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Volumn 19, Issue 6, 2007, Pages 785-799

The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro

Author keywords

Common gamma chain; FOXP3; LY294002; Phosphatidylinositol 3 kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 7; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR FOXP3;

EID: 34447574943     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm047     Document Type: Article
Times cited : (89)

References (84)
  • 1
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6:345.
    • (2005) Nat. Immunol , vol.6 , pp. 345
    • Sakaguchi, S.1
  • 2
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid, Y. and Rouse, B. T. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6:353.
    • (2005) Nat. Immunol , vol.6 , pp. 353
    • Belkaid, Y.1    Rouse, B.T.2
  • 3
    • 2942642383 scopus 로고    scopus 로고
    • In vitro expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang, Q., Henriksen, K. J., Bi, M. et al. 2004. In vitro expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 199:1455.
    • (2004) J. Exp. Med , vol.199 , pp. 1455
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3
  • 5
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S. 1996. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:387.
    • (1996) J. Exp. Med , vol.184 , pp. 387
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 6
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek, T. R. and Bayer, A. L. 2004. Tolerance, not immunity, crucially depends on IL-2. Nat. Rev. Immunol. 4:665.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 665
    • Malek, T.R.1    Bayer, A.L.2
  • 7
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Suzuki, H., Kundig, T. M., Furlonger, C. et al. 1995. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 268:1472.
    • (1995) Science , vol.268 , pp. 1472
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3
  • 8
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Ma, A. and Alt, F. W. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
    • (1995) Immunity , vol.3 , pp. 521
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 9
    • 0028821858 scopus 로고
    • Immunopathology of interleukin (IL) 2-deficient mice: Thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene
    • Kramer, S., Schimpl, A. and Hunig, T. 1995. Immunopathology of interleukin (IL) 2-deficient mice: Thymus dependence and suppression by thymus-dependent cells with an intact IL-2 gene. J. Exp. Med. 182:1769.
    • (1995) J. Exp. Med , vol.182 , pp. 1769
    • Kramer, S.1    Schimpl, A.2    Hunig, T.3
  • 11
    • 0030560797 scopus 로고    scopus 로고
    • Interleukin-2 is indispensable for development of immunological self-tolerance
    • Klebb, G., Autenrieth, I. B., Haber, H. et al. 1996. Interleukin-2 is indispensable for development of immunological self-tolerance. Clin. Immunol. Immunopathol. 81:282.
    • (1996) Clin. Immunol. Immunopathol , vol.81 , pp. 282
    • Klebb, G.1    Autenrieth, I.B.2    Haber, H.3
  • 12
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik, M., de Moraes, M. L., Pontoux, C., Vasseur, F. and Penit, C. 1998. Regulatory CD4 T cells: Expression of IL-2R α chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 10:371.
    • (1998) Int. Immunol , vol.10 , pp. 371
    • Papiernik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 13
    • 0034965185 scopus 로고    scopus 로고
    • + T cells: Evidence for two distinct regulatory mechanisms
    • + T cells: Evidence for two distinct regulatory mechanisms. Eur. J. Immunol. 31:1637.
    • (2001) Eur. J. Immunol , vol.31 , pp. 1637
    • Wolf, M.1    Schimpl, A.2    Hunig, T.3
  • 14
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2
    • Malek, T. R., Yu, A., Vincek, V., Scibelli, P. and Kong, L. 2002. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17:167.
    • (2002) Immunity , vol.17 , pp. 167
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 17
    • 15444374646 scopus 로고    scopus 로고
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201:723.
    • (2005) J. Exp. Med , vol.201 , pp. 723
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 22
    • 14944386649 scopus 로고    scopus 로고
    • + T cells for IL-2 and exploit it for the induction of IL-10 production
    • + T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17:279.
    • (2005) Int. Immunol , vol.17 , pp. 279
    • Barthlott, T.1    Moncrieffe, H.2    Veldhoen, M.3
  • 24
    • 9644295710 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases: Critical roles of the γc-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways
    • Kovanen, P. E. and Leonard, W. J. 2004. Cytokines and immunodeficiency diseases: Critical roles of the γc-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol. Rev. 202:67.
    • (2004) Immunol. Rev , vol.202 , pp. 67
    • Kovanen, P.E.1    Leonard, W.J.2
  • 25
    • 0033491981 scopus 로고    scopus 로고
    • Biology of the interleukin-2 receptor
    • Nelson, B. H. and Willerford, D. M. 1998. Biology of the interleukin-2 receptor. Adv. Immunol. 70:1.
    • (1998) Adv. Immunol , vol.70 , pp. 1
    • Nelson, B.H.1    Willerford, D.M.2
  • 26
    • 0038813748 scopus 로고    scopus 로고
    • Analysis of γc-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling
    • Kovanen, P. E., Rosenwald, A., Fu, J. et al. 2003. Analysis of γc-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling. J. Biol. Chem. 278:5205.
    • (2003) J. Biol. Chem , vol.278 , pp. 5205
    • Kovanen, P.E.1    Rosenwald, A.2    Fu, J.3
  • 27
    • 0346366991 scopus 로고    scopus 로고
    • + T cells that require antigen-specific activation for suppression
    • + T cells that require antigen-specific activation for suppression. J. Immunol. 171:6431.
    • (2003) J. Immunol , vol.171 , pp. 6431
    • Koenen, H.J.1    Fasse, E.2    Joosten, I.3
  • 32
    • 33644508647 scopus 로고    scopus 로고
    • The dichotomous role of IL-2: Tolerance versus immunity
    • Fehervari, Z., Yamaguchi, T. and Sakaguchi, S. 2006. The dichotomous role of IL-2: Tolerance versus immunity. Trends Immunol. 27:109.
    • (2006) Trends Immunol , vol.27 , pp. 109
    • Fehervari, Z.1    Yamaguchi, T.2    Sakaguchi, S.3
  • 33
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot, J. D., Rasmussen, J. P., Gavin, M. A. and Rudensky, A. Y. 2005. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6:1142.
    • (2005) Nat. Immunol , vol.6 , pp. 1142
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 34
    • 27544446622 scopus 로고    scopus 로고
    • + regulatory T cells in the absence of interleukin 2 signaling
    • + regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6:1152.
    • (2005) Nat. Immunol , vol.6 , pp. 1152
    • D'Cruz, L.M.1    Klein, L.2
  • 36
    • 20444380391 scopus 로고    scopus 로고
    • + T regulatory cell-mediated suppression
    • + T regulatory cell-mediated suppression. J. Immunol. 174:7645.
    • (2005) J. Immunol , vol.174 , pp. 7645
    • Pace, L.1    Pioli, C.2    Doria, G.3
  • 37
    • 33644779794 scopus 로고    scopus 로고
    • + T-cells and is expressed by diabetes-suppressive dendritic cells
    • + T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes 55:158.
    • (2006) Diabetes , vol.55 , pp. 158
    • Harnaha, J.1    Machen, J.2    Wright, M.3
  • 40
    • 0036195161 scopus 로고    scopus 로고
    • + immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • + immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 16:311.
    • (2002) Immunity , vol.16 , pp. 311
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3
  • 41
    • 0037080219 scopus 로고    scopus 로고
    • IL-2 and related cytokines can promote T cell survival by activating AKT
    • Kelly, E., Won, A., Refaeli, Y. and Van Parijs, L. 2002. IL-2 and related cytokines can promote T cell survival by activating AKT. J. Immunol. 168:597.
    • (2002) J. Immunol , vol.168 , pp. 597
    • Kelly, E.1    Won, A.2    Refaeli, Y.3    Van Parijs, L.4
  • 43
    • 27644503683 scopus 로고    scopus 로고
    • + regulatory T cell lines from human cord blood have functional and molecular properties of T cell anergy
    • + regulatory T cell lines from human cord blood have functional and molecular properties of T cell anergy. Blood 106:3068.
    • (2005) Blood , vol.106 , pp. 3068
    • Li, L.1    Godfrey, W.R.2    Porter, S.B.3
  • 45
    • 0034331937 scopus 로고    scopus 로고
    • Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation
    • 1:428
    • Matsuda, S., Shibasaki, F., Takehana, K., Mori, H., Nishida, E. and Koyasu, S. 2000. Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. EMBO Rep. 1:428.
    • (2000) EMBO Rep
    • Matsuda, S.1    Shibasaki, F.2    Takehana, K.3    Mori, H.4    Nishida, E.5    Koyasu, S.6
  • 46
    • 0034045947 scopus 로고    scopus 로고
    • Mechanisms of action of cyclosporine
    • Matsuda, S. and Koyasu, S. 2000. Mechanisms of action of cyclosporine. Immunopharmacology 47:119.
    • (2000) Immunopharmacology , vol.47 , pp. 119
    • Matsuda, S.1    Koyasu, S.2
  • 47
    • 0031821875 scopus 로고    scopus 로고
    • + immuno-regulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • + immuno-regulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287.
    • (1998) J. Exp. Med , vol.188 , pp. 287
    • Thornton, A.M.1    Shevach, E.M.2
  • 48
    • 10744227089 scopus 로고    scopus 로고
    • Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases
    • Fujimoto, M., Tsutsui, H., Xinshou, O. et al. 2004. Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases. Int. Immunol. 16:303.
    • (2004) Int. Immunol , vol.16 , pp. 303
    • Fujimoto, M.1    Tsutsui, H.2    Xinshou, O.3
  • 49
    • 0031433362 scopus 로고    scopus 로고
    • An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction
    • Nakajima, H., Liu, X. W., Wynshaw-Boris, A. et al. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: A critical role for Stat5a in IL-2-mediated IL-2 receptor α chain induction. Immunity 7:691.
    • (1997) Immunity , vol.7 , pp. 691
    • Nakajima, H.1    Liu, X.W.2    Wynshaw-Boris, A.3
  • 50
    • 0034897188 scopus 로고    scopus 로고
    • The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: Importance of two widely separated IL-2 response elements
    • Kim, H. P., Kelly, J. and Leonard, W. J. 2001. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: Importance of two widely separated IL-2 response elements. Immunity 15:159.
    • (2001) Immunity , vol.15 , pp. 159
    • Kim, H.P.1    Kelly, J.2    Leonard, W.J.3
  • 51
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295.
    • (2000) J. Exp. Med , vol.192 , pp. 295
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 52
    • 0034679560 scopus 로고    scopus 로고
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303.
    • (2000) J. Exp. Med , vol.192 , pp. 303
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 54
    • 0034776158 scopus 로고    scopus 로고
    • Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells
    • Wang, X. B., Zheng, C. Y., Giscombe, R. and Lefvert, A. K. 2001. Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells. Scand. J. Immunol. 54:453.
    • (2001) Scand. J. Immunol , vol.54 , pp. 453
    • Wang, X.B.1    Zheng, C.Y.2    Giscombe, R.3    Lefvert, A.K.4
  • 55
  • 57
    • 0033846345 scopus 로고    scopus 로고
    • T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation
    • Perola, O., Ripatti, A. and Pelkonen, J. 2000. T-lymphocyte subpopulations do not express identical combinations of interleukin-2 receptor chains in the early phase of their activation and proliferation. Scand. J. Immunol. 52:123.
    • (2000) Scand. J. Immunol , vol.52 , pp. 123
    • Perola, O.1    Ripatti, A.2    Pelkonen, J.3
  • 61
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki, N., Santner-Nanan, B., Martinson, J. et al. 2006. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203:1693.
    • (2006) J. Exp. Med , vol.203 , pp. 1693
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3
  • 62
    • 33646874634 scopus 로고    scopus 로고
    • IL-7Rα gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes
    • Swainson, L., Verhoeyen, E., Cosset, F.-L. and Taylor, N. 2006. IL-7Rα gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes. J. Immunol. 176:6702.
    • (2006) J. Immunol , vol.176 , pp. 6702
    • Swainson, L.1    Verhoeyen, E.2    Cosset, F.-L.3    Taylor, N.4
  • 63
    • 0042834325 scopus 로고    scopus 로고
    • An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death
    • Schmitz, I., Krueger, A., Baumann, S., Schulze-Bergkamen, H., Krammer, P. H. and Kirchhoff, S. 2003. An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death. J. Immunol. 171:2930.
    • (2003) J. Immunol , vol.171 , pp. 2930
    • Schmitz, I.1    Krueger, A.2    Baumann, S.3    Schulze-Bergkamen, H.4    Krammer, P.H.5    Kirchhoff, S.6
  • 64
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
    • Waldmann, T. A., Dubois, S. and Tagaya, Y. 2001. Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy. Immunity 14:105.
    • (2001) Immunity , vol.14 , pp. 105
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 66
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • Yagi, H., Nomura, T., Nakamura, K. et al. 2004. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16:1643.
    • (2004) Int. Immunol , vol.16 , pp. 1643
    • Yagi, H.1    Nomura, T.2    Nakamura, K.3
  • 67
    • 1342303482 scopus 로고    scopus 로고
    • Of mice and not men: Differences between mouse and human immunology
    • Mestas, J. and Hughes, C. C. 2004. Of mice and not men: Differences between mouse and human immunology. J. Immunol. 172:2731.
    • (2004) J. Immunol , vol.172 , pp. 2731
    • Mestas, J.1    Hughes, C.C.2
  • 68
    • 0037313473 scopus 로고    scopus 로고
    • The complementary roles of deletion and regulation in transplantation tolerance
    • Lechler, R., Garden, O. and Turka, L. 2003. The complementary roles of deletion and regulation in transplantation tolerance. Nat. Rev. Immunol. 3:147.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 147
    • Lechler, R.1    Garden, O.2    Turka, L.3
  • 69
    • 0041806547 scopus 로고    scopus 로고
    • In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro
    • Klein, L., Khazaie, K. and von Boehmer, H. 2003. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl Acad. Sci. USA 100:8886.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8886
    • Klein, L.1    Khazaie, K.2    von Boehmer, H.3
  • 70
    • 33646007658 scopus 로고    scopus 로고
    • Interleukin-2-dependent mechanisms of tolerance and immunity in vivo
    • Antony, P. A., Paulos, C. M., Ahmadzadeh, M. et al. 2006. Interleukin-2-dependent mechanisms of tolerance and immunity in vivo. J. Immunol. 176:5255.
    • (2006) J. Immunol , vol.176 , pp. 5255
    • Antony, P.A.1    Paulos, C.M.2    Ahmadzadeh, M.3
  • 72
    • 33846283803 scopus 로고    scopus 로고
    • Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    • Hartigan-O'Connor, D. J., Poon, C., Sinclair, E. and McCune, J. M. 2006. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J. Immunol. Methods 319:41.
    • (2006) J. Immunol. Methods , vol.319 , pp. 41
    • Hartigan-O'Connor, D.J.1    Poon, C.2    Sinclair, E.3    McCune, J.M.4
  • 73
    • 1342345915 scopus 로고    scopus 로고
    • CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells
    • Zheng, Y., Manzotti, C. N., Liu, M., Burke, F., Mead, K. I. and Sansom, D. M. 2004. CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells. J. Immunol. 172:2778.
    • (2004) J. Immunol , vol.172 , pp. 2778
    • Zheng, Y.1    Manzotti, C.N.2    Liu, M.3    Burke, F.4    Mead, K.I.5    Sansom, D.M.6
  • 74
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori, S., Nomura, T. and Sakaguchi, S. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057.
    • (2003) Science , vol.299 , pp. 1057
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 76
    • 33646240855 scopus 로고    scopus 로고
    • Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    • Gavin, M. A., Torgerson, T. R., Houston, E. et al. 2006. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc. Natl Acad. Sci. USA 103:6659.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 6659
    • Gavin, M.A.1    Torgerson, T.R.2    Houston, E.3
  • 78
    • 33747801470 scopus 로고    scopus 로고
    • + regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo. Blood.
    • + regulatory T cells through a STAT dependent mechanism and induces the expansion of these cells in vivo. Blood.
  • 79
    • 33646168597 scopus 로고    scopus 로고
    • FOXP3: Of mice and men
    • Ziegler, S. F. 2006. FOXP3: Of mice and men. Annu. Rev. Immunol. 24:209.
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 209
    • Ziegler, S.F.1
  • 81
    • 0032500730 scopus 로고    scopus 로고
    • Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
    • Bondeva, T., Pirola, L., Bulgarelli-Leva, G., Rubio, I., Wetzker, R. and Wymann, M. P. 1998. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK. Science 282:293.
    • (1998) Science , vol.282 , pp. 293
    • Bondeva, T.1    Pirola, L.2    Bulgarelli-Leva, G.3    Rubio, I.4    Wetzker, R.5    Wymann, M.P.6
  • 82
    • 1542409971 scopus 로고    scopus 로고
    • A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation
    • Lali, F. V., Crawley, J., McCulloch, D. A. and Foxwell, B. M. 2004. A late, prolonged activation of the phosphatidylinositol 3-kinase pathway is required for T cell proliferation. J. Immunol. 172:3527.
    • (2004) J. Immunol , vol.172 , pp. 3527
    • Lali, F.V.1    Crawley, J.2    McCulloch, D.A.3    Foxwell, B.M.4
  • 83
    • 1242272047 scopus 로고    scopus 로고
    • A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
    • Moon, J. J., Rubio, E. D., Martino, A., Krumm, A. and Nelson, B. H. 2004. A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor. J. Biol. Chem. 279:5520.
    • (2004) J. Biol. Chem , vol.279 , pp. 5520
    • Moon, J.J.1    Rubio, E.D.2    Martino, A.3    Krumm, A.4    Nelson, B.H.5


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