메뉴 건너뛰기




Volumn 10, Issue 8, 2004, Pages 801-805

Regulatory T cells and mechanisms of immune system control

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 4043052238     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0804-801     Document Type: Review
Times cited : (694)

References (65)
  • 1
    • 0026077909 scopus 로고
    • Induction and maintenance of anergy in mature T cells
    • Jenkins, M.K. et al. Induction and maintenance of anergy in mature T cells. Adv. Exp. Med. Biol. 292, 167-176 (1991).
    • (1991) Adv. Exp. Med. Biol. , vol.292 , pp. 167-176
    • Jenkins, M.K.1
  • 2
    • 0035180065 scopus 로고    scopus 로고
    • Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: Their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
    • Sakaguchi, S. et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182, 18-32 (2001).
    • (2001) Immunol. Rev. , vol.182 , pp. 18-32
    • Sakaguchi, S.1
  • 3
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • Shevach, E.M. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2, 389-400 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 4
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy, K.J. & Powrie, F. regulatory T cells in the control of immune pathology. Nat. Immunol. 2, 816-822 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 5
    • 0037783493 scopus 로고    scopus 로고
    • Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance
    • Cobbold, S.P., Graca, L., Lin, C.Y., Adams, E. & Waldmann, H. regulatory T cells in the induction and maintenance of peripheral transplantation tolerance. Transpl. Int. 16, 66-75 (2003).
    • (2003) Transpl. Int. , vol.16 , pp. 66-75
    • Cobbold, S.P.1    Graca, L.2    Lin, C.Y.3    Adams, E.4    Waldmann, H.5
  • 6
    • 0028179230 scopus 로고
    • lOW CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • lOW CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J. Exp. Med. 179, 589-600 (1994).
    • (1994) J. Exp. Med. , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 7
    • 0035284804 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10
    • Annacker, O. et al. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166, 3008-3018 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3008-3018
    • Annacker, O.1
  • 8
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux, H. et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 10
    • 0037310355 scopus 로고    scopus 로고
    • Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo
    • Sundstedt, A., O'Neill, E.J., Nicolson, K.S. & Wraith, D.C. Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo. J. Immunol. 170, 1240-1243 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 1240-1243
    • Sundstedt, A.1    O'Neill, E.J.2    Nicolson, K.S.3    Wraith, D.C.4
  • 11
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines
    • Barrat, F.J. et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J. Exp. Med. 195, 603-616 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 603-616
    • Barrat, F.J.1
  • 12
    • 0037371301 scopus 로고    scopus 로고
    • high-induced colitis by a TGF-β-dependent mechanism
    • high-induced colitis by a TGF-β-dependent mechanism. J. Immunol. 170, 2516-2522 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 2516-2522
    • Oida, T.1
  • 13
    • 0016588323 scopus 로고
    • A disquisition on suppressor T cells
    • Gershon, R.K. A disquisition on suppressor T cells. Transplant. Rev. 26, 170-185 (1975).
    • (1975) Transplant. Rev. , vol.26 , pp. 170-185
    • Gershon, R.K.1
  • 14
    • 0025938949 scopus 로고
    • CD4+ Leu-8+ T cell supernatant activity that inhibits Ig production
    • Kanof, M.E., Strober, W., Kwan, W.C., O'Connell, N.A. & James, S.P. CD4+ Leu-8+ T cell supernatant activity that inhibits Ig production. J. Immunol. 147, 155-161 (1991).
    • (1991) J. Immunol. , vol.147 , pp. 155-161
    • Kanof, M.E.1    Strober, W.2    Kwan, W.C.3    O'Connell, N.A.4    James, S.P.5
  • 15
    • 0034084162 scopus 로고    scopus 로고
    • Regulatory T cells in autoimmmunity
    • Shevach, E.M. regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18, 423-449 (2000).
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 423-449
    • Shevach, E.M.1
  • 16
    • 0343878233 scopus 로고    scopus 로고
    • Suppressor T cells: Rebirth, function and homeostasis
    • Shevach, E.M. Suppressor T cells: rebirth, function and homeostasis. Curr Biol. 10, R572-575 (2000).
    • (2000) Curr Biol. , vol.10
    • Shevach, E.M.1
  • 17
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy, K.J. et al. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197, 111-119 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 111-119
    • Maloy, K.J.1
  • 18
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read, S., Malmstrom, V. & Powrie, F. Cytotoxic T lymphocyte- associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 19
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi, T. et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 20
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y. & Sakaguchi, S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol. 3, 135-142 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 21
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • McHugh, R.S. et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16, 311-323 (2002).
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1
  • 22
    • 0034967640 scopus 로고    scopus 로고
    • Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells
    • Suri-Payer, E. & Cantor, H. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J. Autoimmun. 16, 115-123 (2001).
    • (2001) J. Autoimmun. , vol.16 , pp. 115-123
    • Suri-Payer, E.1    Cantor, H.2
  • 23
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. & Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061 (2003).
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 24
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat. Immunol. 4, 337-342 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 25
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat. Immunol. 4, 330-336 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 26
    • 0041931076 scopus 로고    scopus 로고
    • Foxp3 and natural regulatory T cells: Key to a cell lineage?
    • Ramsdell, F. Foxp3 and natural regulatory T cells: key to a cell lineage? Immunity 19, 165-168 (2003).
    • (2003) Immunity , vol.19 , pp. 165-168
    • Ramsdell, F.1
  • 27
    • 0037383757 scopus 로고    scopus 로고
    • Twenty-first century Foxp3
    • O'Garra, A. & Vieira, P. Twenty-first century Foxp3. Nat. Immunol. 4, 304-306 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 304-306
    • O'Garra, A.1    Vieira, P.2
  • 28
    • 0035821985 scopus 로고    scopus 로고
    • Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation
    • Baud, O. et al. Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation. N. Engl. J. Med. 344, 1758-1762 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1758-1762
    • Baud, O.1
  • 29
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3
    • Chen, W. et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198, 1875-1886 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 30
    • 0346969978 scopus 로고    scopus 로고
    • Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells
    • Walker, M.R. et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells. J. Clin. Invest. 112, 1437-1443 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1437-1443
    • Walker, M.R.1
  • 31
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naïve T cells
    • Apostolou, I. & von Boehmer, H. In vivo instruction of suppressor commitment in naïve T cells. J. Exp. Med. 199, 1401-1408 (2004).
    • (2004) J. Exp. Med. , vol.199 , pp. 1401-1408
    • Apostolou, I.1    Von Boehmer, H.2
  • 32
    • 0036196305 scopus 로고    scopus 로고
    • reg cells: Highly potent regulators of diabetes that require TRANCE-RANK signals
    • reg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16, 183-191 (2002).
    • (2002) Immunity , vol.16 , pp. 183-191
    • Green, E.A.1    Choi, Y.2    Flavell, R.A.3
  • 33
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon, B. et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 34
    • 0035869432 scopus 로고    scopus 로고
    • IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    • Hara, M. et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166, 3789-3796 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 3789-3796
    • Hara, M.1
  • 35
    • 0036467522 scopus 로고    scopus 로고
    • CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    • Kingsley, C.I., Karim, M., Bushell, A.R. & Wood, K.J. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168, 1080-1086 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 1080-1086
    • Kingsley, C.I.1    Karim, M.2    Bushell, A.R.3    Wood, K.J.4
  • 36
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4- T cells: A common basis between tumor immunity and autoimmunity
    • Shimizu, J., Yamazaki, S. & Sakaguchi, S. Induction of tumor immunity by removing CD25+CD4- T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163, 5211-5218 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 37
    • 0036858838 scopus 로고    scopus 로고
    • Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens
    • Golgher, D., Jones, E., Powrie, F., Elliott, T. & Gallimore, A. Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens. Eur. J. Immunol. 32, 3267-3275 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3267-3275
    • Golgher, D.1    Jones, E.2    Powrie, F.3    Elliott, T.4    Gallimore, A.5
  • 38
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman, C., Mauze, S., Leach, M.W., Coffman, R.L. & Powrie, F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190, 995-1004 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 39
    • 0141703239 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes
    • Green, E.A., Gorelik, L., McGregor, C.M., Tran, E.H. & Flavell, R.A. CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-β-TGF-β receptor interactions in type 1 diabetes. Proc. Natl. Acad. Sci. USA 100, 10878-10883 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3    Tran, E.H.4    Flavell, R.A.5
  • 40
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • Burkhart, C., Liu, G.Y., Anderton, S.M., Metzler, B. & Wraith, D.C. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int. Immunol. 11, 1625-1634 (1999).
    • (1999) Int. Immunol. , vol.11 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 41
    • 0036732461 scopus 로고    scopus 로고
    • Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
    • Akbari, O. et al. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8, 1024-1032 (2002).
    • (2002) Nat. Med. , vol.8 , pp. 1024-1032
    • Akbari, O.1
  • 42
    • 1042269477 scopus 로고    scopus 로고
    • IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25(+)CD4(+) regulatory T cells
    • Zhang, X. et al. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25(+)CD4(+) regulatory T cells. Int. Immunol. 16, 249-256 (2004).
    • (2004) Int. Immunol. , vol.16 , pp. 249-256
    • Zhang, X.1
  • 43
    • 2442450433 scopus 로고    scopus 로고
    • IL-10 secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • Vieira, P.L. et al. IL-10 secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells. J. Immunol. 172, 5986-5993 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5986-5993
    • Vieira, P.L.1
  • 44
    • 0035801335 scopus 로고    scopus 로고
    • Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • Nakamura, K., Kitani, A. & Strober, W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194, 629-644 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 45
    • 0031964338 scopus 로고    scopus 로고
    • Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo
    • Buer, J. et al. Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo. J. Exp. Med. 187, 177-183 (1998).
    • (1998) J. Exp. Med. , vol.187 , pp. 177-183
    • Buer, J.1
  • 46
    • 0036165718 scopus 로고    scopus 로고
    • Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: The role of IL-10
    • Pontoux, C., Banz, A. & Papiernik, M. Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10. Int. Immunol. 14, 233-239 (2002).
    • (2002) Int. Immunol. , vol.14 , pp. 233-239
    • Pontoux, C.1    Banz, A.2    Papiernik, M.3
  • 47
    • 0033526853 scopus 로고    scopus 로고
    • Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
    • Miller, C., Ragheb, J.A. & Schwartz, R.H. Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo. J. Exp. Med. 190, 53-64 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 53-64
    • Miller, C.1    Ragheb, J.A.2    Schwartz, R.H.3
  • 48
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C. & Medzhitov, R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033-1036 (2003).
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 50
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. & Enk, A.M. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192, 1213-1222 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1213-1222
    • Jonuleit, H.1    Schmitt, E.2    Schuler, G.3    Knop, J.4    Enk, A.M.5
  • 51
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • Schubert, L.A., Jeffery, E., Zhang, Y., Ramsdell, F. & Ziegler, S.F. Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276, 37672-37679 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 52
    • 0035062581 scopus 로고    scopus 로고
    • Human anergic/suppressive CD4(+)CD25(+) T cells: A highly differentiated and apoptosis-prone population
    • Taams, L.S. et al. Human anergic/suppressive CD4(+)CD25(+) T cells: a highly differentiated and apoptosis-prone population. Eur. J. Immunol. 31, 1122-1131 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1122-1131
    • Taams, L.S.1
  • 53
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 54
    • 0043244867 scopus 로고    scopus 로고
    • Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo
    • Walker, L.S., Chodos, A., Eggena, M., Dooms, H. & Abbas, A.K. Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J. Exp. Med. 198, 249-258 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 249-258
    • Walker, L.S.1    Chodos, A.2    Eggena, M.3    Dooms, H.4    Abbas, A.K.5
  • 55
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells
    • Yamazaki, S. et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198, 235-247 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 235-247
    • Yamazaki, S.1
  • 56
    • 0037450727 scopus 로고    scopus 로고
    • T cell regulation as a side effect of homeostasis and competition
    • Barthlott, T., Kassiotis, G. & Stockinger, B. T cell regulation as a side effect of homeostasis and competition. J. Exp. Med. 197, 451-460 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 451-460
    • Barthlott, T.1    Kassiotis, G.2    Stockinger, B.3
  • 57
    • 2242423605 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
    • Belkaid, Y., Piccirillo, C.A., Mendez, S., Shevach, E.M. & Sacks, D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420, 502-507 (2002).
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 58
    • 0026708718 scopus 로고
    • Regulation of immunity to parasites by T cells and T cell-derived cytokines
    • Sher, A. & Coffman, R.L. regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10, 385-409 (1992).
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 385-409
    • Sher, A.1    Coffman, R.L.2
  • 59
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
    • Powrie, F, Carlino, J., Leach, M.W., Mauze, S. & Coffman, R.L. A critical role for transforming growth factor-β but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J. Exp. Med. 183, 2669-2674 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3    Mauze, S.4    Coffman, R.L.5
  • 60
    • 12944310982 scopus 로고    scopus 로고
    • IL-10-producing T cells suppress immune responses in anergic tuberculosis patients
    • Boussiotis, V.A. et al. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J. Clin. Invest. 105, 1317-1325 (2000).
    • (2000) J. Clin. Invest. , vol.105 , pp. 1317-1325
    • Boussiotis, V.A.1
  • 61
    • 0037136284 scopus 로고    scopus 로고
    • Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    • Kullberg, M.C. et al. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196, 505-515 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 505-515
    • Kullberg, M.C.1
  • 62
    • 0035914926 scopus 로고    scopus 로고
    • Regulatory role of T cells producing both interferon γ and interleukin 10 in persistent infection
    • Trinchieri, G. regulatory role of T cells producing both interferon γ and interleukin 10 in persistent infection. J. Exp. Med. 194, F53-57 (2001).
    • (2001) J. Exp. Med. , vol.194
    • Trinchieri, G.1
  • 63
    • 0032797911 scopus 로고    scopus 로고
    • A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice
    • Li, C., Corraliza, I. & Langhorne, J. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect. Immun. 67, 4435-4442 (1999).
    • (1999) Infect. Immun. , vol.67 , pp. 4435-4442
    • Li, C.1    Corraliza, I.2    Langhorne, J.3
  • 64
    • 0037148511 scopus 로고    scopus 로고
    • Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    • McGuirk, P., McCann, C. & Mills, K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195, 221-231 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 221-231
    • McGuirk, P.1    McCann, C.2    Mills, K.H.3
  • 65
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.