Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis

European Journal of Immunology

Volumn 33, Issue 4, 2003, Pages 1073-1083

  Krajina, Tamara ^a   Leithäuser, Frank ^a   Möller, Peter ^a   Trobonjaca, Zlatko ^a   Reimann, Jörg ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Colonic dendritic cell; Mucosal T cell response; Murine colitis

Indexed keywords

B7 ANTIGEN; CD1D ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 23; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN P19; PROTEIN P40; PROTEIN P70; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; CELL CULTURE; CELL ISOLATION; CELL SURFACE; CELL TRANSPLANTATION; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENETIC TRANSCRIPTION; HELPER CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LAMINA PROPRIA; LETHALITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COLITIS; COLON; CYTOKINES; DENDRITIC CELLS; GENES, RAG-1; IMMUNOPHENOTYPING; INFLAMMATORY BOWEL DISEASES; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTERLEUKIN-23; INTERLEUKIN-23 SUBUNIT P19; INTERLEUKINS; INTESTINAL MUCOSA; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN SUBUNITS;

EID: 0038744423     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200323518     Document Type: Review

References (41)

1. MacPherson, G. G. and Liu, L., Intestinal dendritic cells. In Lotze, M. T. and Thomson, A. W. (Eds.) Dendritic Cells. Academic Press, San Diego 2000, pp 142-151.
2. MacPherson, G. G. and Liu, L. M., Dendritic cells and Langerhans cells in the uptake of mucosal antigens. Curr. Top. Microbiol. Immunol. 1999. 236: 33-53.
3. + T cells. J. Immunol. 2000. 164: 2890-2896.
4. Bell, S. J., Rigby, R., English, N., Mann, S. D., Knight, S. C., Kamm, M. A. and Stagg, A. J., Migration and maturation of human colonic dendritic cells. J. Immunol. 2001. 166: 4958-4967.
5. Huang, F. P., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D. and MacPherson, G. G., A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 2000. 191: 435-444.
6. + T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a murine adoptive transfer model. Lab Invest 2001. 81: 1339-1349.
7. Leithäuser, F., Trobonjaca, Z., Reimann, J. and Moller, P., In situ characterization of genetically targeted (green fluorescent) single cells and their microenvironment in an adoptive host. Am. J. Pathol. 2001. 158: 1975-1983.
8. Hamada, H., Hiroi, T., Nishiyama, Y., Takahashi, H., Masunaga, Y., Hachimura, S., Kaminogawa, S., Takahashi-Iwanaga, H., Iwanaga, T., Kiyono, H., Yamamoto, H. and Ishikawa, H., Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J. Immunol. 2002. 168: 57-64.
9. Iqbal, N., Oliver, J. R., Wagner, F. H., Lazenby, A. S., Elson, C. O. and Weaver, C. T., T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J. Exp. Med. 2002. 195: 71-84.
10. Strober, W., Fuss, I. J. and Blumberg, R. S., The immunology of mucosal models of inflammation. Annu. Pev. Immunol. 2002. 20: 495-549.
11. Zitvogel, L., Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J. Exp. Med. 2002. 195: F9-F14.
12. Gerosa, F., Baldani-Guerra, B., Nisii, C., Marchesini, V., Carra, G. and Trinchieri, G., Reciprocal activating Interaction between natural killer cells and dendritic cells. J. Exp. Med. 2002. 195: 327-333.
13. Piccioli, D., Sbrana, S., Melandri, E. and Valiante, N. M., Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J. Exp. Med. 2002. 195: 335-341.
14. Trobonjaca, Z., Leithäuser, F., Moller, P., Schirmbeck, R. and Reimann, J., Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFNγ release by liver NKT cells. J. Immunol. 2001. 167: 1413-1422.
15. Trobonjaca, Z., Kroger, A., Stober, D., Leithäuser, F., Moller, P., Hauser, H., Schirmbeck, R. and Reimann, J., Activating immunity in the liver. II. IFN-β attenuates NK cell-dependent liver injury triggered by liver NKT cell activation. J. Immunol. 2002. 168: 3763-3770.
16. -/- hosts. J. Immunol. 2001. 166: 3804-3812.
17. Esche, C., Shurin, M. R. and Lotze, M. T., IL-12. In Oppenheim, J. and Feldmann, M. (Eds.) Cytokine reference. Academic Press, New York 2001, pp 188-201.
18. Esche, C., Shurin, M. R. and Lotze, M. T., IL-12 receptor. In Oppenheim, J. and Feldmann, M. (Eds.) Cytokine reference. Academic Press, New York 2001, pp 1503-1509.
19. Neurath, M. F., Fuss, I., Kelsall, B. L., Stuber, E. and Strober, W., Antibodies to interleukin 12 abrogate established experimental colitis in mice. J. Exp. Med. 1995. 182: 1281-1290.
20. Davidson, N. J., Hudak, S. A., Lesley, R. E., Menon, S., Leach, M. W. and Rennick, D. M., IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J. Immunol. 1998. 161: 3143-3149.
21. Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., Hunte, B., Vega, F., Yu, N., Wang, J., Singh, K., Zonin, F., Vaisberg, E., Churakova, T., Liu, M., Gorman, D., Wagner, J., Zurawski, S., Liu, Y., Abrams, J. S., Moore, K. W., Rennick, D. M., Waal-Malefyt, R., Hannum, C., Bazan, J. F. and Kastelein, R. A., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000. 13: 715-725.
22. Holscher, C., Atkinson, R. A., Arendse, B., Brown, N., Myburgh, E., Alber, G. and Brombacher, F., A protective and agonistic function of IL-12p40 in mycobacterial infection. J. Immunol. 2001. 167: 6957-6966.
23. Lehmann, J., Bellmann, S., Werner, C., Schroder, R., Schutze, N. and Alber, G., IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J. Immunol. 2001. 167: 5304-5315.
24. Cooper, A. M., Kipnis, A., Turner, J., Magram, J., Ferrante, J. and Orme, I. M., Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J. Immunol. 2002. 168: 1322-1327.
25. Cella, M., Scheidegger, D., Palmer, L. K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
26. DeKruyff, R. H., Gieni, R. S. and Umetsu, D. T., Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 1997. 158: 359-366.
27. Maruo, S., Oh, H. M., Ahn, H. J., Ono, S., Wysocka, M., Kaneko, Y., Yagita, H., Okumura, K., Kikutani, H., Kishimoto, T., Kobayashi, M., Hamaoka, T., Trinchieri, G. and Fujiwara, H. B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions. J. Immunol. 1997. 158: 120-126.
28. Mackey, M. F., Gunn, J. R., Maliszewsky, C., Kikutani, H., Noelle, R. J. and Barth, R. J. Jr., Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J. Immunol. 1998. 161: 2094-2098.
29. Stober, D., Schirmbeck, R. and Reimann, J., IL-12/IL-18-dependent IFNγ release by murine dendritic cells. J. Immunol. 2001. 167: 957-965.
30. Kato, K., Shimozato, O., Hoshi, K., Wakimoto, H., Hamada, H., Yagita, H. and Okumura, K., Local production of the p40 subunit of interleukin 12 suppresses T-helper 1-mediated immune responses and prevents allogeneic myoblast rejection. Proc. Natl. Acad. Sci. USA 1996. 93: 9085-9089.
31. Abdi, K. and Herrmann, S. H., CTL generation in the presence of IL-4 is inhibited by free p40: evidence for early and late IL-12 function. J. Immunol. 1997. 159: 3148-3155.
32. Heinzel, F. P., Hujer, A. M., Ahmed, F. N. and Rerko, R. M., In vivo production and function of IL-12 p40 homodimers. J. Immunol. 1997. 158: 4381-4388.
33. Wiekowski, M. T., Leach, M. W., Evans, E. W., Sullivan, L., Chen, S. C., Vassileva, G., Bazan, J. F., Gorman, D. M., Kastelein, R. A., Narula, S. and Lira, S. A., Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J. Immunol. 2001. 166: 7563-7570.
34. Kontgen, F., Suss, G., Stewart, C., Steinmetz, M. and Bluethmann, H., Targeted disruption of the MHC class II Aα gene in C57BL/6 mice. Int. Immunol. 1993. 5: 957-964.
35. + T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 1995. 182: 993-1004.
36. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. and Papaioannou, V. E., RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992. 68: 869-877.
37. + T cells. Science 1990. 248: 1227-1230.
38. + αβ T cells in SCID mice with colitis. Eur. J. Immunol. 1996. 26: 3074-3083.
39. + T cells in immunodeficient, adoptive hosts depends on their state of activation, IL-12 responsiveness, and CD45RB surface phenotype. J. Immunol. 1999. 162: 3702-3710.
40. + TCR αβ T cells of athymic origin in histocompatible severe combined immunodeficient (SCID) mice. Clin. Exp. Immunol. 1998. 112: 443-452.
41. Lin, Y. C., Canatan, H., Chang, C. J., Hu, Y. F., Chen, R., Yu, C. Y., Brueggemeier, R. W. and Somers, W. J., Detection of keratinocyte growth factor (KGF) transcripts from normal human and archival canine benign prostatic hyperplastic tissues. J. Med. 1994. 25: 41-64.