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Volumn 365, Issue 3, 2016, Pages 591-605

Reactive oxygen species and fibrosis: further evidence of a significant liaison

Author keywords

Antioxidants; Antioxidative enzymes; Fibrosis; Matrix; Reactive oxygen species (ROS)

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84976285793     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-016-2445-3     Document Type: Review
Times cited : (241)

References (171)
  • 1
    • 28444477739 scopus 로고    scopus 로고
    • Scleroderma: from cell and molecular mechanisms to disease models
    • COI: 1:CAS:528:DC%2BD2MXhtFeiu7rJ, PID: 16168711
    • Abraham DJ, Varga J (2005) Scleroderma: from cell and molecular mechanisms to disease models. Trends Immunol 26:587–595
    • (2005) Trends Immunol , vol.26 , pp. 587-595
    • Abraham, D.J.1    Varga, J.2
  • 2
    • 0034685936 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts
    • COI: 1:CAS:528:DC%2BD3cXjsFanu7g%3D, PID: 10809757
    • Abraham DJ, Shiwen X, Black CM, Sa S, Xu Y, Leask A (2000) Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts. J Biol Chem 275:15220–15225
    • (2000) J Biol Chem , vol.275 , pp. 15220-15225
    • Abraham, D.J.1    Shiwen, X.2    Black, C.M.3    Sa, S.4    Xu, Y.5    Leask, A.6
  • 3
    • 77957240694 scopus 로고    scopus 로고
    • Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals
    • COI: 1:CAS:528:DC%2BC3cXht1WlsbfN, PID: 20696238
    • Aguirre J, Lambeth JD (2010) Nox enzymes from fungus to fly to fish and what they tell us about Nox function in mammals. Free Radic Biol Med 49:1342–1353
    • (2010) Free Radic Biol Med , vol.49 , pp. 1342-1353
    • Aguirre, J.1    Lambeth, J.D.2
  • 5
    • 34250359779 scopus 로고    scopus 로고
    • Emerging role of Nrf2 in protecting against hepatic and gastrointestinal
    • COI: 1:CAS:528:DC%2BD2sXmtlWmtbw%3D
    • Aleksunes LM, Manautou JE (2007) Emerging role of Nrf2 in protecting against hepatic and gastrointestinal. Dis Toxicol Pathol 35:459–473
    • (2007) Dis Toxicol Pathol , vol.35 , pp. 459-473
    • Aleksunes, L.M.1    Manautou, J.E.2
  • 7
    • 46249128924 scopus 로고    scopus 로고
    • Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration
    • COI: 1:CAS:528:DC%2BD1cXotVagt7g%3D, PID: 18506890
    • Aram G, Potter JJ, Liu X, Torbenson MS, Mezey E (2008) Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration.Hepatology 47:2051–2058
    • (2008) Hepatology , vol.47 , pp. 2051-2058
    • Aram, G.1    Potter, J.J.2    Liu, X.3    Torbenson, M.S.4    Mezey, E.5
  • 8
    • 63349112427 scopus 로고    scopus 로고
    • Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
    • COI: 1:CAS:528:DC%2BD1MXjvFOmsL4%3D, PID: 19072832
    • Aram G, Potter JJ, Liu X, Wang L, Torbenson MS, Mezey E (2009) Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology 49:911–919
    • (2009) Hepatology , vol.49 , pp. 911-919
    • Aram, G.1    Potter, J.J.2    Liu, X.3    Wang, L.4    Torbenson, M.S.5    Mezey, E.6
  • 10
    • 0031280268 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase
    • COI: 1:CAS:528:DyaK2sXntlCnsL0%3D, PID: 9374111
    • Arsalane K, Dubois CM, Muanza T, Begin R, Boudreau F, Asselin C, Cantin AM (1997) Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase. Am J Respir Cell Mol Biol 17:599–607
    • (1997) Am J Respir Cell Mol Biol , vol.17 , pp. 599-607
    • Arsalane, K.1    Dubois, C.M.2    Muanza, T.3    Begin, R.4    Boudreau, F.5    Asselin, C.6    Cantin, A.M.7
  • 12
    • 84900809399 scopus 로고    scopus 로고
    • NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents
    • COI: 1:CAS:528:DC%2BC3sXhs1ynt7vE, PID: 24155025
    • Babalola O, Mamalis A, Lev-Tov H, Jagdeo J (2014) NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents. Arch Dermatol Res 306:313–330
    • (2014) Arch Dermatol Res , vol.306 , pp. 313-330
    • Babalola, O.1    Mamalis, A.2    Lev-Tov, H.3    Jagdeo, J.4
  • 14
    • 79954570719 scopus 로고    scopus 로고
    • Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
    • COI: 1:CAS:528:DC%2BC3MXks1Wntb4%3D, PID: 21307839
    • Barnes JL, Gorin Y (2011) Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int 79:944–956
    • (2011) Kidney Int , vol.79 , pp. 944-956
    • Barnes, J.L.1    Gorin, Y.2
  • 15
    • 84878544545 scopus 로고    scopus 로고
    • The hypoxia factor Hif-1alpha controls neural crest chemotaxis and epithelial to mesenchymal transition
    • COI: 1:CAS:528:DC%2BC3sXovFekur8%3D, PID: 23712262
    • Barriga EH, Maxwell PH, Reyes AE, Mayor R (2013) The hypoxia factor Hif-1alpha controls neural crest chemotaxis and epithelial to mesenchymal transition. J Cell Biol 201:759–776
    • (2013) J Cell Biol , vol.201 , pp. 759-776
    • Barriga, E.H.1    Maxwell, P.H.2    Reyes, A.E.3    Mayor, R.4
  • 16
    • 79954463134 scopus 로고    scopus 로고
    • Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression
    • COI: 1:CAS:528:DC%2BC3MXlt1Okurk%3D
    • Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW (2011) Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am J Physiol Renal Physiol 300:F898–F905
    • (2011) Am J Physiol Renal Physiol , vol.300 , pp. F898-F905
    • Basu, R.K.1    Hubchak, S.2    Hayashida, T.3    Runyan, C.E.4    Schumacker, P.T.5    Schnaper, H.W.6
  • 20
    • 84866000151 scopus 로고    scopus 로고
    • DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats
    • COI: 1:CAS:528:DC%2BC38XhtFKiu7zN
    • Bian EB, Huang C, Ma TT, Tao H, Zhang H, Cheng C, Lv XW, Li J (2012) DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats. Toxicol Appl Pharmacol 264:13–22
    • (2012) Toxicol Appl Pharmacol , vol.264 , pp. 13-22
    • Bian, E.B.1    Huang, C.2    Ma, T.T.3    Tao, H.4    Zhang, H.5    Cheng, C.6    Lv, X.W.7    Li, J.8
  • 21
    • 0033762343 scopus 로고    scopus 로고
    • Synthesis of glutathione in response to methionine load in control subjects and in patients with cirrhosis
    • COI: 1:CAS:528:DC%2BD3cXot1Gmsb8%3D, PID: 11092507
    • Bianchi G, Brizi M, Rossi B, Ronchi M, Grossi G, Marchesini G (2000) Synthesis of glutathione in response to methionine load in control subjects and in patients with cirrhosis. Metabolism 49:1434–1439
    • (2000) Metabolism , vol.49 , pp. 1434-1439
    • Bianchi, G.1    Brizi, M.2    Rossi, B.3    Ronchi, M.4    Grossi, G.5    Marchesini, G.6
  • 22
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BD2sXisVSgt7o%3D, PID: 17327526
    • Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007) Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297:842–857
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 23
    • 77953152723 scopus 로고    scopus 로고
    • Oxidative metabolism, ROS and NO under oxygen deprivation
    • COI: 1:CAS:528:DC%2BC3cXmtFeqtbc%3D, PID: 20303775
    • Blokhina O, Fagerstedt KV (2010) Oxidative metabolism, ROS and NO under oxygen deprivation. Plant Physiol Biochem 48:359–373
    • (2010) Plant Physiol Biochem , vol.48 , pp. 359-373
    • Blokhina, O.1    Fagerstedt, K.V.2
  • 24
    • 40449111254 scopus 로고    scopus 로고
    • Scleroderma-like fibrosing disorders
    • PID: 18329541
    • Boin F, Hummers LK (2008) Scleroderma-like fibrosing disorders. Rheum Dis Clin North Am 34:199–220
    • (2008) Rheum Dis Clin North Am , vol.34 , pp. 199-220
    • Boin, F.1    Hummers, L.K.2
  • 25
    • 84866390484 scopus 로고    scopus 로고
    • Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells
    • COI: 1:CAS:528:DC%2BC38XhtF2ru7%2FP, PID: 22728268
    • Boudreau HE, Casterline BW, Rada B, Korzeniowska A, Leto TL (2012) Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med 53:1489–1499
    • (2012) Free Radic Biol Med , vol.53 , pp. 1489-1499
    • Boudreau, H.E.1    Casterline, B.W.2    Rada, B.3    Korzeniowska, A.4    Leto, T.L.5
  • 26
    • 70349804297 scopus 로고    scopus 로고
    • Nox proteins in signal transduction
    • COI: 1:CAS:528:DC%2BD1MXht1yjtbjI, PID: 19628035
    • Brown DI, Griendling KK (2009) Nox proteins in signal transduction. Free Radic Biol Med 47:1239–1253
    • (2009) Free Radic Biol Med , vol.47 , pp. 1239-1253
    • Brown, D.I.1    Griendling, K.K.2
  • 27
    • 0028535872 scopus 로고
    • Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair
    • COI: 1:CAS:528:DyaK2MXlt1ensLk%3D, PID: 8790603
    • Bucala R, Spiegel LA, Chesney J, Hogan M, Cerami A (1994) Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1:71–81
    • (1994) Mol Med , vol.1 , pp. 71-81
    • Bucala, R.1    Spiegel, L.A.2    Chesney, J.3    Hogan, M.4    Cerami, A.5
  • 28
    • 55549098874 scopus 로고    scopus 로고
    • Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity
    • COI: 1:CAS:528:DC%2BD1cXhtl2qu7bL, PID: 18845355
    • Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fernandez M (2008) Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol 49:965–976
    • (2008) J Hepatol , vol.49 , pp. 965-976
    • Carmona-Cuenca, I.1    Roncero, C.2    Sancho, P.3    Caja, L.4    Fausto, N.5    Fernandez, M.6
  • 30
    • 84936960918 scopus 로고    scopus 로고
    • TrxR1 as a potent regulator of the Nrf2-Keap1 response system
    • COI: 1:CAS:528:DC%2BC2MXhsFGrurbI, PID: 26058897
    • Cebula M, Schmidt EE, Arner ES (2015) TrxR1 as a potent regulator of the Nrf2-Keap1 response system. Antioxid Redox Signal 23:823–853
    • (2015) Antioxid Redox Signal , vol.23 , pp. 823-853
    • Cebula, M.1    Schmidt, E.E.2    Arner, E.S.3
  • 31
    • 84885185272 scopus 로고    scopus 로고
    • Regulation of the Nrf2 antioxidant pathway by microRNAs: new players in micromanaging redox homeostasis
    • COI: 1:CAS:528:DC%2BC3sXht1GmtbrK, PID: 23880293
    • Cheng X, Ku CH, Siow RC (2013) Regulation of the Nrf2 antioxidant pathway by microRNAs: new players in micromanaging redox homeostasis. Free Radic Biol Med 64:4–11
    • (2013) Free Radic Biol Med , vol.64 , pp. 4-11
    • Cheng, X.1    Ku, C.H.2    Siow, R.C.3
  • 32
    • 84901358645 scopus 로고    scopus 로고
    • Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2cXpslOjt74%3D, PID: 24816297
    • Choi J, Corder NL, Koduru B, Wang Y (2014) Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma. Free Radic Biol Med 72:267–284
    • (2014) Free Radic Biol Med , vol.72 , pp. 267-284
    • Choi, J.1    Corder, N.L.2    Koduru, B.3    Wang, Y.4
  • 34
    • 84929743638 scopus 로고    scopus 로고
    • Anti-inflammatory and antifibrotic effects of resveratrol in the lung
    • COI: 1:CAS:528:DC%2BC2MXhtVKiurbJ, PID: 25515609
    • Conte E, Fagone E, Fruciano M, Gili E, Iemmolo M, Vancheri C (2015) Anti-inflammatory and antifibrotic effects of resveratrol in the lung. Histol Histopathol 30:523–529
    • (2015) Histol Histopathol , vol.30 , pp. 523-529
    • Conte, E.1    Fagone, E.2    Fruciano, M.3    Gili, E.4    Iemmolo, M.5    Vancheri, C.6
  • 35
    • 0036234428 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
    • COI: 1:CAS:528:DC%2BD38XktF2htbY%3D, PID: 11981751
    • Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, Housset C, Rosmorduc O (2002) Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 35:1010–1021
    • (2002) Hepatology , vol.35 , pp. 1010-1021
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Kinnman, N.4    Rey, C.5    Poupon, R.6    Housset, C.7    Rosmorduc, O.8
  • 36
    • 27644456575 scopus 로고    scopus 로고
    • NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts
    • COI: 1:CAS:528:DC%2BD2MXhtFCitr%2FP
    • Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S (2005) NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 97:900–907
    • (2005) Circ Res , vol.97 , pp. 900-907
    • Cucoranu, I.1    Clempus, R.2    Dikalova, A.3    Phelan, P.J.4    Ariyan, S.5    Dikalov, S.6
  • 37
    • 80052023895 scopus 로고    scopus 로고
    • NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation
    • COI: 1:CAS:528:DC%2BC3MXhtVOktrnO, PID: 21618578
    • Cui W, Matsuno K, Iwata K, Ibi M, Matsumoto M, Zhang J, Zhu K, Katsuyama M, Torok NJ, Yabe-Nishimura C (2011) NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation. Hepatology 54:949–958
    • (2011) Hepatology , vol.54 , pp. 949-958
    • Cui, W.1    Matsuno, K.2    Iwata, K.3    Ibi, M.4    Matsumoto, M.5    Zhang, J.6    Zhu, K.7    Katsuyama, M.8    Torok, N.J.9    Yabe-Nishimura, C.10
  • 38
    • 84876105336 scopus 로고    scopus 로고
    • Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics
    • COI: 1:CAS:528:DC%2BC3sXlsF2lu74%3D, PID: 22946823
    • Cyr AR, Hitchler MJ, Domann FE (2013) Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics. Antioxid Redox Signal 18:1946–1955
    • (2013) Antioxid Redox Signal , vol.18 , pp. 1946-1955
    • Cyr, A.R.1    Hitchler, M.J.2    Domann, F.E.3
  • 39
    • 37549066891 scopus 로고    scopus 로고
    • Antioxidants as potential therapeutics for lung fibrosis
    • COI: 1:CAS:528:DC%2BD1cXht1SgsA%3D%3D, PID: 17999627
    • Day BJ (2008) Antioxidants as potential therapeutics for lung fibrosis. Antioxid Redox Signal 10:355–370
    • (2008) Antioxid Redox Signal , vol.10 , pp. 355-370
    • Day, B.J.1
  • 41
    • 84905053231 scopus 로고    scopus 로고
    • Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections
    • COI: 1:CAS:528:DC%2BC2cXht1WmsLbJ
    • Deffert C, Cachat J, Krause KH (2014) Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. Cell Microbiol 16:1168–1178
    • (2014) Cell Microbiol , vol.16 , pp. 1168-1178
    • Deffert, C.1    Cachat, J.2    Krause, K.H.3
  • 42
    • 0029816451 scopus 로고    scopus 로고
    • Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease
    • COI: 1:STN:280:DyaK28vgs1Gjuw%3D%3D, PID: 8810624
    • Dekhuijzen PN, Aben KK, Dekker I, Aarts LP, Wielders PL, van Herwaarden CL, Bast A (1996) Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease. Am J Respir Crit Care Med 154:813–816
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 813-816
    • Dekhuijzen, P.N.1    Aben, K.K.2    Dekker, I.3    Aarts, L.P.4    Wielders, P.L.5    van Herwaarden, C.L.6    Bast, A.7
  • 45
    • 77953518507 scopus 로고    scopus 로고
    • The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1
    • COI: 1:CAS:528:DC%2BC3cXpsFCqur0%3D, PID: 20427574
    • Diebold I, Petry A, Hess J, Gorlach A (2010b) The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1. Mol Biol Cell 21:2087–2096
    • (2010) Mol Biol Cell , vol.21 , pp. 2087-2096
    • Diebold, I.1    Petry, A.2    Hess, J.3    Gorlach, A.4
  • 46
    • 3242661855 scopus 로고    scopus 로고
    • Wanted! the best cell for cardiac regeneration
    • PID: 15261949
    • Dimmeler S, Zeiher AM (2004) Wanted! the best cell for cardiac regeneration. J Am Coll Cardiol 44:464–466
    • (2004) J Am Coll Cardiol , vol.44 , pp. 464-466
    • Dimmeler, S.1    Zeiher, A.M.2
  • 48
    • 58049219027 scopus 로고    scopus 로고
    • Nox-2 is a modulator of fibrogenesis in kidney allografts
    • COI: 1:CAS:528:DC%2BD1MXitlWnurs%3D, PID: 18976289
    • Djamali A, Vidyasagar A, Adulla M, Hullett D, Reese S (2009) Nox-2 is a modulator of fibrogenesis in kidney allografts. Am J Transplant 9:74–82
    • (2009) Am J Transplant , vol.9 , pp. 74-82
    • Djamali, A.1    Vidyasagar, A.2    Adulla, M.3    Hullett, D.4    Reese, S.5
  • 49
    • 0022891340 scopus 로고
    • Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • COI: 1:STN:280:DyaL2s%2FmsV2mtw%3D%3D, PID: 3537791
    • Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650–1659
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 50
    • 0021745313 scopus 로고
    • Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds
    • COI: 1:CAS:528:DyaL2MXjvF2k, PID: 6387242
    • Dvorak HF, Form DM, Manseau EJ, Smith BD (1984) Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds. J Natl Cancer Inst 73:1195–1205
    • (1984) J Natl Cancer Inst , vol.73 , pp. 1195-1205
    • Dvorak, H.F.1    Form, D.M.2    Manseau, E.J.3    Smith, B.D.4
  • 52
    • 0348230942 scopus 로고    scopus 로고
    • Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system
    • COI: 1:CAS:528:DC%2BD2cXhs1entw%3D%3D, PID: 14713336
    • Fernandes AP, Holmgren A (2004) Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid Redox Signal 6:63–74
    • (2004) Antioxid Redox Signal , vol.6 , pp. 63-74
    • Fernandes, A.P.1    Holmgren, A.2
  • 53
    • 78650988662 scopus 로고    scopus 로고
    • Ascorbate and glutathione: the heart of the redox hub
    • COI: 1:CAS:528:DC%2BC3MXksFags7g%3D, PID: 21205630
    • Foyer CH, Noctor G (2011) Ascorbate and glutathione: the heart of the redox hub. Plant Physiol 155:2–18
    • (2011) Plant Physiol , vol.155 , pp. 2-18
    • Foyer, C.H.1    Noctor, G.2
  • 54
    • 44449148691 scopus 로고    scopus 로고
    • Oxidative stress, DNA methylation and carcinogenesis
    • COI: 1:CAS:528:DC%2BD1cXmsFKksrw%3D, PID: 18372104
    • Franco R, Schoneveld O, Georgakilas AG, Panayiotidis MI (2008) Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett 266:6–11
    • (2008) Cancer Lett , vol.266 , pp. 6-11
    • Franco, R.1    Schoneveld, O.2    Georgakilas, A.G.3    Panayiotidis, M.I.4
  • 55
    • 84957536768 scopus 로고    scopus 로고
    • Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells
    • PID: 26311624
    • Ganjam GK, Chi TF, Kietzmann T, Dimova EY (2015) Resveratrol: beneficial or not? Opposite effects of resveratrol on hypoxia-dependent PAI-1 expression in tumour and primary cells. Thromb Haemost 115:461–463
    • (2015) Thromb Haemost , vol.115 , pp. 461-463
    • Ganjam, G.K.1    Chi, T.F.2    Kietzmann, T.3    Dimova, E.Y.4
  • 56
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: pathogenesis and new therapeutic targets
    • COI: 1:CAS:528:DC%2BC3MXhtlOksbzK, PID: 21920463
    • Gao B, Bataller R (2011) Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141:1572–1585
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 58
    • 77954509272 scopus 로고    scopus 로고
    • Redox control systems in the nucleus: mechanisms and functions
    • COI: 1:CAS:528:DC%2BC3cXot1aksLg%3D, PID: 20210649
    • Go YM, Jones DP (2010) Redox control systems in the nucleus: mechanisms and functions. Antioxid Redox Signal 13:489–509
    • (2010) Antioxid Redox Signal , vol.13 , pp. 489-509
    • Go, Y.M.1    Jones, D.P.2
  • 60
    • 0042366348 scopus 로고    scopus 로고
    • Reactive oxygen species and matrix remodeling in diabetic kidney
    • COI: 1:CAS:528:DC%2BD3sXmslCqsLo%3D, PID: 12874440
    • Ha H, Lee HB (2003) Reactive oxygen species and matrix remodeling in diabetic kidney. J Am Soc Nephrol 14:S246–S249
    • (2003) J Am Soc Nephrol , vol.14 , pp. S246-S249
    • Ha, H.1    Lee, H.B.2
  • 61
    • 0034176645 scopus 로고    scopus 로고
    • The antioxidant paradox
    • COI: 1:STN:280:DC%2BD3c3ltVSgtw%3D%3D, PID: 10791396
    • Halliwell B (2000) The antioxidant paradox. Lancet 355:1179–1180
    • (2000) Lancet , vol.355 , pp. 1179-1180
    • Halliwell, B.1
  • 63
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD3sXpt1Sgu7k%3D, PID: 14638353
    • Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S (2003) Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 98:2485–2490
    • (2003) Am J Gastroenterol , vol.98 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 64
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • COI: 1:CAS:528:DC%2BC2cXksVWrtLg%3D
    • Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39:199–218
    • (2014) Trends Biochem Sci , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 65
    • 69949114515 scopus 로고    scopus 로고
    • NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
    • COI: 1:CAS:528:DC%2BD1MXhtVersbjM, PID: 19701206
    • Hecker L, Vittal R, Jones T, Jagirdar R, Luckhardt TR, Horowitz JC (2009) NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat Med 15:1077–1081
    • (2009) Nat Med , vol.15 , pp. 1077-1081
    • Hecker, L.1    Vittal, R.2    Jones, T.3    Jagirdar, R.4    Luckhardt, T.R.5    Horowitz, J.C.6
  • 66
    • 79959348136 scopus 로고    scopus 로고
    • Reversible differentiation of myofibroblasts by MyoD
    • COI: 1:CAS:528:DC%2BC3MXotVGgtbw%3D, PID: 21440539
    • Hecker L, Jagirdar R, Jin T, Thannickal VJ (2011) Reversible differentiation of myofibroblasts by MyoD. Exp Cell Res 317:1914–1921
    • (2011) Exp Cell Res , vol.317 , pp. 1914-1921
    • Hecker, L.1    Jagirdar, R.2    Jin, T.3    Thannickal, V.J.4
  • 68
    • 84886808679 scopus 로고    scopus 로고
    • Chromatin proteins and modifications as drug targets
    • COI: 1:CAS:528:DC%2BC3sXhs1Krt77E, PID: 24153301
    • Helin K, Dhanak D (2013) Chromatin proteins and modifications as drug targets. Nature 502:480–488
    • (2013) Nature , vol.502 , pp. 480-488
    • Helin, K.1    Dhanak, D.2
  • 70
    • 34848862650 scopus 로고    scopus 로고
    • Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells
    • PID: 17965603
    • Hitchler MJ, Wikainapakul K, Yu L, Powers K, Attatippaholkun W, Domann FE (2006) Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells. Epigenetics 1:163–171
    • (2006) Epigenetics , vol.1 , pp. 163-171
    • Hitchler, M.J.1    Wikainapakul, K.2    Yu, L.3    Powers, K.4    Attatippaholkun, W.5    Domann, F.E.6
  • 71
    • 0034132033 scopus 로고    scopus 로고
    • Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus
    • COI: 1:STN:280:DC%2BD3c7jt1ynsw%3D%3D, PID: 10666400
    • Hogaboam CM, Blease K, Mehrad B, Steinhauser ML, Standiford TJ, Kunkel SL, Lukacs NW (2000) Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am J Pathol 156:723–732
    • (2000) Am J Pathol , vol.156 , pp. 723-732
    • Hogaboam, C.M.1    Blease, K.2    Mehrad, B.3    Steinhauser, M.L.4    Standiford, T.J.5    Kunkel, S.L.6    Lukacs, N.W.7
  • 72
    • 79955506452 scopus 로고    scopus 로고
    • The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established
    • COI: 1:CAS:528:DC%2BC3MXltlCqu7s%3D, PID: 21451125
    • Hollman PC, Cassidy A, Comte B, Heinonen M, Richelle M, Richling E, Serafini M, Scalbert A, Sies H, Vidry S (2011) The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr 141:989S–1009S
    • (2011) J Nutr , vol.141 , pp. 989S-1009S
    • Hollman, P.C.1    Cassidy, A.2    Comte, B.3    Heinonen, M.4    Richelle, M.5    Richling, E.6    Serafini, M.7    Scalbert, A.8    Sies, H.9    Vidry, S.10
  • 74
    • 77951645401 scopus 로고    scopus 로고
    • Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial
    • COI: 1:CAS:528:DC%2BC3cXlsV2msb4%3D, PID: 20424250
    • House AA, Eliasziw M, Cattran DC, Churchill DN, Oliver MJ, Fine A, Dresser GK, Spence JD (2010) Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial. JAMA 303:1603–1609
    • (2010) JAMA , vol.303 , pp. 1603-1609
    • House, A.A.1    Eliasziw, M.2    Cattran, D.C.3    Churchill, D.N.4    Oliver, M.J.5    Fine, A.6    Dresser, G.K.7    Spence, J.D.8
  • 76
    • 0037438730 scopus 로고    scopus 로고
    • Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells
    • COI: 1:CAS:528:DC%2BD3sXotVWk, PID: 12521597
    • Imai H, Nakagawa Y (2003) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic Biol Med 34:145–169
    • (2003) Free Radic Biol Med , vol.34 , pp. 145-169
    • Imai, H.1    Nakagawa, Y.2
  • 77
    • 0344862115 scopus 로고    scopus 로고
    • Differential cellular and subcellular localization of heme-binding protein 23/peroxiredoxin I and heme oxygenase-1 in rat liver
    • COI: 1:CAS:528:DC%2BD3sXpsFGhtbc%3D, PID: 14623930
    • Immenschuh S, Baumgart-Vogt E, Tan M, Iwahara S, Ramadori G, Fahimi HD (2003) Differential cellular and subcellular localization of heme-binding protein 23/peroxiredoxin I and heme oxygenase-1 in rat liver. J Histochem Cytochem 51:1621–1631
    • (2003) J Histochem Cytochem , vol.51 , pp. 1621-1631
    • Immenschuh, S.1    Baumgart-Vogt, E.2    Tan, M.3    Iwahara, S.4    Ramadori, G.5    Fahimi, H.D.6
  • 78
    • 0026644988 scopus 로고
    • Thrombolytic and pharmacokinetic properties of an immunoconjugate of single-chain urokinase-type plasminogen activator (u-PA) and a bispecific monoclonal antibody against fibrin and against u-PA in baboons
    • COI: 1:CAS:528:DyaK38XktVSmurg%3D, PID: 1571545
    • Imura Y, Stassen JM, Kurokawa T, Iwasa S, Lijnen HR, Collen D (1992) Thrombolytic and pharmacokinetic properties of an immunoconjugate of single-chain urokinase-type plasminogen activator (u-PA) and a bispecific monoclonal antibody against fibrin and against u-PA in baboons. Blood 79:2322–2329
    • (1992) Blood , vol.79 , pp. 2322-2329
    • Imura, Y.1    Stassen, J.M.2    Kurokawa, T.3    Iwasa, S.4    Lijnen, H.R.5    Collen, D.6
  • 80
    • 0030614518 scopus 로고    scopus 로고
    • TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase
    • COI: 1:CAS:528:DyaK2sXht1agtLY%3D, PID: 9034240
    • Islam KN, Kayanoki Y, Kaneto H, Suzuki K, Asahi M, Fujii J, Taniguchi N (1997) TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. Free Radic Biol Med 22:1007–1017
    • (1997) Free Radic Biol Med , vol.22 , pp. 1007-1017
    • Islam, K.N.1    Kayanoki, Y.2    Kaneto, H.3    Suzuki, K.4    Asahi, M.5    Fujii, J.6    Taniguchi, N.7
  • 81
    • 47749116455 scopus 로고    scopus 로고
    • Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation
    • COI: 1:CAS:528:DC%2BD1cXntFSmsrc%3D, PID: 18434303
    • Jain AK, Mahajan S, Jaiswal AK (2008) Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. J Biol Chem 283:17712–17720
    • (2008) J Biol Chem , vol.283 , pp. 17712-17720
    • Jain, A.K.1    Mahajan, S.2    Jaiswal, A.K.3
  • 84
    • 77954351631 scopus 로고    scopus 로고
    • High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    • COI: 1:CAS:528:DC%2BC3cXot1Wks7s%3D
    • Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, Zhang DD (2010) High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res 70:5486–5496
    • (2010) Cancer Res , vol.70 , pp. 5486-5496
    • Jiang, T.1    Chen, N.2    Zhao, F.3    Wang, X.J.4    Kong, B.5    Zheng, W.6    Zhang, D.D.7
  • 85
    • 84881161493 scopus 로고    scopus 로고
    • A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-beta1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis
    • COI: 1:CAS:528:DC%2BC3sXht1WisbvL, PID: 23515048
    • Jiang L, Qiu W, Zhou Y, Wen P, Fang L, Cao H, Zen K, He W, Zhang C, Dai C, Yang J (2013) A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-beta1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis. Kidney Int 84:285–296
    • (2013) Kidney Int , vol.84 , pp. 285-296
    • Jiang, L.1    Qiu, W.2    Zhou, Y.3    Wen, P.4    Fang, L.5    Cao, H.6    Zen, K.7    He, W.8    Zhang, C.9    Dai, C.10    Yang, J.11
  • 87
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • COI: 1:CAS:528:DC%2BD28XjslGitLw%3D, PID: 16572188
    • Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6:392–401
    • (2006) Nat Rev Cancer , vol.6 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 88
    • 33744960738 scopus 로고    scopus 로고
    • Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes?
    • COI: 1:CAS:528:DC%2BD28XmtVOksb0%3D, PID: 16738198
    • Kaminski N (2006) Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes? Proc Am Thorac Soc 3:339–344
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 339-344
    • Kaminski, N.1
  • 90
    • 0028222546 scopus 로고
    • Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes
    • COI: 1:CAS:528:DyaK2cXktVWqtLc%3D, PID: 7515058
    • Kayanoki Y, Fujii J, Suzuki K, Kawata S, Matsuzawa Y, Taniguchi N (1994) Suppression of antioxidative enzyme expression by transforming growth factor-beta 1 in rat hepatocytes. J Biol Chem 269:15488–15492
    • (1994) J Biol Chem , vol.269 , pp. 15488-15492
    • Kayanoki, Y.1    Fujii, J.2    Suzuki, K.3    Kawata, S.4    Matsuzawa, Y.5    Taniguchi, N.6
  • 91
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • COI: 1:CAS:528:DC%2BD2sXit1altrg%3D, PID: 16968214
    • Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89–116
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 92
    • 0032509217 scopus 로고    scopus 로고
    • Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. potential mechanisms for autocrine fibrogenesis in response to injury
    • COI: 1:CAS:528:DyaK1MXivFE%3D
    • Kim Y, Ratziu V, Choi SG, Lalazar A, Theiss G, Dang Q, Kim SJ, Friedman SL (1998) Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. potential mechanisms for autocrine fibrogenesis in response to injury. J Biol Chem 273:33750–33758
    • (1998) J Biol Chem , vol.273 , pp. 33750-33758
    • Kim, Y.1    Ratziu, V.2    Choi, S.G.3    Lalazar, A.4    Theiss, G.5    Dang, Q.6    Kim, S.J.7    Friedman, S.L.8
  • 94
    • 0034253463 scopus 로고    scopus 로고
    • Role of redox-regulated transcription factors in inflammation, aging and age-related diseases
    • COI: 1:CAS:528:DC%2BD3cXmt1ajs7g%3D, PID: 10978675
    • Lavrovsky Y, Chatterjee B, Clark RA, Roy AK (2000) Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol 35:521–532
    • (2000) Exp Gerontol , vol.35 , pp. 521-532
    • Lavrovsky, Y.1    Chatterjee, B.2    Clark, R.A.3    Roy, A.K.4
  • 95
    • 2142646426 scopus 로고    scopus 로고
    • TGF-beta signaling and the fibrotic response
    • COI: 1:CAS:528:DC%2BD2cXjvVOnt70%3D, PID: 15117886
    • Leask A, Abraham DJ (2004) TGF-beta signaling and the fibrotic response. FASEB J 18:816–827
    • (2004) FASEB J , vol.18 , pp. 816-827
    • Leask, A.1    Abraham, D.J.2
  • 96
    • 1642452822 scopus 로고    scopus 로고
    • Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma
    • COI: 1:CAS:528:DC%2BD2cXmsFCmtg%3D%3D, PID: 14962082
    • Leask A, Denton CP, Abraham DJ (2004) Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma. J Invest Dermatol 122:1–6
    • (2004) J Invest Dermatol , vol.122 , pp. 1-6
    • Leask, A.1    Denton, C.P.2    Abraham, D.J.3
  • 97
    • 84898785937 scopus 로고    scopus 로고
    • Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics
    • COI: 1:CAS:528:DC%2BC2cXovVKjt7s%3D, PID: 24681256
    • Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM (2014) Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics. Free Radic Biol Med 71:196–207
    • (2014) Free Radic Biol Med , vol.71 , pp. 196-207
    • Levonen, A.L.1    Hill, B.G.2    Kansanen, E.3    Zhang, J.4    Darley-Usmar, V.M.5
  • 98
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • COI: 1:CAS:528:DC%2BD1MXkt1CktQ%3D%3D
    • Lin SL, Kisseleva T, Brenner DA, Duffield JS (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173:1617–1627
    • (2008) Am J Pathol , vol.173 , pp. 1617-1627
    • Lin, S.L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 100
    • 84878704486 scopus 로고    scopus 로고
    • Nrf2 protection against liver injury produced by various hepatotoxicants
    • PID: 23766851
    • Liu J, Wu KC, Lu YF, Ekuase E, Klaassen CD (2013) Nrf2 protection against liver injury produced by various hepatotoxicants. Oxid Med Cell Longev 2013:305861
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 305861
    • Liu, J.1    Wu, K.C.2    Lu, Y.F.3    Ekuase, E.4    Klaassen, C.D.5
  • 101
    • 80052000670 scopus 로고    scopus 로고
    • Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities
    • COI: 1:CAS:528:DC%2BC3MXhtVGltLfN, PID: 21087145
    • Lubos E, Loscalzo J, Handy DE (2011) Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 15:1957–1997
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1957-1997
    • Lubos, E.1    Loscalzo, J.2    Handy, D.E.3
  • 102
    • 0023916551 scopus 로고
    • Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium
    • COI: 1:CAS:528:DyaL1cXktFOlu7o%3D, PID: 2967299
    • Lyons RM, Keski-Oja J, Moses HL (1988) Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium. J Cell Biol 106:1659–1665
    • (1988) J Cell Biol , vol.106 , pp. 1659-1665
    • Lyons, R.M.1    Keski-Oja, J.2    Moses, H.L.3
  • 103
    • 84867041441 scopus 로고    scopus 로고
    • Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2
    • COI: 1:CAS:528:DC%2BC3sXhslaksg%3D%3D, PID: 22966037
    • Ma Q, He X (2012) Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev 64:1055–1081
    • (2012) Pharmacol Rev , vol.64 , pp. 1055-1081
    • Ma, Q.1    He, X.2
  • 106
    • 84895457867 scopus 로고    scopus 로고
    • Superoxide dismutases: you’ve come a long way, baby
    • COI: 1:CAS:528:DC%2BC2cXjsFCrtrs%3D, PID: 23924157
    • McCord JM, Fridovich I (2014) Superoxide dismutases: you’ve come a long way, baby. Antioxid Redox Signal 20:1548–1549
    • (2014) Antioxid Redox Signal , vol.20 , pp. 1548-1549
    • McCord, J.M.1    Fridovich, I.2
  • 107
    • 79551557991 scopus 로고    scopus 로고
    • TGF-beta regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells
    • COI: 1:CAS:528:DC%2BC3MXisFyisbg%3D, PID: 21131394
    • Michaeloudes C, Sukkar MB, Khorasani NM, Bhavsar PK, Chung KF (2011) TGF-beta regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 300:L295–L304
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300 , pp. L295-L304
    • Michaeloudes, C.1    Sukkar, M.B.2    Khorasani, N.M.3    Bhavsar, P.K.4    Chung, K.F.5
  • 109
    • 0031670654 scopus 로고    scopus 로고
    • Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1
    • COI: 1:CAS:528:DyaK1cXmtFSruro%3D, PID: 9725916
    • Munger JS, Harpel JG, Giancotti FG, Rifkin DB (1998) Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell 9:2627–2638
    • (1998) Mol Biol Cell , vol.9 , pp. 2627-2638
    • Munger, J.S.1    Harpel, J.G.2    Giancotti, F.G.3    Rifkin, D.B.4
  • 110
    • 33745202365 scopus 로고    scopus 로고
    • NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure
    • COI: 1:CAS:528:DC%2BD28Xmt1ygsr0%3D, PID: 16631149
    • Murdoch CE, Zhang M, Cave AC, Shah AM (2006) NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure. Cardiovasc Res 71:208–215
    • (2006) Cardiovasc Res , vol.71 , pp. 208-215
    • Murdoch, C.E.1    Zhang, M.2    Cave, A.C.3    Shah, A.M.4
  • 111
    • 84870859466 scopus 로고    scopus 로고
    • Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells
    • COI: 1:CAS:528:DC%2BC38XhvV2qsbvF, PID: 23236440
    • Narasimhan M, Patel D, Vedpathak D, Rathinam M, Henderson G, Mahimainathan L (2012) Identification of novel microRNAs in post-transcriptional control of Nrf2 expression and redox homeostasis in neuronal, SH-SY5Y cells. PLoS One 7:e51111
    • (2012) PLoS One , vol.7
    • Narasimhan, M.1    Patel, D.2    Vedpathak, D.3    Rathinam, M.4    Henderson, G.5    Mahimainathan, L.6
  • 112
    • 84890128687 scopus 로고    scopus 로고
    • Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases
    • COI: 1:CAS:528:DC%2BC3sXot1Cit70%3D, PID: 23660153
    • Nauseef WM (2014) Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases. Biochim Biophys Acta 1840:757–767
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 757-767
    • Nauseef, W.M.1
  • 113
    • 0034306791 scopus 로고    scopus 로고
    • Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
    • COI: 1:CAS:528:DC%2BD3cXnslWlt7Y%3D, PID: 10998361
    • Nomura K, Imai H, Koumura T, Kobayashi T, Nakagawa Y (2000) Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis. Biochem J 351:183–193
    • (2000) Biochem J , vol.351 , pp. 183-193
    • Nomura, K.1    Imai, H.2    Koumura, T.3    Kobayashi, T.4    Nakagawa, Y.5
  • 114
    • 0035865858 scopus 로고    scopus 로고
    • Localization of the thioredoxin system in normal rat kidney
    • COI: 1:CAS:528:DC%2BD3MXhtFegsbk%3D, PID: 11182297
    • Oberley TD, Verwiebe E, Zhong W, Kang SW, Rhee SG (2001) Localization of the thioredoxin system in normal rat kidney. Free Radic Biol Med 30:412–424
    • (2001) Free Radic Biol Med , vol.30 , pp. 412-424
    • Oberley, T.D.1    Verwiebe, E.2    Zhong, W.3    Kang, S.W.4    Rhee, S.G.5
  • 117
    • 79955091590 scopus 로고    scopus 로고
    • The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice
    • COI: 1:CAS:528:DC%2BC3MXltVygu7w%3D
    • Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, Brenner DA (2011) The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology 53:1730–1741
    • (2011) Hepatology , vol.53 , pp. 1730-1741
    • Paik, Y.H.1    Iwaisako, K.2    Seki, E.3    Inokuchi, S.4    Schnabl, B.5    Osterreicher, C.H.6    Kisseleva, T.7    Brenner, D.A.8
  • 119
    • 54449087661 scopus 로고    scopus 로고
    • Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure
    • COI: 1:CAS:528:DC%2BD1cXht1Onu7nO
    • Pelclova D, Fenclova Z, Kacer P, Kuzma M, Navratil T, Lebedova J (2008) Increased 8-isoprostane, a marker of oxidative stress in exhaled breath condensate in subjects with asbestos exposure. Ind Health 46:484–489
    • (2008) Ind Health , vol.46 , pp. 484-489
    • Pelclova, D.1    Fenclova, Z.2    Kacer, P.3    Kuzma, M.4    Navratil, T.5    Lebedova, J.6
  • 123
    • 84896727760 scopus 로고    scopus 로고
    • FibromiRs: translating molecular discoveries into new anti-fibrotic drugs
    • COI: 1:CAS:528:DC%2BC2cXivFCrt7s%3D, PID: 24560301
    • Pottier N, Cauffiez C, Perrais M, Barbry P, Mari B (2014) FibromiRs: translating molecular discoveries into new anti-fibrotic drugs. Trends Pharmacol Sci 35:119–126
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 119-126
    • Pottier, N.1    Cauffiez, C.2    Perrais, M.3    Barbry, P.4    Mari, B.5
  • 124
    • 0032446729 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress
    • COI: 1:STN:280:DyaK1M%2FmsFKnsQ%3D%3D, PID: 9847257
    • Pratico D, Basili S, Vieri M, Cordova C, Violi F, Fitzgerald GA (1998) Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. Am J Respir Crit Care Med 158:1709–1714
    • (1998) Am J Respir Crit Care Med , vol.158 , pp. 1709-1714
    • Pratico, D.1    Basili, S.2    Vieri, M.3    Cordova, C.4    Violi, F.5    Fitzgerald, G.A.6
  • 125
    • 33847651241 scopus 로고    scopus 로고
    • TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells
    • PID: 17311678
    • Proell V, Carmona-Cuenca I, Murillo MM, Huber H, Fabregat I, Mikulits W (2007) TGF-beta dependent regulation of oxygen radicals during transdifferentiation of activated hepatic stellate cells to myofibroblastoid cells. Comp Hepatol 6:1
    • (2007) Comp Hepatol , vol.6 , pp. 1
    • Proell, V.1    Carmona-Cuenca, I.2    Murillo, M.M.3    Huber, H.4    Fabregat, I.5    Mikulits, W.6
  • 126
    • 84865402736 scopus 로고    scopus 로고
    • Influence of transforming growth factor-beta1 and tumor necrosis factor-alpha genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients
    • COI: 1:CAS:528:DC%2BC38Xot12ntL8%3D, PID: 22682513
    • Radwan MI, Pasha HF, Mohamed RH, Hussien HI, El-Khshab MN (2012) Influence of transforming growth factor-beta1 and tumor necrosis factor-alpha genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients. Cytokine 60:271–276
    • (2012) Cytokine , vol.60 , pp. 271-276
    • Radwan, M.I.1    Pasha, H.F.2    Mohamed, R.H.3    Hussien, H.I.4    El-Khshab, M.N.5
  • 127
    • 84867801009 scopus 로고    scopus 로고
    • Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis
    • COI: 1:CAS:528:DC%2BC38XhsFCjsrzJ, PID: 22942279
    • Ramani K, Tomasi ML, Yang H, Ko K, Lu SC (2012) Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. J Biol Chem 287:36341–36355
    • (2012) J Biol Chem , vol.287 , pp. 36341-36355
    • Ramani, K.1    Tomasi, M.L.2    Yang, H.3    Ko, K.4    Lu, S.C.5
  • 129
    • 84865562868 scopus 로고    scopus 로고
    • Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype
    • COI: 1:CAS:528:DC%2BC3sXhvF2isro%3D, PID: 22938014
    • Robinson CM, Neary R, Levendale A, Watson CJ, Baugh JA (2012) Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype. Respir Res 13:74
    • (2012) Respir Res , vol.13 , pp. 74
    • Robinson, C.M.1    Neary, R.2    Levendale, A.3    Watson, C.J.4    Baugh, J.A.5
  • 130
    • 84925060829 scopus 로고    scopus 로고
    • Fibrosis—a common pathway to organ injury and failure
    • COI: 1:CAS:528:DC%2BC2MXlsVaku7o%3D, PID: 25785971
    • Rockey DC, Bell PD, Hill JA (2015) Fibrosis—a common pathway to organ injury and failure. N Engl J Med 372:1138–1149
    • (2015) N Engl J Med , vol.372 , pp. 1138-1149
    • Rockey, D.C.1    Bell, P.D.2    Hill, J.A.3
  • 131
    • 0030734831 scopus 로고    scopus 로고
    • Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta 1
    • COI: 1:CAS:528:DyaK2sXnsFWlt74%3D, PID: 9401768
    • Romanelli RG, Caligiuri A, Carloni V, DeFranco R, Montalto P, Ceni E, Casini A, Gentilini P, Pinzani M (1997) Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta 1. Br J Pharmacol 122:1047–1054
    • (1997) Br J Pharmacol , vol.122 , pp. 1047-1054
    • Romanelli, R.G.1    Caligiuri, A.2    Carloni, V.3    DeFranco, R.4    Montalto, P.5    Ceni, E.6    Casini, A.7    Gentilini, P.8    Pinzani, M.9
  • 132
    • 0028890174 scopus 로고
    • The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells
    • COI: 1:STN:280:DyaK2M7msVOhsA%3D%3D, PID: 7532191
    • Ronnov-Jessen L, Petersen OW, Koteliansky VE, Bissell MJ (1995) The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells. J Clin Invest 95:859–873
    • (1995) J Clin Invest , vol.95 , pp. 859-873
    • Ronnov-Jessen, L.1    Petersen, O.W.2    Koteliansky, V.E.3    Bissell, M.J.4
  • 133
    • 0034681457 scopus 로고    scopus 로고
    • Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery
    • COI: 1:CAS:528:DC%2BD3cXhtlOqs7k%3D, PID: 10678830
    • Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA (2000) Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 287:1253–1258
    • (2000) Science , vol.287 , pp. 1253-1258
    • Rudolph, K.L.1    Chang, S.2    Millard, M.3    Schreiber-Agus, N.4    DePinho, R.A.5
  • 134
    • 84876461744 scopus 로고    scopus 로고
    • Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence
    • COI: 1:CAS:528:DC%2BC3sXhvFejtrvJ, PID: 23458328
    • Samoylenko A, Hossain JA, Mennerich D, Kellokumpu S, Hiltunen JK, Kietzmann T (2013) Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence. Antioxid Redox Signal 19:2157–2196
    • (2013) Antioxid Redox Signal , vol.19 , pp. 2157-2196
    • Samoylenko, A.1    Hossain, J.A.2    Mennerich, D.3    Kellokumpu, S.4    Hiltunen, J.K.5    Kietzmann, T.6
  • 135
    • 84866851052 scopus 로고    scopus 로고
    • NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development
    • COI: 1:CAS:528:DC%2BC38XhsVOmu7vN, PID: 23049784
    • Sancho P, Mainez J, Crosas-Molist E, Roncero C, Fernandez-Rodriguez CM, Pinedo F (2012) NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development. PLoS One 7:e45285
    • (2012) PLoS One , vol.7
    • Sancho, P.1    Mainez, J.2    Crosas-Molist, E.3    Roncero, C.4    Fernandez-Rodriguez, C.M.5    Pinedo, F.6
  • 137
    • 84885054027 scopus 로고    scopus 로고
    • NADPH oxidases, reactive oxygen species, and the kidney: friend and foe
    • COI: 1:CAS:528:DC%2BC3sXhslSns7%2FK, PID: 23970124
    • Sedeek M, Nasrallah R, Touyz RM, Hebert RL (2013) NADPH oxidases, reactive oxygen species, and the kidney: friend and foe. J Am Soc Nephrol 24:1512–1518
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1512-1518
    • Sedeek, M.1    Nasrallah, R.2    Touyz, R.M.3    Hebert, R.L.4
  • 138
    • 29144531843 scopus 로고    scopus 로고
    • Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases
    • COI: 1:CAS:528:DC%2BD2MXht1GnurjN, PID: 16198621
    • Seki S, Kitada T, Sakaguchi H (2005) Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases. Hepatol Res 33:132–134
    • (2005) Hepatol Res , vol.33 , pp. 132-134
    • Seki, S.1    Kitada, T.2    Sakaguchi, H.3
  • 139
    • 0001015125 scopus 로고    scopus 로고
    • Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate
    • COI: 1:CAS:528:DC%2BD3cXkvVyiu70%3D, PID: 10751410
    • Seo MS, Kang SW, Kim K, Baines IC, Lee TH, Rhee SG (2000) Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. J Biol Chem 275:20346–20354
    • (2000) J Biol Chem , vol.275 , pp. 20346-20354
    • Seo, M.S.1    Kang, S.W.2    Kim, K.3    Baines, I.C.4    Lee, T.H.5    Rhee, S.G.6
  • 140
  • 141
    • 79959250326 scopus 로고    scopus 로고
    • Latent TGF-beta structure and activation
    • COI: 1:CAS:528:DC%2BC3MXnsFOrt7k%3D, PID: 21677751
    • Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T, Springer TA (2011) Latent TGF-beta structure and activation. Nature 474:343–349
    • (2011) Nature , vol.474 , pp. 343-349
    • Shi, M.1    Zhu, J.2    Wang, R.3    Chen, X.4    Mi, L.5    Walz, T.6    Springer, T.A.7
  • 142
    • 35548939066 scopus 로고    scopus 로고
    • Involvement of NADPH oxidases in cardiac remodelling and heart failure
    • COI: 1:CAS:528:DC%2BD2sXht1Wgt7fK, PID: 17901689
    • Sirker A, Zhang M, Murdoch C, Shah AM (2007) Involvement of NADPH oxidases in cardiac remodelling and heart failure. Am J Nephrol 27:649–660
    • (2007) Am J Nephrol , vol.27 , pp. 649-660
    • Sirker, A.1    Zhang, M.2    Murdoch, C.3    Shah, A.M.4
  • 144
    • 33646593852 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells
    • COI: 1:CAS:528:DC%2BD28Xks1Slurg%3D, PID: 16227320
    • Sturrock A, Cahill B, Norman K, Huecksteadt TP, Hill K, Sanders K (2006) Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 290:L661–L673
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290 , pp. L661-L673
    • Sturrock, A.1    Cahill, B.2    Norman, K.3    Huecksteadt, T.P.4    Hill, K.5    Sanders, K.6
  • 145
    • 84893703420 scopus 로고    scopus 로고
    • Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice
    • COI: 1:CAS:528:DC%2BC2cXhs1equ7w%3D, PID: 24033682
    • Sueblinvong V, Kerchberger VE, Saghafi R, Mills ST, Fan X, Guidot DM (2014a) Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice. Alcohol Clin Exp Res 38:336–343
    • (2014) Alcohol Clin Exp Res , vol.38 , pp. 336-343
    • Sueblinvong, V.1    Kerchberger, V.E.2    Saghafi, R.3    Mills, S.T.4    Fan, X.5    Guidot, D.M.6
  • 148
    • 84906547871 scopus 로고    scopus 로고
    • Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis
    • COI: 1:CAS:528:DC%2BC2cXps1Crsbs%3D, PID: 24480825
    • Tampe B, Tampe D, Muller CA, Sugimoto H, LeBleu V, Xu X, Muller GA, Zeisberg EM, Kalluri R, Zeisberg M (2014) Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis. J Am Soc Nephrol 25:905–912
    • (2014) J Am Soc Nephrol , vol.25 , pp. 905-912
    • Tampe, B.1    Tampe, D.2    Muller, C.A.3    Sugimoto, H.4    LeBleu, V.5    Xu, X.6    Muller, G.A.7    Zeisberg, E.M.8    Kalluri, R.9    Zeisberg, M.10
  • 150
    • 84856017594 scopus 로고    scopus 로고
    • Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis
    • COI: 1:CAS:528:DC%2BC38XoslaqsA%3D%3D, PID: 22064654
    • Teoh-Fitzgerald ML, Fitzgerald MP, Jensen TJ, Futscher BW, Domann FE (2012) Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis. Mol Cancer Res 10:40–51
    • (2012) Mol Cancer Res , vol.10 , pp. 40-51
    • Teoh-Fitzgerald, M.L.1    Fitzgerald, M.P.2    Jensen, T.J.3    Futscher, B.W.4    Domann, F.E.5
  • 151
    • 77955093090 scopus 로고    scopus 로고
    • Aging, antagonistic pleiotropy and fibrotic disease
    • COI: 1:CAS:528:DC%2BC3cXptlaksbw%3D, PID: 20595011
    • Thannickal VJ (2010) Aging, antagonistic pleiotropy and fibrotic disease. Int J Biochem Cell Biol 42:1398–1400
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1398-1400
    • Thannickal, V.J.1
  • 153
    • 0029001483 scopus 로고
    • DNA adduct 8-hydroxyl-2′-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase
    • COI: 1:CAS:528:DyaK2MXlvFSrs7g%3D, PID: 7767994
    • Turk PW, Laayoun A, Smith SS, Weitzman SA (1995) DNA adduct 8-hydroxyl-2′-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase. Carcinogenesis 16:1253–1255
    • (1995) Carcinogenesis , vol.16 , pp. 1253-1255
    • Turk, P.W.1    Laayoun, A.2    Smith, S.S.3    Weitzman, S.A.4
  • 156
    • 42249088093 scopus 로고    scopus 로고
    • Reconciling the chemistry and biology of reactive oxygen species
    • COI: 1:CAS:528:DC%2BD1cXkvVSmtLo%3D, PID: 18421291
    • Winterbourn CC (2008) Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol 4:278–286
    • (2008) Nat Chem Biol , vol.4 , pp. 278-286
    • Winterbourn, C.C.1
  • 157
    • 0028114890 scopus 로고
    • The reaction of superoxide with reduced glutathione
    • COI: 1:CAS:528:DyaK2MXhvV2gtLo%3D, PID: 7979367
    • Winterbourn CC, Metodiewa D (1994) The reaction of superoxide with reduced glutathione. Arch Biochem Biophys 314:284–290
    • (1994) Arch Biochem Biophys , vol.314 , pp. 284-290
    • Winterbourn, C.C.1    Metodiewa, D.2
  • 158
    • 0242668686 scopus 로고    scopus 로고
    • Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling
    • COI: 1:CAS:528:DC%2BD3sXjtVylsr8%3D, PID: 12714747
    • Wood ZA, Poole LB, Karplus PA (2003) Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 300:650–653
    • (2003) Science , vol.300 , pp. 650-653
    • Wood, Z.A.1    Poole, L.B.2    Karplus, P.A.3
  • 159
    • 77952234615 scopus 로고    scopus 로고
    • Fibrosis under arrest
    • COI: 1:CAS:528:DC%2BC3cXls12qtrg%3D
    • Wynn TA (2010) Fibrosis under arrest. Nat Med 16:523–525
    • (2010) Nat Med , vol.16 , pp. 523-525
    • Wynn, T.A.1
  • 160
    • 84928389740 scopus 로고    scopus 로고
    • Epigenetic repression of Kruppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis
    • COI: 1:CAS:528:DC%2BC2MXht1eitLjJ, PID: 25892014
    • Xiao X, Tang W, Yuan Q, Peng L, Yu P (2015) Epigenetic repression of Kruppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis. Int J Mol Med 35:1596–1602
    • (2015) Int J Mol Med , vol.35 , pp. 1596-1602
    • Xiao, X.1    Tang, W.2    Yuan, Q.3    Peng, L.4    Yu, P.5
  • 161
    • 52649098886 scopus 로고    scopus 로고
    • The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
    • COI: 1:CAS:528:DC%2BD1cXhtFGhs7jP, PID: 18679376
    • Xu W, Hellerbrand C, Kohler UA, Bugnon P, Kan YW, Werner S, Beyer TA (2008) The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis. Lab Invest 88:1068–1078
    • (2008) Lab Invest , vol.88 , pp. 1068-1078
    • Xu, W.1    Hellerbrand, C.2    Kohler, U.A.3    Bugnon, P.4    Kan, Y.W.5    Werner, S.6    Beyer, T.A.7
  • 162
    • 84936802418 scopus 로고    scopus 로고
    • Snail is a direct target of HIF1a in hypoxia-induced endothelial to mesenchymal transition of human coronary endothelial cells
    • COI: 1:CAS:528:DC%2BC2MXhtFSktLvP, PID: 25971970
    • Xu X, Tan X, Tampe B, Sanchez E, Zeisberg M, Zeisberg EM (2015) Snail is a direct target of HIF1a in hypoxia-induced endothelial to mesenchymal transition of human coronary endothelial cells. J Biol Chem 290:16653–16664
    • (2015) J Biol Chem , vol.290 , pp. 16653-16664
    • Xu, X.1    Tan, X.2    Tampe, B.3    Sanchez, E.4    Zeisberg, M.5    Zeisberg, E.M.6
  • 164
    • 20244378531 scopus 로고    scopus 로고
    • Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor
    • COI: 1:CAS:528:DC%2BD2MXjtlKlt70%3D, PID: 15851615
    • Yoon YS, Uchida S, Masuo O, Cejna M, Park JS, Gwon HC, Kirchmair R, Bahlman F, Walter D, Curry C, Hanley A, Isner JM, Losordo DW (2005) Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 111:2073–2085
    • (2005) Circulation , vol.111 , pp. 2073-2085
    • Yoon, Y.S.1    Uchida, S.2    Masuo, O.3    Cejna, M.4    Park, J.S.5    Gwon, H.C.6    Kirchmair, R.7    Bahlman, F.8    Walter, D.9    Curry, C.10    Hanley, A.11    Isner, J.M.12    Losordo, D.W.13
  • 166
    • 0037443517 scopus 로고    scopus 로고
    • Cellular response to hypoxia involves signaling via Smad proteins
    • COI: 1:CAS:528:DC%2BD3sXit1egsbo%3D, PID: 12411310
    • Zhang H, Akman HO, Smith EL, Zhao J, Murphy-Ullrich JE, Batuman OA (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101:2253–2260
    • (2003) Blood , vol.101 , pp. 2253-2260
    • Zhang, H.1    Akman, H.O.2    Smith, E.L.3    Zhao, J.4    Murphy-Ullrich, J.E.5    Batuman, O.A.6
  • 167
    • 77952952816 scopus 로고    scopus 로고
    • Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
    • COI: 1:CAS:528:DC%2BC3cXmsVekt74%3D, PID: 20350562
    • Zhang YK, Yeager RL, Tanaka Y, Klaassen CD (2010) Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol 245:326–334
    • (2010) Toxicol Appl Pharmacol , vol.245 , pp. 326-334
    • Zhang, Y.K.1    Yeager, R.L.2    Tanaka, Y.3    Klaassen, C.D.4
  • 168
    • 84877578496 scopus 로고    scopus 로고
    • DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B
    • COI: 1:STN:280:DC%2BC3snhsVSkug%3D%3D, PID: 23647960
    • Zhao Q, Fan YC, Zhao J, Gao S, Zhao ZH, Wang K (2013) DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B. J Viral Hepat 20:430–437
    • (2013) J Viral Hepat , vol.20 , pp. 430-437
    • Zhao, Q.1    Fan, Y.C.2    Zhao, J.3    Gao, S.4    Zhao, Z.H.5    Wang, K.6
  • 169
    • 58149474525 scopus 로고    scopus 로고
    • Genetic polymorphisms in the transforming growth factor-beta signaling pathways and breast cancer risk and survival
    • COI: 1:CAS:528:DC%2BD1cXhsVeqt7fI, PID: 19107437
    • Zheng W (2009) Genetic polymorphisms in the transforming growth factor-beta signaling pathways and breast cancer risk and survival. Methods Mol Biol 472:265–277
    • (2009) Methods Mol Biol , vol.472 , pp. 265-277
    • Zheng, W.1
  • 170
    • 79956196320 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis
    • COI: 1:CAS:528:DC%2BC3MXmsVGgsrY%3D, PID: 21419141
    • Ziech D, Franco R, Pappa A, Panayiotidis MI (2011) Reactive oxygen species (ROS)-induced genetic and epigenetic alterations in human carcinogenesis. Mutat Res 711:167–173
    • (2011) Mutat Res , vol.711 , pp. 167-173
    • Ziech, D.1    Franco, R.2    Pappa, A.3    Panayiotidis, M.I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.