Targeting of Gamma-Glutamyl-Cysteine Ligase by miR-433 Reduces Glutathione Biosynthesis and Promotes TGF-β-Dependent Fibrogenesis

Antioxidants and Redox Signaling

Volumn 23, Issue 14, 2015, Pages 1092-1105

  Espinosa Diez, Cristina ^a   Fierro Fernandez, Marta ^a   Sanchez Gomez, Francisco ^a   Rodriguez Pascual, Fernando ^a   Alique, Matilde ^a   Ruiz Ortega, Marta ^a   Beraza, Naiara ^b   Martinez Chantar, Maria L ^b   Fernandez Hernando, Carlos ^c   Lamas, Santiago ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRONECTIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; KIDNEY INJURY MOLECULE 1; LUCIFERASE; MESSENGER RNA; MICRORNA; MICRORNA 144; MICRORNA 433; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; GCLC PROTEIN, HUMAN; GLUTAMATE-CYSTEINE LIGASE MODIFIER SUBUNIT, HUMAN; MIRN433 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCATALYSIS; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FIBROGENESIS; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; KIDNEY FIBROSIS; KIDNEY INJURY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MALE; MOUSE; NITRATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PEPTIDE SYNTHESIS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SUBUNIT; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; URETER OBSTRUCTION; ANIMAL; BINDING SITE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CHLOROCEBUS AETHIOPS; COS CELL LINE; ENZYME REPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; RNA INTERFERENCE;

3' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME REPRESSION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MICE, INBRED C57BL; MICRORNAS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; RNA INTERFERENCE;

EID: 84942762143     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.6025     Document Type: Article

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