메뉴 건너뛰기




Volumn 24, Issue 1, 2012, Pages 50-57

Induction of Treg cells in the mouse colonic mucosa: A central mechanism to maintain host-microbiota homeostasis

Author keywords

Clostridium; Germ free; Intestinal microbiota; Treg

Indexed keywords

INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

EID: 84857063957     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2011.11.009     Document Type: Review
Times cited : (56)

References (119)
  • 2
    • 77950353786 scopus 로고    scopus 로고
    • Homeostasis and inflammation in the intestine
    • Garrett W.S., Gordon J.I., Glimcher L.H. Homeostasis and inflammation in the intestine. Cell 2010, 140:859-870.
    • (2010) Cell , vol.140 , pp. 859-870
    • Garrett, W.S.1    Gordon, J.I.2    Glimcher, L.H.3
  • 3
    • 77954607064 scopus 로고    scopus 로고
    • A pathobiont of the microbiota balances host colonization and intestinal inflammation
    • Chow J., Mazmanian S.K. A pathobiont of the microbiota balances host colonization and intestinal inflammation. Cell Host Microbe 2010, 7:265-276.
    • (2010) Cell Host Microbe , vol.7 , pp. 265-276
    • Chow, J.1    Mazmanian, S.K.2
  • 5
    • 77952318832 scopus 로고    scopus 로고
    • Intestinal bacteria and the regulation of immune cell homeostasis
    • Hill D.A., Artis D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu Rev Immunol 2010, 28:623-667.
    • (2010) Annu Rev Immunol , vol.28 , pp. 623-667
    • Hill, D.A.1    Artis, D.2
  • 6
    • 78650647326 scopus 로고    scopus 로고
    • Has the microbiota played a critical role in the evolution of the adaptive immune system?
    • Lee Y.K., Mazmanian S.K. Has the microbiota played a critical role in the evolution of the adaptive immune system?. Science 2010, 330:1768-1773.
    • (2010) Science , vol.330 , pp. 1768-1773
    • Lee, Y.K.1    Mazmanian, S.K.2
  • 7
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    • Garrett W.S., Lord G.M., Punit S., Lugo-Villarino G., Mazmanian S.K., Ito S., et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007, 131:33-45.
    • (2007) Cell , vol.131 , pp. 33-45
    • Garrett, W.S.1    Lord, G.M.2    Punit, S.3    Lugo-Villarino, G.4    Mazmanian, S.K.5    Ito, S.6
  • 8
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E., Strowig T., Kau A.L., Henao-Mejia J., Thaiss C.A., Booth C.J., et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757.
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3    Henao-Mejia, J.4    Thaiss, C.A.5    Booth, C.J.6
  • 9
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach J.F. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002, 347:911-920.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 10
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu H.J., Ivanov I.I., Darce J., Hattori K., Shima T., Umesaki Y., et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010, 32:815-827.
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.J.1    Ivanov, I.I.2    Darce, J.3    Hattori, K.4    Shima, T.5    Umesaki, Y.6
  • 11
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • Lee Y.K., Menezes J.S., Umesaki Y., Mazmanian S.K. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2011, 108(Suppl. 1):4615-4622.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.SUPPL. 1 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 12
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of Type 1 diabetes
    • Wen L., Ley R.E., Volchkov P.Y., Stranges P.B., Avanesyan L., Stonebraker A.C., et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008, 455:1109-1113.
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1    Ley, R.E.2    Volchkov, P.Y.3    Stranges, P.B.4    Avanesyan, L.5    Stonebraker, A.C.6
  • 13
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra D., Brezillon C., Berard M., Werts C., Varona R., Boneca I.G., et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008, 456:507-510.
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1    Brezillon, C.2    Berard, M.3    Werts, C.4    Varona, R.5    Boneca, I.G.6
  • 14
    • 57849117363 scopus 로고    scopus 로고
    • RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    • Sanos S.L., Bui V.L., Mortha A., Oberle K., Heners C., Johner C., et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 2009, 10:83-91.
    • (2009) Nat Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1    Bui, V.L.2    Mortha, A.3    Oberle, K.4    Heners, C.5    Johner, C.6
  • 15
    • 80052966918 scopus 로고    scopus 로고
    • IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
    • Ota N., Wong K., Valdez P.A., Zheng Y., Crellin N.K., Diehl L., et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat Immunol 2011, 12:941-948.
    • (2011) Nat Immunol , vol.12 , pp. 941-948
    • Ota, N.1    Wong, K.2    Valdez, P.A.3    Zheng, Y.4    Crellin, N.K.5    Diehl, L.6
  • 16
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov I.I., Atarashi K., Manel N., Brodie E.L., Shima T., Karaoz U., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009, 139:485-498.
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3    Brodie, E.L.4    Shima, T.5    Karaoz, U.6
  • 17
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi K., Tanoue T., Shima T., Imaoka A., Kuwahara T., Momose Y., et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011, 331:337-341.
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3    Imaoka, A.4    Kuwahara, T.5    Momose, Y.6
  • 18
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round J.L., Mazmanian S.K. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009, 9:313-323.
    • (2009) Nat Rev Immunol , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 19
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau V., Rakotobe S., Lecuyer E., Mulder I., Lan A., Bridonneau C., et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009, 31:677-689.
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1    Rakotobe, S.2    Lecuyer, E.3    Mulder, I.4    Lan, A.5    Bridonneau, C.6
  • 20
    • 79960983258 scopus 로고    scopus 로고
    • Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
    • Kriegel M.A., Sefik E., Hill J.A., Wu H.J., Benoist C., Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A 2011, 108:11548-11553.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 11548-11553
    • Kriegel, M.A.1    Sefik, E.2    Hill, J.A.3    Wu, H.J.4    Benoist, C.5    Mathis, D.6
  • 21
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • Round J.L., Lee S.M., Li J., Tran G., Jabri B., Chatila T.A., et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011, 332:974-977.
    • (2011) Science , vol.332 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3    Tran, G.4    Jabri, B.5    Chatila, T.A.6
  • 22
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round J.L., Mazmanian S.K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A 2010, 107:12204-12209.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 23
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 24
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • Chatila T.A., Blaeser F., Ho N., Lederman H.M., Voulgaropoulos C., Helms C., et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 2000, 106:R75-R81.
    • (2000) J Clin Invest , vol.106
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3    Lederman, H.M.4    Voulgaropoulos, C.5    Helms, C.6
  • 25
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 27
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan P., Zheng L., Ishihara S., Reed J., Lenardo M.J. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007, 8:1353-1362.
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 28
    • 48249103057 scopus 로고    scopus 로고
    • Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • Onishi Y., Fehervari Z., Yamaguchi T., Sakaguchi S. Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A 2008, 105:10113-10118.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehervari, Z.2    Yamaguchi, T.3    Sakaguchi, S.4
  • 29
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch M.A., Tucker-Heard G., Perdue N.R., Killebrew J.R., Urdahl K.B., Campbell D.J. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009, 10:595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 30
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y., Chaudhry A., Kas A., deRoos P., Kim J.M., Chu T.T., et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009, 458:351-356.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    deRoos, P.4    Kim, J.M.5    Chu, T.T.6
  • 31
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A., Rudra D., Treuting P., Samstein R.M., Liang Y., Kas A., et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009, 326:986-991.
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6
  • 32
    • 33746377279 scopus 로고    scopus 로고
    • Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
    • Izcue A., Coombes J.L., Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 2006, 212:256-271.
    • (2006) Immunol Rev , vol.212 , pp. 256-271
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 33
    • 70049098536 scopus 로고    scopus 로고
    • Regulatory T cells reinforce intestinal homeostasis
    • Barnes M.J., Powrie F. Regulatory T cells reinforce intestinal homeostasis. Immunity 2009, 31:401-411.
    • (2009) Immunity , vol.31 , pp. 401-411
    • Barnes, M.J.1    Powrie, F.2
  • 34
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy K.J., Salaun L., Cahill R., Dougan G., Saunders N.J., Powrie F. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 2003, 197:111-119.
    • (2003) J Exp Med , vol.197 , pp. 111-119
    • Maloy, K.J.1    Salaun, L.2    Cahill, R.3    Dougan, G.4    Saunders, N.J.5    Powrie, F.6
  • 35
    • 26844450449 scopus 로고    scopus 로고
    • How defects in central tolerance impinge on a deficiency in regulatory T cells
    • Chen Z., Benoist C., Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A 2005, 102:14735-14740.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14735-14740
    • Chen, Z.1    Benoist, C.2    Mathis, D.3
  • 36
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri E., Torgerson T.R., Ochs H.D. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr Opin Rheumatol 2003, 15:430-435.
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.R.2    Ochs, H.D.3
  • 37
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001, 27:20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 38
    • 0242407709 scopus 로고    scopus 로고
    • Transcription factors in autoimmunity
    • Ramsdell F., Ziegler S.F. Transcription factors in autoimmunity. Curr Opin Immunol 2003, 15:718-724.
    • (2003) Curr Opin Immunol , vol.15 , pp. 718-724
    • Ramsdell, F.1    Ziegler, S.F.2
  • 39
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A., Balschun T., Karlsen T.H., Sventoraityte J., Nikolaus S., Mayr G., et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008, 40:1319-1323.
    • (2008) Nat Genet , vol.40 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3    Sventoraityte, J.4    Nikolaus, S.5    Mayr, G.6
  • 40
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie F., Leach M.W., Mauze S., Menon S., Caddle L.B., Coffman R.L. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994, 1:553-562.
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Menon, S.4    Caddle, L.B.5    Coffman, R.L.6
  • 41
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R., Lohler J., Rennick D., Rajewsky K., Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 42
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
    • Kullberg M.C., Ward J.M., Gorelick P.L., Caspar P., Hieny S., Cheever A., et al. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 1998, 66:5157-5166.
    • (1998) Infect Immun , vol.66 , pp. 5157-5166
    • Kullberg, M.C.1    Ward, J.M.2    Gorelick, P.L.3    Caspar, P.4    Hieny, S.5    Cheever, A.6
  • 43
    • 9244237038 scopus 로고    scopus 로고
    • T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    • Roers A., Siewe L., Strittmatter E., Deckert M., Schluter D., Stenzel W., et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med 2004, 200:1289-1297.
    • (2004) J Exp Med , vol.200 , pp. 1289-1297
    • Roers, A.1    Siewe, L.2    Strittmatter, E.3    Deckert, M.4    Schluter, D.5    Stenzel, W.6
  • 44
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • Rubtsov Y.P., Rasmussen J.P., Chi E.Y., Fontenot J., Castelli L., Ye X., et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 2008, 28:546-558.
    • (2008) Immunity , vol.28 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3    Fontenot, J.4    Castelli, L.5    Ye, X.6
  • 45
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker E.O., Kotlarz D., Boztug K., Gertz E.M., Schaffer A.A., Noyan F., et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med 2009, 361:2033-2045.
    • (2009) N Engl J Med , vol.361 , pp. 2033-2045
    • Glocker, E.O.1    Kotlarz, D.2    Boztug, K.3    Gertz, E.M.4    Schaffer, A.A.5    Noyan, F.6
  • 46
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K., Clausen B.E., Kaisho T., Tsujimura T., Terada N., Forster I., et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999, 10:39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6
  • 47
    • 78650209225 scopus 로고    scopus 로고
    • T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells
    • Park S.G., Mathur R., Long M., Hosh N., Hao L., Hayden M.S., et al. T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells. Immunity 2010, 33:791-803.
    • (2010) Immunity , vol.33 , pp. 791-803
    • Park, S.G.1    Mathur, R.2    Long, M.3    Hosh, N.4    Hao, L.5    Hayden, M.S.6
  • 48
    • 79954608612 scopus 로고    scopus 로고
    • Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
    • Chaudhry A., Samstein R.M., Treuting P., Liang Y., Pils M.C., Heinrich J.M., et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 2011, 34:566-578.
    • (2011) Immunity , vol.34 , pp. 566-578
    • Chaudhry, A.1    Samstein, R.M.2    Treuting, P.3    Liang, Y.4    Pils, M.C.5    Heinrich, J.M.6
  • 49
    • 79954620910 scopus 로고    scopus 로고
    • Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner
    • Huber S., Gagliani N., Esplugues E., O'Connor W., Huber F.J., Chaudhry A., et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 2011, 34:554-565.
    • (2011) Immunity , vol.34 , pp. 554-565
    • Huber, S.1    Gagliani, N.2    Esplugues, E.3    O'Connor, W.4    Huber, F.J.5    Chaudhry, A.6
  • 50
    • 34548131112 scopus 로고    scopus 로고
    • Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10
    • Maynard C.L., Harrington L.E., Janowski K.M., Oliver J.R., Zindl C.L., Rudensky A.Y., et al. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol 2007, 8:931-941.
    • (2007) Nat Immunol , vol.8 , pp. 931-941
    • Maynard, C.L.1    Harrington, L.E.2    Janowski, K.M.3    Oliver, J.R.4    Zindl, C.L.5    Rudensky, A.Y.6
  • 51
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C., Jin H., Awasthi A., Liu S.M., Lai C.Y., Madan R., et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol 2009, 183:797-801.
    • (2009) J Immunol , vol.183 , pp. 797-801
    • Pot, C.1    Jin, H.2    Awasthi, A.3    Liu, S.M.4    Lai, C.Y.5    Madan, R.6
  • 52
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L., Quintana F.J., Pot C., Joller N., Xiao S., Kumar D., et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 2010, 11:854-861.
    • (2010) Nat Immunol , vol.11 , pp. 854-861
    • Apetoh, L.1    Quintana, F.J.2    Pot, C.3    Joller, N.4    Xiao, S.5    Kumar, D.6
  • 53
    • 79952955744 scopus 로고    scopus 로고
    • The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
    • Cretney E., Xin A., Shi W., Minnich M., Masson F., Miasari M., et al. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol 2011, 12:304-311.
    • (2011) Nat Immunol , vol.12 , pp. 304-311
    • Cretney, E.1    Xin, A.2    Shi, W.3    Minnich, M.4    Masson, F.5    Miasari, M.6
  • 54
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
    • Powrie F., Carlino J., Leach M.W., Mauze S., Coffman R.L. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996, 183:2669-2674.
    • (1996) J Exp Med , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3    Mauze, S.4    Coffman, R.L.5
  • 55
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T Lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • Read S., Malmstrom V., Powrie F., Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med 2000, 192:295-302.
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 56
    • 34248592104 scopus 로고    scopus 로고
    • T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    • Li M.O., Wan Y.Y., Flavell R.A. T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 2007, 26:579-591.
    • (2007) Immunity , vol.26 , pp. 579-591
    • Li, M.O.1    Wan, Y.Y.2    Flavell, R.A.3
  • 57
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    • Fahlen L., Read S., Gorelik L., Hurst S.D., Coffman R.L., Flavell R.A., et al. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005, 201:737-746.
    • (2005) J Exp Med , vol.201 , pp. 737-746
    • Fahlen, L.1    Read, S.2    Gorelik, L.3    Hurst, S.D.4    Coffman, R.L.5    Flavell, R.A.6
  • 58
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison L.W., Workman C.J., Kuo T.T., Boyd K., Wang Y., Vignali K.M., et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450:566-569.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3    Boyd, K.4    Wang, Y.5    Vignali, K.M.6
  • 59
    • 0033730056 scopus 로고    scopus 로고
    • Animal models of autoimmunity and their relevance to human diseases
    • Sakaguchi S. Animal models of autoimmunity and their relevance to human diseases. Curr Opin Immunol 2000, 12:684-690.
    • (2000) Curr Opin Immunol , vol.12 , pp. 684-690
    • Sakaguchi, S.1
  • 61
    • 31344480633 scopus 로고    scopus 로고
    • LAT-mediated signaling in CD4+CD25+ regulatory T cell development
    • Koonpaew S., Shen S., Flowers L., Zhang W. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med 2006, 203:119-129.
    • (2006) J Exp Med , vol.203 , pp. 119-129
    • Koonpaew, S.1    Shen, S.2    Flowers, L.3    Zhang, W.4
  • 62
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek T.R., Yu A., Vincek V., Scibelli P., Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002, 17:167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 63
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik M., de Moraes M.L., Pontoux C., Vasseur F., Penit C. Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 1998, 10:371-378.
    • (1998) Int Immunol , vol.10 , pp. 371-378
    • Papiernik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 64
    • 0036839102 scopus 로고    scopus 로고
    • Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers
    • Almeida A.R., Legrand N., Papiernik M., Freitas A.A. Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol 2002, 169:4850-4860.
    • (2002) J Immunol , vol.169 , pp. 4850-4860
    • Almeida, A.R.1    Legrand, N.2    Papiernik, M.3    Freitas, A.A.4
  • 65
    • 15444374646 scopus 로고    scopus 로고
    • Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • Setoguchi R., Hori S., Takahashi T., Sakaguchi S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 2005, 201:723-735.
    • (2005) J Exp Med , vol.201 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 66
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells
    • Burchill M.A., Yang J., Vogtenhuber C., Blazar B.R., Farrar M.A. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol 2007, 178:280-290.
    • (2007) J Immunol , vol.178 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 67
    • 54349086262 scopus 로고    scopus 로고
    • Differential requirement of PKC-theta in the development and function of natural regulatory T cells
    • Gupta S., Manicassamy S., Vasu C., Kumar A., Shang W., Sun Z. Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol 2008, 46:213-224.
    • (2008) Mol Immunol , vol.46 , pp. 213-224
    • Gupta, S.1    Manicassamy, S.2    Vasu, C.3    Kumar, A.4    Shang, W.5    Sun, Z.6
  • 69
    • 65549146581 scopus 로고    scopus 로고
    • CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells
    • Molinero L.L., Yang J., Gajewski T., Abraham C., Farrar M.A., Alegre M.L. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. J Immunol 2009, 182:6736-6743.
    • (2009) J Immunol , vol.182 , pp. 6736-6743
    • Molinero, L.L.1    Yang, J.2    Gajewski, T.3    Abraham, C.4    Farrar, M.A.5    Alegre, M.L.6
  • 72
    • 33748999526 scopus 로고    scopus 로고
    • TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
    • Sato S., Sanjo H., Tsujimura T., Ninomiya-Tsuji J., Yamamoto M., Kawai T., et al. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol 2006, 18:1405-1411.
    • (2006) Int Immunol , vol.18 , pp. 1405-1411
    • Sato, S.1    Sanjo, H.2    Tsujimura, T.3    Ninomiya-Tsuji, J.4    Yamamoto, M.5    Kawai, T.6
  • 73
    • 33746111852 scopus 로고    scopus 로고
    • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    • Wan Y.Y., Chi H., Xie M., Schneider M.D., Flavell R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 2006, 7:851-858.
    • (2006) Nat Immunol , vol.7 , pp. 851-858
    • Wan, Y.Y.1    Chi, H.2    Xie, M.3    Schneider, M.D.4    Flavell, R.A.5
  • 74
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Zheng Y., Josefowicz S., Chaudhry A., Peng X.P., Forbush K., Rudensky A.Y. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 2010, 463:808-812.
    • (2010) Nature , vol.463 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 75
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007, 317:256-260.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6
  • 76
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 2007, 204:1757-1764.
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6
  • 77
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007, 204:1775-1785.
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6
  • 78
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W., Jin W., Hardegen N., Lei K.J., Li L., Marinos N., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003, 198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 80
    • 65549100376 scopus 로고    scopus 로고
    • Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1
    • Josefowicz S.Z., Wilson C.B., Rudensky A.Y. Cutting edge: TCR stimulation is sufficient for induction of Foxp3 expression in the absence of DNA methyltransferase 1. J Immunol 2009, 182:6648-6652.
    • (2009) J Immunol , vol.182 , pp. 6648-6652
    • Josefowicz, S.Z.1    Wilson, C.B.2    Rudensky, A.Y.3
  • 81
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 2007, 8:967-974.
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 82
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang X.O., Nurieva R., Martinez G.J., Kang H.S., Chung Y., Pappu B.P., et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008, 29:44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6
  • 83
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007, 26:371-381.
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 85
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • Haribhai D., Williams J.B., Jia S., Nickerson D., Schmitt E.G., Edwards B., et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 2011, 35:109-122.
    • (2011) Immunity , vol.35 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3    Nickerson, D.4    Schmitt, E.G.5    Edwards, B.6
  • 87
    • 77951638740 scopus 로고    scopus 로고
    • Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells
    • Thornton A.M., Korty P.E., Tran D.Q., Wohlfert E.A., Murray P.E., Belkaid Y., et al. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol 2010, 184:3433-3441.
    • (2010) J Immunol , vol.184 , pp. 3433-3441
    • Thornton, A.M.1    Korty, P.E.2    Tran, D.Q.3    Wohlfert, E.A.4    Murray, P.E.5    Belkaid, Y.6
  • 88
    • 79956315886 scopus 로고    scopus 로고
    • Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    • Geuking M.B., Cahenzli J., Lawson M.A., Ng D.C., Slack E., Hapfelmeier S., et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 2011, 34:794-806.
    • (2011) Immunity , vol.34 , pp. 794-806
    • Geuking, M.B.1    Cahenzli, J.2    Lawson, M.A.3    Ng, D.C.4    Slack, E.5    Hapfelmeier, S.6
  • 89
    • 80054020840 scopus 로고    scopus 로고
    • Peripheral education of the immune system by colonic commensal microbiota
    • Lathrop S.K., Bloom S.M., Rao S.M., Nutsch K., Lio C.-W., Santacruz N., et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 2011, 478:250-254.
    • (2011) Nature , vol.478 , pp. 250-254
    • Lathrop, S.K.1    Bloom, S.M.2    Rao, S.M.3    Nutsch, K.4    Lio, C.-W.5    Santacruz, N.6
  • 90
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • Benson M.J., Pino-Lagos K., Rosemblatt M., Noelle R.J. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007, 204:1765-1774.
    • (2007) J Exp Med , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 91
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • Denning T.L., Wang Y.C., Patel S.R., Williams I.R., Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 2007, 8:1086-1094.
    • (2007) Nat Immunol , vol.8 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.C.2    Patel, S.R.3    Williams, I.R.4    Pulendran, B.5
  • 92
    • 77955634800 scopus 로고    scopus 로고
    • Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine
    • Manicassamy S., Reizis B., Ravindran R., Nakaya H., Salazar-Gonzalez R.M., Wang Y.C., et al. Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 2010, 329:849-853.
    • (2010) Science , vol.329 , pp. 849-853
    • Manicassamy, S.1    Reizis, B.2    Ravindran, R.3    Nakaya, H.4    Salazar-Gonzalez, R.M.5    Wang, Y.C.6
  • 93
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • Ivanov I.I., Frutos Rde L., Manel N., Yoshinaga K., Rifkin D.B., Sartor R.B., et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008, 4:337-349.
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1    Frutos Rde, L.2    Manel, N.3    Yoshinaga, K.4    Rifkin, D.B.5    Sartor, R.B.6
  • 94
    • 34447580869 scopus 로고    scopus 로고
    • Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis
    • Min B., Thornton A., Caucheteux S.M., Younes S.A., Oh K., Hu-Li J., et al. Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur J Immunol 2007, 37:1916-1923.
    • (2007) Eur J Immunol , vol.37 , pp. 1916-1923
    • Min, B.1    Thornton, A.2    Caucheteux, S.M.3    Younes, S.A.4    Oh, K.5    Hu-Li, J.6
  • 95
    • 44949127290 scopus 로고    scopus 로고
    • Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells
    • Ishikawa H., Tanaka K., Maeda Y., Aiba Y., Hata A., Tsuji N.M., et al. Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells. Clin Exp Immunol 2008, 153:127-135.
    • (2008) Clin Exp Immunol , vol.153 , pp. 127-135
    • Ishikawa, H.1    Tanaka, K.2    Maeda, Y.3    Aiba, Y.4    Hata, A.5    Tsuji, N.M.6
  • 97
    • 27444440273 scopus 로고    scopus 로고
    • Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis
    • Strauch U.G., Obermeier F., Grunwald N., Gurster S., Dunger N., Schultz M., et al. Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis. Gut 2005, 54:1546-1552.
    • (2005) Gut , vol.54 , pp. 1546-1552
    • Strauch, U.G.1    Obermeier, F.2    Grunwald, N.3    Gurster, S.4    Dunger, N.5    Schultz, M.6
  • 98
    • 78149310029 scopus 로고    scopus 로고
    • A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota
    • Chinen T., Volchkov P.Y., Chervonsky A.V., Rudensky A.Y. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med 2010, 207:2323-2330.
    • (2010) J Exp Med , vol.207 , pp. 2323-2330
    • Chinen, T.1    Volchkov, P.Y.2    Chervonsky, A.V.3    Rudensky, A.Y.4
  • 99
    • 14844349149 scopus 로고    scopus 로고
    • Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells
    • Di Giacinto C., Marinaro M., Sanchez M., Strober W., Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 2005, 174:3237-3246.
    • (2005) J Immunol , vol.174 , pp. 3237-3246
    • Di Giacinto, C.1    Marinaro, M.2    Sanchez, M.3    Strober, W.4    Boirivant, M.5
  • 100
    • 61449199478 scopus 로고    scopus 로고
    • Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice
    • Karimi K., Inman M.D., Bienenstock J., Forsythe P. Lactobacillus reuteri-induced regulatory T cells protect against an allergic airway response in mice. Am J Respir Crit Care Med 2009, 179:186-193.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 186-193
    • Karimi, K.1    Inman, M.D.2    Bienenstock, J.3    Forsythe, P.4
  • 101
    • 74249088146 scopus 로고    scopus 로고
    • Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response
    • Livingston M., Loach D., Wilson M., Tannock G.W., Baird M. Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response. Immunol Cell Biol 2009, 88:99-102.
    • (2009) Immunol Cell Biol , vol.88 , pp. 99-102
    • Livingston, M.1    Loach, D.2    Wilson, M.3    Tannock, G.W.4    Baird, M.5
  • 102
    • 34548842184 scopus 로고    scopus 로고
    • Lactobacillus Acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines
    • Torii A., Torii S., Fujiwara S., Tanaka H., Inagaki N., Nagai H. Lactobacillus Acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines. Allergol Int 2007, 56:293-301.
    • (2007) Allergol Int , vol.56 , pp. 293-301
    • Torii, A.1    Torii, S.2    Fujiwara, S.3    Tanaka, H.4    Inagaki, N.5    Nagai, H.6
  • 104
    • 33947308933 scopus 로고    scopus 로고
    • Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice
    • Forsythe P., Inman M.D., Bienenstock J. Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice. Am J Respir Crit Care Med 2007, 175:561-569.
    • (2007) Am J Respir Crit Care Med , vol.175 , pp. 561-569
    • Forsythe, P.1    Inman, M.D.2    Bienenstock, J.3
  • 105
    • 50849119097 scopus 로고    scopus 로고
    • Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activation
    • O'Mahony C., Scully P., O'Mahony D., Murphy S., O'Brien F., Lyons A., et al. Commensal-induced regulatory T cells mediate protection against pathogen-stimulated NF-kappaB activation. PLoS Pathog 2008, 4:e1000112.
    • (2008) PLoS Pathog , vol.4
    • O'Mahony, C.1    Scully, P.2    O'Mahony, D.3    Murphy, S.4    O'Brien, F.5    Lyons, A.6
  • 106
    • 0030297089 scopus 로고    scopus 로고
    • The indigenous gastrointestinal microflora
    • Berg R.D. The indigenous gastrointestinal microflora. Trends Microbiol 1996, 4:430-435.
    • (1996) Trends Microbiol , vol.4 , pp. 430-435
    • Berg, R.D.1
  • 107
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • Mazmanian S.K., Round J.L., Kasper D.L. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008, 453:620-625.
    • (2008) Nature , vol.453 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 108
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • Mazmanian S.K., Liu C.H., Tzianabos A.O., Kasper D.L. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122:107-118.
    • (2005) Cell , vol.122 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3    Kasper, D.L.4
  • 109
    • 0021923837 scopus 로고
    • Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice
    • Itoh K., Mitsuoka T. Characterization of clostridia isolated from faeces of limited flora mice and their effect on caecal size when associated with germ-free mice. Lab Anim 1985, 19:111-118.
    • (1985) Lab Anim , vol.19 , pp. 111-118
    • Itoh, K.1    Mitsuoka, T.2
  • 110
    • 0035815750 scopus 로고    scopus 로고
    • Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta
    • D'Angelo M., Billings P.C., Pacifici M., Leboy P.S., Kirsch T. Authentic matrix vesicles contain active metalloproteases (MMP). a role for matrix vesicle-associated MMP-13 in activation of transforming growth factor-beta. J Biol Chem 2001, 276:11347-11353.
    • (2001) J Biol Chem , vol.276 , pp. 11347-11353
    • D'Angelo, M.1    Billings, P.C.2    Pacifici, M.3    Leboy, P.S.4    Kirsch, T.5
  • 112
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • Sokol H., Pigneur B., Watterlot L., Lakhdari O., Bermudez-Humaran L.G., Gratadoux J.J., et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 2008, 105:16731-16736.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3    Lakhdari, O.4    Bermudez-Humaran, L.G.5    Gratadoux, J.J.6
  • 113
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank D.N., St Amand A.L., Feldman R.A., Boedeker E.C., Harpaz N., Pace N.R. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 2007, 104:13780-13785.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3    Boedeker, E.C.4    Harpaz, N.5    Pace, N.R.6
  • 114
    • 79956078164 scopus 로고    scopus 로고
    • Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
    • Bloom S.M., Bijanki V.N., Nava G.M., Sun L., Malvin N.P., Donermeyer D.L., et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe 2011, 9:390-403.
    • (2011) Cell Host Microbe , vol.9 , pp. 390-403
    • Bloom, S.M.1    Bijanki, V.N.2    Nava, G.M.3    Sun, L.4    Malvin, N.P.5    Donermeyer, D.L.6
  • 115
    • 79952389800 scopus 로고    scopus 로고
    • Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens
    • DePaolo R.W., Abadie V., Tang F., Fehlner-Peach H., Hall J.A., Wang W., et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature 2011, 471:220-224.
    • (2011) Nature , vol.471 , pp. 220-224
    • DePaolo, R.W.1    Abadie, V.2    Tang, F.3    Fehlner-Peach, H.4    Hall, J.A.5    Wang, W.6
  • 116
    • 72949102295 scopus 로고    scopus 로고
    • Tissue-mediated control of immunopathology in coeliac disease
    • Jabri B., Sollid L.M. Tissue-mediated control of immunopathology in coeliac disease. Nat Rev Immunol 2009, 9:858-870.
    • (2009) Nat Rev Immunol , vol.9 , pp. 858-870
    • Jabri, B.1    Sollid, L.M.2
  • 117
    • 0042324649 scopus 로고    scopus 로고
    • Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease
    • Mention J.J., Ben Ahmed M., Begue B., Barbe U., Verkarre V., Asnafi V., et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003, 125:730-745.
    • (2003) Gastroenterology , vol.125 , pp. 730-745
    • Mention, J.J.1    Ben Ahmed, M.2    Begue, B.3    Barbe, U.4    Verkarre, V.5    Asnafi, V.6
  • 118
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-1133.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 119
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • Qin J., Li R., Raes J., Arumugam M., Burgdorf K.S., Manichanh C., et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010, 464:59-65.
    • (2010) Nature , vol.464 , pp. 59-65
    • Qin, J.1    Li, R.2    Raes, J.3    Arumugam, M.4    Burgdorf, K.S.5    Manichanh, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.