Chronic Alcohol Ingestion Primes the Lung for Bleomycin-Induced Fibrosis in Mice

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 2, 2014, Pages 336-343

  Sueblinvong, Viranuj ^a   Kerchberger, Vern E ^a   Saghafi, Ramin ^a   Mills, Stephen T ^a   Fan, Xian ^a,b   Guidot, David M ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Acute Respiratory Distress Syndrome; Fibrosis; Glutathione; S Adenosylmethionine; TGF 1

Indexed keywords

ALCOHOL; BLEOMYCIN; COLLAGEN; DRINKING WATER; HYDROXYPROLINE; MESSENGER RNA; S ADENOSYLMETHIONINE; SCLEROPROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; FIBROGENESIS; GENE EXPRESSION; HISTOPATHOLOGY; IN VITRO STUDY; LUNG FIBROBLAST; LUNG PARENCHYMA; MOUSE; MYOFIBROBLAST; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

MUS;

ACUTE RESPIRATORY DISTRESS SYNDROME; FIBROSIS; GLUTATHIONE; S-ADENOSYLMETHIONINE; TGFΒ1;

ACTINS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIET; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHANOL; FIBROBLASTS; HYDROXYPROLINE; LUNG; MICE; MICE, INBRED C57BL; MYOFIBROBLASTS; OXIDATIVE STRESS; PNEUMONIA; PULMONARY FIBROSIS; RNA, MESSENGER; S-ADENOSYLMETHIONINE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84893703420     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12232     Document Type: Article

References (28)

1. Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM (2004) Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am J Respir Crit Care Med 170:188-194.
2. Behr J, Demedts M, Buhl R, Costabel U, Dekhuijzen RP, Jansen HM, Macnee W, Thomeer M, Wallaert B, Laurent F, Nicholson AG, Verbeken EK, Verschakelen J, Flower CD, Petruzzelli S, de Vuyst P, van den Bosch JM, Rodriguez-Becerra E, Lankhorst I, Sardina M, Boissard G (2009) Lung function in idiopathic pulmonary fibrosis-extended analyses of the IFIGENIA trial. Respir Res 10:101.
3. Beier JI, Arteel GE, McClain CJ (2011) Advances in alcoholic liver disease. Curr Gastroenterol Rep 13:56-64.
4. Biernacka A, Dobaczewski M, Frangogiannis NG (2011) TGF-beta signaling in fibrosis. Growth Factors 29:196-202.
5. Brown LA, Ritzenthaler JD, Guidot DM, Roman J (2007) Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation. Alcohol 41:317-324.
6. Brown SD, Brown LA (2012) Ethanol (EtOH)-induced TGF-beta(1) and reactive oxygen species production are necessary for EtOH-induced alveolar macrophage dysfunction and induction of alternative activation. Alcohol Clin Exp Res 36:1952-1962.
7. Cantin AM, Hubbard RC, Crystal RG (1989) Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis. Am Rev Respir Dis 139:370-372.
8. Coward WR, Saini G, Jenkins G (2010) The pathogenesis of idiopathic pulmonary fibrosis. Ther Adv Respir Dis 4:367-388.
9. Dobson R (2003) Heavy drinking costs the NHS 1.7bn pounds sterling a year, says report. BMJ 327:701.
10. Dooley S, ten Dijke P (2012) TGF-beta in progression of liver disease. Cell Tissue Res 347:245-256.
11. Gauthier TW, Young PA, Gabelaia L, Tang SM, Ping XD, Harris FL, Brown LA (2009) In utero ethanol exposure impairs defenses against experimental group B streptococcus in the term guinea pig lung. Alcohol Clin Exp Res 33:300-306.
12. Guidot D, Moss M, Holguin F, Lois M, Brown L (1999) Ethanol ingestion impairs alveolar epithelial glutathione homeostasis and function, and predisposes to endotoxin-mediated acute lung injury. Chest 116:82S.
13. Holguin F, Moss I, Brown LA, Guidot DM (1998) Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats. J Clin Invest 101:761-768.
14. Homma S, Azuma A, Taniguchi H, Ogura T, Mochiduki Y, Sugiyama Y, Nakata K, Yoshimura K, Takeuchi M, Kudoh S (2012) Efficacy of inhaled N-acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis. Respirology 17:467-477.
15. Liu RM, Vayalil PK, Ballinger C, Dickinson DA, Huang WT, Wang S, Kavanagh TJ, Matthews QL, Postlethwait EM (2012) Transforming growth factor beta suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radic Biol Med 53:554-563.
16. Merikangas KR, McClair VL (2012) Epidemiology of substance use disorders. Hum Genet 131:779-789.
17. Meyer A, Buhl R, Magnussen H (1994) The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur Respir J 7:431-436.
18. Moss M, Bucher B, Moore FA, Moore EE, Parsons PE (1996) The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA 275:50-54.
19. Moss M, Burnham EL (2006) Alcohol abuse in the critically ill patient. Lancet 368:2231-2242.
20. Moss M, Guidot DM, Wong-Lambertina M, ten Hoor T, Perez RL, Brown LA (2000) The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am J Respir Crit Care Med 161:414-419.
21. Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, Eaton S, Cotsonis GA (2003) Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med 31:869-877.
22. Phan SH, Kunkel SL (1992) Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res 18:29-43.
23. Rocco PR, dos Santos C, Pelosi P (2009) Lung parenchyma remodeling in acute respiratory distress syndrome. Minerva Anestesiol 75:730-740.
24. Roman J, Ritzenthaler JD, Bechara R, Brown LA, Guidot D (2005) Ethanol stimulates the expression of fibronectin in lung fibroblasts via kinase-dependent signals that activate CREB. Am J Physiol Lung Cell Mol Physiol 288:L975-L987.
25. Sueblinvong V, Loi R, Eisenhauer PL, Bernstein IM, Suratt BT, Spees JL, Weiss DJ (2008) Derivation of lung epithelium from human cord blood-derived mesenchymal stem cells. Am J Respir Crit Care Med 177:701-711.
26. Sugiura H, Ichikawa T, Liu X, Kobayashi T, Wang XQ, Kawasaki S, Togo S, Kamio K, Mao L, Ann Y, Ichinose M, Rennard SI (2009) N-acetyl-l-cysteine inhibits TGF-beta1-induced profibrotic responses in fibroblasts. Pulm Pharmacol Ther 22:487-491.
27. Velasquez A, Bechara RI, Lewis JF, Malloy J, McCaig L, Brown LA, Guidot DM (2002) Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats. Alcohol Clin Exp Res 26:1245-1251.
28. Zhang K, Flanders KC, Phan SH (1995) Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis. Am J Pathol 147:352-361.