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Volumn 13, Issue 1, 2014, Pages 3-10

Innate and adaptive immunity in inflammatory bowel disease

Author keywords

Autophagy; Cytokines; Innate lymphoid cell; T cell

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; MUCIN 2; MUCIN 3; MUCIN 4; MUCIN 5B; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; POLYPEPTIDE ANTIBIOTIC AGENT; SECUKINUMAB;

EID: 84886951561     PISSN: 15689972     EISSN: 18730183     Source Type: Journal    
DOI: 10.1016/j.autrev.2013.06.004     Document Type: Review
Times cited : (757)

References (106)
  • 1
    • 33744804299 scopus 로고    scopus 로고
    • Metagenomic analysis of the human distal gut microbiome
    • Gill S.R., Pop M., Deboy R.T., et al. Metagenomic analysis of the human distal gut microbiome. Science 2006, 312:1355-1359.
    • (2006) Science , vol.312 , pp. 1355-1359
    • Gill, S.R.1    Pop, M.2    Deboy, R.T.3
  • 2
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
    • Loftus E.V. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004, 126:1504-1517.
    • (2004) Gastroenterology , vol.126 , pp. 1504-1517
    • Loftus, E.V.1
  • 3
    • 0035044890 scopus 로고    scopus 로고
    • The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study
    • Bernstein C.N., Blanchard J.F., Rawsthorne P., Yu N. The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol 2001, 96:1116-1122.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1116-1122
    • Bernstein, C.N.1    Blanchard, J.F.2    Rawsthorne, P.3    Yu, N.4
  • 4
    • 24144497765 scopus 로고    scopus 로고
    • The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study
    • Bernstein C.N., Wajda A., Blanchard J.F. The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterology 2005, 129:827-836.
    • (2005) Gastroenterology , vol.129 , pp. 827-836
    • Bernstein, C.N.1    Wajda, A.2    Blanchard, J.F.3
  • 5
    • 34248136340 scopus 로고    scopus 로고
    • Inflammatory bowel disease: clinical aspects and established and evolving therapies
    • Baumgart D.C., Sandborn W.J. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007, 369:1641-1657.
    • (2007) Lancet , vol.369 , pp. 1641-1657
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 6
    • 0030209985 scopus 로고    scopus 로고
    • Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • Fuss I.J., Neurath M., Boirivant M., Klein J.S., de la Motte C., Strong S.A., et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996, 157:1261-1270.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1    Neurath, M.2    Boirivant, M.3    Klein, J.S.4    de la Motte, C.5    Strong, S.A.6
  • 7
    • 84858066817 scopus 로고    scopus 로고
    • The IL-23/IL-17 pathway in inflammatory bowel disease
    • Geremia A., Jewell D.P. The IL-23/IL-17 pathway in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol 2012, 6:223-237.
    • (2012) Expert Rev Gastroenterol Hepatol , vol.6 , pp. 223-237
    • Geremia, A.1    Jewell, D.P.2
  • 9
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficient in the mucin Muc2
    • Velcich A., Yang W., Heyer J., Fragale A., Nicholas C., Viani S., et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 2002, 295:1726-1729.
    • (2002) Science , vol.295 , pp. 1726-1729
    • Velcich, A.1    Yang, W.2    Heyer, J.3    Fragale, A.4    Nicholas, C.5    Viani, S.6
  • 11
    • 78650096816 scopus 로고    scopus 로고
    • Importance of disrupted intestinal barrier in inflammatory bowel diseases
    • Salim S.Y., Soderholm J.D. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis 2011, 17:362-381.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 362-381
    • Salim, S.Y.1    Soderholm, J.D.2
  • 12
    • 70649103789 scopus 로고    scopus 로고
    • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
    • Barrett J.C., Lee J.C., Lees C.W., et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet 2009, 41:1330-1334.
    • (2009) Nat Genet , vol.41 , pp. 1330-1334
    • Barrett, J.C.1    Lee, J.C.2    Lees, C.W.3
  • 13
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson C.A., Boucher G., Lees C.W., et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011, 43:246-252.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3
  • 14
    • 34247239745 scopus 로고    scopus 로고
    • Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
    • Uehara A., Fujimoto Y., Fukase K., Takada H. Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol 2007, 44:3100-3111.
    • (2007) Mol Immunol , vol.44 , pp. 3100-3111
    • Uehara, A.1    Fujimoto, Y.2    Fukase, K.3    Takada, H.4
  • 15
    • 0142026070 scopus 로고    scopus 로고
    • Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis
    • Wehkamp J., Harder J., Weichenthal M., et al. Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 2003, 9:215-223.
    • (2003) Inflamm Bowel Dis , vol.9 , pp. 215-223
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 16
    • 29144483937 scopus 로고    scopus 로고
    • Reduced Paneth cell alpha-defensins in ileal Crohn's disease
    • Wehkamp J., Salzman N.H., Porter E., et al. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A 2005, 102:18129-18134.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18129-18134
    • Wehkamp, J.1    Salzman, N.H.2    Porter, E.3
  • 17
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp J., Harder J., Weichenthal M., et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 2004, 53:1658-1664.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 18
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 19
    • 80052140148 scopus 로고    scopus 로고
    • Intracellular sensors of extracellular bacteria
    • Clarke T.B., Weiser J.N. Intracellular sensors of extracellular bacteria. Immunol Rev 2011, 243:9-25.
    • (2011) Immunol Rev , vol.243 , pp. 9-25
    • Clarke, T.B.1    Weiser, J.N.2
  • 20
    • 66749174867 scopus 로고    scopus 로고
    • The inflammasomes: guardians of the body
    • Martinon F., Mayor A., Tschopp J. The inflammasomes: guardians of the body. Annu Rev Immunol 2009, 27:229-265.
    • (2009) Annu Rev Immunol , vol.27 , pp. 229-265
    • Martinon, F.1    Mayor, A.2    Tschopp, J.3
  • 21
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J.P., Chamaillard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 22
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y., Bonen D.K., Inohara N., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001, 411(6837):603-606.
    • (2001) Nature , vol.411 , Issue.6837 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 23
    • 11144279151 scopus 로고    scopus 로고
    • Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis
    • Economou M., Trikalinos T.A., Loizou K.T., Tsianos E., Ioannidis J.P. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol 2004, 99:2393-2404.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2393-2404
    • Economou, M.1    Trikalinos, T.A.2    Loizou, K.T.3    Tsianos, E.4    Ioannidis, J.P.5
  • 24
    • 0036373539 scopus 로고    scopus 로고
    • Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease
    • Yamazaki K., Takazoe M., Tanaka T., Kazumori T., Nakamura Y. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet 2002, 47:469-472.
    • (2002) J Hum Genet , vol.47 , pp. 469-472
    • Yamazaki, K.1    Takazoe, M.2    Tanaka, T.3    Kazumori, T.4    Nakamura, Y.5
  • 25
    • 21844440348 scopus 로고    scopus 로고
    • Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease
    • Kugathasan S., Loizides A., Babusukumar U., et al. Comparative phenotypic and CARD15 mutational analysis among African American, Hispanic, and White children with Crohn's disease. Inflamm Bowel Dis 2005, 11:631-638.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 631-638
    • Kugathasan, S.1    Loizides, A.2    Babusukumar, U.3
  • 26
    • 33745536739 scopus 로고    scopus 로고
    • Functional consequences of NOD2 (CARD15) mutations
    • Abraham C., Cho J.H. Functional consequences of NOD2 (CARD15) mutations. Inflamm Bowel Dis 2006, 12:641-650.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 641-650
    • Abraham, C.1    Cho, J.H.2
  • 27
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • Watanabe T., Kitani A., Murray P.J., Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004, 5:800-808.
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Strober, W.4
  • 28
    • 65249115914 scopus 로고    scopus 로고
    • A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
    • Noguchi E., Homma Y., Kang X., Netea M.G., Ma X. A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol 2009, 10:471-479.
    • (2009) Nat Immunol , vol.10 , pp. 471-479
    • Noguchi, E.1    Homma, Y.2    Kang, X.3    Netea, M.G.4    Ma, X.5
  • 29
    • 74049127960 scopus 로고    scopus 로고
    • Genomewide association study of leprosy
    • Zhang F.R., Huang W., Chen S.M., et al. Genomewide association study of leprosy. N Engl J Med 2009, 361:2609-2618.
    • (2009) N Engl J Med , vol.361 , pp. 2609-2618
    • Zhang, F.R.1    Huang, W.2    Chen, S.M.3
  • 30
    • 34249317564 scopus 로고    scopus 로고
    • NOD2/CARD15 disease associations other than Crohn's disease
    • Henckaerts L., Vermeire S. NOD2/CARD15 disease associations other than Crohn's disease. Inflamm Bowel Dis 2007, 13:235-241.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 235-241
    • Henckaerts, L.1    Vermeire, S.2
  • 31
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J., Franke A., Rosenstiel P., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007, 39:207-211.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3
  • 32
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M., Barrett J.C., Prescott N.J., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007, 39:830-832.
    • (2007) Nat Genet , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 34
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R., Baker J., Brain O., et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010, 16:90-97.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 35
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos L.H., Carneiro L.A., Ramjeet M., et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010, 11:55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 36
    • 79955555098 scopus 로고    scopus 로고
    • Autophagy, microbial sensing, endoplasmic reticulum stress and epithelial function in inflammatory bowel disease
    • Kaser A., Blumberg R.S. Autophagy, microbial sensing, endoplasmic reticulum stress and epithelial function in inflammatory bowel disease. Gastroenterology 2011, 140:1738-1747.
    • (2011) Gastroenterology , vol.140 , pp. 1738-1747
    • Kaser, A.1    Blumberg, R.S.2
  • 37
    • 3042657319 scopus 로고    scopus 로고
    • Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis
    • Vermeire S., Rutgeerts P., Van Steen K., et al. Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. Gut 2004, 53:980-986.
    • (2004) Gut , vol.53 , pp. 980-986
    • Vermeire, S.1    Rutgeerts, P.2    Van Steen, K.3
  • 38
    • 0346656707 scopus 로고    scopus 로고
    • A genome scan in 260 inflammatory bowel disease-affected relative pairs
    • Barmada M.M., Brant S.R., Nicolae D.L., et al. A genome scan in 260 inflammatory bowel disease-affected relative pairs. Inflamm Bowel Dis 2004, 10:513-520.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 513-520
    • Barmada, M.M.1    Brant, S.R.2    Nicolae, D.L.3
  • 39
    • 0033358425 scopus 로고    scopus 로고
    • A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
    • Hampe J., Schreiber S., Shaw S.H., et al. A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet 1999, 64:808-816.
    • (1999) Am J Hum Genet , vol.64 , pp. 808-816
    • Hampe, J.1    Schreiber, S.2    Shaw, S.H.3
  • 40
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser A., Lee A.H., Franke A., et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008, 134:743-756.
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1    Lee, A.H.2    Franke, A.3
  • 41
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R.H., Taylor K.D., Brant S.R., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006, 314:1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 42
    • 33846608131 scopus 로고    scopus 로고
    • A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    • Cargill M., Schrodi S.J., Chang M., et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am J Hum Genet 2007, 80:273-290.
    • (2007) Am J Hum Genet , vol.80 , pp. 273-290
    • Cargill, M.1    Schrodi, S.J.2    Chang, M.3
  • 43
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Burton P.R., Clayton D.G., Cardon L.R., et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 2007, 39:1329-1337.
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
    • Burton, P.R.1    Clayton, D.G.2    Cardon, L.R.3
  • 44
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett J.C., Hansoul S., Nicolae D.L., et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008, 40:955-962.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 45
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher S.A., Tremelling M., Anderson C.A., et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet 2008, 40:710-712.
    • (2008) Nat Genet , vol.40 , pp. 710-712
    • Fisher, S.A.1    Tremelling, M.2    Anderson, C.A.3
  • 46
    • 44349173654 scopus 로고    scopus 로고
    • Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
    • Franke A., Balschun T., Karlsen T.H., et al. Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. Nat Genet 2008, 40:713-715.
    • (2008) Nat Genet , vol.40 , pp. 713-715
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 47
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: the sentinels of the immune system
    • Cua D.J., Tato C.M. Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol 2010, 10:479-489.
    • (2010) Nat Rev Immunol , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 48
    • 60549102720 scopus 로고    scopus 로고
    • Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    • Takatori H., Kanno Y., Watford W.T., et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 2009, 206:35-41.
    • (2009) J Exp Med , vol.206 , pp. 35-41
    • Takatori, H.1    Kanno, Y.2    Watford, W.T.3
  • 49
    • 59649099774 scopus 로고    scopus 로고
    • A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    • Cella M., Fuchs A., Vermi W., et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 2009, 457:722-725.
    • (2009) Nature , vol.457 , pp. 722-725
    • Cella, M.1    Fuchs, A.2    Vermi, W.3
  • 50
    • 77149135298 scopus 로고    scopus 로고
    • Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells
    • Crellin N.K., Trifari S., Kaplan C.D., Cupedo T., Spits H. Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+lineage distinct from conventional natural killer cells. J Exp Med 2010, 207:281-290.
    • (2010) J Exp Med , vol.207 , pp. 281-290
    • Crellin, N.K.1    Trifari, S.2    Kaplan, C.D.3    Cupedo, T.4    Spits, H.5
  • 51
    • 77149155687 scopus 로고    scopus 로고
    • IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors
    • Satoh-Takayama N., Lesjean-Pottier S., Vieira P., et al. IL-7 and IL-15 independently program the differentiation of intestinal CD3-NKp46+ cell subsets from Id2-dependent precursors. J Exp Med 2010, 207:273-280.
    • (2010) J Exp Med , vol.207 , pp. 273-280
    • Satoh-Takayama, N.1    Lesjean-Pottier, S.2    Vieira, P.3
  • 52
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore S., Ahern P.P., Uhlig H.H., et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 2010, 464:1371-1375.
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1    Ahern, P.P.2    Uhlig, H.H.3
  • 53
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia A., Arancibia-Cárcamo C.V., Fleming M.P., et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. J Exp Med 2011, 208:1127-1133.
    • (2011) J Exp Med , vol.208 , pp. 1127-1133
    • Geremia, A.1    Arancibia-Cárcamo, C.V.2    Fleming, M.P.3
  • 54
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994, 12:227-257.
    • (1994) Annu Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 56
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky D.K. Inflammatory bowel disease. N Engl J Med 2002, 347:417-429.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 57
    • 0033168120 scopus 로고    scopus 로고
    • Bioactive IL-18 expression is up-regulated in Crohn's disease
    • Monteleone G., Trapasso F., Parrello T., et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J Immunol 1999, 163:143-147.
    • (1999) J Immunol , vol.163 , pp. 143-147
    • Monteleone, G.1    Trapasso, F.2    Parrello, T.3
  • 58
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G., Biancone L., Marasco R., et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997, 112:1169-1178.
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 59
    • 0027441514 scopus 로고
    • Intereukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • Breese E., Braegger C.P., Corrigan C.J., Walker-Smith J.A., MacDonald T.T. Intereukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993, 78:127-131.
    • (1993) Immunology , vol.78 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3    Walker-Smith, J.A.4    MacDonald, T.T.5
  • 60
    • 0028787818 scopus 로고
    • Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease
    • [Suppl.]
    • Noguchi M., Hiwatashi N., Liu Z., Toyota T. Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease. J Gastroenterol 1995, 8:52-55. [Suppl.].
    • (1995) J Gastroenterol , vol.8 , pp. 52-55
    • Noguchi, M.1    Hiwatashi, N.2    Liu, Z.3    Toyota, T.4
  • 62
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F., Florian P., Bojarski C., et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005, 129:550-564.
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 63
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • Fuss I.J., Heller F., Boirivant M., et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004, 113:1490-1497.
    • (2004) J Clin Invest , vol.113 , pp. 1490-1497
    • Fuss, I.J.1    Heller, F.2    Boirivant, M.3
  • 65
    • 72549107316 scopus 로고    scopus 로고
    • Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease
    • Rovedatti L., Kudo T., Biancheri P., et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut 2009, 58:1629-1636.
    • (2009) Gut , vol.58 , pp. 1629-1636
    • Rovedatti, L.1    Kudo, T.2    Biancheri, P.3
  • 66
    • 0033790206 scopus 로고    scopus 로고
    • Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease
    • Vainer B., Nielsen O.H., Hendel J., Horn T., Kirman I. Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease. Cytokine 2000, 12:1531-1536.
    • (2000) Cytokine , vol.12 , pp. 1531-1536
    • Vainer, B.1    Nielsen, O.H.2    Hendel, J.3    Horn, T.4    Kirman, I.5
  • 67
    • 4644345071 scopus 로고    scopus 로고
    • Intestinal interleukin-13 in pediatric inflammatory bowel disease patients
    • Kadivar K., Ruchelli E.D., Markowitz J.E., et al. Intestinal interleukin-13 in pediatric inflammatory bowel disease patients. Inflamm Bowel Dis 2004, 10:593-598.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 593-598
    • Kadivar, K.1    Ruchelli, E.D.2    Markowitz, J.E.3
  • 68
    • 78649829431 scopus 로고    scopus 로고
    • Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity
    • Wilson M.S., Ramalingam T.R., Rivollier A., et al. Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology 2011, 140:254-264.
    • (2011) Gastroenterology , vol.140 , pp. 254-264
    • Wilson, M.S.1    Ramalingam, T.R.2    Rivollier, A.3
  • 69
    • 84860333121 scopus 로고    scopus 로고
    • IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and T cells they stimulate
    • Bernardo D., Vallejo-Díez S., Mann E.R., et al. IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and T cells they stimulate. Eur J Immunol 2012, 42:1337-1353.
    • (2012) Eur J Immunol , vol.42 , pp. 1337-1353
    • Bernardo, D.1    Vallejo-Díez, S.2    Mann, E.R.3
  • 70
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., Ivanov I.I., Spolski R., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8:967-974.
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3
  • 72
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005, 6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 73
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17
    • Annunziato F., Cosmi L., Santarlasci V., et al. Phenotypic and functional features of human Th17. J Exp Med 2007, 204:1849-1861.
    • (2007) J Exp Med , vol.204 , pp. 1849-1861
    • Annunziato, F.1    Cosmi, L.2    Santarlasci, V.3
  • 74
    • 56549104968 scopus 로고    scopus 로고
    • IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease
    • Kobayashi T., Okamoto S., Hisamatsu T., et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut 2008, 57:1682-1689.
    • (2008) Gut , vol.57 , pp. 1682-1689
    • Kobayashi, T.1    Okamoto, S.2    Hisamatsu, T.3
  • 75
    • 77952222918 scopus 로고    scopus 로고
    • The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease
    • Sugihara T., Kobori A., Imaeda H., et al. The increased mucosal mRNA expressions of complement C3 and interleukin-17 in inflammatory bowel disease. Clin Exp Immunol 2010, 160:386-393.
    • (2010) Clin Exp Immunol , vol.160 , pp. 386-393
    • Sugihara, T.1    Kobori, A.2    Imaeda, H.3
  • 76
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S., Andoh A., Bamba S., et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003, 52:65-70.
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 77
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    • Monteleone G., Monteleone I., Fina D., et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 2005, 128:687-694.
    • (2005) Gastroenterology , vol.128 , pp. 687-694
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3
  • 78
    • 77954422428 scopus 로고    scopus 로고
    • Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases
    • Sarra M., Monteleone I., Stolfi C., et al. Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. Inflamm Bowel Dis 2010, 16:1332-1339.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1332-1339
    • Sarra, M.1    Monteleone, I.2    Stolfi, C.3
  • 79
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and Th17 cell response by interleukin-21
    • Fina D., Sarra M., Fantini M.C., et al. Regulation of gut inflammation and Th17 cell response by interleukin-21. Gastroenterology 2008, 134:1038-1048.
    • (2008) Gastroenterology , vol.134 , pp. 1038-1048
    • Fina, D.1    Sarra, M.2    Fantini, M.C.3
  • 80
    • 4043052238 scopus 로고    scopus 로고
    • Regulatory T cells and mechanisms of immune system control
    • O'Garra A., Vieira P. Regulatory T cells and mechanisms of immune system control. Nat Med 2004, 10:801-805.
    • (2004) Nat Med , vol.10 , pp. 801-805
    • O'Garra, A.1    Vieira, P.2
  • 82
    • 33646251141 scopus 로고    scopus 로고
    • Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
    • Fantini M.C., Becker C., Tubbe I., et al. Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 2006, 55:671-680.
    • (2006) Gut , vol.55 , pp. 671-680
    • Fantini, M.C.1    Becker, C.2    Tubbe, I.3
  • 83
    • 0035180067 scopus 로고    scopus 로고
    • Control of intestinal inflammation by regulatory T cells
    • Singh B., Read S., Asseman C., et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev 2001, 182:190-200.
    • (2001) Immunol Rev , vol.182 , pp. 190-200
    • Singh, B.1    Read, S.2    Asseman, C.3
  • 84
    • 70149087732 scopus 로고    scopus 로고
    • Diminution of circulating CD4+CD25 high T cells in naïve Crohn's disease
    • Chamouard P., Monneaux F., Richert Z., et al. Diminution of circulating CD4+CD25 high T cells in naïve Crohn's disease. Dig Dis Sci 2009, 54:2084-2093.
    • (2009) Dig Dis Sci , vol.54 , pp. 2084-2093
    • Chamouard, P.1    Monneaux, F.2    Richert, Z.3
  • 85
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
    • Maul J., Loddenkemper C., Mundt P., et al. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 2005, 128:1868-1878.
    • (2005) Gastroenterology , vol.128 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3
  • 86
    • 36249014365 scopus 로고    scopus 로고
    • Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease
    • Saruta M., Yu Q.T., Fleshner P.R., et al. Characterization of FOXP3+CD4+ regulatory T cells in Crohn's disease. Clin Immunol 2007, 125:281-290.
    • (2007) Clin Immunol , vol.125 , pp. 281-290
    • Saruta, M.1    Yu, Q.T.2    Fleshner, P.R.3
  • 87
    • 77249137663 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells Th17 effector cells, and cytokine environment in inflammatory bowel disease
    • Eastaff-Leung N., Mabarrack N., Barbour A., Cummins A., Barry S. Foxp3+ regulatory T cells Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol 2010, 30:80-89.
    • (2010) J Clin Immunol , vol.30 , pp. 80-89
    • Eastaff-Leung, N.1    Mabarrack, N.2    Barbour, A.3    Cummins, A.4    Barry, S.5
  • 89
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-β escape control by CD4(+)CD25(+) regulatory T cells
    • Fahlen L., Read S., Gorelik L., et al. T cells that cannot respond to TGF-β escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005, 201:737-746.
    • (2005) J Exp Med , vol.201 , pp. 737-746
    • Fahlen, L.1    Read, S.2    Gorelik, L.3
  • 90
    • 62949223226 scopus 로고    scopus 로고
    • Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
    • Fantini M.C., Rizzo A., Fina D., et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009, 136:1308-1316.
    • (2009) Gastroenterology , vol.136 , pp. 1308-1316
    • Fantini, M.C.1    Rizzo, A.2    Fina, D.3
  • 92
    • 0029814859 scopus 로고    scopus 로고
    • Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation
    • Pender S.L., Lionetti P., Murch S.H., Wathan N., MacDonald T.T. Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation. Gut 1996, 39:284-290.
    • (1996) Gut , vol.39 , pp. 284-290
    • Pender, S.L.1    Lionetti, P.2    Murch, S.H.3    Wathan, N.4    MacDonald, T.T.5
  • 93
    • 70349232511 scopus 로고    scopus 로고
    • Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits Th1 cytokine production and T-box transcription factor T-bet in inflammatory bowel disease
    • Di Sabatino A., Rovedatti L., Kaur R., et al. Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits Th1 cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol 2009, 183:3454-3462.
    • (2009) J Immunol , vol.183 , pp. 3454-3462
    • Di Sabatino, A.1    Rovedatti, L.2    Kaur, R.3
  • 94
    • 84860390304 scopus 로고    scopus 로고
    • The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease
    • Di Sabatino A., Battista N., Biancheri P., et al. The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunol 2011, 4:574-583.
    • (2011) Mucosal Immunol , vol.4 , pp. 574-583
    • Di Sabatino, A.1    Battista, N.2    Biancheri, P.3
  • 97
    • 0034666165 scopus 로고    scopus 로고
    • Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement
    • Ceponis P.J., Botelho F., Richards C.D., McKay D.M. Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement. J Biol Chem 2000, 275:29132-29137.
    • (2000) J Biol Chem , vol.275 , pp. 29132-29137
    • Ceponis, P.J.1    Botelho, F.2    Richards, C.D.3    McKay, D.M.4
  • 98
    • 27744551342 scopus 로고    scopus 로고
    • Inflammatory processed have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    • Prasad S., Mingrino R., Kaukinen K., et al. Inflammatory processed have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest 2005, 85:1139-1162.
    • (2005) Lab Invest , vol.85 , pp. 1139-1162
    • Prasad, S.1    Mingrino, R.2    Kaukinen, K.3
  • 99
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    • Heller F., Fuss I.J., Nieuwenhuis E.E., Blumberg R.S., Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 2002, 17:629-638.
    • (2002) Immunity , vol.17 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3    Blumberg, R.S.4    Strober, W.5
  • 100
    • 0033136695 scopus 로고    scopus 로고
    • NF-kappa B-inducing kinase is a common mediator of IL-17-, TNFalpha-, and IL-1beta-induced chemokine promoter activation in intestinal epithelial cells
    • Awane M., Andres P.G., Li D.J., Reinecker H.C. NF-kappa B-inducing kinase is a common mediator of IL-17-, TNFalpha-, and IL-1beta-induced chemokine promoter activation in intestinal epithelial cells. J Immunol 1999, 162:5337-5344.
    • (1999) J Immunol , vol.162 , pp. 5337-5344
    • Awane, M.1    Andres, P.G.2    Li, D.J.3    Reinecker, H.C.4
  • 101
    • 5644277476 scopus 로고    scopus 로고
    • IL-17 family members and inflammation
    • Kolls J.K., Linden A. IL-17 family members and inflammation. Immunity 2004, 21:467-476.
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 102
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
    • Hueber W., Sands B.E., Lewitzky S., et al. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 2012, 61:1693-1700.
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3
  • 103
    • 78149341767 scopus 로고    scopus 로고
    • Inside the microbial and immune labyrinth: totally gutted
    • Macdonald T.T. Inside the microbial and immune labyrinth: totally gutted. Nat Med 2010, 16:1194-1195.
    • (2010) Nat Med , vol.16 , pp. 1194-1195
    • Macdonald, T.T.1
  • 104
    • 82655168813 scopus 로고    scopus 로고
    • New knowledge in genetics and inflammatory bowel disease. Are there any practical applications?]
    • Iborra M., Beltrán B., Nos P. New knowledge in genetics and inflammatory bowel disease. Are there any practical applications?]. Gastroenterol Hepatol 2011, 34:591-598.
    • (2011) Gastroenterol Hepatol , vol.34 , pp. 591-598
    • Iborra, M.1    Beltrán, B.2    Nos, P.3
  • 105
    • 84864385195 scopus 로고    scopus 로고
    • Updated assessment of the prevalence, spectrum and case definition of autoimmune disease
    • Hayter S.M., Cook M.C. Updated assessment of the prevalence, spectrum and case definition of autoimmune disease. Autoimmun Rev 2012, 11:754-765.
    • (2012) Autoimmun Rev , vol.11 , pp. 754-765
    • Hayter, S.M.1    Cook, M.C.2


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