MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Nature Communications

Volumn 7, Issue , 2016, Pages

  Zhang, Xiaoli ^a   Cheng, Xiping ^a   Yu, Lu ^a   Yang, Junsheng ^a,b   Calvo, Raul ^c   Patnaik, Samarjit ^c   Hu, Xin ^c   Gao, Qiong ^a   Yang, Meimei ^a   Lawas, Maria ^a   Delling, Markus ^d   Marugan, Juan ^c   Ferrer, Marc ^c   Xu, Haoxing ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; ENHANCED GREEN FLUORESCENT PROTEIN; FURA 2; MAMMALIAN TARGET OF RAPAMYCIN; PARKIN; REACTIVE OXYGEN METABOLITE; ROTENONE; TOSYLCHLORAMIDE SODIUM; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL M L1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CALCIUM; MAP1LC3B PROTEIN, HUMAN; MCOLN1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; TFEB PROTEIN, HUMAN;

ADAPTATION; GENE EXPRESSION; INHIBITION; METABOLISM; OXYGEN; PHYSIOLOGICAL RESPONSE; SENSORY SYSTEM;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL MEMBRANE DEPOLARIZATION; CELL PH; CELLULAR STRESS RESPONSE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; COS 1 CELL LINE; DNA SEQUENCE; FIBROBLAST; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LYSOSOME; LYSOSOME MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; ORGANELLE BIOGENESIS; OXIDATIVE STRESS; STOMACH PARIETAL CELL; ANIMAL; CHLOROCEBUS AETHIOPS; CV-1 CELL LINE; METABOLISM; MOUSE; PATCH CLAMP TECHNIQUE;

ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CALCIUM; CERCOPITHECUS AETHIOPS; COS CELLS; HEK293 CELLS; HELA CELLS; HUMANS; LYSOSOMES; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; ORGANELLE BIOGENESIS; PATCH-CLAMP TECHNIQUES; REACTIVE OXYGEN SPECIES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84977119521     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12109     Document Type: Article

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