UHPLC–MS(/MS) analysis of pesticides in food

Ultra Performance Liquid Chromatography Mass Spectrometry: Evaluation and Applications in Food Analysis

Volumn , Issue , 2014, Pages 17-49

  Lucci, Paolo ^a   Busquets, Rosa ^b   Núñez, Oscar ^c  

^a PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^b UNIVERSITY OF BRIGHTON   (United Kingdom)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURAL PRODUCTS; CROPS; DEGRADATION; DISEASE CONTROL; ENVIRONMENTAL REGULATIONS; FOOD STORAGE; HEALTH RISKS; PESTICIDES; PUBLIC RISKS; QUALITY CONTROL; RISK PERCEPTION;

AGRICULTURAL PRODUCTIONS; ANALYTICAL METHODOLOGY; DEGRADATION PRODUCTS; FRUITS AND VEGETABLES; LOW CONCENTRATION LEVELS; MAXIMUM RESIDUE LEVELS; PESTICIDE ACTIVE INGREDIENTS; TOXICOLOGICAL TESTING;

CHEMICAL CONTAMINATION;

EID: 85008221564     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b16670     Document Type: Chapter

References (130)

1. Grob, K., Biedermann, M., Scherbaum, E., Roth, M., and Rieger, K. 2006. Food contamination with organic materials in perspective: Packaging materials as the largest and least controlled source? A view focusing on the European Situation. Crit. Rev. Food Sci. Nutr. 46:529–535.
2. Fernandez-Alba, A. R. and Garcia-Reyes, J. F. 2008. Large-scale multi-residue methods for pesticides and their degradation products in food by advanced LC-MS. TrAC, Trends Anal. Chem. 27:973–990.
3. European Union. 1999. Council Directive 91/414/EEC of 15 July 1991 concerning the placing of plant protection products on the market, European Commission, Brussels. Official Journal L 230:1.
4. European Commission. 1999. Commission Directive 1999/39/EC of 6 May 1999 amending Directive 96/5/EC on processed cereal-based foods and baby foods for infants and young children. European Commission, Brussels.
5. European Commission. 1999. Commission Directive 1999/50/EC of 25 May 1999 amending Directive 96/5/EC on infant formulae and follow-on formulae. European Commission, Brussels.
6. European Commission 2003. Commission Directive 2003/13/EC of 6 May 1999 amending Directive 96/5/EC on processed cereal based foods and baby foods for infants and young children. European Commission, Brussels.
7. European Commission 2003. Commission Directive 2003/14/EC of 25 May 1999 amending Directive 91/321/EEC on infant formulae and follow-on formulae. European Commission, Brussels.
8. Toledano, R. M., Cortes, J. M., Andini, J. C., Villen, J., and Vazquez, A. 2010. Large volume injection of water in gas chromatography–mass spectrometry using the through oven transfer adsorption desorption interface: Application to multiresidue analysis of pesticides. J. Chromatogr. A 1217:4738–4742.
9. Koesukwiwat, U., Lehotay, S. J., and Leepipatpiboon, N. 2011. Fast, low-pressure gas chromatography triple quadrupole tandem mass spectrometry for analysis of 150 pesticide residues in fruits and vegetables. J. Chromatogr. A 1218:7039–7050.
10. Matsuoka, T., Akiyama, Y., and Mitsuhashi, T. 2011. Application of multi-residue analytical method for determination of 496 pesticides in frozen gyoza dumplings by GC–MS and LC–MS. J. Pestic. Sci. 36:486–491.
11. Vukovic, G., Shtereva, D., Bursic, V., Mladenova, R., and Lazic, S. 2012. Application of GC-MSD and LC-MS/MS for the determination of priority pesticides in baby foods in Serbian market. LWT— Food Sci. Technol. 49:312–319.
12. Kwon, H., Lehotay, S. J., and Geis-Asteggiante, L. 2012. Variability of matrix effects in liquid and gas chromatography–mass spectrometry analysis of pesticide residues after QuEChERS sample preparation of different food crops. J. Chromatogr. A 1270:235–245.
13. Alder, L. 2011. Targeted pesticide residue analysis using triple quad LC-MS/MS. Methods Mol. Biol. 747:173–191.
14. Kujawski, M. W. and Namiesnik, J. 2011. Levels of 13 multi-class pesticide residues in Polish honeys determined by LC-ESI-MS/MS. Food Control 22:914–919.
15. Kmellar, B., Pareja, L., Ferrer, C., Fodor, P., and Fernandez-Alba, A. R. 2011. Study of the effects of operational parameters on multiresidue pesticide analysis by LC-MS/MS. Talanta 84:262–273.
16. Sack, C., Smoker, M., Chamkasem, N., Thompson, R., Satterfield, G., Masse, C., Mercer, G. et al. 2011. Collaborative validation of the QuEChERS procedure for the determination of pesticides in food by LC-MS/MS. J. Agric. Food Chem. 59:6383–6411.
17. Núñez, O., Gallart-Ayala, H., Ferrer, I., Moyano, E., and Galceran, M. T. 2012. Strategies for the multi-residue analysis of 100 pesticides by liquid chromatography–triple quadrupole mass spectrometry. J. Chromatogr. A 1249:164–180.
18. Camino-Sanchez, F. J., Zafra-Gomez, A., Oliver-Rodriguez, B., Ballesteros, O., Navalon, A., Crovetto, G., and Vilchez, J. L. 2010. UNE-EN ISO/IEC 17025:2005-accredited method for the determination of pesticide residues in fruit and vegetable samples by LC-MS/MS. Food Addit. Contam., Part A 27:1532–1544.
19. Di Stefano, V., Avellone, G., Bongiorno, D., Cunsolo, V., Muccilli, V., Sforza, S., Dossena, A., Drahos, L., and Vekey, K. 2012. Applications of liquid chromatography–mass spectrometry for food analysis. J. Chromatogr. A 1259:74–85.
20. D’Orazio, G., Rocco, A., and Fanali, S. 2012. Fast-liquid chromatography using columns of different internal diameters packed with sub-2 Î1/4m silica particles. J. Chromatogr. A 1228:213–220.
21. Núñez, O., Gallart-Ayala, H., Martins, C. P. B., and Lucci, P. 2012. New trends in fast liquid chromatography for food and environmental analysis. J. Chromatogr. A 1228:298–323.
22. Fekete, S. and Fekete, J. 2011. Fast gradient screening of pharmaceuticals with 5 cm long, narrow bore reversed-phase columns packed with sub-3 micro m core-shell and sub-2 micro m totally porous particles. Talanta 84:416–423.
23. Fekete, S., Ganzler, K., and Fekete, J. 2011. Efficiency of the new sub-2 micro m core-shell (Kinetex?) column in practice, applied for small and large molecule separation. J. Pharm. Biomed. Anal. 54:482–490.
24. Van Deemter, J. J., Zuiderweg, F. J., and Klingengerg, A. 1956. Longitudinal diffusion and resistance to mass transfer as causes of nonideality in chromatography. J. Chem. Eng. Sci. 5:271–289.
25. Wang, J., Chow, W., and Cheung, W. 2011. Application of a tandem mass spectrometer and core-shell particle column for the determination of 151 pesticides in grains. J. Agric. Food Chem. 59:8589–8608.
26. Anastassiades, M., Lehotay, S. J., Stajnbaher, D., and Schenck, F. J. 2003. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and “dispersive solid-phase extraction” for the determination of pesticide residues in produce. J. AOAC Int. 86:412–431.
27. Lucci, P., Pacetti, D., Núñez, O., and Frega, N.G. 2012. Current trends in sample treatment techniques for environmental and food analysis. In Chromatography: The Most Versatile Method of Chemical Analysis, ed. L.A. Calderon, InTech Publisher, Rijeka (CR), pp. 127–164, ISBN: 978-953-51-0813-9.
28. Lehotay, S. J. 2011. QuEChERS sample preparation approach for mass spectrometric analysis of pesticide residues in foods. Methods Mol. Biol. 747:65–91.
29. Schurmann, A., Dvorak, V., Cruzer, C., Butcher, P., and Kaufmann, A. 2009. False-positive liquid chromatography/tandem mass spectrometric confirmation of sebuthylazine residues using the identification points system according to EU directive 2002/657/EC due to a biogenic insecticide in tarragon. Rapid Commun. Mass Spectrom. 23:1196–1200.
30. Ferrer, I., Thurman, E. M., and Zweigenbaum, J. 2011. LC/TOF-MS analysis of pesticides in fruits and vegetables: The emerging role of accurate mass in the unambiguous identification of pesticides in food. Methods Mol. Biol. 747:193–218.
31. Ahmed, F. E. 2001. Analyses of pesticides and their metabolites in foods and drinks. TrAC, Trends Anal. Chem. 20:649–661.
32. Picó, Y., Font, G., Ruiz, M. J., and Fernandez, M. 2006. Control of pesticide residues by liquid chromatography–mass spectrometry to ensure food safety. Mass Spectrom. Rev. 25:917–960.
33. Fuentes, E., Baez, M. E., and Quinones, A. 2008. Suitability of microwave-assisted extraction coupled with solid-phase extraction for organophosphorus pesticide determination in olive oil. J. Chromatogr. A 1207:38–45.
34. Hernandez-Borges, J., Ravelo-Perez, L. M., Hernandez-Suarez, E. M., Carnero, A., and Rodriguez-Delgado, M. A. 2008. Determination of abamectin residues in avocados by microwave-assisted extraction and HPLC with fluorescence detection. Chromatographia 67:69–75.
35. Mezcua, M., Repetti, M. R., Aguera, A., Ferrer, C., Garcia-Reyes, J. F., and Fernandez-Alba, A. R. 2007. Determination of pesticides in milk-based infant formulas by pressurized liquid extraction followed by gas chromatography tandem mass spectrometry. Anal. Bioanal. Chem. 389:1833–1840.
36. Blasco, C., Font, G., and Pico, Y. 2005. Analysis of pesticides in fruits by pressurized liquid extraction and liquid chromatography–ion trap–triple stage mass spectrometry. J. Chromatogr. A 1098:37–43.
37. Garces-Garcia, M., Brun, E. M., Puchades, R., and Maquieira, A. 2006. Immunochemical determination of four organophosphorus insecticide residues in olive oil using a rapid extraction process. Anal. Chim. Acta 556:347–354.
38. Rissato, S. R., Galhiane, M. S., Knoll, F. R. N., and Apon, B. M. 2004. Supercritical fluid extraction for pesticide multiresidue analysis in honey: Determination by gas chromatography with electron-capture and mass spectrometry detection. J. Chromatogr. A 1048:153–159.
39. Richter, B. E., Jones, B. A., Ezzell, J. L., Porter, N. L., Avdalovic, N., and Pohl, C. 1996. Accelerated solvent extraction: A technique for sample preparation. Anal. Chem. 68:1033–1039.
40. Gilbert-Lopez, B., Garcia-Reyes, J. F., and Molina-Diaz, A. 2009. Sample treatment and determination of pesticide residues in fatty vegetable matrices: A review. Talanta 79:109–128.
41. Fernandez Moreno, J. L., Arrebola Liebanas, F. J., Garrido Frenich, A., and Martinez Vidal, J. L. 2006. Evaluation of different sample treatments for determining pesticide residues in fat vegetable matrices like avocado by low-pressure gas chromatography-tandem mass spectrometry. J. Chromatogr. A 1111:97–105.
42. Economou, A., Botitsi, H., Antoniou, S., and Tsipi, D. 2009. Determination of multi-class pesticides in wines by solid-phase extraction and liquid chromatography–tandem mass spectrometry. J. Chromatogr. A 1216:5856–5867.
43. Yang, X., Zhang, H., Liu, Y., Wang, J., Zhang, Y. C., Dong, A. J., Zhao, H. T., Sun, C. H., and Cui, J. 2011. Multiresidue method for determination of 88 pesticides in berry fruits using solid-phase extraction and gas chromatography–mass spectrometry: Determination of 88 pesticides in berries using SPE and GC-MS. Food Chem. 127:855–865.
44. Durovic, R., Milinovic, J., Markovic, M., and Markovic, D. 2007. Headspace solid phase microextraction in pesticide residues analysis: 2. Apple samples. Pestic. Fitomed. 22:173–176.
45. Blasco, C., Fernandez, M., Pico, Y., and Font, G. 2004. Comparison of solid-phase microextraction and stir bar sorptive extraction for determining six organophosphorus insecticides in honey by liquid chromatography–mass spectrometry. J. Chromatogr. A 1030:77–85.
46. Blasco, C., Font, G., Manes, J., and Pico, Y. 2003. Solid-phase microextraction liquid chromatography/tandem mass spectrometry to determine postharvest fungicides in fruits. Anal. Chem. 75:3606–3615.
47. Gilbert-Lopez, B., Garcia-Reyes, J. F., Lozano, A., Fernandez-Alba, A. R., and Molina-Diaz, A. 2010. Large-scale pesticide testing in olives by liquid chromatography–electrospray tandem mass spectrometry using two sample preparation methods based on matrix solid-phase dispersion and QuEChERS. J. Chromatogr. A 1217:6022–6035.
48. Silva, M. G. D., Aquino, A., Dorea, H. S., and Navickiene, S. 2008. Simultaneous determination of eight pesticide residues in coconut using MSPD and GC/MS. Talanta 76:680–684.
49. Pereira, L. A. and Rath, S. 2009. Molecularly imprinted solid-phase extraction for the determination of fenitrothion in tomatoes. Anal. Bioanal. Chem. 393:1063–1072.
50. Xin, J., Qiao, X., Ma, Y., and Xu, Z. 2012. Simultaneous separation and determination of eight organophosphorous pesticide residues in vegetables through molecularly imprinted solid-phase extraction coupled to gas chromatography. J. Sep. Sci. 35:3501–3508.
51. Wang, Y., Zhang, Q., Li, P., Zhang, W., Li, Y., and Ding, X. 2011. Selective sample cleanup by immunoaffinity chromatography for determination of fenvalerate in vegetables. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 879:3531–3537.
52. Xu, Z., Fang, G., and Wang, S. 2009. Molecularly imprinted solid phase extraction coupled to high-performance liquid chromatography for determination of trace dichlorvos residues in vegetables. Food Chem. 119:845–850.
53. Qian, K., Fang, G., He, J., Pan, M., and Wang, S. 2010. Preparation and application of a molecularly imprinted polymer for the determination of trace metolcarb in food matrices by high performance liquid chromatography. J. Sep. Sci. 33:2079–2085.
54. Barahona, F., Turiel, E., Cormack, P. A. G., and Martin-Esteban, A. 2011. Synthesis of core-shell molecularly imprinted polymer microspheres by precipitation polymerization for the inline molecularly imprinted solid-phase extraction of thiabendazole from citrus fruits and orange juice samples. J. Sep. Sci. 34:217–224.
55. Viglino, L., Aboulfadl, K., Mahvelat, A. D., Prevost, M., and Sauve, S. 2008. On-line solid phase extraction and liquid chromatography/tandem mass spectrometry to quantify pharmaceuticals, pesticides and some metabolites in wastewaters, drinking, and surface waters. J. Environ. Monit. 10:482–489.
56. Garcia-Ac, A., Segura, P. A., Viglino, L., Fuertoes, A., Gagnon, C., Prevost, M., and Sauve, S. 2009. On-line solid-phase extraction of large-volume injections coupled to liquid chromatography–tandem mass spectrometry for the quantitation and confirmation of 14 selected trace organic contaminants in drinking and surface water. J. Chromatogr. A 1216:8518–8527.
57. Riediker, S., Obrist, H., Varga, N., and Stadler, R. H. 2002. Determination of chlormequat and mepiquat in pear, tomato, and wheat flour using on-line solid-phase extraction (Prospekt) coupled with liquid chromatography–electrospray ionization tandem mass spectrometry. J. Chromatogr. A 966:15–23.
58. Koesukwiwat, U., Lehotay, S. J., Miao, S., and Leepipatpiboon, N. 2010. High throughput analysis of 150 pesticides in fruits and vegetables using QuEChERS and low-pressure gas chromatography-time-of-flight mass spectrometry. J. Chromatogr. A 1217:6692–6703.
59. Kmellar, B., Abranko, L., Fodor, P., and Lehotay, S. J. 2010. Routine approach to qualitatively screening 300 pesticides and quantification of those frequently detected in fruit and vegetables using liquid chromatography tandem mass spectrometry (LC-MS/MS). Food Addit. Contam. 27:1415–1430.
60. Lehotay, S. J., Mastovska, K., and Yun, S. J. 2005. Evaluation of two fast and easy methods for pesticide residue analysis in fatty food matrixes. J. AOAC Int. 88:630–638.
61. Koesukwiwat, U., Lehotay, S. J., Mastovska, K., Dorweiler, K. J., and Leepipatpiboon, N. 2010. Extension of the QuEChERS method for pesticide residues in cereals to flaxseeds, peanuts, and doughs. J. Agric. Food Chem. 58:5950–5958.
62. Garcia-Reyes, J. F., Ferrer, C., Gomez-Ramos, M. J., Fernandez-Alba, A. R., Garcia-Reyes, J. F., and Molina-Diaz, A. 2007. Determination of pesticide residues in olive oil and olives. TrAC, Trends Anal. Chem. 26:239–251.
63. Jeong, I. S., Kwak, B. M., Ahn, J. H., and Jeong, S. H. 2012. Determination of pesticide residues in milk using a QuEChERS-based method developed by response surface methodology. Food Chem. 133:473–481.
64. Fields, S. M. 1996. Silica xerogel as a continuous column support for high-performance liquid chromatography. Anal. Chem. 68:2709–2712.
65. Minakuchi, H., Nakanishi, K., Soga, N., Ishizuka, N., and Tanaka, N. 1996. Octadecylsilylated porous silica rods as separation media for reversed-phase liquid chromatography. Anal. Chem. 68:3498–3501.
66. Laemmerhofer, M., Svec, F., Frechet, J. M. J., and Lindner, W. 2000. Chiral monolithic columns for enantioselective capillary electrochromatography prepared by copolymerization of a monomer with quinidine functionality. 2. Effect of chromatographic conditions on the chiral separations. Anal. Chem. 72:4623–4628.
67. Premstaller, A., Oberacher, H., Walcher, W., Timperio, A. M., Zolla, L., Chervet, J. P., Cavusoglu, N., van Dorsselaer, A., and Huber, C. G. 2001. High-performance liquid chromatography-electrospray ionization mass spectrometry using monolithic capillary columns for proteomic studies. Anal. Chem. 73:2390–2396.
68. De Villiers, A., Lestremau, F., Szucs, R., Gelebart, S., David, F., and Sandra, P. 2006. Evaluation of ultra performance liquid chromatography. Par I. Possibilities and limitations. J. Chromatogr. A 1127:60–69.
69. Plumb, R. S., Rainville, P., Smith, B. W., Johnson, K. A., Castro-Perez, J., Wilson, I. D., and Nicholson, J. K. 2006. Generation of ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities. Anal. Chem. 78:7278–7283.
70. MacNair, J. E., Lewis, K. C., and Jorgenson, J. W. 1997. Ultrahigh-pressure reversed-phase liquid chromatography in packed capillary columns. Anal. Chem. 69:983–989.
71. Wang, Y., Ai, F., Ng, S. C., and Tan, T. T. Y. 2012. Sub-2 μm porous silica materials for enhanced separation performance in liquid chromatography. J. Chromatogr. A 1228:99–109.
72. Wang, X., Barber, W. E., and Long, W. J. 2012. Applications of superficially porous particles: High speed, high efficiency or both? J. Chromatogr. A 1228:72–88.
73. Fekete, S., Olah, E., and Fekete, J. 2012. Fast liquid chromatography: The domination of core-shell and very fine particles. J. Chromatogr. A 1228:57–71.
74. Diaz, R., Ibanez, M., Sancho, J. V., and Hernandez, F. 2013. Qualitative validation of a liquid chromatography–quadrupole–time of flight mass spectrometry screening method for organic pollutants in waters. J. Chromatogr. A 1276:47–57.
75. Bakirci, G. T. and Hisil, Y. 2012. Fast and simple extraction of pesticide residues in selected fruits and vegetables using tetrafluoroethane and toluene followed by ultrahigh-performance liquid chromatography/tandem mass spectrometry. Food Chem. 135:1901–1913.
76. Gao, F., Zhao, Y., Shao, B., and Zhang, J. 2012. Determination of residues of pesticides and veterinary drugs in milk by ultra performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry. Se Pu 30:560–567.
77. Chen, G., Cao, P., and Liu, R. 2011. A multi-residue method for fast determination of pesticides in tea by ultra performance liquid chromatography–electrospray tandem mass spectrometry combined with modified QuEChERS sample preparation procedure. Food Chem. 125:1406–1411.
78. Queiroz, S. C. N., Ferracini, V. L., and Rosa, M. A. 2012. Multiresidue method validation for determination of pesticides in food using QuEChERS and UPLC-MS/MS. Quim. Nova 35:185–192.
79. Kong, Z., Dong, F., Xu, J., Liu, X., Zhang, C., Li, J., Li, Y., Chen, X., Shan, W., and Zheng, Y. 2011. Determination of difenoconazole residue in tomato during home canning by UPLC-MS/MS. Food Control 23:542–546.
80. Yang, R. Z, Wang, J. H., Wang, M. l., Zhang, R., Lu, X. Y., and Liu, W. H. 2011. Dispersive solid-phase extraction cleanup combined with accelerated solvent extraction for the determination of carbamate pesticide residues in radix glycyrrhizae samples by UPLC-MS-MS. J. Chromatogr. Sci. 49:702–708.
81. Lin, Q. B., Xue, Y. Y., and Song, H. 2010. Determination of the residues of 18 carbamate pesticides in chestnut and pine nut by GPC cleanup and UPLC-MS-MS. J. Chromatogr. Sci. 48:7–11.
82. Liu, X. G., Xu, J., Dong, F. S., Li, Y. B., Song, W. C., and Zheng, Y. Q. 2011. Residue analysis of four diacylhydrazine insecticides in fruits and vegetables by Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method using ultra-performance liquid chromatography coupled to tandem mass spectrometry. Anal. Bioanal. Chem. 401:1051–1058.
83. Xu, J., Dong, F., Liu, X., Li, J., Li, Y., Shan, W., and Zheng, Y. 2012. Determination of sulfoxaflor residues in vegetables, fruits and soil using ultra-performance liquid chromatography/tandem mass spectrometry. Anal. Methods 4:4019–4024.
84. Mol, H. G. J., Zomer, P., and de Koning, M. 2012. Qualitative aspects and validation of a screening method for pesticides in vegetables and fruits based on liquid chromatography coupled to full scan high resolution (Orbitrap) mass spectrometry. Anal. Bioanal. Chem. 403:2891–2908.
85. Hayward, D. G., Wong, J. W., Zhang, K., Chang, J., Shi, F., Banerjee, K., and Yang, P. 2011. Multiresidue pesticide analysis in ginseng and spinach by nontargeted and targeted screening procedures. J. AOAC Int. 94:1741–1751.
86. European Commission 2002. Commission Decision of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. European Commission, Brussels.
87. Chen, L., Song, F., Zheng, Z., Xing, J., Liu, Z., and Liu, S. 2012. Studies on the determination method of pesticide multi-residues in ginseng by ultra performance liquid chromatography tandem mass spectrometry. Huaxue Xuebao 70:843–851.
88. Chung, S. W. C. and Lam, C. H. 2012. Development and validation of a method for determination of residues of 15 pyrethroids and two metabolites of dithiocarbamates in foods by ultra-performance liquid chromatography–tandem mass spectrometry. Anal. Bioanal. Chem. 403:885–896.
89. Botitsi, H. V., Garbis, S. D., Economou, A., and Tsipi, D. F. 2011. Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices. Mass Spectrom. Rev. 30:907–939.
90. Zhang, X. Z., Luo, F. J., Liu, G. M., Lou, Z. Y., and Chen, Z. M. 2011. Determination of diafenthiuron and its metabolites in tea and soil by ultra performance liquid chromatography–electrospray ionization tandem mass spectrometry. Fenxi Huaxue 39:1329–1335.
91. SANCO/2009/10684. 2010. European Council No. Guidance document on method validation and quality control procedures for pesticide residues analysis in food and feed.
92. Van Eeenoo, P. and Delbeke, F. T. 2004. Criteria in chromatography and mass spectrometry—A comparison between regulations in the field of residue and doping analysis. Chromatogr. Suppl. 59:S39–S44.
93. Pozo, O. J., Sancho, J. V., Ibanez, M., Hernandez, F., and Niessen, W. M. A. 2006. Confirmation of organic micropollutants detected in environmental samples by liquid chromatography tandem mass spectrometry: Achievements and pitfalls. TrAC, Trends Anal. Chem. 25:1030–1042.
94. Kaufmann, A. and Butcher, P. 2006. Strategies to avoid false negative findings in residue analysis using liquid chromatography coupled to time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 20:3566–3572.
95. Jiwan, J. L. H., Wallemacq, P., and Herent, M. F. 2011. HPLC-high resolution mass spectrometry in clinical laboratory? Clin. Biochem. 44:136–147.
96. Rogers, R. P., Schaub, T. M., and Marshall, A. G. 2005. MS returns to its roots. Anal. Chem. 77:A21-A27.
97. Thurman, E.M. and Ferrer, I. 2003. Comparison of quadrupole, time-of-flight, triple quadrupole, and ion-trap mass spectrometry for the analysis of emerging contaminants. In Liquid Chromatography/Mass Spectrometry/Mass Spectrometry and Time-of-Flight Mass Spectrometry for the Analysis of Emerging Contaminants. American Chemical Society Symposium Vol. 850, pp. 14–31.
98. Thurman, E. M., Ferrer, I., and Fernandez-Alba, A. R. 2005. Matching unknown empirical formulas to chemical structure using LC/MS TOF accurate mass and database searching: Example of unknown pesticides on tomato skin. J. Chromatogr. A 1067:127–134.
99. Thurman, E. M., Ferrer, I., Garcia-Reyes, J. F., Zweigenbaum, J., Woodman, M., and Fernandez-Alba, A. R. 2005. Discovering metabolites of post harvest fungicides in citrus with liquid chromatography/time-of-flight mass spectrometry and ion trap tandem mass spectrometry. J. Chromatogr. A 1082:71–80.
100. Kellmann, M., Muenster, H., Zomer, P., and Mol, H. 2009. Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: How much resolving power is required? J. Am. Soc. Mass Spectrom. 20:1464–1476.
101. Ferrer, I., Thurman, E. M., and Fernandez-Alba, A. R. 2005. Quantitation and accurate mass analysis of pesticides in vegetables by LC/TOF-MS. Anal. Chem. 77:2818–2825.
102. Wang, J., Leung, D., and Chow, W. 2010. Applications of LC/ESI-MS/MS and UHPLC QqTOF MS for the determination of 148 pesticides in berries. J. Agric. Food Chem. 58:5904–5925.
103. Wang, J., Chow, W., and Leung, D. 2010. Applications of LC/ESI-MS/MS and UHPLC QqTOF MS for the determination of 148 pesticides in fruits and vegetables. Anal. Bioanal. Chem. 396:1513–1538.
104. Lacina, O., Urbanova, J., Poustka, J., and Hajslova, J. 2010. Identification/quantification of multiple pesticide residues in food plants by ultra-high-performance liquid chromatography–time-of-flight mass spectrometry. J. Chromatogr. A 1217:648–659.
105. Diaz, R., Ibanez, M., Sancho, J. V., and Hernandez, F. 2012. Target and non-target screening strategies for organic contaminants, residues and illicit substances in food, environmental and human biological samples by UHPLC-QTOF-MS. Anal. Methods 4:196–209.
106. Grimalt, S., Sancho, J. V., Pozo, O. J., and Hernandez, F. 2010. Quantification, confirmation and screening capability of UHPLC coupled to triple quadrupole and hybrid quadrupole time-of-flight mass spectrometry in pesticide residue analysis. J. Mass Spectrom. 45:421–436.
107. Filigenzi, M. S., Ehrke, N., Aston, L. S., and Poppenga, R. H. 2011. Evaluation of a rapid screening method for chemical contaminants of concern in four food-related matrices using QuEChERS extraction, UHPLC and high resolution mass spectrometry. Food Addit. Contam., Part A 28:1324–1339.
108. Wode, F., Reilich, C., van Baar, P., Duennbier, U., Jekel, M., and Reemtsma, T. 2012. Multiresidue analytical method for the simultaneous determination of 72 micropollutants in aqueous samples with ultra high performance liquid chromatography–high resolution mass spectrometry. J. Chromatogr. A 1270:118–126.
109. Gomez-Perez, M. L., Plaza-Bolanos, P., Romero-Gonzalez, R., Martinez-Vidal, J. L., and Garrido-Frenich, A. 2012. Comprehensive qualitative and quantitative determination of pesticides and veterinary drugs in honey using liquid chromatography–Orbitrap high resolution mass spectrometry. J. Chromatogr. A 1248:130–138.
110. Wang, J., Chow, W., Leung, D., and Chang, J. 2012. Application of ultrahigh-performance liquid chromatography and electrospray ionization quadrupole orbitrap high-resolution mass spectrometry for determination of 166 pesticides in fruits and vegetables. J. Agric. Food Chem. 60:12088–12104.
111. Wang, J., Chow, W., and Leung, D. 2011. Applications of LC/ESI-MS/MS and UHPLC/Qq-TOF-MS for the determination of 141 pesticides in tea. J. AOAC Int. 94:1685–1714.
112. Pesticide EU-MRLs Database. 2005. Regulation (EC) n. 396/2005. http://ec.europa.eu/sanco_pesticides/public/index.cfm
113. U.S. EPA Office of Pesticide Programs. What the Pesticide Residue Limits Are on Food. Available at http://www.epa.gov/pesticides/food/viewtools.html
114. Pérez-Parada, A., Colazzo, M., Besil, N., Dellacassa, E., Cesio, V., Heinzen, H., and Fernández-Alba, A.R. 2011. Pesticide residues in natural products with pharmaceutical use: occurrence, analytical advances and perspectives. In Pesticides in the Modern World–Trends in Pesticide Analysis, ed. L.M. Stoytcheva, InTech Publisher, Rijeka (CR), pp. 357–390. ISBN: 978-953-307-437-5.
115. European Food Safety Authority. 2011. The 2009 European Union Report of Pesticide Residues in Food. EFSA Journal 9(11):2430.
116. European Food Safety Authority. 2013. The 2010 European Union Report of Pesticide Residues in Food. EFSA Journal 11(3):3130.
117. Chai, M. K. and Tan, G. H. 2009. Validation of a headspace solid-phase microextraction procedure with gas chromatography-electron capture detection of pesticide residues in fruits and vegetables. Food Chem. 117:561–567.
118. Huskova, R., Matisova, E., Hrouzkova, S., and Svorc, L. 2009. Analysis of pesticide residues by fast gas chromatography in combination with negative chemical ionization mass spectrometry. J. Chromatogr. A 1216:6326–6334.
119. Arrebola, F. J., Martinez Vidal, J. L., Gonzalez-Rodriguez, M. J., Garrido-Frenich, A., and Sanchez Morito, N. 2003. Reduction of analysis time in gas chromatography. Application of low-pressure gas chromatography-tandem mass spectrometry to the determination of pesticide residues in vegetables. J. Chromatogr. A 1005:131–141.
120. Nguyen, T. D., Yu, J. E., Lee, D. M., and Lee, G. H. 2008. A multiresidue method for the determination of 107 pesticides in cabbage and radish using QuEChERS sample preparation method and gas chromatography mass spectrometry. Food Chem. 110:207–213.
121. Rial Otero, R., Cancho Grande, B., and Simal Gandara, J. 2003. Multiresidue method for fourteen fungicides in white grapes by liquid–liquid and solid-phase extraction followed by liquid chromatography–diode array detection. J. Chromatogr. A 992:121–131.
122. Venkateswarlu, P., Mohan, K. R., Kumar, C., and Seshaiah, K. 2007. Monitoring of multi-class pesticide residues in fresh grape samples using liquid chromatography with electrospray tandem mass spectrometry. Food Chem. 105:1760–1766.
123. Soler, C., Manes, J., and Pico, Y. 2005. Routine application using single quadrupole liquid chromatography–mass spectrometry to pesticides analysis in citrus fruits. J. Chromatogr. A 1088:224–233.
124. Fenoll, J., Hellin, P., Martinez, C. M., Miguel, M., and Flores, P. 2007. Multiresidue method for analysis of pesticides in pepper and tomato by gas chromatography with nitrogen-phosphorus detection. Food Chem. 105:711–719.
125. Zamora, T., Pozo, O. J., Lopez, F. J., and Hernandez, F. 2004. Determination of tridemorph and other fungicide residues in fruit samples by liquid chromatography–electrospray tandem mass spectrometry. J. Chromatogr. A 1045:137–143.
126. Huang, Z., Li, Y., Chen, B., and Yao, S. 2007. Simultaneous determination of 102 pesticide residues in Chinese teas by gas chromatography–mass spectrometry. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 853:154–162.
127. Walorczyk, S., Drozdzynski, D., Kowalska, J., Remlein-Starosta, D., Ziolkowski, A., Przewozniak, M., and Gnusowski, B. 2013. Pesticide residues determination in Polish organic crops in 2007–2010 applying gas chromatography–tandem quadrupole mass spectrometry. Food Chem. 139:482–487.
128. Garcia de Llasera, M. P. and Reyes-Reyes, M. L. 2009. A validated matrix solid-phase dispersion method for the extraction of organophosphorus pesticides from bovine samples. Food Chem. 114:1510–1516.
129. Garrido, F. A., Martinez, V. J. L., Cruz, S. A. D., Gonzalez, R. M. J., and Plaza, B. P. 2006. Multiresidue analysis of organochlorine and organophosphorus pesticides in muscle of chicken, pork and lamb by gas chromatography-triple quadrupole mass spectrometry. Anal. Chim. Acta 558:42–52.
130. Bolaños, P. P., Frenich, A. G., and Vidal, J. L. M. 2007. Application of gas chromatography-triple quadrupole mass spectrometry in the quantification-confirmation of pesticides and polychlorinated biphenyls in eggs at trace levels. J. Chromatogr. A 1167:9–17.