , pp. 28472-28480
    • Zhang, C.1    Browne, A.2    Child, D.3    Tanzi, R.E.4


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