Developmental plasticity of Th17 and Treg cells

Current Opinion in Immunology

Volumn 21, Issue 3, 2009, Pages 274-280

  Lee, Yun Kyung ^a,b   Mukasa, Ryuta ^a,c   Hatton, Robin D ^a   Weaver, Casey T ^a,b  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; DNA; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 6; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ADAPTIVE IMMUNITY; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA MODIFICATION; EFFECTOR CELL; EPIGENETICS; GENE EXPRESSION; HUMAN; IMMUNOCOMPETENT CELL; INFECTION RESISTANCE; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; PLASTICITY; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; TISSUE INJURY;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-6; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 67049097104     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.05.021     Document Type: Review

References (42)

1. Weaver C.T., Hatton R.D., Mangan P.R., and Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25 (2007) 821-852
2. McGeachy M.J., and Cua D.J. Th17 cell differentiation: the long and winding road. Immunity 28 (2008) 445-453
3. ••].
4. ••].
5. ••] this study established roles for TGF-β and IL-6 in the development of Th17 cells.
6. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., and Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
7. •].
8. •].
9. •] this study established that IL-21, induced by IL-6, can act in an autocrine manner to support the development of Th17 cells.
10. Wei L., Laurence A., Elias K.M., and O'Shea J.J. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 282 (2007) 34605-34610
11. Li M.O., Wan Y.Y., Sanjabi S., Robertson A.K., and Flavell R.A. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24 (2005) 99-146
12. Zheng Y., and Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 8 (2007) 457-462
13. Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., and Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133. This study identified RORγt as a central transcription factor specific for Th17 development.
14. Yang X.O., Pappu B.P., Nurieva R., Akimzhanov A., Kang H.S., Chung Y., Ma L., Shah B., Panopoulos A.D., Schluns K.S., et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28 (2008) 29-39. This study identified RORα as a second Th17-specific transcription factor.
15. •].
16. •].
17. •].
18. •] this study identified competitive antagonism between the transcription factors RORα or RORγt and Foxp3.
19. Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., and Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
20. Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., and Powrie F. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204 (2007) 1757-1764
21. Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., and Belkaid Y. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204 (2007) 1775-1785
22. Benson M.J., Pino-Lagos K., Rosemblatt M., and Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 204 (2007) 1765-1774
23. Schambach F., Schupp M., Lazar M.A., and Reiner S.L. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. Eur J Immunol 37 (2007) 2396-2399
24. Lochner M., Peduto L., Cherrier M., Sawa S., Langa F., Varona R., Riethmacher D., Si-Tahar M., Di Santo J.P., and Eberl G. In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 205 (2008) 1381-1393
25. Voo K.S., Wang Y.H., Santori F.R., Boggiano C., Wang Y.H., Arima K., Bover L., Hanabuchi S., Khalili J., Marinova E., et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A 106 (2009) 4793-4798
26. ••].
27. ••] this study described a Th1-independent and Th2-independent pathway for Th17 cell development, establishing Th17 as a third effector lineage.
28. Kastelein R.A., Hunter C.A., and Cua D.J. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 25 (2007) 221-242
29. •].
30. •].
31. •] this study described plasticity of Th17 cells for conversion to distinct effector phenotypes.
32. Lin J.T., Martin S.L., Xia L., and Gorham J.D. TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J Immunol 174 (2005) 5950-5958
33. Park I.K., Shultz L.D., Letterio J.J., and Gorham J.D. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J Immunol 175 (2005) 5666-5674
34. Shi G., Cox C.A., Vistica B.P., Tan C., Wawrousek E.F., and Gery I. Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells. J Immunol 181 (2008) 7205-7213
35. Bending D., De La Pena H., Veldhoen M., Phillips J.M., Uyttenhove C., Stockinger B., and Cooke A. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 119 (2009) 566-572
36. Martin-Orozco N., Chung Y., Chang S.H., Wang Y.H., and Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 39 (2009) 216-224
37. Xu L., Kitani A., Fuss I., and Strober W. Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol 178 (2007) 6725-6729
38. Osorio F., LeibundGut-Landmann S., Lochner M., Lahl K., Sparwasser T., Eberl G., and Reis e Sousa C. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 38 (2008) 3274-3281
39. Wei G., Wei L., Zhu J., Zang C., Hu-Li J., Yao Z., Cui K., Kanno Y., Roh T.Y., Watford W.T., et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30 (2009) 155-167. This study reported genome-wide analyses of epigenetic modifications that distinguish each of the well-characterized effector and regulatory CD4 T cell lineages.
40. Ansel K.M., Lee D.U., and Rao A. An epigenetic view of helper T cell differentiation. Nat Immunol 4 (2003) 616-623
41. Wilson C.B., Rowell E., and Sekimata M. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol 9 (2009) 91-105
42. Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B.M., Tato C., Yoshimura A., Hennighausen L., and O'Shea J.J. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc Natl Acad Sci U S A 103 (2006) 8137-8142