Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases

Clinical and Experimental Immunology

Volumn 176, Issue 2, 2014, Pages 266-274

  Serriari, N E ^a   Eoche, M ^b   Lamotte, L ^c   Lion, J ^a   Fumery, M ^b   Marcelo, P ^c   Chatelain, D ^b   Barre, A ^a,b   Nguyen Khac, E ^b   Lantz, O ^d   Dupas, J L ^b   Treiner, E ^a,b  

^a INSERM   (France)

^b AMIENS UNIVERSITY HOSPITAL   (France)

^c UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^d INSTITUT CURIE   (France)

Author keywords

Immune system; Inflammatory bowel diseases; Innate T cells; MHC class I like

Indexed keywords

AZATHIOPRINE; B AND T LYMPHOCYTE ATTENUATOR; CORTICOSTEROID; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 17; INTERLEUKIN 22; KI 67 ANTIGEN; LYMPHOCYTE RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; TUMOR NECROSIS FACTOR INHIBITOR; UNCLASSIFIED DRUG;

ADULT; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; BLOOD; CELL ISOLATION; CLINICAL ARTICLE; COLON BIOPSY; COLON SURGERY; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFLAMMATORY BOWEL DISEASE; LYMPHOCYTE FUNCTION; MALE; MUCOSAL ASSOCIATED INVARIANT T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ULCERATIVE COLITIS;

IMMUNE SYSTEM; INFLAMMATORY BOWEL DISEASES; INNATE T CELLS; MHC CLASS I-LIKE;

ADULT; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNITY, INNATE; INFLAMMATORY BOWEL DISEASES; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKINS; INTESTINAL MUCOSA; KI-67 ANTIGEN; LYMPHOCYTE ACTIVATION; MALE; MICROSCOPY, CONFOCAL; NATURAL KILLER T-CELLS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTE SUBSETS;

EID: 84897937905     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12277     Document Type: Article

References (32)

1. Fuss IJ, Heller F, Boirivant M etal. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004; 113:1490-1497.
2. Fuss IJ, Strober W. The role of IL-13 and NK T cells in experimental and human ulcerative colitis. Mucosal Immunol 2008; 1 (Suppl. 1):S31-33.
3. Heller F, Florian P, Bojarski C etal. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005; 129:550-564.
4. Treiner E, Duban L, Moura IC, Hansen T, Gilfillan S, Lantz O. Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset. Microbes Infect 2005; 7:552-559.
5. Tilloy F, Treiner E, Park SH etal. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med 1999; 189:1907-1921.
6. Treiner E, Duban L, Bahram S etal. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 2003; 422:164-169.
7. Martin E, Treiner E, Duban L etal. Stepwise development of MAIT cells in mouse and human. PLOS Biol 2009; 7:e54.
8. Dusseaux M, Martin E, Serriari N etal. Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood 2011; 117:1250-1259.
9. Le Bourhis L, Martin E, Peguillet I etal. Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol 2010; 11:701-708.
10. Kjer-Nielsen L, Patel O, Corbett AJ etal. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 2012; 491:717-723.
11. Le Bourhis L, Guerri L, Dusseaux M, Martin E, Soudais C, Lantz O. Mucosal-associated invariant T cells: unconventional development and function. Trends Immunol 2011; 32:212-218.
12. Billerbeck E, Kang YH, Walker L etal. Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci USA 2010; 107:3006-3011.
13. Annibali V, Ristori G, Angelini DF etal. CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis. Brain 2011; 134:542-554.
14. Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S. Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Arthritis Rheum 2012; 64:153-161.
15. Giacomelli R, Parzanese I, Frieri G etal. Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease. Clin Exp Immunol 1994; 98:83-88.
16. Pariente B, Mocan I, Camus M etal. Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease. Gastroenterology 2011; 141:217-226, 26 e1-2.
17. Allez M, Tieng V, Nakazawa A etal. CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions. Gastroenterology 2007; 132:2346-2358.
18. Kaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annu Rev Immunol 2010; 28:573-621.
19. Gold MC, Cerri S, Smyk-Pearson S etal. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol 2010; 8:e1000407.
20. Peterfalvi A, Gomori E, Magyarlaki T etal. Invariant Valpha7.2-Jalpha33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells. Int Immunol 2008; 20:1517-1525.
21. Leeansyah E, Ganesh A, Quigley MF etal. Activation, exhaustion and persistent decline of the anti-microbial MR1-restricted MAIT cell population in chronic HIV-1 infection. Blood 2013; 121:1124-1135.
22. Cosgrove C, Ussher JE, Rauch A etal. Early and non-reversible decrease of CD161++/MAIT cells in HIV infection. Blood 2013; 121:951-956.
23. Serriari NE, Gondois-Rey F, Guillaume Y etal. B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J Immunol 2010; 185:3140-3148.
24. Zhang C, Zhang J, Niu J, Zhang J, Tian Z. Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation. Cytokine 2008; 42:128-136.
25. Zhang C, Zhang J, Niu J, Zhou Z, Zhang J, Tian Z. Interleukin-12 improves cytotoxicity of natural killer cells via upregulated expression of NKG2D. Hum Immunol 2008; 69:490-500.
26. Marwaha AK, Leung NJ, McMurchy AN, Levings MK. TH17 cells in autoimmunity and immunodeficiency: protective or pathogenic? Front Immunol 2012; 3:129.
27. Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 2011; 140:1756-1767.
28. Dunne MR, Elliott L, Hussey S etal. Persistent changes in circulating and intestinal gammadelta T cell subsets, invariant natural killer T cells and mucosal-associated invariant T cells in children and adults with coeliac disease. PLOS ONE 2013; 8:e76008.
29. Rajilic-Stojanovic M, Shanahan F, Guarner F, de Vos WM. Phylogenetic analysis of dysbiosis in ulcerative colitis during remission. Inflamm Bowel Dis 2013; 19:481-488.
30. Andoh A, Kuzuoka H, Tsujikawa T etal. Multicenter analysis of fecal microbiota profiles in Japanese patients with Crohn's disease. J Gastroenterol 2012; 47:1298-1307.
31. Schoepfer AM, Beglinger C, Straumann A etal. Fecal calprotectin correlates more closely with the Simple Endoscopic Score for Crohn's disease (SES-CD) than CRP, blood leukocytes, and the CDAI. Am J Gastroenterol 2010; 105:162-169.
32. Regueiro M, Kip KE, Schraut W etal. Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection. Inflamm Bowel Dis 2011; 17:118-126.