Peripheral and intestinal regulatory CD4+CD25high T cells in inflammatory bowel disease

Gastroenterology

Volumn 128, Issue 7, 2005, Pages 1868-1878

  Maul, Jochen ^a   Loddenkemper, Christoph ^a   Mundt, Pamela ^a   Berg, Erika ^a   Giese, Thomas ^b   Stallmach, Andreas ^c   Zeitz, Martin ^a   Duchmann, Rainer ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c Clin Gastroenterol and Hepatol   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD; BLOOD SAMPLING; CELL ISOLATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CORRELATION ANALYSIS; CYTOMETRY; DISEASE ACTIVITY; ENTERITIS; FEMALE; FUNCTIONAL DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE BIOPSY; INTESTINE DIVERTICULOSIS; INTESTINE FUNCTION; INTESTINE INJURY; INTESTINE MUCOSA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

EID: 20444434616     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.03.043     Document Type: Article

References (34)

1. R. Blumberg, W. Strober Prospects for research in inflammatory bowel disease JAMA 285 2001 643 647
2. F. Autschbach, T. Giese, N. Gassler, B. Sido, G. Heuschen, U. Heuschen, I. Zuna, P. Schulz, H. Weckauf, I. Berger, H.F. Otto, S.C. Meuer Cytokine/chemokine messenger-RNA expression profiles in ulcerative colitis and Crohn's disease Virchows Arch 441 2002 500 513
3. W. Strober, I.J. Fuss, R.S. Blumberg The immunology of mucosal models of inflammation Annu Rev Immunol 20 2002 495 549
4. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 1995 1151 1164
5. E. Suri-Payer, A.Z. Amar, A.M. Thornton, E.M. Shevach CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells J Immunol 160 1998 1212 1218
6. L. Graca, S. Thompson, C.Y. Lin, E. Adams, S.P. Cobbold, H. Waldmann Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance J Immunol 168 2002 5558 5565
7. M. Hara, C.I. Kingsley, M. Niimi, S. Read, S.E. Turvey, A.R. Bushell, P.J. Morris, F. Powrie, K.J. Wood IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo J Immunol 166 2001 3789 3796
8. C.I. Kingsley, M. Karim, A.R. Bushell, K.J. Wood CD25+CD4+ regulatory T cells prevent graft rejection CTLA-4- and IL-10- dependent immunoregulation of alloresponses J Immunol 168 2002 1080 1086
9. X. Zhang, L. Izikson, L. Liu, H.L. Weiner Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration J Immunol 167 2001 4245 4253
10. M. Gad, J. Brimnes, M.H. Claesson CD4+ T regulatory cells from the colonic lamina propria of normal mice inhibit proliferation of enterobacteria-reactive, disease-inducing Th1- cells from SCID mice with colitis Clin Exp Immunol 131 2003 34 40
11. S. Read, V. Malmstrom, F. Powrie Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 192 2000 295 302
12. C. Mottet, H.H. Uhlig, F. Powrie Cutting edge cure of colitis by CD4(+)CD25(+) regulatory T cells J Immunol 170 2003 3939 3943
13. J. Lehmann, J. Huehn, M. de la Rosa, F. Maszyna, U. Kretschmer, V. Krenn, M. Brunner, A. Scheffold, A. Hamann Expression of the integrin α Eβ 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells Proc Natl Acad Sci U S A 99 2002 13031 13036
14. C. Baecher-Allan, J.A. Brown, G.J. Freeman, D.A. Hafler CD4+CD25 high regulatory cells in human peripheral blood J Immunol 167 2001 1245 1253
15. D. Dieckmann, H. Plottner, S. Berchtold, T. Berger, G. Schuler Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood J Exp Med 193 2001 1303 1310
16. H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, A.H. Enk Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood J Exp Med 193 2001 1285 1294
17. M.K. Levings, R. Sangregorio, M.G. Roncarolo Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function J Exp Med 193 2001 1295 1302
18. K. Wing, A. Ekmark, H. Karlsson, A. Rudin, E. Suri-Payer Characterization of human CD25+ CD4+ T cells in thymus, cord and adult blood Immunology 106 2002 190 199
19. L.A. Stephens, C. Mottet, D. Mason, F. Powrie Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro Eur J Immunol 31 2001 1247 1254
20. S. Makita, T. Kanai, S. Oshima, K. Uraushihara, T. Totsuka, T. Sawada, T. Nakamura, K. Koganei, T. Fukushima, M. Watanabe CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells J Immunol 173 2004 3119 3130
21. L.S. Taams, J. Smith, M.H. Rustin, M. Salmon, L.W. Poulter, A.N. Akbar Human anergic/suppressive CD4(+)CD25(+) T cells a highly differentiated and apoptosis-prone population Eur J Immunol 31 2001 1122 1131
22. D. Cao, V. Malmstrom, C. Baecher-Allan, D. Hafler, L. Klareskog, C. Trollmo Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis Eur J Immunol 33 2003 215 223
23. S. Hori, T. Nomura, S. Sakaguchi Control of regulatory T-cell development by the transcription factor Foxp3 Science 299 2003 1057 1061
24. H. Yagi, T. Nomura, K. Nakamura, S. Yamazaki, T. Kitawaki, S. Hori, M. Maeda, M. Onodera, T. Uchiyama, S. Fujii, S. Sakaguchi Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells Int Immunol 16 2004 1643 1656
25. W.R. Best, J.M. Becktel, J.W. Singleton Rederived values of the eight coefficients of the Crohn's disease activity index (CDAI) Gastroenterology 77 1979 843 846
26. S.C. Truelove, L.J. Witts Cortisone in ulcerative colitis final report on a therapeutic trial Br Med J 1955 1041 1048
27. J.D. Fontenot, M.A. Gavin, A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 2003 330 336
28. R. Khattri, T. Cox, S.A. Yasayko, F. Ramsdell An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat Immunol 4 2003 337 342
29. B. Singh, S. Read, C. Asseman, V. Malmstrom, C. Mottet, L.A. Stephens, R. Stepankova, H. Tlaskalova, F. Powrie Control of intestinal inflammation by regulatory T cells Immunol Rev 182 2001 190 200
30. S. Kontiainen, T. Scheinin, L. Halme Number of activated T-helper cells and NK cells in peripheral blood is decreased in severe Crohn's disease APMIS 104 1996 355 361
31. S. Schreiber, R.P. MacDermott, A. Raedler, R. Pinnau, M.J. Bertovich, G.S. Nash Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease Gastroenterology 101 1991 1020 1030
32. F. Pallone, S. Fais, O. Squarcia, L. Biancone, P. Pozzilli, M. Boirivant Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens Gut 28 1987 745 753
33. S. Sakaguchi Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors J Exp Med 197 2003 397 401
34. V. Viglietta, C. Baecher-Allan, H.L. Weiner, D.A. Hafler Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 199 2004 971 979