-
1
-
-
60849138547
-
IL-23 and autoimmunity: New insights into the pathogenesis of inflammatory bowel disease
-
Abraham C, Cho JH. IL-23 and autoimmunity: new insights into the pathogenesis of inflammatory bowel disease. Annu Rev Med. 2009;60: 97-110.
-
(2009)
Annu Rev Med.
, vol.60
, pp. 97-110
-
-
Abraham, C.1
Cho, J.H.2
-
2
-
-
84886951561
-
Innate and adaptive immunity in inflammatory bowel disease
-
Geremia A, Biancheri P, Allan P, et al. Innate and adaptive immunity in inflammatory bowel disease. Autoimmun Rev. 2014;13:3-10.
-
(2014)
Autoimmun Rev.
, vol.13
, pp. 3-10
-
-
Geremia, A.1
Biancheri, P.2
Allan, P.3
-
3
-
-
17044385039
-
TLR signaling in the gut in health and disease
-
Abreu MT, Fukata M, Arditi M. TLR signaling in the gut in health and disease. J Immunol. 2005;174:4453-4460.
-
(2005)
J Immunol.
, vol.174
, pp. 4453-4460
-
-
Abreu, M.T.1
Fukata, M.2
Arditi, M.3
-
6
-
-
33745746660
-
Muc2-Deficient mice spontaneously develop colitis, indicating that MUC2 is Critical for colonic protection
-
Van der Sluis M, De Koning BAE, De Bruijn ACJM, et al. Muc2-Deficient mice spontaneously develop colitis, indicating that MUC2 is Critical for colonic protection. Gastroenterology. 2006;131:117-129.
-
(2006)
Gastroenterology.
, vol.131
, pp. 117-129
-
-
Van Der Sluis, M.1
De Koning, B.A.E.2
De Bruijn, A.C.J.M.3
-
7
-
-
0036500996
-
Colorectal Cancer in mice genetically deficient in the mucin Muc2
-
Velcich A, Yang W, Heyer J, et al. Colorectal Cancer in mice genetically deficient in the mucin Muc2. Science. 2002;295:1726-1729.
-
(2002)
Science.
, vol.295
, pp. 1726-1729
-
-
Velcich, A.1
Yang, W.2
Heyer, J.3
-
9
-
-
80054767981
-
Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation
-
Larsson JM, Karlsson H, Crespo JG, et al. Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. Inflamm Bowel Dis. 2011;17:2299-2307.
-
(2011)
Inflamm Bowel Dis.
, vol.17
, pp. 2299-2307
-
-
Larsson, J.M.1
Karlsson, H.2
Crespo, J.G.3
-
10
-
-
78650096816
-
Importance of disrupted intestinal barrier in inflammatory bowel diseases
-
Salim SY, Soderholm JD. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis. 2011;17:362-381.
-
(2011)
Inflamm Bowel Dis.
, vol.17
, pp. 362-381
-
-
Salim, S.Y.1
Soderholm, J.D.2
-
11
-
-
0019996563
-
Intestinal permeability in children with Crohn?s disease and coeliac disease
-
Pearson AD, Eastham EJ, Laker MF, et al. Intestinal permeability in children with Crohn?s disease and coeliac disease. Br Med J (Clin Res Ed). 1982;285:20-21.
-
(1982)
Br Med J (Clin Res Ed).
, vol.285
, pp. 20-21
-
-
Pearson, A.D.1
Eastham, E.J.2
Laker, M.F.3
-
12
-
-
70649103789
-
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
-
Consortium UIG, Barrett JC, Lee JC, et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet. 2009;41:1330-1334.
-
(2009)
Nat Genet.
, vol.41
, pp. 1330-1334
-
-
Consortium, U.I.G.1
Barrett, J.C.2
Lee, J.C.3
-
13
-
-
84888219662
-
Defective antibacterial barrier in inflammatory bowel disease
-
Klag T, Stange EF, Wehkamp J. Defective antibacterial barrier in inflammatory bowel disease. Dig Dis. 2013;31:310-316.
-
(2013)
Dig Dis.
, vol.31
, pp. 310-316
-
-
Klag, T.1
Stange, E.F.2
Wehkamp, J.3
-
14
-
-
0037165196
-
Antimicrobial peptides of multicellular organisms
-
Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002;415:389-395.
-
(2002)
Nature.
, vol.415
, pp. 389-395
-
-
Zasloff, M.1
-
15
-
-
0028933794
-
Peptide antibiotics and their role in innate immunity
-
Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immunol. 1995;13:61-92.
-
(1995)
Annu Rev Immunol.
, vol.13
, pp. 61-92
-
-
Boman, H.G.1
-
16
-
-
84864335926
-
Human a-defensin 6 promotes mucosal innate immunity through self-Assembled peptide nanonets
-
Chu H, Pazgier M, Jung G, et al. Human a-defensin 6 promotes mucosal innate immunity through self-Assembled peptide nanonets. Science. 2012;337:477-481.
-
(2012)
Science.
, vol.337
, pp. 477-481
-
-
Chu, H.1
Pazgier, M.2
Jung, G.3
-
17
-
-
17644366913
-
NOD-LRR proteins: Role in host-microbial Interactions and inflammatory disease
-
Inohara N, Chamaillard M, McDonald C, et al. NOD-LRR proteins: Role in host-microbial Interactions and inflammatory disease. Annu Rev Biochem. 2005;74:355-383.
-
(2005)
Annu Rev Biochem.
, vol.74
, pp. 355-383
-
-
Inohara, N.1
Chamaillard, M.2
McDonald, C.3
-
18
-
-
0036202885
-
The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
-
Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002;122:867-874.
-
(2002)
Gastroenterology.
, vol.122
, pp. 867-874
-
-
Cuthbert, A.P.1
Fisher, S.A.2
Mirza, M.M.3
-
19
-
-
29144483937
-
Reduced Paneth cell a-defensins in ileal Crohn?s disease
-
Wehkamp J, Salzman NH, Porter E, et al. Reduced Paneth cell a-defensins in ileal Crohn?s disease. Proc Natl Acad Sci U S A. 2005;102: 18129-18134.
-
(2005)
Proc Natl Acad Sci U S A.
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
Salzman, N.H.2
Porter, E.3
-
20
-
-
37349070287
-
The Paneth cell alpha-defensin deficiency of ileal Crohn?s disease is linked to Wnt/Tcf-4
-
Wehkamp J, Wang G, Kubler I, et al. The Paneth cell alpha-defensin deficiency of ileal Crohn?s disease is linked to Wnt/Tcf-4. J Immunol. 2007;179:3109-3118.
-
(2007)
J Immunol.
, vol.179
, pp. 3109-3118
-
-
Wehkamp, J.1
Wang, G.2
Kubler, I.3
-
21
-
-
7244257312
-
NOD2 (CARD15) mutations in Crohn?s disease are associated with diminished mucosal a-defensin expression
-
Wehkamp J, Harder J, Weichenthal M, et al. NOD2 (CARD15) mutations in Crohn?s disease are associated with diminished mucosal a-defensin expression. Gut. 2004;53:1658-1664.
-
(2004)
Gut.
, vol.53
, pp. 1658-1664
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
-
22
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207-211.
-
(2007)
Nat Genet.
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
-
23
-
-
50249086073
-
XBP1 links ER Stress to intestinal Inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee A-H, Franke A, et al. XBP1 links ER Stress to intestinal Inflammation and confers genetic risk for human inflammatory bowel disease. Cell. 134:743-756.
-
Cell.
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.-H.2
Franke, A.3
-
24
-
-
77957834845
-
KCNN4 gene variant is associated with ileal Crohn?s disease in the Australian and New Zealand population
-
Simms LA, Doecke JD, Roberts RL, et al. KCNN4 gene variant is associated with ileal Crohn?s disease in the Australian and New Zealand population. Am J Gastroenterol. 2010;105:2209-2217.
-
(2010)
Am J Gastroenterol.
, vol.105
, pp. 2209-2217
-
-
Simms, L.A.1
Doecke, J.D.2
Roberts, R.L.3
-
25
-
-
0142026070
-
Inducible and constitutive beta-defensins are differentially expressed in Crohn?s disease and ulcerative colitis
-
Wehkamp J, Harder J, Weichenthal M, et al. Inducible and constitutive beta-defensins are differentially expressed in Crohn?s disease and ulcerative colitis. Inflamm Bowel Dis. 2003;9:215-223.
-
(2003)
Inflamm Bowel Dis.
, vol.9
, pp. 215-223
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
-
26
-
-
34548130847
-
Reduced mucosal antimicrobial activity in Crohn?s disease of the colon
-
Nuding S, Fellermann K, Wehkamp J, et al. Reduced mucosal antimicrobial activity in Crohn?s disease of the colon. Gut. 2007;56: 1240-1247.
-
(2007)
Gut.
, vol.56
, pp. 1240-1247
-
-
Nuding, S.1
Fellermann, K.2
Wehkamp, J.3
-
27
-
-
34047167850
-
Comparative study of the intestinal mucus barrier in normal and inflamed colon
-
Swidsinski A, Loening-Baucke V, Theissig F, et al. Comparative study of the intestinal mucus barrier in normal and inflamed colon. Gut. 2007; 56:343-350.
-
(2007)
Gut.
, vol.56
, pp. 343-350
-
-
Swidsinski, A.1
Loening-Baucke, V.2
Theissig, F.3
-
28
-
-
66549093053
-
Toll-like receptors and their role in gastrointestinal disease
-
Testro AG, Visvanathan K. Toll-like receptors and their role in gastrointestinal disease. J Gastroenterol Hepatol. 2009;24:943-954.
-
(2009)
J Gastroenterol Hepatol.
, vol.24
, pp. 943-954
-
-
Testro, A.G.1
Visvanathan, K.2
-
29
-
-
36849077704
-
Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease
-
Szebeni B, Veres G, Dezsofi A, et al. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin Exp Immunol. 2008;151:34-41.
-
(2008)
Clin Exp Immunol.
, vol.151
, pp. 34-41
-
-
Szebeni, B.1
Veres, G.2
Dezsofi, A.3
-
30
-
-
35349016235
-
Recognition of microorganisms and activation of the immune response
-
Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature. 2007;449:819-826.
-
(2007)
Nature.
, vol.449
, pp. 819-826
-
-
Medzhitov, R.1
-
31
-
-
84964978448
-
Gut mucosal DAMPs in IBD: From mechanisms to therapeutic implications
-
Boyapati RK, Rossi AG, Satsangi J, et al. Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications. Mucosal Immunol. 2016.
-
(2016)
Mucosal Immunol.
-
-
Boyapati, R.K.1
Rossi, A.G.2
Satsangi, J.3
-
32
-
-
77956289824
-
Toll-like receptors in inflammatory bowel diseases: A decade later
-
Cario E. Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis. 2010;16:1583-1597.
-
(2010)
Inflamm Bowel Dis.
, vol.16
, pp. 1583-1597
-
-
Cario, E.1
-
33
-
-
34447532521
-
TLRs in the Gut IV negative regulation of toll-like receptors and intestinal homeostasis: Addition by subtraction
-
Shibolet O, Podolsky DK. TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. Am J Physiol Gastrointest Liver Physiol. 2007;292: G1469-G1473.
-
(2007)
Am J Physiol Gastrointest Liver Physiol.
, vol.292
, pp. G1469-G1473
-
-
Shibolet, O.1
Podolsky, D.K.2
-
34
-
-
0037799912
-
Toll-like receptordependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
-
Kobayashi M, Kweon MN, Kuwata H, et al. Toll-like receptordependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J Clin Invest. 2003;111: 1297-1308.
-
(2003)
J Clin Invest.
, vol.111
, pp. 1297-1308
-
-
Kobayashi, M.1
Kweon, M.N.2
Kuwata, H.3
-
35
-
-
84962047657
-
Functions of NOD-like receptors in human diseases
-
Zhong Y, Kinio A, Saleh M. Functions of NOD-like receptors in human diseases. Front Immunol. 2013;4:333.
-
(2013)
Front Immunol.
, vol.4
, pp. 333
-
-
Zhong, Y.1
Kinio, A.2
Saleh, M.3
-
36
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn?s disease
-
Hugot J-P, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn?s disease. Nature. 2001;411:599-603.
-
(2001)
Nature.
, vol.411
, pp. 599-603
-
-
Hugot, J.-P.1
Chamaillard, M.2
Zouali, H.3
-
37
-
-
21144468350
-
Muramyl dipeptide and toll-like receptor sensitivity in NOD2-Associated Crohn?s disease
-
van Heel DA, Ghosh S, Butler M, et al. Muramyl dipeptide and toll-like receptor sensitivity in NOD2-Associated Crohn?s disease. Lancet. 2005; 365:1794-1796.
-
(2005)
Lancet.
, vol.365
, pp. 1794-1796
-
-
Van Heel, D.A.1
Ghosh, S.2
Butler, M.3
-
38
-
-
79953771887
-
The prognostic power of the NOD2 genotype for complicated Crohn?s disease: A meta-Analysis
-
Adler J, Rangwalla SC, Dwamena BA, et al. The prognostic power of the NOD2 genotype for complicated Crohn?s disease: a meta-Analysis. Am J Gastroenterol. 2011;106:699-712.
-
(2011)
Am J Gastroenterol.
, vol.106
, pp. 699-712
-
-
Adler, J.1
Rangwalla, S.C.2
Dwamena, B.A.3
-
39
-
-
4444253690
-
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
-
Watanabe T, Kitani A, Murray PJ, et al. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol. 2004;5:800-808.
-
(2004)
Nat Immunol.
, vol.5
, pp. 800-808
-
-
Watanabe, T.1
Kitani, A.2
Murray, P.J.3
-
40
-
-
84920072880
-
Inflammasomes and the microbiota-partners in the preservation of mucosal homeostasis
-
Levy M, Thaiss CA, Katz MN, et al. Inflammasomes and the microbiota-partners in the preservation of mucosal homeostasis. Semin Immunopathol. 2015;37:39-46.
-
(2015)
Semin Immunopathol.
, vol.37
, pp. 39-46
-
-
Levy, M.1
Thaiss, C.A.2
Katz, M.N.3
-
41
-
-
84858677223
-
Sensing and reacting to microbes through the inflammasomes
-
Franchi L, Munoz-Planillo R, Nunez G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol. 2012;13:325-332.
-
(2012)
Nat Immunol.
, vol.13
, pp. 325-332
-
-
Franchi, L.1
Munoz-Planillo, R.2
Nunez, G.3
-
42
-
-
84925790780
-
Role of inflammasomes in intestinal inflammation and Crohn?s disease
-
Opipari A, Franchi L. Role of inflammasomes in intestinal inflammation and Crohn?s disease. Inflamm Bowel Dis. 2015;21:173-181.
-
(2015)
Inflamm Bowel Dis.
, vol.21
, pp. 173-181
-
-
Opipari, A.1
Franchi, L.2
-
43
-
-
84879596906
-
K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
-
Muñoz-Planillo R, Kuffa P, Martínez-Colón G, et al. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 38:1142-1153.
-
Immunity.
, vol.38
, pp. 1142-1153
-
-
Muñoz-Planillo, R.1
Kuffa, P.2
Martínez-Colón, G.3
-
44
-
-
77956128040
-
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
-
Bauer C, Duewell P, Mayer C, et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 2010;59:1192-1199.
-
(2010)
Gut.
, vol.59
, pp. 1192-1199
-
-
Bauer, C.1
Duewell, P.2
Mayer, C.3
-
45
-
-
84867716442
-
Protective and aggravating effects of NLRP3 inflammasome activation in IBD models: Influence of genetic and environmental factors
-
Bauer C, Duewell P, Lehr HA, et al. Protective and aggravating effects of NLRP3 inflammasome activation in IBD models: influence of genetic and environmental factors. Dig Dis. 2012;30(suppl 1):82-90.
-
(2012)
Dig Dis.
, vol.30
, pp. 82-90
-
-
Bauer, C.1
Duewell, P.2
Lehr, H.A.3
-
46
-
-
66949174089
-
Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn?s disease in Swedish men
-
Schoultz I, Verma D, Halfvarsson J, et al. Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn?s disease in Swedish men. Am J Gastroenterol. 2009;104:1180-1188.
-
(2009)
Am J Gastroenterol.
, vol.104
, pp. 1180-1188
-
-
Schoultz, I.1
Verma, D.2
Halfvarsson, J.3
-
47
-
-
58149159542
-
Common variants in the NLRP3 region contribute to Crohn?s disease susceptibility
-
Villani A-C, Lemire M, Fortin G, et al. Common variants in the NLRP3 region contribute to Crohn?s disease susceptibility. Nat Genet. 2009;41: 71-76.
-
(2009)
Nat Genet.
, vol.41
, pp. 71-76
-
-
Villani, A.-C.1
Lemire, M.2
Fortin, G.3
-
48
-
-
79955825352
-
Genetic association between NLRP3 variants and Crohn?s disease does not replicate in a large UK panel
-
Lewis GJ, Massey DCO, Zhang H, et al. Genetic association between NLRP3 variants and Crohn?s disease does not replicate in a large UK panel. Inflamm Bowel Dis. 2011;17:1387-1391.
-
(2011)
Inflamm Bowel Dis.
, vol.17
, pp. 1387-1391
-
-
Lewis, G.J.1
Massey, D.C.O.2
Zhang, H.3
-
49
-
-
84866362664
-
IL-1b mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells
-
Coccia M, Harrison OJ, Schiering C, et al. IL-1b mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells. J Exp Med. 2012;209: 1595-1609.
-
(2012)
J Exp Med.
, vol.209
, pp. 1595-1609
-
-
Coccia, M.1
Harrison, O.J.2
Schiering, C.3
-
50
-
-
84885077685
-
TLR-induced PAI-2 expression suppresses IL-1beta processing via increasing autophagy and NLRP3 degradation
-
Chuang SY, Yang CH, Chou CC, et al. TLR-induced PAI-2 expression suppresses IL-1beta processing via increasing autophagy and NLRP3 degradation. Proc Natl Acad Sci U S A. 2013;110:16079-16084.
-
(2013)
Proc Natl Acad Sci U S A.
, vol.110
, pp. 16079-16084
-
-
Chuang, S.Y.1
Yang, C.H.2
Chou, C.C.3
-
51
-
-
80051550866
-
Crohn?s diseaseassociated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
-
Plantinga TS, Crisan TO, Oosting M, et al. Crohn?s diseaseassociated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut. 2011;60:1229-1235.
-
(2011)
Gut.
, vol.60
, pp. 1229-1235
-
-
Plantinga, T.S.1
Crisan, T.O.2
Oosting, M.3
-
52
-
-
80052389178
-
ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation
-
Plantinga TS, Joosten LA, Netea MG. ATG16L1 polymorphisms are associated with NOD2-induced hyperinflammation. Autophagy. 2011; 7:1074-1075.
-
(2011)
Autophagy.
, vol.7
, pp. 1074-1075
-
-
Plantinga, T.S.1
Joosten, L.A.2
Netea, M.G.3
-
53
-
-
78650735879
-
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
-
Hu B, Elinav E, Huber S, et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A. 2010;107:21635-21640.
-
(2010)
Proc Natl Acad Sci U S A.
, vol.107
, pp. 21635-21640
-
-
Hu, B.1
Elinav, E.2
Huber, S.3
-
54
-
-
80053379974
-
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
-
Kofoed EM, Vance RE. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. 2011;477: 592-595.
-
(2011)
Nature.
, vol.477
, pp. 592-595
-
-
Kofoed, E.M.1
Vance, R.E.2
-
55
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao Y, Yang J, Shi J, et al. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature. 2011;477: 596-600.
-
(2011)
Nature.
, vol.477
, pp. 596-600
-
-
Zhao, Y.1
Yang, J.2
Shi, J.3
-
56
-
-
3142654767
-
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
-
Mariathasan S, Newton K, Monack DM, et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature. 2004; 430:213-218.
-
(2004)
Nature.
, vol.430
, pp. 213-218
-
-
Mariathasan, S.1
Newton, K.2
Monack, D.M.3
-
57
-
-
36248940773
-
Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation
-
Franchi L, Stoolman J, Kanneganti T-D, et al. Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur J Immunol. 2007;37:3030-3039.
-
(2007)
Eur J Immunol.
, vol.37
, pp. 3030-3039
-
-
Franchi, L.1
Stoolman, J.2
Kanneganti, T.-D.3
-
58
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav E, Strowig T, Kau AL, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145:745-757.
-
(2011)
Cell.
, vol.145
, pp. 745-757
-
-
Elinav, E.1
Strowig, T.2
Kau, A.L.3
-
59
-
-
79959369355
-
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial selfrenewal and colorectal carcinogenesis upon injury
-
Normand S, Delanoye-Crespin A, Bressenot A, et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial selfrenewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011;108:9601-9606.
-
(2011)
Proc Natl Acad Sci U S A.
, vol.108
, pp. 9601-9606
-
-
Normand, S.1
Delanoye-Crespin, A.2
Bressenot, A.3
-
60
-
-
84888633713
-
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
-
Elinav E, Nowarski R, Thaiss CA, et al. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013;13:759-771.
-
(2013)
Nat Rev Cancer.
, vol.13
, pp. 759-771
-
-
Elinav, E.1
Nowarski, R.2
Thaiss, C.A.3
-
61
-
-
84929663292
-
The unusual suspects-innate lymphoid cells as novel therapeutic targets in IBD
-
Goldberg R, Prescott N, Lord GM, et al. The unusual suspects-innate lymphoid cells as novel therapeutic targets in IBD. Nat Rev Gastroenterol Hepatol. 2015;12:271-283.
-
(2015)
Nat Rev Gastroenterol Hepatol.
, vol.12
, pp. 271-283
-
-
Goldberg, R.1
Prescott, N.2
Lord, G.M.3
-
62
-
-
84872977452
-
Innate lymphoid cells-A proposal for uniform nomenclature
-
Spits H, Artis D, Colonna M, et al. Innate lymphoid cells-A proposal for uniform nomenclature. Nat Rev Immunol. 2013;13:145-149.
-
(2013)
Nat Rev Immunol.
, vol.13
, pp. 145-149
-
-
Spits, H.1
Artis, D.2
Colonna, M.3
-
63
-
-
85027945857
-
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
-
Bernink JH. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol. 2013;14:221-229.
-
(2013)
Nat Immunol.
, vol.14
, pp. 221-229
-
-
Bernink, J.H.1
-
64
-
-
84876780238
-
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12-and IL-15-responsive IFN-gamma-producing cells
-
Fuchs A. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12-and IL-15-responsive IFN-gamma-producing cells. Immunity. 2013;38:769-781.
-
(2013)
Immunity.
, vol.38
, pp. 769-781
-
-
Fuchs, A.1
-
65
-
-
77951878587
-
Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
-
Buonocore S. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 2010;464:1371-1375.
-
(2010)
Nature.
, vol.464
, pp. 1371-1375
-
-
Buonocore, S.1
-
66
-
-
0033591698
-
An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals
-
Tilloy F, Treiner E, Park SH, et al. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med. 1999;189:1907-1921.
-
(1999)
J Exp Med.
, vol.189
, pp. 1907-1921
-
-
Tilloy, F.1
Treiner, E.2
Park, S.H.3
-
67
-
-
18044371224
-
Mucosal-Associated invariant T (MAIT) cells: An evolutionarily conserved T cell subset
-
Treiner E, Duban L, Moura IC, et al. Mucosal-Associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset. Microbes Infect. 2005;7:552-559.
-
(2005)
Microbes Infect.
, vol.7
, pp. 552-559
-
-
Treiner, E.1
Duban, L.2
Moura, I.C.3
-
68
-
-
84900551126
-
T-cell activation by transitory neo-Antigens derived from distinct microbial pathways
-
Corbett AJ, Eckle SB, Birkinshaw RW, et al. T-cell activation by transitory neo-Antigens derived from distinct microbial pathways. Nature. 2014;509:361-365.
-
(2014)
Nature.
, vol.509
, pp. 361-365
-
-
Corbett, A.J.1
Eckle, S.B.2
Birkinshaw, R.W.3
-
69
-
-
84870284140
-
MR1 presents microbial Vitamin B metabolites to MAIT cells
-
Kjer-Nielsen L, Patel O, Corbett AJ, et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature. 2012;491:717-723.
-
(2012)
Nature.
, vol.491
, pp. 717-723
-
-
Kjer-Nielsen, L.1
Patel, O.2
Corbett, A.J.3
-
70
-
-
77954914800
-
Antimicrobial activity of mucosal-Associated invariant T cells
-
Le Bourhis L, Martin E, Peguillet I, et al. Antimicrobial activity of mucosal-Associated invariant T cells. Nat Immunol. 2010;11:701-708.
-
(2010)
Nat Immunol.
, vol.11
, pp. 701-708
-
-
Le Bourhis, L.1
Martin, E.2
Peguillet, I.3
-
71
-
-
78751575411
-
The non-conventional MHC class i MR1 molecule controls infection by Klebsiella pneumoniae in mice
-
Georgel P, Radosavljevic M, Macquin C, et al. The non-conventional MHC class I MR1 molecule controls infection by Klebsiella pneumoniae in mice. Mol Immunol. 2011;48:769-775.
-
(2011)
Mol Immunol.
, vol.48
, pp. 769-775
-
-
Georgel, P.1
Radosavljevic, M.2
Macquin, C.3
-
72
-
-
0026354288
-
Role of gamma interferon and tumor necrosis factor alpha in resistance to salmonella typhimurium infection
-
Nauciel C, Espinasse-Maes F. Role of gamma interferon and tumor necrosis factor alpha in resistance to salmonella typhimurium infection. Infect Immun. 1992;60:450-454.
-
(1992)
Infect Immun.
, vol.60
, pp. 450-454
-
-
Nauciel, C.1
Espinasse-Maes, F.2
-
73
-
-
84885981736
-
Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-Associated invariant T cells
-
Reantragoon R, Corbett AJ, Sakala IG, et al. Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-Associated invariant T cells. J Exp Med. 2013;210:2305-2320.
-
(2013)
J Exp Med.
, vol.210
, pp. 2305-2320
-
-
Reantragoon, R.1
Corbett, A.J.2
Sakala, I.G.3
-
74
-
-
84964555709
-
MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis
-
Haga K, Chiba A, Shibuya T, et al. MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis. J Gastroenterol Hepatol. 2015.
-
(2015)
J Gastroenterol Hepatol.
-
-
Haga, K.1
Chiba, A.2
Shibuya, T.3
-
75
-
-
84897937905
-
Innate mucosal-Associated invariant T (MAIT) cells are activated in inflammatory bowel diseases
-
Serriari NE, Eoche M, Lamotte L, et al. Innate mucosal-Associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. Clin Exp Immunol. 2014;176:266-274.
-
(2014)
Clin Exp Immunol.
, vol.176
, pp. 266-274
-
-
Serriari, N.E.1
Eoche, M.2
Lamotte, L.3
-
76
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K, Ogawa A, Mizoguchi E, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest. 2008; 118:534-544.
-
(2008)
J Clin Invest.
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
-
77
-
-
84932092385
-
Reduced numbers and proapoptotic features of mucosal-Associated invariant T cells as a characteristic finding in patients with IBD
-
Hiejima E, Kawai T, Nakase H, et al. Reduced numbers and proapoptotic features of mucosal-Associated invariant T cells as a characteristic finding in patients with IBD. Inflamm Bowel Dis. 2015.
-
(2015)
Inflamm Bowel Dis.
-
-
Hiejima, E.1
Kawai, T.2
Nakase, H.3
-
78
-
-
67651219166
-
Mesenteric lymph nodes confine dendritic cell-mediated dissemination of Salmonella enterica serovar Typhimurium and limit systemic disease in mice
-
Voedisch S, Koenecke C, David S, et al. Mesenteric lymph nodes confine dendritic cell-mediated dissemination of Salmonella enterica serovar Typhimurium and limit systemic disease in mice. Infect Immun. 2009;77: 3170-3180.
-
(2009)
Infect Immun.
, vol.77
, pp. 3170-3180
-
-
Voedisch, S.1
Koenecke, C.2
David, S.3
-
79
-
-
34547788180
-
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
-
Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007;204:1757-1764.
-
(2007)
J Exp Med.
, vol.204
, pp. 1757-1764
-
-
Coombes, J.L.1
Siddiqui, K.R.2
Arancibia-Carcamo, C.V.3
-
80
-
-
26844538936
-
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
-
Johansson-Lindbom B, Svensson M, Pabst O, et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med. 2005;202:1063-1073.
-
(2005)
J Exp Med.
, vol.202
, pp. 1063-1073
-
-
Johansson-Lindbom, B.1
Svensson, M.2
Pabst, O.3
-
81
-
-
77951737056
-
Gut CD103+ dendritic cells express indoleamine 2, 3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
-
Matteoli G, Mazzini E, Iliev ID, et al. Gut CD103+ dendritic cells express indoleamine 2, 3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut. 2010;59:595-604.
-
(2010)
Gut.
, vol.59
, pp. 595-604
-
-
Matteoli, G.1
Mazzini, E.2
Iliev, I.D.3
-
82
-
-
0036099957
-
Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin
-
Stagg AJ, Kamm MA, Knight SC. Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. Eur J Immunol. 2002;32: 1445-1454.
-
(2002)
Eur J Immunol.
, vol.32
, pp. 1445-1454
-
-
Stagg, A.J.1
Kamm, M.A.2
Knight, S.C.3
-
83
-
-
0038744423
-
Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis
-
Krajina T, Leithauser F, Moller P, et al. Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur J Immunol. 2003;33: 1073-1083.
-
(2003)
Eur J Immunol.
, vol.33
, pp. 1073-1083
-
-
Krajina, T.1
Leithauser, F.2
Moller, P.3
-
84
-
-
0035337241
-
CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice
-
Malmstrom V, Shipton D, Singh B, et al. CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice. J Immunol. 2001;166:6972-6981.
-
(2001)
J Immunol.
, vol.166
, pp. 6972-6981
-
-
Malmstrom, V.1
Shipton, D.2
Singh, B.3
-
85
-
-
0037255218
-
Increased expression of DCSIGN+IL-12+IL-18+ and CD83+IL-12-IL-18-dendritic cell populations in the colonic mucosa of patients with Crohn?s disease
-
te Velde AA, van Kooyk Y, Braat H, et al. Increased expression of DCSIGN+IL-12+IL-18+ and CD83+IL-12-IL-18-dendritic cell populations in the colonic mucosa of patients with Crohn?s disease. Eur J Immunol. 2003;33:143-151.
-
(2003)
Eur J Immunol.
, vol.33
, pp. 143-151
-
-
Te Velde, A.A.1
Van Kooyk, Y.2
Braat, H.3
-
86
-
-
47149110368
-
Mucosal macrophages and the regulation of immune responses in the intestine
-
Platt AM, Mowat AM. Mucosal macrophages and the regulation of immune responses in the intestine. Immunol Lett. 2008;119:22-31.
-
(2008)
Immunol Lett.
, vol.119
, pp. 22-31
-
-
Platt, A.M.1
Mowat, A.M.2
-
87
-
-
78650807608
-
Intestinal macrophages and response to microbial encroachment
-
Smith PD, Smythies LE, Shen R, et al. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 2011;4:31-42.
-
(2011)
Mucosal Immunol.
, vol.4
, pp. 31-42
-
-
Smith, P.D.1
Smythies, L.E.2
Shen, R.3
-
88
-
-
34548764423
-
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
-
Denning TL, Wang YC, Patel SR, et al. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol. 2007;8: 1086-1094.
-
(2007)
Nat Immunol.
, vol.8
, pp. 1086-1094
-
-
Denning, T.L.1
Wang, Y.C.2
Patel, S.R.3
-
89
-
-
21144456383
-
The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance
-
Lin HH, Faunce DE, Stacey M, et al. The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med. 2005;201:1615-1625.
-
(2005)
J Exp Med.
, vol.201
, pp. 1615-1625
-
-
Lin, H.H.1
Faunce, D.E.2
Stacey, M.3
-
90
-
-
45749107055
-
Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis
-
Kamada N. Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-gamma axis. J Clin Invest. 2008;118:2269-2280.
-
(2008)
J Clin Invest.
, vol.118
, pp. 2269-2280
-
-
Kamada, N.1
-
91
-
-
0036080092
-
Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
-
Hausmann M, Kiessling S, Mestermann S, et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology. 2002;122:1987-2000.
-
(2002)
Gastroenterology.
, vol.122
, pp. 1987-2000
-
-
Hausmann, M.1
Kiessling, S.2
Mestermann, S.3
-
92
-
-
44649193919
-
The biology of intestinal immunoglobulin A responses
-
Cerutti A, Rescigno M. The biology of intestinal immunoglobulin A responses. Immunity. 2008;28:740-750.
-
(2008)
Immunity.
, vol.28
, pp. 740-750
-
-
Cerutti, A.1
Rescigno, M.2
-
93
-
-
44349195660
-
The regulation of IgA class switching
-
Cerutti A. The regulation of IgA class switching. Nat Rev Immunol. 2008;8:421-434.
-
(2008)
Nat Rev Immunol.
, vol.8
, pp. 421-434
-
-
Cerutti, A.1
-
94
-
-
23344433145
-
The polymeric immunoglobulin receptor: Bridging innate and adaptive immune responses at mucosal surfaces
-
Kaetzel CS. The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunological Rev. 2005;206:83-99.
-
(2005)
Immunological Rev.
, vol.206
, pp. 83-99
-
-
Kaetzel, C.S.1
-
95
-
-
84870252354
-
New concepts in the generation and functions of IgA
-
Pabst O. New concepts in the generation and functions of IgA. Nat Rev Immunol. 2012;12:821-832.
-
(2012)
Nat Rev Immunol.
, vol.12
, pp. 821-832
-
-
Pabst, O.1
-
96
-
-
84902601983
-
Microbiota activation and regulation of innate and adaptive immunity
-
Alexander KL, Targan SR, Elson CO III, Microbiota activation and regulation of innate and adaptive immunity. Immunol Rev. 2014. 260: 206-220.
-
(2014)
Immunol Rev
, vol.260
, pp. 206-220
-
-
Alexander, K.L.1
Targan, S.R.2
Elson, C.O.3
-
97
-
-
58149097584
-
The who, how and where of antigen presentation to B cells
-
Batista FD, Harwood NE. The who, how and where of antigen presentation to B cells. Nat Rev Immunol. 2009;9:15-27.
-
(2009)
Nat Rev Immunol.
, vol.9
, pp. 15-27
-
-
Batista, F.D.1
Harwood, N.E.2
-
98
-
-
77951667958
-
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
-
e8
-
Amu S, Saunders SP, Kronenberg M, et al. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immunol. 2010. 125: 1114-1124.e8.
-
(2010)
J Allergy Clin Immunol.
, vol.125
, pp. 1114-1124
-
-
Amu, S.1
Saunders, S.P.2
Kronenberg, M.3
-
99
-
-
79955539126
-
The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-Tumor response in a murine tumor model
-
Tadmor T, Zhang Y, Cho HM, et al. The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-Tumor response in a murine tumor model. Cancer Immunol Immunother. 2011;60:609-619.
-
(2011)
Cancer Immunol Immunother.
, vol.60
, pp. 609-619
-
-
Tadmor, T.1
Zhang, Y.2
Cho, H.M.3
-
101
-
-
79955777196
-
Allergen-specific transforming growth factor-beta-producing CD19+CD5+ regulatory B-cell (Br3) responses in human late eczematous allergic reactions to cow?s milk
-
Lee JH, Noh J, Noh G, et al. Allergen-specific transforming growth factor-beta-producing CD19+CD5+ regulatory B-cell (Br3) responses in human late eczematous allergic reactions to cow?s milk. J Interferon Cytokine Res. 2011;31:441-449.
-
(2011)
J Interferon Cytokine Res.
, vol.31
, pp. 441-449
-
-
Lee, J.H.1
Noh, J.2
Noh, G.3
-
102
-
-
84885952982
-
Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice
-
Liu ZQ, Wu Y, Song JP, et al. Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice. Allergy. 2013;68: 1241-1248.
-
(2013)
Allergy.
, vol.68
, pp. 1241-1248
-
-
Liu, Z.Q.1
Wu, Y.2
Song, J.P.3
-
103
-
-
84855997669
-
B1a lymphocytes in the rectal mucosa of ulcerative colitis patients
-
Polese L, Boetto R, De Franchis G, et al. B1a lymphocytes in the rectal mucosa of ulcerative colitis patients. World J Gastroenterol. 2012;18: 144-149.
-
(2012)
World J Gastroenterol.
, vol.18
, pp. 144-149
-
-
Polese, L.1
Boetto, R.2
De Franchis, G.3
-
104
-
-
84871631237
-
Identification of disease-Associated DNA methylation in B cells from Crohn?s disease and ulcerative colitis patients
-
Lin Z, Hegarty JP, Yu W, et al. Identification of disease-Associated DNA methylation in B cells from Crohn?s disease and ulcerative colitis patients. Dig Dis Sci. 2012;57:3145-3153.
-
(2012)
Dig Dis Sci.
, vol.57
, pp. 3145-3153
-
-
Lin, Z.1
Hegarty, J.P.2
Yu, W.3
-
105
-
-
0028288179
-
Lymphokine production by human T cells in disease states
-
Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol. 1994;12:227-257.
-
(1994)
Annu Rev Immunol.
, vol.12
, pp. 227-257
-
-
Romagnani, S.1
-
106
-
-
0030995575
-
Interleukin 12 is expressed and actively released by Crohn?s disease intestinal lamina propria mononuclear cells
-
Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn?s disease intestinal lamina propria mononuclear cells. Gastroenterology. 112:1169-1178.
-
Gastroenterology.
, vol.112
, pp. 1169-1178
-
-
Monteleone, G.1
Biancone, L.2
Marasco, R.3
-
107
-
-
0033168120
-
Bioactive IL-18 expression is up-regulated in Crohn?s disease
-
Monteleone G, Trapasso F, Parrello T, et al. Bioactive IL-18 expression is up-regulated in Crohn?s disease. J Immunol. 1999;163:143-147.
-
(1999)
J Immunol.
, vol.163
, pp. 143-147
-
-
Monteleone, G.1
Trapasso, F.2
Parrello, T.3
-
109
-
-
0027441514
-
Interleukin-2-and interferongamma-secreting T cells in normal and diseased human intestinal mucosa
-
Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2-and interferongamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology. 1993;78:127-131.
-
(1993)
Immunology.
, vol.78
, pp. 127-131
-
-
Breese, E.1
Braegger, C.P.2
Corrigan, C.J.3
-
110
-
-
85047690640
-
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
-
Fuss IJ, Heller F, Boirivant M, et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest. 2004;113:1490-1497.
-
(2004)
J Clin Invest.
, vol.113
, pp. 1490-1497
-
-
Fuss, I.J.1
Heller, F.2
Boirivant, M.3
-
112
-
-
36749038197
-
Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease
-
Kugathasan S, Saubermann LJ, Smith L, et al. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut. 2007;56:1696-1705.
-
(2007)
Gut.
, vol.56
, pp. 1696-1705
-
-
Kugathasan, S.1
Saubermann, L.J.2
Smith, L.3
-
113
-
-
84902653958
-
TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
-
Gerlach K, Hwang Y, Nikolaev A, et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol. 2014;15:676-686.
-
(2014)
Nat Immunol.
, vol.15
, pp. 676-686
-
-
Gerlach, K.1
Hwang, Y.2
Nikolaev, A.3
-
114
-
-
0023739985
-
Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity
-
Uyttenhove C, Simpson RJ, Van Snick J. Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc Natl Acad Sci U S A. 1988;85:6934-6938.
-
(1988)
Proc Natl Acad Sci U S A.
, vol.85
, pp. 6934-6938
-
-
Uyttenhove, C.1
Simpson, R.J.2
Van Snick, J.3
-
115
-
-
84960194325
-
IL-9 signaling as key driver of chronic inflammation in mucosal immunity
-
Neurath MF, Finotto S. IL-9 signaling as key driver of chronic inflammation in mucosal immunity. Cytokine Growth Factor Rev. 2016.
-
(2016)
Cytokine Growth Factor Rev.
-
-
Neurath, M.F.1
Finotto, S.2
-
116
-
-
84873638253
-
Th9 cells: Differentiation and disease
-
Kaplan MH. Th9 cells: differentiation and disease. Immunological Rev. 2013;252:104-115.
-
(2013)
Immunological Rev.
, vol.252
, pp. 104-115
-
-
Kaplan, M.H.1
-
118
-
-
0035865357
-
Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: Role in IL-8 release
-
Abdelilah S, Latifa K, Esra N, et al. Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release. J Immunol. 2001;166:2768-2774.
-
(2001)
J Immunol.
, vol.166
, pp. 2768-2774
-
-
Abdelilah, S.1
Latifa, K.2
Esra, N.3
-
119
-
-
4444262198
-
IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
-
Shimbara A, Christodoulopoulos P, Soussi-Gounni A, et al. IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. J Allergy Clin Immunol. 2000;105(1 pt 1):108-115.
-
(2000)
J Allergy Clin Immunol.
, vol.105
, Issue.1 PT1
, pp. 108-115
-
-
Shimbara, A.1
Christodoulopoulos, P.2
Soussi-Gounni, A.3
-
120
-
-
0034082119
-
Murine bone marrow-derived mast cells as potent producers of IL-9: Costimulatory function of IL-10 and kit ligand in the presence of IL-1
-
Stassen M, Arnold M, Hultner L, et al. Murine bone marrow-derived mast cells as potent producers of IL-9: costimulatory function of IL-10 and kit ligand in the presence of IL-1. J Immunol. 2000;164:5549-5555.
-
(2000)
J Immunol.
, vol.164
, pp. 5549-5555
-
-
Stassen, M.1
Arnold, M.2
Hultner, L.3
-
121
-
-
56349154943
-
Transforming growth factor-beta ?reprograms? the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
-
Veldhoen M, Uyttenhove C, van Snick J, et al. Transforming growth factor-beta ?reprograms? the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol. 2008;9: 1341-1346.
-
(2008)
Nat Immunol.
, vol.9
, pp. 1341-1346
-
-
Veldhoen, M.1
Uyttenhove, C.2
Van Snick, J.3
-
122
-
-
84883404826
-
Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction
-
Tamiya T, Ichiyama K, Kotani H, et al. Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction. J Immunol. 2013;191: 2360-2371.
-
(2013)
J Immunol.
, vol.191
, pp. 2360-2371
-
-
Tamiya, T.1
Ichiyama, K.2
Kotani, H.3
-
123
-
-
77952584843
-
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
-
Chang HC, Sehra S, Goswami R, et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol. 2010;11:527-534.
-
(2010)
Nat Immunol.
, vol.11
, pp. 527-534
-
-
Chang, H.C.1
Sehra, S.2
Goswami, R.3
-
124
-
-
0029949409
-
Multiple transcription factors are required for activation of human interleukin 9 gene in T cells
-
Zhu YX, Kang LY, Luo W, et al. Multiple transcription factors are required for activation of human interleukin 9 gene in T cells. J Biol Chem. 1996;271:15815-15822.
-
(1996)
J Biol Chem.
, vol.271
, pp. 15815-15822
-
-
Zhu, Y.X.1
Kang, L.Y.2
Luo, W.3
-
125
-
-
84863010992
-
STAT6-dependent regulation of Th9 development
-
Goswami R, Jabeen R, Yagi R, et al. STAT6-dependent regulation of Th9 development. J Immunol. 2012;188:968-975.
-
(2012)
J Immunol.
, vol.188
, pp. 968-975
-
-
Goswami, R.1
Jabeen, R.2
Yagi, R.3
-
126
-
-
84928584525
-
IL-9 and its receptor are predominantly involved in the pathogenesis of UC
-
Nalleweg N, Chiriac MT, Podstawa E, et al. IL-9 and its receptor are predominantly involved in the pathogenesis of UC. Gut. 2015;64: 743-755.
-
(2015)
Gut.
, vol.64
, pp. 743-755
-
-
Nalleweg, N.1
Chiriac, M.T.2
Podstawa, E.3
-
127
-
-
85031832953
-
P042 circulating il9 in inflammatory bowel disease: Possible marker of mucosal non-healing
-
Neubauer K, Krzystek-Korpacka M, M M, et al. P042. Circulating IL9 in inflammatory bowel disease: possible marker of mucosal non-healing. J Crohn?s Colitis. 2016;10(suppl 1):S110-S111.
-
(2016)
J Crohn?s Colitis.
, vol.10
, pp. S110-S111
-
-
Neubauer, K.1
Krzystek-Korpacka, M.2
-
128
-
-
27544490377
-
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-1132.
-
(2005)
Nat Immunol.
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
-
129
-
-
34547188748
-
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou L, Ivanov II, Spolski R, et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007;8:967-974.
-
(2007)
Nat Immunol.
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
-
130
-
-
84948983885
-
Th17 plasticity and its changes associated with inflammatory bowel disease
-
Ueno A, Ghosh A, Hung D, et al. Th17 plasticity and its changes associated with inflammatory bowel disease. World J Gastroenterol. 2015; 21:12283-12295.
-
(2015)
World J Gastroenterol.
, vol.21
, pp. 12283-12295
-
-
Ueno, A.1
Ghosh, A.2
Hung, D.3
-
132
-
-
53349173070
-
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
-
Ivanov II, Frutos Rde L, Manel N, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008;4:337-349.
-
(2008)
Cell Host Microbe.
, vol.4
, pp. 337-349
-
-
Ivanov, I.I.1
Frutos Rde, L.2
Manel, N.3
-
133
-
-
78649489009
-
Genome-wide meta-Analysis increases to 71 the number of confirmed Crohn?s disease susceptibility loci
-
Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-Analysis increases to 71 the number of confirmed Crohn?s disease susceptibility loci. Nat Genet. 2010;42:1118-1125.
-
(2010)
Nat Genet.
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.2
Barrett, J.C.3
-
134
-
-
56549104968
-
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn?s disease
-
Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn?s disease. Gut. 2008;57:1682-1689.
-
(2008)
Gut.
, vol.57
, pp. 1682-1689
-
-
Kobayashi, T.1
Okamoto, S.2
Hisamatsu, T.3
-
135
-
-
72549107316
-
Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
-
Rovedatti L, Kudo T, Biancheri P, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut. 2009;58:1629-1636.
-
(2009)
Gut.
, vol.58
, pp. 1629-1636
-
-
Rovedatti, L.1
Kudo, T.2
Biancheri, P.3
-
136
-
-
80655122800
-
TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation
-
Olsen T, Rismo R, Cui G, et al. TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. Cytokine. 2011;56:633-640.
-
(2011)
Cytokine.
, vol.56
, pp. 633-640
-
-
Olsen, T.1
Rismo, R.2
Cui, G.3
-
137
-
-
33646397611
-
IL-23 is essential for T cellmediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cellmediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006;116:1310-1316.
-
(2006)
J Clin Invest.
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
138
-
-
34250026960
-
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
-
Elson CO, Cong Y, Weaver CT, et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology. 2007;132:2359-2370.
-
(2007)
Gastroenterology.
, vol.132
, pp. 2359-2370
-
-
Elson, C.O.1
Cong, Y.2
Weaver, C.T.3
-
139
-
-
33646804892
-
Critical role of IL-17 receptor signaling in acute TNBS-induced colitis
-
Zhang Z, Zheng M, Bindas J, et al. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis. 2006;12: 382-388.
-
(2006)
Inflamm Bowel Dis.
, vol.12
, pp. 382-388
-
-
Zhang, Z.1
Zheng, M.2
Bindas, J.3
-
141
-
-
65749091607
-
A protective function for interleukin 17A in T cell-mediated intestinal inflammation
-
O?Connor W Jr, Kamanaka M, Booth CJ, et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol. 2009;10:603-609.
-
(2009)
Nat Immunol.
, vol.10
, pp. 603-609
-
-
O'Connor, W.1
Kamanaka, M.2
Booth, C.J.3
-
142
-
-
65749088279
-
IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation
-
Awasthi A, Kuchroo VK. IL-17A directly inhibits TH1 cells and thereby suppresses development of intestinal inflammation. Nat Immunol. 2009; 10:568-570.
-
(2009)
Nat Immunol.
, vol.10
, pp. 568-570
-
-
Awasthi, A.1
Kuchroo, V.K.2
-
143
-
-
84868680312
-
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn?s disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
Hueber W, Sands BE, Lewitzky S, et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn?s disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut. 2012;61:1693-1700.
-
(2012)
Gut.
, vol.61
, pp. 1693-1700
-
-
Hueber, W.1
Sands, B.E.2
Lewitzky, S.3
-
144
-
-
53049091561
-
A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-To-severe Crohn?s disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-To-severe Crohn?s disease. Gastroenterology. 2008;135:1130-1141.
-
(2008)
Gastroenterology.
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
145
-
-
84992075713
-
768 a phase 3 randomized, multicenter, double-blind, placebo-controlled study of ustekinumab maintenance therapy in moderate-severe Crohn?s disease patients: Results from IM-UNITI
-
Sandborn W, Feagan BG, Gasink C, et al. 768 a phase 3 randomized, multicenter, double-blind, placebo-controlled study of ustekinumab maintenance therapy in moderate-severe Crohn?s disease patients: results from IM-UNITI. Gastroenterology. 150:S157-S158.
-
Gastroenterology.
, vol.150
, pp. S157-S158
-
-
Sandborn, W.1
Feagan, B.G.2
Gasink, C.3
-
146
-
-
84883772859
-
Induced and natural regulatory T cells in the development of inflammatory bowel disease
-
Mayne CG, Williams CB. Induced and natural regulatory T cells in the development of inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19:1772-1788.
-
(2013)
Inflamm Bowel Dis.
, vol.19
, pp. 1772-1788
-
-
Mayne, C.G.1
Williams, C.B.2
-
147
-
-
79960453738
-
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
-
Haribhai D, Williams JB, Jia S, et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. 2011;35:109-122.
-
(2011)
Immunity.
, vol.35
, pp. 109-122
-
-
Haribhai, D.1
Williams, J.B.2
Jia, S.3
-
148
-
-
33846805925
-
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes
-
Caudy AA, Reddy ST, Chatila T, et al. CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes. J Allergy Clin Immunol. 2007;119:482-487.
-
(2007)
J Allergy Clin Immunol.
, vol.119
, pp. 482-487
-
-
Caudy, A.A.1
Reddy, S.T.2
Chatila, T.3
-
149
-
-
70049098536
-
Regulatory T cells reinforce intestinal homeostasis
-
Barnes MJ, Powrie F. Regulatory T cells reinforce intestinal homeostasis. Immunity. 2009;31:401-411.
-
(2009)
Immunity.
, vol.31
, pp. 401-411
-
-
Barnes, M.J.1
Powrie, F.2
-
151
-
-
0348223787
-
Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med. 2003;198:1875-1886.
-
(2003)
J Exp Med.
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
-
152
-
-
79953164640
-
Microbiotal influence on T cell subset development
-
Atarashi K, Umesaki Y, Honda K. Microbiotal influence on T cell subset development. Semin Immunol. 2011;23:146-153.
-
(2011)
Semin Immunol.
, vol.23
, pp. 146-153
-
-
Atarashi, K.1
Umesaki, Y.2
Honda, K.3
-
153
-
-
84857063957
-
Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis
-
Tanoue T, Honda K. Induction of Treg cells in the mouse colonic mucosa: a central mechanism to maintain host-microbiota homeostasis. Semin Immunol. 2012;24:50-57.
-
(2012)
Semin Immunol.
, vol.24
, pp. 50-57
-
-
Tanoue, T.1
Honda, K.2
-
154
-
-
4043052238
-
Regulatory T cells and mechanisms of immune system control
-
O?Garra A, Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med. 2004;10:801-805.
-
(2004)
Nat Med.
, vol.10
, pp. 801-805
-
-
O'Garra, A.1
Vieira, P.2
-
155
-
-
0034960320
-
TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu
-
Chen W, Frank ME, Jin W, et al. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity. 2001;14: 715-725.
-
(2001)
Immunity.
, vol.14
, pp. 715-725
-
-
Chen, W.1
Frank, M.E.2
Jin, W.3
-
156
-
-
65749103989
-
Regulatory lymphocytes and intestinal inflammation
-
Izcue A, Coombes JL, Powrie F. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol. 2009;27:313-338.
-
(2009)
Annu Rev Immunol.
, vol.27
, pp. 313-338
-
-
Izcue, A.1
Coombes, J.L.2
Powrie, F.3
-
157
-
-
0034894059
-
Blocking Smad7 restores TGF-b1 signaling in chronic inflammatory bowel disease
-
Monteleone G, Kumberova A, Croft NM, et al. Blocking Smad7 restores TGF-b1 signaling in chronic inflammatory bowel disease. J Clin Invest. 2001;108:601-609.
-
(2001)
J Clin Invest.
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
-
158
-
-
84925064199
-
Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn?s disease
-
Monteleone G, Neurath MF, Ardizzone S, et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn?s disease. New Engl J Med. 2015;372:1104-1113.
-
(2015)
New Engl J Med.
, vol.372
, pp. 1104-1113
-
-
Monteleone, G.1
Neurath, M.F.2
Ardizzone, S.3
-
159
-
-
0027521572
-
Interleukin-10-deficient mice develop chronic enterocolitis
-
Kuhn R, Lohler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75:263-274.
-
(1993)
Cell.
, vol.75
, pp. 263-274
-
-
Kuhn, R.1
Lohler, J.2
Rennick, D.3
-
160
-
-
0030942666
-
Altered immune responses in interleukin 10 transgenic mice
-
Hagenbaugh A, Sharma S, Dubinett SM, et al. Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 1997;185: 2101-2110.
-
(1997)
J Exp Med.
, vol.185
, pp. 2101-2110
-
-
Hagenbaugh, A.1
Sharma, S.2
Dubinett, S.M.3
-
161
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
-
Powrie F, Leach MW, Mauze S, et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity. 1994;1:553-562.
-
(1994)
Immunity.
, vol.1
, pp. 553-562
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
-
162
-
-
0034714188
-
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
-
Steidler L, Hans W, Schotte L, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science. 2000;289: 1352-1355.
-
(2000)
Science.
, vol.289
, pp. 1352-1355
-
-
Steidler, L.1
Hans, W.2
Schotte, L.3
-
163
-
-
55049111426
-
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
-
Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 2008;40:1319-1323.
-
(2008)
Nat Genet.
, vol.40
, pp. 1319-1323
-
-
Franke, A.1
Balschun, T.2
Karlsen, T.H.3
-
164
-
-
70949087383
-
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
-
Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361: 2033-2045.
-
(2009)
N Engl J Med.
, vol.361
, pp. 2033-2045
-
-
Glocker, E.O.1
Kotlarz, D.2
Boztug, K.3
-
165
-
-
0031821875
-
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
-
Thornton AM, Shevach EM. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med. 1998;188:287-296.
-
(1998)
J Exp Med.
, vol.188
, pp. 287-296
-
-
Thornton, A.M.1
Shevach, E.M.2
-
166
-
-
5644302161
-
Human T regulatory cells can use the perforin pathway to cause autologous target cell death
-
Grossman WJ, Verbsky JW, Barchet W, et al. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity. 2004;21:589-601.
-
(2004)
Immunity.
, vol.21
, pp. 589-601
-
-
Grossman, W.J.1
Verbsky, J.W.2
Barchet, W.3
-
167
-
-
33646567156
-
Activated CD4+CD25+ T cells selectively kill B lymphocytes
-
Zhao DM, Thornton AM, DiPaolo RJ, et al. Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood. 2006;107:3925-3932.
-
(2006)
Blood.
, vol.107
, pp. 3925-3932
-
-
Zhao, D.M.1
Thornton, A.M.2
DiPaolo, R.J.3
-
168
-
-
48249103057
-
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
-
Onishi Y, Fehervari Z, Yamaguchi T, et al. Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A. 2008;105: 10113-10118.
-
(2008)
Proc Natl Acad Sci U S A.
, vol.105
, pp. 10113-10118
-
-
Onishi, Y.1
Fehervari, Z.2
Yamaguchi, T.3
-
169
-
-
70350244517
-
Cytotoxic T-lymphocyte-Associated antigen 4 antibody-induced colitis and its management with infliximab
-
Johnston RL, Lutzky J, Chodhry A, et al. Cytotoxic T-lymphocyte-Associated antigen 4 antibody-induced colitis and its management with infliximab. Dig Dis Sci. 2009;54:2538-2540.
-
(2009)
Dig Dis Sci.
, vol.54
, pp. 2538-2540
-
-
Johnston, R.L.1
Lutzky, J.2
Chodhry, A.3
-
170
-
-
78649526238
-
Mechanisms of impaired regulation by CD4(+)CD25(+) FOXP3(+) regulatory T cells in human autoimmune diseases
-
Buckner JH. Mechanisms of impaired regulation by CD4(+)CD25(+) FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol. 2010;10:849-859.
-
(2010)
Nat Rev Immunol.
, vol.10
, pp. 849-859
-
-
Buckner, J.H.1
-
171
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4:330-336.
-
(2003)
Nat Immunol.
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
172
-
-
0027517545
-
Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C
-
Powrie F, Leach MW, Mauze S, et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol. 1993;5:1461-1471.
-
(1993)
B-17 Scid Mice. Int Immunol.
, vol.5
, pp. 1461-1471
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
-
173
-
-
67049097104
-
Developmental plasticity of Th17 and Treg cells
-
Lee YK, Mukasa R, Hatton RD, et al. Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol. 2009;21:274-280.
-
(2009)
Curr Opin Immunol.
, vol.21
, pp. 274-280
-
-
Lee, Y.K.1
Mukasa, R.2
Hatton, R.D.3
-
174
-
-
34447574943
-
The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro
-
Yates J, Rovis F, Mitchell P, et al. The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro. Int Immunol. 2007;19: 785-799.
-
(2007)
Int Immunol.
, vol.19
, pp. 785-799
-
-
Yates, J.1
Rovis, F.2
Mitchell, P.3
-
175
-
-
70149087732
-
Diminution of circulating CD4+CD25high T cells in naïve Crohn?s disease
-
Chamouard P, Monneaux F, Richert Z, et al. Diminution of circulating CD4+CD25high T cells in naïve Crohn?s disease. Dig Dis Sci. 2009;54: 2084-2093.
-
(2009)
Dig Dis Sci.
, vol.54
, pp. 2084-2093
-
-
Chamouard, P.1
Monneaux, F.2
Richert, Z.3
-
176
-
-
20444434616
-
Peripheral and intestinal regulatory CD4+CD25high T cells in inflammatory bowel disease
-
Maul J, Loddenkemper C, Mundt P, et al. Peripheral and intestinal regulatory CD4+CD25high T cells in inflammatory bowel disease. Gastroenterology.128:1868-1878.
-
Gastroenterology.
, vol.128
, pp. 1868
-
-
Maul, J.1
Loddenkemper, C.2
Mundt, P.3
-
177
-
-
33745275219
-
Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity
-
Holmen N, Lundgren A, Lundin S, et al. Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm Bowel Dis. 2006;12:447-456.
-
(2006)
Inflamm Bowel Dis.
, vol.12
, pp. 447-456
-
-
Holmen, N.1
Lundgren, A.2
Lundin, S.3
-
178
-
-
55149094300
-
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
-
Koenen HJ, Smeets RL, Vink PM, et al. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood. 2008; 112:2340-2352.
-
(2008)
Blood.
, vol.112
, pp. 2340-2352
-
-
Koenen, H.J.1
Smeets, R.L.2
Vink, P.M.3
-
179
-
-
33845647693
-
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
-
Boirivant M, Pallone F, Di Giacinto C, et al. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology. 2006;131:1786-1798.
-
(2006)
Gastroenterology.
, vol.131
, pp. 1786-1798
-
-
Boirivant, M.1
Pallone, F.2
Di Giacinto, C.3
-
180
-
-
0031578808
-
Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells
-
Tan KB, Harrop J, Reddy M, et al. Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells. Gene. 1997;204:35-46.
-
(1997)
Gene.
, vol.204
, pp. 35-46
-
-
Tan, K.B.1
Harrop, J.2
Reddy, M.3
-
181
-
-
2942652655
-
Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation
-
Prehn JL, Mehdizadeh S, Landers CJ, et al. Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol. 2004;112:66-77.
-
(2004)
Clin Immunol.
, vol.112
, pp. 66-77
-
-
Prehn, J.L.1
Mehdizadeh, S.2
Landers, C.J.3
-
182
-
-
10744225786
-
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease
-
Bamias G, Martin C, Marini M, et al. Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol. 2003;171:4868-4874.
-
(2003)
J Immunol.
, vol.171
, pp. 4868-4874
-
-
Bamias, G.1
Martin, C.2
Marini, M.3
-
183
-
-
84942278854
-
Tumor necrosis factor-like cytokine TL1A and its receptors DR3 and DcR3: Important new factors in mucosal homeostasis and inflammation
-
Siakavellas SI, Bamias G. Tumor necrosis factor-like cytokine TL1A and its receptors DR3 and DcR3: important new factors in mucosal homeostasis and inflammation. Inflamm Bowel Dis. 2015.
-
(2015)
Inflamm Bowel Dis.
-
-
Siakavellas, S.I.1
Bamias, G.2
-
184
-
-
84903893820
-
Interferon-gamma produced by tumorinfiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in vascular endothelial cells
-
Lu Y, Gu X, Chen L, et al. Interferon-gamma produced by tumorinfiltrating NK cells and CD4+ T cells downregulates TNFSF15 expression in vascular endothelial cells. Angiogenesis. 2014;17:529-540.
-
(2014)
Angiogenesis.
, vol.17
, pp. 529-540
-
-
Lu, Y.1
Gu, X.2
Chen, L.3
-
185
-
-
70249128323
-
TLR8-mediated activation of human monocytes inhibits TL1A expression
-
Saruta M, Michelsen KS, Thomas LS, et al. TLR8-mediated activation of human monocytes inhibits TL1A expression. Eur J Immunol. 2009;39: 2195-2202.
-
(2009)
Eur J Immunol.
, vol.39
, pp. 2195-2202
-
-
Saruta, M.1
Michelsen, K.S.2
Thomas, L.S.3
-
186
-
-
79551556334
-
Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia
-
Taraban VY, Slebioda TJ, Willoughby JE, et al. Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia. Mucosal Immunol. 2011;4:186-196.
-
(2011)
Mucosal Immunol.
, vol.4
, pp. 186-196
-
-
Taraban, V.Y.1
Slebioda, T.J.2
Willoughby, J.E.3
-
187
-
-
84873546540
-
Cloning, expression, and functional characterization of TL1A-Ig
-
Khan SQ, Tsai MS, Schreiber TH, et al. Cloning, expression, and functional characterization of TL1A-Ig. J Immunol. 2013;190:1540-1550.
-
(2013)
J Immunol.
, vol.190
, pp. 1540-1550
-
-
Khan, S.Q.1
Tsai, M.S.2
Schreiber, T.H.3
-
188
-
-
84885575846
-
Genetic factors conferring an increased susceptibility to develop Crohn?s disease also influence disease phenotype: Results from the IBDchip European Project
-
Cleynen I, Gonzalez JR, Figueroa C, et al. Genetic factors conferring an increased susceptibility to develop Crohn?s disease also influence disease phenotype: results from the IBDchip European Project. Gut. 2013;62: 1556-1565.
-
(2013)
Gut.
, vol.62
, pp. 1556-1565
-
-
Cleynen, I.1
Gonzalez, J.R.2
Figueroa, C.3
-
189
-
-
84908260866
-
TNFSF15 is an independent predictor for the development of Crohn?s disease-related complications in Koreans
-
Yang DH, Yang SK, Song K, et al. TNFSF15 is an independent predictor for the development of Crohn?s disease-related complications in Koreans. J Crohns Colitis. 2014;8:1315-1326.
-
(2014)
J Crohns Colitis.
, vol.8
, pp. 1315-1326
-
-
Yang, D.H.1
Yang, S.K.2
Song, K.3
-
190
-
-
78249287838
-
Genetic predictors of medically refractory ulcerative colitis
-
Haritunians T, Taylor KD, Targan SR, et al. Genetic predictors of medically refractory ulcerative colitis. Inflamm Bowel Dis. 2010;16:1830-1840.
-
(2010)
Inflamm Bowel Dis.
, vol.16
, pp. 1830-1840
-
-
Haritunians, T.1
Taylor, K.D.2
Targan, S.R.3
-
191
-
-
79551529001
-
The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation
-
Meylan F, Song YJ, Fuss I, et al. The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunol. 2011; 4:172-185.
-
(2011)
Mucosal Immunol.
, vol.4
, pp. 172-185
-
-
Meylan, F.1
Song, Y.J.2
Fuss, I.3
-
192
-
-
48549106477
-
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and Thelper 17 activation
-
Takedatsu H, Michelsen KS, Wei B, et al. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and Thelper 17 activation. Gastroenterology. 2008;135:552-567.
-
(2008)
Gastroenterology.
, vol.135
, pp. 552-567
-
-
Takedatsu, H.1
Michelsen, K.S.2
Wei, B.3
-
193
-
-
43549087629
-
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
-
Pappu BP, Borodovsky A, Zheng TS, et al. TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med. 2008;205:1049-1062.
-
(2008)
J Exp Med.
, vol.205
, pp. 1049-1062
-
-
Pappu, B.P.1
Borodovsky, A.2
Zheng, T.S.3
-
194
-
-
84924591327
-
TL1A regulates TCRgammadelta+intraepithelial lymphocytes and gut microbial composition
-
Tougaard P, Skov S, Pedersen AE, et al. TL1A regulates TCRgammadelta+intraepithelial lymphocytes and gut microbial composition. Eur J Immunol. 2015;45:865-875.
-
(2015)
Eur J Immunol.
, vol.45
, pp. 865-875
-
-
Tougaard, P.1
Skov, S.2
Pedersen, A.E.3
-
195
-
-
79251581032
-
Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis
-
Shih DQ, Barrett R, Zhang X, et al. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One. 2011;6:e16090.
-
(2011)
PLoS One.
, vol.6
, pp. e16090
-
-
Shih, D.Q.1
Barrett, R.2
Zhang, X.3
-
196
-
-
84886089221
-
Sustained TL1A expression on both lymphoid and myeloid cells leads to MILD spontaneous intestinal inflammation and fibrosis
-
Zheng L, Zhang X, Chen J, et al. Sustained TL1A expression on both lymphoid and myeloid cells leads to MILD spontaneous intestinal inflammation and fibrosis. Eur J Microbiol Immunol (Bp). 2013;3: 11-20.
-
(2013)
Eur J Microbiol Immunol (Bp).
, vol.3
, pp. 11-20
-
-
Zheng, L.1
Zhang, X.2
Chen, J.3
-
197
-
-
84862927426
-
Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces s
-
Barrett R, Zhang X, Koon HW, et al. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces s. Am J Pathol. 2012;180: 636-649.
-
(2012)
Am J Pathol.
, vol.180
, pp. 636-649
-
-
Barrett, R.1
Zhang, X.2
Koon, H.W.3
-
198
-
-
84908200305
-
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis
-
Shih DQ, Zheng L, Zhang X, et al. Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol. 2014;7: 1492-1503.
-
(2014)
Mucosal Immunol.
, vol.7
, pp. 1492-1503
-
-
Shih, D.Q.1
Zheng, L.2
Zhang, X.3
|