-
1
-
-
77955635233
-
Cancer statistics 2010
-
Jemal, A., Siegel, R., Xu, J. & Ward, E. Cancer statistics, 2010. CA Cancer J. Clin. 60, 277-300 (2010).
-
(2010)
CA Cancer J. Clin
, vol.60
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
2
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428-435 (2008).
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
3
-
-
0022891340
-
Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
-
Dvorak, H. F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650-1659 (1986).
-
(1986)
N. Engl. J. Med
, vol.315
, pp. 1650-1659
-
-
Dvorak, H.F.1
-
4
-
-
84965199448
-
An address on the value of pathological experiments
-
This is the first account of inflammatory processes that accompany cancer development in tissues
-
Virchow, R. An address on the value of pathological experiments. Br. Med. J. 2, 198-203 (1881). This is the first account of inflammatory processes that accompany cancer development in tissues.
-
(1881)
Br. Med. J
, vol.2
, pp. 198-203
-
-
Virchow, R.1
-
5
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
0033831517
-
Infections as a major preventable cause of human cancer
-
Kuper, H., Adami, H. O. & Trichopoulos, D. Infections as a major preventable cause of human cancer. J. Intern. Med. 248, 171-183 (2000).
-
(2000)
J. Intern. Med
, vol.248
, pp. 171-183
-
-
Kuper, H.1
Adami, H.O.2
Trichopoulos, D.3
-
7
-
-
84868613705
-
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
-
This paper shows a role for products derived from the commensal microbiota in tumour-induced inflammation and tumour promotion.
-
Grivennikov, S. I. et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 491, 254-258 (2012). This paper shows a role for products derived from the commensal microbiota in tumour-induced inflammation and tumour promotion.
-
(2012)
Nature
, vol.491
, pp. 254-258
-
-
Grivennikov, S.I.1
-
8
-
-
80053079336
-
Polyamine catabolism contributes to enterotoxigenic bacteroides fragilis-induced colon tumorigenesis
-
Goodwin, A. C. et al. Polyamine catabolism contributes to enterotoxigenic bacteroides fragilis-induced colon tumorigenesis. Proc. Natl Acad. Sci. USA 108, 15354-15359 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 15354-15359
-
-
Goodwin, A.C.1
-
9
-
-
78651564013
-
The association of streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role
-
Abdulamir, A. S., Hafidh, R. R. & Abu Bakar, F. The association of streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role. J. Exp. Clin. Cancer Res. 30, 11 (2011).
-
(2011)
J. Exp. Clin. Cancer Res
, vol.30
, pp. 11
-
-
Abdulamir, A.S.1
Hafidh, R.R.2
Abu Bakar, F.3
-
10
-
-
84867192879
-
Intestinal inflammation targets cancer-inducing activity of the microbiota
-
This article shows the genotoxic and tumour-promoting potential of a pathobiont of the commensal microflora that blooms under inflammatory conditions.
-
Arthur, J. C. et al. Intestinal inflammation targets cancer-inducing activity of the microbiota. Science 338, 120-123 (2012). This article shows the genotoxic and tumour-promoting potential of a pathobiont of the commensal microflora that blooms under inflammatory conditions.
-
(2012)
Science
, vol.338
, pp. 120-123
-
-
Arthur, J.C.1
-
11
-
-
34047174559
-
A module of negative feedback regulators defines growth factor signaling
-
Amit, I. et al. A module of negative feedback regulators defines growth factor signaling. Nature Genet. 39, 503-512 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 503-512
-
-
Amit, I.1
-
12
-
-
54549102284
-
Derailed endocytosis: An emerging feature of cancer
-
Mosesson, Y., Mills, G. B. & Yarden, Y. Derailed endocytosis: An emerging feature of cancer. Nature Rev. Cancer 8, 835-850 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 835-850
-
-
Mosesson, Y.1
Mills, G.B.2
Yarden, Y.3
-
13
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson, T. R. et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 487, 505-509 (2012).
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
-
14
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman, R. et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 487, 500-504 (2012).
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
-
15
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
Prahallad, A. et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483, 100-103 (2012).
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
-
16
-
-
84861520898
-
Spatial regulation of receptor tyrosine kinases in development and cancer
-
Casaletto, J. B. & McClatchey, A. I. Spatial regulation of receptor tyrosine kinases in development and cancer. Nature Rev. Cancer 12, 387-400 (2012).
-
(2012)
Nature Rev. Cancer
, vol.12
, pp. 387-400
-
-
Casaletto, J.B.1
McClatchey, A.I.2
-
17
-
-
79953761842
-
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
-
Fukuda, A. et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 19, 441-455 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 441-455
-
-
Fukuda, A.1
-
18
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina, M. et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 19, 456-469 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
-
19
-
-
58649101347
-
Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath, J. et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15, 91-102 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
-
20
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
-
21
-
-
58349115660
-
Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo
-
Bronte-Tinkew, D. M. et al. Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. Cancer Res. 69, 632-639 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 632-639
-
-
Bronte-Tinkew, D.M.1
-
22
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
Gao, S. P. et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J. Clin. Invest. 117, 3846-3856 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 3846-3856
-
-
Gao, S.P.1
-
23
-
-
84869758362
-
Interleukin-6 - A key regulator of colorectal cancer development
-
Waldner, M. J., Foersch, S. & Neurath, M. F. Interleukin-6 - a key regulator of colorectal cancer development. Int. J. Biol. Sci. 8, 1248-1253 (2012).
-
(2012)
Int. J. Biol. Sci
, vol.8
, pp. 1248-1253
-
-
Waldner, M.J.1
Foersch, S.2
Neurath, M.F.3
-
24
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu, H., Pardoll, D. & Jove, R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nature Rev. Cancer 9, 798-809 (2009).
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
25
-
-
84872406787
-
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer
-
Liang, J. et al. Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 23, 107-120 (2013).
-
(2013)
Cancer Cell
, vol.23
, pp. 107-120
-
-
Liang, J.1
-
26
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park, E. J. et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140, 197-208 (2010).
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
-
27
-
-
70350778443
-
An epigenetic switch involving NF-B, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
-
Iliopoulos, D., Hirsch, H. A. & Struhl, K. An epigenetic switch involving NF-B, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706 (2009).
-
(2009)
Cell
, vol.139
, pp. 693-706
-
-
Iliopoulos, D.1
Hirsch, H.A.2
Struhl, K.3
-
28
-
-
77950346282
-
Immunity inflammation, and cancer
-
Grivennikov, S. I., Greten, F. R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883-899 (2010).
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
29
-
-
25844459154
-
NF-B: Linking inflammation and immunity to cancer development and progression
-
Karin, M. & Greten, F. R. NF-B: linking inflammation and immunity to cancer development and progression. Nature Rev. Immunol. 5, 749-759 (2005).
-
(2005)
Nature Rev. Immunol
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
30
-
-
80052014052
-
Inflammation meets cancer, with NF-B as the matchmaker
-
Ben-Neriah, Y. & Karin, M. Inflammation meets cancer, with NF-B as the matchmaker. Nature Immunol. 12, 715-723 (2011).
-
(2011)
Nature Immunol
, vol.12
, pp. 715-723
-
-
Ben-Neriah, Y.1
Karin, M.2
-
31
-
-
4644324186
-
NF-B functions as a tumour promoter in inflammation-associated cancer
-
Pikarsky, E. et al. NF-B functions as a tumour promoter in inflammation-associated cancer. Nature 431, 461-466 (2004).
-
(2004)
Nature
, vol.431
, pp. 461-466
-
-
Pikarsky, E.1
-
32
-
-
4043088499
-
IKK links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
This paper and reference 31 first showed a connection between inflammation and cancer growth through the transcription factor NF-B.
-
Greten, F. R. et al. IKK links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296 (2004). This paper and reference 31 first showed a connection between inflammation and cancer growth through the transcription factor NF-B.
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
-
33
-
-
38849171267
-
Blocking TNF- in mice reduces colorectal carcinogenesis associated with chronic colitis
-
Popivanova, B. K. et al. Blocking TNF- in mice reduces colorectal carcinogenesis associated with chronic colitis. J. Clin. Invest. 118, 560-570 (2008).
-
(2008)
J. Clin. Invest
, vol.118
, pp. 560-570
-
-
Popivanova, B.K.1
-
34
-
-
84866382229
-
IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis
-
Cataisson, C. et al. IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis. J. Exp. Med. 209, 1689-1702 (2012).
-
(2012)
J. Exp. Med
, vol.209
, pp. 1689-1702
-
-
Cataisson, C.1
-
35
-
-
79955504743
-
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophages
-
Schiechl, G. et al. Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11bhighGr1low macrophages. J. Clin. Invest. 121, 1692-1708 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1692-1708
-
-
Schiechl, G.1
-
36
-
-
84867605321
-
STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation
-
Tye, H. et al. STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. Cancer Cell 22, 466-478 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 466-478
-
-
Tye, H.1
-
37
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz, L. A. et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29, 947-957 (2008).
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
-
38
-
-
79955030498
-
Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
-
Sonnenberg, G. F., Fouser, L. A. & Artis, D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nature Immunol. 12, 383-390 (2011).
-
(2011)
Nature Immunol
, vol.12
, pp. 383-390
-
-
Sonnenberg, G.F.1
Fouser, L.A.2
Artis, D.3
-
39
-
-
67650474246
-
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
-
Pickert, G. et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465-1472 (2009).
-
(2009)
J. Exp. Med
, vol.206
, pp. 1465-1472
-
-
Pickert, G.1
-
40
-
-
84868615556
-
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
-
Huber, S. et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259-263 (2012).
-
(2012)
Nature
, vol.491
, pp. 259-263
-
-
Huber, S.1
-
41
-
-
80052023399
-
Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3
-
Jiang, R. et al. Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3. Hepatology 54, 900-909 (2011).
-
(2011)
Hepatology
, vol.54
, pp. 900-909
-
-
Jiang, R.1
-
42
-
-
79955776494
-
In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression
-
Park, O. et al. In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression. Hepatology 54, 252-261 (2011).
-
(2011)
Hepatology
, vol.54
, pp. 252-261
-
-
Park, O.1
-
43
-
-
84872600554
-
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties
-
Schwitalla, S. et al. Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell 152, 25-38 (2013).
-
(2013)
Cell
, vol.152
, pp. 25-38
-
-
Schwitalla, S.1
-
44
-
-
84878889056
-
ROS production and NF-B activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation
-
Myant, K. B. et al. ROS production and NF-B activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation. Cell Stem Cell 12, 761-773 (2013).
-
(2013)
Cell Stem Cell
, vol.12
, pp. 761-773
-
-
Myant, K.B.1
-
45
-
-
79959956046
-
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24-stem cell-like breast cancer cells in human tumors
-
Marotta, L. L. et al. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24-stem cell-like breast cancer cells in human tumors. J. Clin. Invest. 121, 2723-2735 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 2723-2735
-
-
Marotta, L.L.1
-
46
-
-
84863584311
-
Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer
-
Ho, P. L., Lay, E. J., Jian, W., Parra, D. & Chan, K. S. Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer. Cancer Res. 72, 3135-3142 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 3135-3142
-
-
Ho, P.L.1
Lay, E.J.2
Jian, W.3
Parra, D.4
Chan, K.S.5
-
47
-
-
36048963331
-
Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance
-
Zhou, J. et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc. Natl Acad. Sci. USA 104, 16158-16163 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 16158-16163
-
-
Zhou, J.1
-
48
-
-
84868530288
-
Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer
-
Scheitz, C. J., Lee, T. S., McDermitt, D. J. & Tumbar, T. Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer. EMBO J. 31, 4124-4139 (2012).
-
(2012)
EMBO J
, vol.31
, pp. 4124-4139
-
-
Scheitz, C.J.1
Lee, T.S.2
McDermitt, D.J.3
Tumbar, T.4
-
49
-
-
84862909168
-
Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
-
Quante, M. et al. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia. Cancer Cell 21, 36-51 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 36-51
-
-
Quante, M.1
-
50
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
Campisi, J. & dAdda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nature Rev. Mol. Cell Biol. 8, 729-740 (2007).
-
(2007)
Nature Rev. Mol. Cell Biol
, vol.8
, pp. 729-740
-
-
Campisi, J.1
Dadda Di Fagagna, F.2
-
51
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue, W. et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007).
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
-
52
-
-
80054789761
-
Control of the senescence-associated secretory phenotype by NF-B promotes senescence and enhances chemosensitivity
-
Chien, Y. et al. Control of the senescence-associated secretory phenotype by NF-B promotes senescence and enhances chemosensitivity. Genes Dev. 25, 2125-2136 (2011).
-
(2011)
Genes Dev
, vol.25
, pp. 2125-2136
-
-
Chien, Y.1
-
53
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
Kang, T. W. et al. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479, 547-551 (2011).
-
(2011)
Nature
, vol.479
, pp. 547-551
-
-
Kang, T.W.1
-
54
-
-
84874192617
-
T-helper-1-cell cytokines drive cancer into senescence
-
Braumuller, H. et al. T-helper-1-cell cytokines drive cancer into senescence. Nature 494, 361-365 (2013).
-
(2013)
Nature
, vol.494
, pp. 361-365
-
-
Braumuller, H.1
-
55
-
-
84881526073
-
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism
-
Pribluda, A. et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 24, 242-256 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 242-256
-
-
Pribluda, A.1
-
56
-
-
47949096781
-
Cancer-related inflammation
-
Mantovani, A., Allavena, P., Sica, A. & Balkwill, F. Cancer-related inflammation. Nature 454, 436-444 (2008).
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
Allavena, P.2
Sica, A.3
Balkwill, F.4
-
57
-
-
44149115260
-
Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells
-
Campregher, C., Luciani, M. G. & Gasche, C. Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. Gut 57, 780-787 (2008).
-
(2008)
Gut
, vol.57
, pp. 780-787
-
-
Campregher, C.1
Luciani, M.G.2
Gasche, C.3
-
58
-
-
0037660900
-
The role of DNA breaks in genomic instability and tumorigenesis
-
Mills, K. D., Ferguson, D. O. & Alt, F. W. The role of DNA breaks in genomic instability and tumorigenesis. Immunol. Rev. 194, 77-95 (2003).
-
(2003)
Immunol. Rev
, vol.194
, pp. 77-95
-
-
Mills, K.D.1
Ferguson, D.O.2
Alt, F.W.3
-
59
-
-
59149102040
-
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations
-
Takai, A. et al. A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations. Oncogene 28, 469-478 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 469-478
-
-
Takai, A.1
-
60
-
-
34249782578
-
Role of AID in tumorigenesis
-
Okazaki, I. M., Kotani, A. & Honjo, T. Role of AID in tumorigenesis. Adv. Immunol. 94, 245-273 (2007).
-
(2007)
Adv. Immunol
, vol.94
, pp. 245-273
-
-
Okazaki, I.M.1
Kotani, A.2
Honjo, T.3
-
61
-
-
51249087746
-
Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers
-
Endo, Y. et al. Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers. Gastroenterology 135, 889-898 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 889-898
-
-
Endo, Y.1
-
62
-
-
40949132893
-
Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma
-
Komori, J. et al. Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma. Hepatology 47, 888-896 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 888-896
-
-
Komori, J.1
-
63
-
-
67650151005
-
Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
-
Colotta, F., Allavena, P., Sica, A., Garlanda, C. & Mantovani, A. Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30, 1073-1081 (2009).
-
(2009)
Carcinogenesis
, vol.30
, pp. 1073-1081
-
-
Colotta, F.1
Allavena, P.2
Sica, A.3
Garlanda, C.4
Mantovani, A.5
-
64
-
-
74049140048
-
Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways
-
Schetter, A. J., Heegaard, N. H. & Harris, C. C. Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 31, 37-49 (2010).
-
(2010)
Carcinogenesis
, vol.31
, pp. 37-49
-
-
Schetter, A.J.1
Heegaard, N.H.2
Harris, C.C.3
-
65
-
-
34248224164
-
Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells
-
Singh B., Vincent, L., Berry, J. A., Multani, A. S. & Lucci, A. Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells. J. Surg. Res. 140, 220-226 (2007).
-
(2007)
J. Surg. Res
, vol.140
, pp. 220-226
-
-
Singh, B.1
Vincent, L.2
Berry, J.A.3
Multani, A.S.4
Lucci, A.5
-
66
-
-
57749090255
-
Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
-
Hahn, M. A. et al. Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res. 68, 10280-10289 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 10280-10289
-
-
Hahn, M.A.1
-
67
-
-
84869006006
-
Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation
-
Mishra, A. et al. Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell 22, 645-655 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 645-655
-
-
Mishra, A.1
-
68
-
-
77955015464
-
AACR centennial series: The biology of cancer metastasis: Historical perspective
-
Talmadge, J. E. & Fidler, I. J. AACR centennial series: the biology of cancer metastasis: historical perspective. Cancer Res. 70, 5649-5669 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 5649-5669
-
-
Talmadge, J.E.1
Fidler, I.J.2
-
69
-
-
79952070774
-
The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts
-
Peinado, H., Lavotshkin, S. & Lyden, D. The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Semin. Cancer Biol. 21, 139-146 (2011).
-
(2011)
Semin. Cancer Biol
, vol.21
, pp. 139-146
-
-
Peinado, H.1
Lavotshkin, S.2
Lyden, D.3
-
70
-
-
77950950894
-
Macrophage diversity enhances tumor progression and metastasis
-
Qian, B. Z. & Pollard, J. W. Macrophage diversity enhances tumor progression and metastasis. Cell 141, 39-51 (2010).
-
(2010)
Cell
, vol.141
, pp. 39-51
-
-
Qian, B.Z.1
Pollard, J.W.2
-
71
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri, R. & Weinberg, R. A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 1420-1428 (2009).
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
72
-
-
0037572319
-
Tumor necrosis factor- stimulates the epithelial-to-mesenchymal transition of human colonic organoids
-
Bates, R. C. & Mercurio, A. M. Tumor necrosis factor- stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol. Biol. Cell 14, 1790-1800 (2003).
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 1790-1800
-
-
Bates, R.C.1
Mercurio, A.M.2
-
73
-
-
69249221254
-
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
-
Sullivan, N. J. et al. Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene 28, 2940-2947 (2009).
-
(2009)
Oncogene
, vol.28
, pp. 2940-2947
-
-
Sullivan, N.J.1
-
74
-
-
65349092794
-
Stabilization of snail by NF-B is required for inflammation-induced cell migration and invasion
-
Wu, Y. et al. Stabilization of snail by NF-B is required for inflammation-induced cell migration and invasion. Cancer Cell 15, 416-428 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 416-428
-
-
Wu, Y.1
-
75
-
-
0037418208
-
IL-1 is required for tumor invasiveness and angiogenesis
-
Voronov, E. et al. IL-1 is required for tumor invasiveness and angiogenesis. Proc. Natl Acad. Sci. USA 100, 2645-2650 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 2645-2650
-
-
Voronov, E.1
-
76
-
-
75849117800
-
Inflammation and oncogenesis: A vicious connection
-
Grivennikov, S. I. & Karin, M. Inflammation and oncogenesis: A vicious connection. Curr. Opin. Genet. Dev. 20, 65-71 (2010).
-
(2010)
Curr. Opin. Genet. Dev
, vol.20
, pp. 65-71
-
-
Grivennikov, S.I.1
Karin, M.2
-
77
-
-
76149146398
-
IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
-
Gocheva, V. et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 24, 241-255 (2010).
-
(2010)
Genes Dev
, vol.24
, pp. 241-255
-
-
Gocheva, V.1
-
78
-
-
67651160649
-
CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
-
DeNardo, D. G. et al. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 16, 91-102 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 91-102
-
-
Denardo, D.G.1
-
79
-
-
34047138860
-
SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion
-
Kitamura, T. et al. SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nature Genet. 39, 467-475 (2007).
-
(2007)
Nature Genet
, vol.39
, pp. 467-475
-
-
Kitamura, T.1
-
80
-
-
47949090079
-
The role of myeloid cells in the promotion of tumour angiogenesis
-
Murdoch, C., Muthana, M., Coffelt, S. B. & Lewis, C. E. The role of myeloid cells in the promotion of tumour angiogenesis. Nature Rev. Cancer 8, 618-631 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 618-631
-
-
Murdoch, C.1
Muthana, M.2
Coffelt, S.B.3
Lewis, C.E.4
-
81
-
-
79955509614
-
Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice
-
Lerner, I. et al. Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice. J. Clin. Invest. 121, 1709-1721 (2011).
-
(2011)
J. Clin. Invest
, vol.121
, pp. 1709-1721
-
-
Lerner, I.1
-
82
-
-
34047246527
-
Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors
-
Wyckoff, J. B. et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67, 2649-2656 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 2649-2656
-
-
Wyckoff, J.B.1
-
83
-
-
33748537056
-
Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms
-
Grivennikov, S. I., Kuprash, D. V., Liu, Z. G. & Nedospasov, S. A. Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms. Int. Rev. Cytol. 252, 129-161 (2006).
-
(2006)
Int. Rev. Cytol
, vol.252
, pp. 129-161
-
-
Grivennikov, S.I.1
Kuprash, D.V.2
Liu, Z.G.3
Nedospasov, S.A.4
-
84
-
-
63049090100
-
Metastasis: From dissemination to organ-specific colonization
-
Nguyen, D. X., Bos, P. D. & Massague, J. Metastasis: from dissemination to organ-specific colonization. Nature Rev. Cancer 9, 274-284 (2009).
-
(2009)
Nature Rev. Cancer
, vol.9
, pp. 274-284
-
-
Nguyen, D.X.1
Bos, P.D.2
Massague, J.3
-
85
-
-
68349101949
-
Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms
-
McDonald, B. et al. Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms. Int. J. Cancer 125, 1298-1305 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 1298-1305
-
-
McDonald, B.1
-
86
-
-
79953747613
-
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3
-
Chen, J. et al. CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19, 541-555 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 541-555
-
-
Chen, J.1
-
87
-
-
79960411324
-
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
-
Qian, B. Z. et al. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475, 222-225 (2011).
-
(2011)
Nature
, vol.475
, pp. 222-225
-
-
Qian, B.Z.1
-
88
-
-
84863756518
-
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
-
Wolf, M. J. et al. Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway. Cancer Cell 22, 91-105 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 91-105
-
-
Wolf, M.J.1
-
89
-
-
84880757177
-
Deciphering and reversing tumor immune suppression
-
Motz, G. T. & Coukos, G. Deciphering and reversing tumor immune suppression. Immunity 39, 61-73 (2013).
-
(2013)
Immunity
, vol.39
, pp. 61-73
-
-
Motz, G.T.1
Coukos, G.2
-
90
-
-
84880276438
-
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells
-
Robbins, P. F. et al. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nature Med. 19, 747-752 (2013).
-
(2013)
Nature Med
, vol.19
, pp. 747-752
-
-
Robbins, P.F.1
-
91
-
-
0029842830
-
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
-
Gabrilovich, D. I. et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nature Med. 2, 1096-1103 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 1096-1103
-
-
Gabrilovich, D.I.1
-
92
-
-
0038273853
-
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
-
Curiel, T. J. et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nature Med. 9, 562-567 (2003).
-
(2003)
Nature Med
, vol.9
, pp. 562-567
-
-
Curiel, T.J.1
-
93
-
-
0033561648
-
TGF- 1 prevents the noncognate maturation of human dendritic Langerhans cells
-
Geissmann, F. et al. TGF- 1 prevents the noncognate maturation of human dendritic Langerhans cells. J. Immunol. 162, 4567-4575 (1999).
-
(1999)
J. Immunol
, vol.162
, pp. 4567-4575
-
-
Geissmann, F.1
-
94
-
-
0033105695
-
Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8+ T cells resulting in a failure to lyse tumor cells
-
Steinbrink, K. et al. Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8+ T cells resulting in a failure to lyse tumor cells. Blood 93, 1634-1642 (1999).
-
(1999)
Blood
, vol.93
, pp. 1634-1642
-
-
Steinbrink, K.1
-
95
-
-
0032535002
-
Inhibition of the differentiation of dendritic cells from CD34+ progenitors by tumor cells: Role of interleukin-6 and macrophage colony-stimulating factor
-
Menetrier-Caux, C. et al. Inhibition of the differentiation of dendritic cells from CD34+ progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood 92, 4778-4791 (1998).
-
(1998)
Blood
, vol.92
, pp. 4778-4791
-
-
Menetrier-Caux, C.1
-
96
-
-
84862150896
-
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
-
Bayne, L. J. et al. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21, 822-835 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 822-835
-
-
Bayne, L.J.1
-
97
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Gabrilovich, D. I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nature Rev. Immunol. 9, 162-174 (2009).
-
(2009)
Nature Rev. Immunol
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
98
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
-
99
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
-
Facciabene, A. et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells. Nature 475, 226-230 (2011).
-
(2011)
Nature
, vol.475
, pp. 226-230
-
-
Facciabene, A.1
-
100
-
-
84860507700
-
T-regulatory cells: Key players in tumor immune escape and angiogenesis
-
Facciabene, A., Motz, G. T. & Coukos, G. T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res. 72, 2162-2171 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 2162-2171
-
-
Facciabene, A.1
Motz, G.T.2
Coukos, G.3
-
101
-
-
38049141544
-
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
-
Zarek, P. E. et al. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood 111, 251-259 (2008).
-
(2008)
Blood
, vol.111
, pp. 251-259
-
-
Zarek, P.E.1
-
102
-
-
69249232549
-
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells
-
Garrett, W. S. et al. Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell 16, 208-219 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 208-219
-
-
Garrett, W.S.1
-
103
-
-
84873372079
-
NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
-
Couturier-Maillard, A. et al. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J. Clin. Invest. 123, 700-711 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 700-711
-
-
Couturier-Maillard, A.1
-
104
-
-
78649489748
-
Why do viruses cause cancer Highlights of the first century of human tumour virology
-
Moore, P. S. & Chang, Y. Why do viruses cause cancer Highlights of the first century of human tumour virology. Nature Rev. Cancer 10, 878-889 (2010).
-
(2010)
Nature Rev. Cancer
, vol.10
, pp. 878-889
-
-
Moore, P.S.1
Chang, Y.2
-
105
-
-
0001720417
-
An address on a characteristic organism of cancer
-
Russell, W. An address on a characteristic organism of cancer. Br. Med. J. 2, 1356-1360 (1890).
-
(1890)
Br. Med. J
, vol.2
, pp. 1356-1360
-
-
Russell, W.1
-
106
-
-
0001398538
-
Cultural properties and pathogenicity of certain microorganisms obtained from various proliferative and neoplastic diseases
-
Wuerthele-Caspe, V. et al. Cultural properties and pathogenicity of certain microorganisms obtained from various proliferative and neoplastic diseases. Am. J. Med. Sci. 220, 638-646 (1950).
-
(1950)
Am. J. Med. Sci
, vol.220
, pp. 638-646
-
-
Wuerthele-Caspe, V.1
-
107
-
-
76549156615
-
An experimental biologic approach to the treatment of neoplastic disease; Determination of actinomycin in urine and cultures as an aid to diagnosis and prognosis
-
Livingston, V. W. & Alexander-Jackson, E. An experimental biologic approach to the treatment of neoplastic disease; determination of actinomycin in urine and cultures as an aid to diagnosis and prognosis. J. Am. Med. Womens Assoc. 20, 858-866 (1965).
-
(1965)
J. Am. Med. Womens Assoc
, vol.20
, pp. 858-866
-
-
Livingston, V.W.1
Alexander-Jackson, E.2
-
108
-
-
0026161109
-
Livingston-Wheeler therapy
-
Unproven methods of cancer management
-
Unproven methods of cancer management. Livingston-Wheeler therapy. CA Cancer J. Clin. 41, A7-A12 (1991).
-
(1991)
CA Cancer J. Clin
, vol.41
-
-
-
109
-
-
77952903266
-
Helicobacter pylori: Gastric cancer and beyond
-
Polk, D. B. & Peek, R. M. Jr. Helicobacter pylori: gastric cancer and beyond. Nature Rev. Cancer 10, 403-414 (2010).
-
(2010)
Nature Rev. Cancer
, vol.10
, pp. 403-414
-
-
Polk, D.B.1
Peek Jr., R.M.2
-
110
-
-
23044463653
-
Activation of -catenin by carcinogenic Helicobacter pylori
-
Franco, A. T. et al. Activation of -catenin by carcinogenic Helicobacter pylori. Proc. Natl Acad. Sci. USA 102, 10646-10651 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 10646-10651
-
-
Franco, A.T.1
-
111
-
-
77954153647
-
Chronic bacterial and parasitic infections and cancer: A review
-
Samaras, V., Rafailidis, P. I., Mourtzoukou, E. G., Peppas, G. & Falagas, M. E. Chronic bacterial and parasitic infections and cancer: A review. J. Infect. Dev. Ctries 4, 267-281 (2010).
-
(2010)
J. Infect. Dev. Ctries
, vol.4
, pp. 267-281
-
-
Samaras, V.1
Rafailidis, P.I.2
Mourtzoukou, E.G.3
Peppas, G.4
Falagas, M.E.5
-
112
-
-
0029282251
-
Chronic bacterial infection and subsequent human carcinogenesis
-
Hill, M. J. Chronic bacterial infection and subsequent human carcinogenesis. Eur. J. Cancer Prev. 4, 127-128 (1995).
-
(1995)
Eur. J. Cancer Prev
, vol.4
, pp. 127-128
-
-
Hill, M.J.1
-
113
-
-
84862276328
-
Structure, function and diversity of the healthy human microbiome
-
Structure, function and diversity of the healthy human microbiome. Nature 486, 207-214 (2012).
-
(2012)
Nature
, vol.486
, pp. 207-214
-
-
-
114
-
-
84861982483
-
Honor thy gut symbionts redux
-
Gordon, J. I. Honor thy gut symbionts redux. Science 336, 1251-1253 (2012).
-
(2012)
Science
, vol.336
, pp. 1251-1253
-
-
Gordon, J.I.1
-
115
-
-
34447296425
-
Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
-
Rakoff-Nahoum, S. & Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127 (2007).
-
(2007)
Science
, vol.317
, pp. 124-127
-
-
Rakoff-Nahoum, S.1
Medzhitov, R.2
-
116
-
-
77953196709
-
ERK activation drives intestinal tumorigenesis in Apcmin/+ mice
-
Lee, S. H. et al. ERK activation drives intestinal tumorigenesis in Apcmin/+ mice. Nature Med. 16, 665-670 (2010).
-
(2010)
Nature Med
, vol.16
, pp. 665-670
-
-
Lee, S.H.1
-
117
-
-
67650299380
-
Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
-
Uronis, J. M. et al. Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS ONE 4, e6026 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Uronis, J.M.1
-
118
-
-
77955350419
-
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin
-
Salcedo, R. et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin .J. Exp. Med. 207, 1625-1636 (2010).
-
(2010)
J. Exp. Med
, vol.207
, pp. 1625-1636
-
-
Salcedo, R.1
-
119
-
-
36549082403
-
Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
-
Fukata, M. et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133, 1869-1881 (2007).
-
(2007)
Gastroenterology
, vol.133
, pp. 1869-1881
-
-
Fukata, M.1
-
120
-
-
77958610178
-
Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer
-
Lowe, E. L. et al. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS ONE 5, e13027 (2010).
-
(2010)
PLoS ONE
, vol.5
-
-
Lowe, E.L.1
-
121
-
-
84874028928
-
Integrative inflammasome activity in the regulation of intestinal mucosal immune responses
-
Elinav, E., Henao-Mejia, J. & Flavell, R. A. Integrative inflammasome activity in the regulation of intestinal mucosal immune responses. Mucosal Immunol. 6, 4-13 (2013).
-
(2013)
Mucosal Immunol
, vol.6
, pp. 4-13
-
-
Elinav, E.1
Henao-Mejia, J.2
Flavell, R.A.3
-
122
-
-
78650735879
-
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
-
Hu, B. et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc. Natl Acad. Sci. USA 107, 21635-21640 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 21635-21640
-
-
Hu, B.1
-
123
-
-
78049488908
-
IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
-
Zaki, M. H., Vogel, P., Body-Malapel, M., Lamkanfi, M. & Kanneganti, T. D. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J. Immunol. 185, 4912-4920 (2010).
-
(2010)
J. Immunol
, vol.185
, pp. 4912-4920
-
-
Zaki, M.H.1
Vogel, P.2
Body-Malapel, M.3
Lamkanfi, M.4
Kanneganti, T.D.5
-
124
-
-
79959540809
-
A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
-
Chen, G. Y., Liu, M., Wang, F., Bertin, J. & Nunez, G. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186, 7187-7194 (2011).
-
(2011)
J. Immunol
, vol.186
, pp. 7187-7194
-
-
Chen, G.Y.1
Liu, M.2
Wang, F.3
Bertin, J.4
Nunez, G.5
-
125
-
-
79959369355
-
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
-
Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl Acad. Sci. USA 108, 9601-9606 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 9601-9606
-
-
Normand, S.1
-
126
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745-757 (2011).
-
(2011)
Cell
, vol.145
, pp. 745-757
-
-
Elinav, E.1
-
127
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia, J. et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179-185 (2012).
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
-
128
-
-
84878971321
-
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
-
This paper, together with reference 103, shows that the intestinal dysbiosis that results from innate immune deficiency leads to transmissible colon cancer.
-
Hu, B. et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc. Natl Acad. Sci. USA http://dx.doi.org/10.1073/pnas.1307575110 (2013). This paper, together with reference 103, shows that the intestinal dysbiosis that results from innate immune deficiency leads to transmissible colon cancer.
-
(2013)
Proc. Natl Acad. Sci. USA
-
-
Hu, B.1
-
129
-
-
79551571717
-
Microbial dysbiosis in colorectal cancer (CRC) patients
-
Sobhani, I. et al. Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS ONE 6, e16393 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Sobhani, I.1
-
130
-
-
79956359184
-
Towards the human colorectal cancer microbiome
-
Marchesi, J. R. et al. Towards the human colorectal cancer microbiome. PLoS ONE 6, e20447 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Marchesi, J.R.1
-
131
-
-
84856534859
-
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
-
Castellarin, M. et al. Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res. 22, 299-306 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 299-306
-
-
Castellarin, M.1
-
132
-
-
84863022950
-
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
-
Kostic, A. D. et al. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 22, 292-298 (2012).
-
(2012)
Genome Res
, vol.22
, pp. 292-298
-
-
Kostic, A.D.1
-
133
-
-
79959474060
-
Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host
-
Strauss, J. et al. Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host. Inflamm. Bowel Dis. 17, 1971-1978 (2011).
-
(2011)
Inflamm. Bowel Dis
, vol.17
, pp. 1971-1978
-
-
Strauss, J.1
-
134
-
-
84882354326
-
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
-
Kostic, A. D. et al. Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment. Cell Host Microbe. 14, 207-215 (2013)
-
(2013)
Cell Host Microbe
, vol.14
, pp. 207-215
-
-
Kostic, A.D.1
-
135
-
-
84882334105
-
Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/-Catenin Signaling via its FadA Adhesin
-
Rubinstein, M. R., et al. Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/-Catenin Signaling via its FadA Adhesin. Cell Host Microbe. 14, 195-206 (2013)
-
(2013)
Cell Host Microbe
, vol.14
, pp. 195-206
-
-
Rubinstein, M.R.1
-
136
-
-
69949120571
-
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
-
This paper shows the direct involvement of a member of the commensal microflora in inflammation and tumorigenesis.
-
Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nature Med. 15, 1016-1022 (2009). This paper shows the direct involvement of a member of the commensal microflora in inflammation and tumorigenesis.
-
(2009)
Nature Med
, vol.15
, pp. 1016-1022
-
-
Wu, S.1
-
137
-
-
84859812538
-
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4
-
Dapito, D. H. et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504-516 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 504-516
-
-
Dapito, D.H.1
-
138
-
-
84879888338
-
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
-
This report links microbiota-derived products to carcinogenesis and cellular senescence
-
Yoshimoto, S. et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499, 97-101 (2013). This report links microbiota-derived products to carcinogenesis and cellular senescence.
-
(2013)
Nature
, vol.499
, pp. 97-101
-
-
Yoshimoto, S.1
-
139
-
-
39049104004
-
Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis
-
Yusuf, N. et al. Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis. Cancer Res. 68, 615-622 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 615-622
-
-
Yusuf, N.1
-
140
-
-
38649087921
-
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
-
Swann, J. B. et al. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc. Natl Acad. Sci. USA 105, 652-656 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 652-656
-
-
Swann, J.B.1
-
141
-
-
20544478077
-
Inflammation and cancer: Is the link as simple as we think
-
Nickoloff, B. J., Ben-Neriah, Y. & Pikarsky, E. Inflammation and cancer: Is the link as simple as we think. J. Invest Dermatol. 124, 10-14 (2005).
-
(2005)
J. Invest Dermatol
, vol.124
, pp. 10-14
-
-
Nickoloff, B.J.1
Ben-Neriah, Y.2
Pikarsky, E.3
-
142
-
-
84875863443
-
An update on the use and investigation of probiotics in health and disease
-
Sanders, M. E. et al. An update on the use and investigation of probiotics in health and disease. Gut 62, 787-796 (2013).
-
(2013)
Gut
, vol.62
, pp. 787-796
-
-
Sanders, M.E.1
-
143
-
-
84878233113
-
Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model
-
Maroof, H., Hassan, Z. M., Mobarez, A. M. & Mohamadabadi, M. A. Lactobacillus acidophilus could modulate the immune response against breast cancer in murine model. J. Clin. Immunol. 32, 1353-1359 (2012).
-
(2012)
J. Clin. Immunol
, vol.32
, pp. 1353-1359
-
-
Maroof, H.1
Hassan, Z.M.2
Mobarez, A.M.3
Mohamadabadi, M.A.4
-
144
-
-
84867387387
-
Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria
-
Bassaganya-Riera, J., Viladomiu, M., Pedragosa, M., De Simone, C. & Hontecillas, R. Immunoregulatory mechanisms underlying prevention of colitis-associated colorectal cancer by probiotic bacteria. PLoS ONE 7, e34676 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Bassaganya-Riera, J.1
Viladomiu, M.2
Pedragosa, M.3
De Simone, C.4
Hontecillas, R.5
-
145
-
-
33947135858
-
Cross-talk between probiotic bacteria and the host immune system
-
Corthesy, B., Gaskins, H. R. & Mercenier, A. Cross-talk between probiotic bacteria and the host immune system. J. Nutr. 137, 781S-790S (2007).
-
(2007)
J. Nutr
, vol.137
-
-
Corthesy, B.1
Gaskins, H.R.2
Mercenier, A.3
-
146
-
-
60749120342
-
Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines
-
Orlando, A., Messa, C., Linsalata, M., Cavallini, A. & Russo, F. Effects of Lactobacillus rhamnosus GG on proliferation and polyamine metabolism in HGC-27 human gastric and DLD-1 colonic cancer cell lines. Immunopharmacol. Immunotoxicol 31, 108-116 (2009).
-
(2009)
Immunopharmacol. Immunotoxicol
, vol.31
, pp. 108-116
-
-
Orlando, A.1
Messa, C.2
Linsalata, M.3
Cavallini, A.4
Russo, F.5
-
147
-
-
43049084033
-
Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212
-
Kim, Y. et al. Inhibition of proliferation in colon cancer cell lines and harmful enzyme activity of colon bacteria by Bifidobacterium adolescentis SPM0212. Arch. Pharm. Res. 31, 468-473 (2008).
-
(2008)
Arch. Pharm. Res
, vol.31
, pp. 468-473
-
-
Kim, Y.1
-
148
-
-
18344377930
-
A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon
-
Le Leu, R. K. et al. A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon. J. Nutr. 135, 996-1001 (2005).
-
(2005)
J. Nutr
, vol.135
, pp. 996-1001
-
-
Le Leu, R.K.1
-
149
-
-
10244219948
-
Lactobacillus-and bifidobacterium-mediated antigenotoxicity in the colon of rats
-
Pool-Zobel, B. L. et al. Lactobacillus-and bifidobacterium-mediated antigenotoxicity in the colon of rats. Nutr. Cancer 26, 365-380 (1996).
-
(1996)
Nutr. Cancer
, vol.26
, pp. 365-380
-
-
Pool-Zobel, B.L.1
|