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Volumn 20, Issue 17, 2014, Pages 2854-2872

Role of NADPH oxidases in liver fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN II; BILE SALT; LEPTIN; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 3; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 5; SMAD PROTEIN; SUPEROXIDE DISMUTASE; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84901056473     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5619     Document Type: Review
Times cited : (188)

References (206)
  • 1
    • 79952453566 scopus 로고    scopus 로고
    • The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C Trial cohort
    • Abu Dayyeh BK, Yang M, Dienstag JL, and Chung RT. The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C Trial cohort. Dig Dis Sci 56: 564-568, 2011
    • (2011) Dig Dis Sci , vol.56 , pp. 564-568
    • Abu Dayyeh, B.K.1    Yang, M.2    Dienstag, J.L.3    Chung, R.T.4
  • 2
    • 20044393839 scopus 로고    scopus 로고
    • NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells
    • Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K, and Kawata S. NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology 41: 1272-1281, 2005
    • (2005) Hepatology , vol.41 , pp. 1272-1281
    • Adachi, T.1    Togashi, H.2    Suzuki, A.3    Kasai, S.4    Ito, J.5    Sugahara, K.6    Kawata, S.7
  • 3
    • 33845927120 scopus 로고    scopus 로고
    • Alcohol, oxidative stress and free radical damage
    • Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 65: 278-290, 2006
    • (2006) Proc Nutr Soc , vol.65 , pp. 278-290
    • Albano, E.1
  • 4
    • 77956036249 scopus 로고    scopus 로고
    • NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts
    • Amara N, Goven D, Prost F, Muloway R, Crestani B, and Boczkowski J. NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts. Thorax 65: 733-738, 2010
    • (2010) Thorax , vol.65 , pp. 733-738
    • Amara, N.1    Goven, D.2    Prost, F.3    Muloway, R.4    Crestani, B.5    Boczkowski, J.6
  • 5
    • 8544270180 scopus 로고    scopus 로고
    • Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
    • Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, and Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem 279: 45935-45941, 2004
    • (2004) J Biol Chem , vol.279 , pp. 45935-45941
    • Ambasta, R.K.1    Kumar, P.2    Griendling, K.K.3    Schmidt, H.H.4    Busse, R.5    Brandes, R.P.6
  • 6
    • 77956810224 scopus 로고    scopus 로고
    • Toll-like receptor signaling and liver fibrosis
    • DOI: 10.1155/2010/192543
    • Aoyama T, Paik YH, and Seki E. Toll-like receptor signaling and liver fibrosis. Gastroenterol Res Pract 2010, 2010. DOI: 10.1155/2010/192543
    • (2010) Gastroenterol Res Pract , vol.2010
    • Aoyama, T.1    Paik, Y.H.2    Seki, E.3
  • 8
    • 63349112427 scopus 로고    scopus 로고
    • Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration
    • Aram G, Potter JJ, Liu X, Wang L, Torbenson MS, and Mezey E. Deficiency of nicotinamide adenine dinucleotide phosphate, reduced form oxidase enhances hepatocellular injury but attenuates fibrosis after chronic carbon tetrachloride administration. Hepatology 49: 911-919, 2009
    • (2009) Hepatology , vol.49 , pp. 911-919
    • Aram, G.1    Potter, J.J.2    Liu, X.3    Wang, L.4    Torbenson, M.S.5    Mezey, E.6
  • 9
    • 0037371816 scopus 로고    scopus 로고
    • Oxidants and antioxidants in alcohol-induced liver disease
    • Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124: 778-790, 2003
    • (2003) Gastroenterology , vol.124 , pp. 778-790
    • Arteel, G.E.1
  • 10
    • 0842321777 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B
    • Asehnoune K, Strassheim D, Mitra S, Kim JY, and Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol 172: 2522-2529, 2004
    • (2004) J Immunol , vol.172 , pp. 2522-2529
    • Asehnoune, K.1    Strassheim, D.2    Mitra, S.3    Kim, J.Y.4    Abraham, E.5
  • 11
    • 84859897794 scopus 로고    scopus 로고
    • Regulation of reactive oxygen species generation in cell signaling
    • Bae YS, Oh H, Rhee SG, and Yoo YD. Regulation of reactive oxygen species generation in cell signaling. Mol Cells 32: 491-509, 2011
    • (2011) Mol Cells , vol.32 , pp. 491-509
    • Bae, Y.S.1    Oh, H.2    Rhee, S.G.3    Yoo, Y.D.4
  • 12
    • 0038789165 scopus 로고    scopus 로고
    • Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
    • Banfi B, Clark RA, Steger K, and Krause KH. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem 278: 3510-3513, 2003
    • (2003) J Biol Chem , vol.278 , pp. 3510-3513
    • Banfi, B.1    Clark, R.A.2    Steger, K.3    Krause, K.H.4
  • 13
    • 0034809804 scopus 로고    scopus 로고
    • Hepatic stellate cells as a target for the treatment of liver fibrosis
    • Bataller R and Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 21: 437-451, 2001
    • (2001) Semin Liver Dis , vol.21 , pp. 437-451
    • Bataller, R.1    Brenner, D.A.2
  • 16
    • 0842300376 scopus 로고    scopus 로고
    • Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells
    • Bataller R, Paik YH, Lindquist JN, Lemasters JJ, and Brenner DA. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Gastroenterology 126: 529-540, 2004
    • (2004) Gastroenterology , vol.126 , pp. 529-540
    • Bataller, R.1    Paik, Y.H.2    Lindquist, J.N.3    Lemasters, J.J.4    Brenner, D.A.5
  • 19
    • 33846595768 scopus 로고    scopus 로고
    • Hydrophobic bile salts trigger ceramide formation through endosomal acidification
    • Becker S, Reinehr R, Grether-Beck S, Eberle A, and Haussinger D. Hydrophobic bile salts trigger ceramide formation through endosomal acidification. Biol Chem 388: 185-196, 2007
    • (2007) Biol Chem , vol.388 , pp. 185-196
    • Becker, S.1    Reinehr, R.2    Grether-Beck, S.3    Eberle, A.4    Haussinger, D.5
  • 20
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • Beckman JS and Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly. Am J Physiol 271: C1424-C1437, 1996
    • (1996) Am J Physiol , vol.271
    • Beckman, J.S.1    Koppenol, W.H.2
  • 21
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROSgenerating NADPH oxidases: Physiology and pathophysiology
    • Bedard K and Krause KH. The NOX family of ROSgenerating NADPH oxidases: Physiology and pathophysiology. Physiol Rev 87: 245-313, 2007
    • (2007) Physiol Rev , vol.87 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 22
    • 77955716367 scopus 로고    scopus 로고
    • Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-Activated apoptosis during renal ischemia/reperfusion injury
    • Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E, and Vandewalle A. Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-Activated apoptosis during renal ischemia/reperfusion injury. Cell Death Differ 17: 1474-1485, 2010
    • (2010) Cell Death Differ , vol.17 , pp. 1474-1485
    • Ben Mkaddem, S.1    Pedruzzi, E.2    Werts, C.3    Coant, N.4    Bens, M.5    Cluzeaud, F.6    Goujon, J.M.7    Ogier-Denis, E.8    Vandewalle, A.9
  • 24
    • 72849147487 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: A new contributor to HCVinduced oxidative stress
    • Boudreau HE, Emerson SU, Korzeniowska A, Jendrysik MA, and Leto TL. Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: A new contributor to HCVinduced oxidative stress. J Virol 83: 12934-12946, 2009
    • (2009) J Virol , vol.83 , pp. 12934-12946
    • Boudreau, H.E.1    Emerson, S.U.2    Korzeniowska, A.3    Jendrysik, M.A.4    Leto, T.L.5
  • 27
  • 28
    • 33750471197 scopus 로고    scopus 로고
    • Mutual cross-Talk between reactive oxygen species and nuclear factor-kappa B: Molecular basis and biological significance
    • Bubici C, Papa S, Dean K, and Franzoso G.Mutual cross-Talk between reactive oxygen species and nuclear factor-kappa B: Molecular basis and biological significance. Oncogene 25: 6731-6748, 2006
    • (2006) Oncogene , vol.25 , pp. 6731-6748
    • Bubici, C.1    Papa, S.2    Dean, K.3    Franzoso, G.4
  • 29
    • 0035933837 scopus 로고    scopus 로고
    • Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase
    • Bureau C, Bernad J, Chaouche N, Orfila C, Beraud M, Gonindard C, Alric L, Vinel JP, and Pipy B. Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase. J Biol Chem 276: 23077-23083, 2001
    • (2001) J Biol Chem , vol.276 , pp. 23077-23083
    • Bureau, C.1    Bernad, J.2    Chaouche, N.3    Orfila, C.4    Beraud, M.5    Gonindard, C.6    Alric, L.7    Vinel, J.P.8    Pipy, B.9
  • 30
    • 0024407187 scopus 로고
    • Biochemistry of oxygen toxicity
    • Cadenas E. Biochemistry of oxygen toxicity. Annu Rev Biochem 58: 79-110, 1989
    • (1989) Annu Rev Biochem , vol.58 , pp. 79-110
    • Cadenas, E.1
  • 31
    • 70350212686 scopus 로고    scopus 로고
    • Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4
    • Caja L, Sancho P, Bertran E, Iglesias-Serret D, Gil J, and Fabregat I. Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. Cancer Res 69: 7595-7602, 2009
    • (2009) Cancer Res , vol.69 , pp. 7595-7602
    • Caja, L.1    Sancho, P.2    Bertran, E.3    Iglesias-Serret, D.4    Gil, J.5    Fabregat, I.6
  • 33
  • 34
    • 33645660479 scopus 로고    scopus 로고
    • EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death
    • Carmona-Cuenca I, Herrera B, Ventura JJ, Roncero C, Fernandez M, and Fabregat I. EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death. J Cell Physiol 207: 322-330, 2006
    • (2006) J Cell Physiol , vol.207 , pp. 322-330
    • Carmona-Cuenca, I.1    Herrera, B.2    Ventura, J.J.3    Roncero, C.4    Fernandez, M.5    Fabregat, I.6
  • 35
    • 55549098874 scopus 로고    scopus 로고
    • Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-Apoptotic activity
    • Carmona-Cuenca I, Roncero C, Sancho P, Caja L, Fausto N, Fernandez M, and Fabregat I. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-Apoptotic activity. J Hepatol 49: 965-976, 2008
    • (2008) J Hepatol , vol.49 , pp. 965-976
    • Carmona-Cuenca, I.1    Roncero, C.2    Sancho, P.3    Caja, L.4    Fausto, N.5    Fernandez, M.6    Fabregat, I.7
  • 39
    • 84870939278 scopus 로고    scopus 로고
    • From form to function: The role of Nox4 in the cardiovascular system
    • Chen F, Haigh S, Barman S, and Fulton DJ. From form to function: The role of Nox4 in the cardiovascular system. Front Physiol 3: 412, 2012
    • (2012) Front Physiol , vol.3 , pp. 412
    • Chen, F.1    Haigh, S.2    Barman, S.3    Fulton, D.J.4
  • 40
    • 70349341899 scopus 로고    scopus 로고
    • Downstream targets and intracellular compartmentalization in Nox signaling
    • Chen K, Craige SE, and Keaney JF Jr. Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal 11: 2467-2480, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2467-2480
    • Chen, K.1    Craige, S.E.2    Keaney Jr., J.F.3
  • 41
    • 46249108461 scopus 로고    scopus 로고
    • Regulation of ROS signal transduction by NADPH oxidase 4 localization
    • Chen K, Kirber MT, Xiao H, Yang Y, and Keaney JF Jr. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181: 1129-1139, 2008
    • (2008) J Cell Biol , vol.181 , pp. 1129-1139
    • Chen, K.1    Kirber, M.T.2    Xiao, H.3    Yang, Y.4    Keaney Jr., J.F.5
  • 43
    • 33645819203 scopus 로고    scopus 로고
    • Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus
    • Choi J and Ou JH. Mechanisms of liver injury. III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 290: G847-G851, 2006
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Choi, J.1    Ou, J.H.2
  • 45
    • 77950618056 scopus 로고    scopus 로고
    • Angiotensin II antagonists in patients with recurrent hepatitis C virus infection after liver transplantation
    • Cholongitas E, Vibhakorn S, Lodato F, and Burroughs AK. Angiotensin II antagonists in patients with recurrent hepatitis C virus infection after liver transplantation. Liver Int 30: 334-335, 2010
    • (2010) Liver Int , vol.30 , pp. 334-335
    • Cholongitas, E.1    Vibhakorn, S.2    Lodato, F.3    Burroughs, A.K.4
  • 46
    • 84864345542 scopus 로고    scopus 로고
    • NADPH oxidase inhibitors: A decade of discovery from Nox2ds to HTS
    • Cifuentes-Pagano E, Csanyi G, and Pagano PJ. NADPH oxidase inhibitors: A decade of discovery from Nox2ds to HTS. Cell Mol Life Sci 69: 2315-2325, 2012
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2315-2325
    • Cifuentes-Pagano, E.1    Csanyi, G.2    Pagano, P.J.3
  • 53
    • 27644456575 scopus 로고    scopus 로고
    • NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts
    • Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, and Sorescu D. NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res 97: 900-907, 2005
    • (2005) Circ Res , vol.97 , pp. 900-907
    • Cucoranu, I.1    Clempus, R.2    Dikalova, A.3    Phelan, P.J.4    Ariyan, S.5    Dikalov, S.6    Sorescu, D.7
  • 54
    • 80052023895 scopus 로고    scopus 로고
    • NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation
    • Cui W, Matsuno K, Iwata K, Ibi M, Matsumoto M, Zhang J, Zhu K, Katsuyama M, Torok NJ, and Yabe-Nishimura C. NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation. Hepatology 54: 949-958, 2011
    • (2011) Hepatology , vol.54 , pp. 949-958
    • Cui, W.1    Matsuno, K.2    Iwata, K.3    Ibi, M.4    Matsumoto, M.5    Zhang, J.6    Zhu, K.7    Katsuyama, M.8    Torok, N.J.9    Yabe-Nishimura, C.10
  • 55
    • 35948979743 scopus 로고    scopus 로고
    • Cell signaling in oxidative stress-induced liver injury
    • Czaja MJ. Cell signaling in oxidative stress-induced liver injury. Semin Liver Dis 27: 378-389, 2007
    • (2007) Semin Liver Dis , vol.27 , pp. 378-389
    • Czaja, M.J.1
  • 56
    • 0033607653 scopus 로고    scopus 로고
    • Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells
    • De Bleser PJ, Xu G, Rombouts K, Rogiers V, and Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 274: 33881-33887, 1999
    • (1999) J Biol Chem , vol.274 , pp. 33881-33887
    • De Bleser, P.J.1    Xu, G.2    Rombouts, K.3    Rogiers, V.4    Geerts, A.5
  • 57
    • 33745739887 scopus 로고    scopus 로고
    • NADPH oxidase in the liver: Defensive offensive or fibrogenic?
    • De Minicis S, Bataller R, and Brenner DA. NADPH oxidase in the liver: Defensive, offensive, or fibrogenic?. Gastroenterology 131: 272-275, 2006
    • (2006) Gastroenterology , vol.131 , pp. 272-275
    • De Minicis, S.1    Bataller, R.2    Brenner, D.A.3
  • 58
    • 58149380810 scopus 로고    scopus 로고
    • Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells
    • De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, and Brenner DA. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology 48: 2016-2026, 2008
    • (2008) Hepatology , vol.48 , pp. 2016-2026
    • De Minicis, S.1    Seki, E.2    Oesterreicher, C.3    Schnabl, B.4    Schwabe, R.F.5    Brenner, D.A.6
  • 60
    • 77954236285 scopus 로고    scopus 로고
    • Hepatocyte NAD(P) H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection
    • De Mochel NS, Seronello S, Wang SH, Ito C, Zheng JX, Liang TJ, Lambeth JD, and Choi J. Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection. Hepatology 52: 47-59, 2010
    • (2010) Hepatology , vol.52 , pp. 47-59
    • De Mochel, N.S.1    Seronello, S.2    Wang, S.H.3    Ito, C.4    Zheng, J.X.5    Liang, T.J.6    Lambeth, J.D.7    Choi, J.8
  • 61
    • 0034607821 scopus 로고    scopus 로고
    • Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly
    • DeLeo FR, Burritt JB, Yu L, Jesaitis AJ, Dinauer MC, and Nauseef WM. Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly. J Biol Chem 275: 13986-13993, 2000
    • (2000) J Biol Chem , vol.275 , pp. 13986-13993
    • DeLeo, F.R.1    Burritt, J.B.2    Yu, L.3    Jesaitis, A.J.4    Dinauer, M.C.5    Nauseef, W.M.6
  • 62
    • 0347364750 scopus 로고    scopus 로고
    • Normal and pathologic soft tissue remodeling: Role of the myofibroblast, with special emphasis on liver and kidney fibrosis
    • Desmouliere A, Darby IA, and Gabbiani G. Normal and pathologic soft tissue remodeling: Role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest 83: 1689-1707, 2003
    • (2003) Lab Invest , vol.83 , pp. 1689-1707
    • Desmouliere, A.1    Darby, I.A.2    Gabbiani, G.3
  • 63
    • 66949125400 scopus 로고    scopus 로고
    • Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2
    • Diebold I, Djordjevic T, Petry A, Hatzelmann A, Tenor H, Hess J, and Gorlach A. Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2. Circ Res 104: 1169-1177, 2009
    • (2009) Circ Res , vol.104 , pp. 1169-1177
    • Diebold, I.1    Djordjevic, T.2    Petry, A.3    Hatzelmann, A.4    Tenor, H.5    Hess, J.6    Gorlach, A.7
  • 65
    • 79957890939 scopus 로고    scopus 로고
    • Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
    • Drummond GR, Selemidis S, Griendling KK, and Sobey CG. Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov 10: 453-471, 2011
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 453-471
    • Drummond, G.R.1    Selemidis, S.2    Griendling, K.K.3    Sobey, C.G.4
  • 66
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • e1261
    • El-Serag HB. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142: 1264-1273.e1261, 2012
    • (2012) Gastroenterology , vol.142 , pp. 1264-1273
    • El-Serag, H.B.1
  • 67
    • 25844507931 scopus 로고    scopus 로고
    • PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: Possible involvement of PKCdelta in vascular hypertrophy
    • Fan CY, Katsuyama M, and Yabe-Nishimura C. PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: Possible involvement of PKCdelta in vascular hypertrophy. Biochem J 390: 761-767, 2005
    • (2005) Biochem J , vol.390 , pp. 761-767
    • Fan, C.Y.1    Katsuyama, M.2    Yabe-Nishimura, C.3
  • 68
    • 60749137151 scopus 로고    scopus 로고
    • NADPH oxidasedependent signaling in endothelial cells: Role in physiology and pathophysiology
    • Frey RS, Ushio-Fukai M, and Malik AB. NADPH oxidasedependent signaling in endothelial cells: Role in physiology and pathophysiology. Antioxid Redox Signal 11: 791-810, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 791-810
    • Frey, R.S.1    Ushio-Fukai, M.2    Malik, A.B.3
  • 69
    • 0020644952 scopus 로고
    • Superoxide radical: An endogenous toxicant
    • Fridovich I. Superoxide radical: An endogenous toxicant. Annu Rev Pharmacol Toxicol 23: 239-257, 1983
    • (1983) Annu Rev Pharmacol Toxicol , vol.23 , pp. 239-257
    • Fridovich, I.1
  • 70
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenterology 134: 1655-1669, 2008
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 71
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250, 2000
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 72
    • 0001520008 scopus 로고
    • Hepatic lipocytes: The principal collagen-producing cells of normal rat liver
    • Friedman SL, Roll FJ, Boyles J, and Bissell DM. Hepatic lipocytes: The principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82: 8681-8685, 1985
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8681-8685
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Bissell, D.M.4
  • 73
    • 0037090069 scopus 로고    scopus 로고
    • Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: Studies in p47phox-/-And gp91phox-/-mice
    • Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, and Malik AB. Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: Studies in p47phox-/-And gp91phox-/-mice. J Immunol 168: 3974-3982, 2002
    • (2002) J Immunol , vol.168 , pp. 3974-3982
    • Gao, X.P.1    Standiford, T.J.2    Rahman, A.3    Newstead, M.4    Holland, S.M.5    Dinauer, M.C.6    Liu, Q.H.7    Malik, A.B.8
  • 75
    • 62949101948 scopus 로고    scopus 로고
    • NADPH oxidases and angiotensin II receptor signaling
    • Garrido AM and Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 302: 148-158, 2009
    • (2009) Mol Cell Endocrinol , vol.302 , pp. 148-158
    • Garrido, A.M.1    Griendling, K.K.2
  • 80
    • 0034725652 scopus 로고    scopus 로고
    • Reactive oxygen species as mediators of angiotensin II signaling
    • Griendling KK and Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 91: 21-27, 2000
    • (2000) Regul Pept , vol.91 , pp. 21-27
    • Griendling, K.K.1    Ushio-Fukai, M.2
  • 81
    • 77249116145 scopus 로고    scopus 로고
    • Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells
    • Guimaraes EL, Empsen C, Geerts A, and van Grunsven LA. Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol 52: 389-397, 2010
    • (2010) J Hepatol , vol.52 , pp. 389-397
    • Guimaraes, E.L.1    Empsen, C.2    Geerts, A.3    Van Grunsven, L.A.4
  • 84
    • 67649947512 scopus 로고    scopus 로고
    • Emerging concepts in the pathogenesis of lung fibrosis
    • Hardie WD, Glasser SW, and Hagood JS. Emerging concepts in the pathogenesis of lung fibrosis. Am J Pathol 175: 3-16, 2009
    • (2009) Am J Pathol , vol.175 , pp. 3-16
    • Hardie, W.D.1    Glasser, S.W.2    Hagood, J.S.3
  • 86
    • 84864356954 scopus 로고    scopus 로고
    • Targeting NOX enzymes in pulmonary fibrosis
    • Hecker L, Cheng J, and Thannickal VJ. Targeting NOX enzymes in pulmonary fibrosis. Cell Mol Life Sci 69: 2365-2371, 2012
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2365-2371
    • Hecker, L.1    Cheng, J.2    Thannickal, V.J.3
  • 89
    • 65349125859 scopus 로고    scopus 로고
    • Identification of structural elements in Nox1 and Nox4 controlling localization and activity
    • Helmcke I, Heumuller S, Tikkanen R, Schroder K, and Brandes RP. Identification of structural elements in Nox1 and Nox4 controlling localization and activity. Antioxid Redox Signal 11: 1279-1287, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1279-1287
    • Helmcke, I.1    Heumuller, S.2    Tikkanen, R.3    Schroder, K.4    Brandes, R.P.5
  • 90
    • 0034874036 scopus 로고    scopus 로고
    • Activation of caspases occurs downstream from radical oxygen species production BclxL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes
    • Herrera B, Fernandez M, Alvarez AM, Roncero C, Benito M, Gil J, and Fabregat I. Activation of caspases occurs downstream from radical oxygen species production, BclxL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes. Hepatology 34: 548-556, 2001
    • (2001) Hepatology , vol.34 , pp. 548-556
    • Herrera, B.1    Fernandez, M.2    Alvarez, A.M.3    Roncero, C.4    Benito, M.5    Gil, J.6    Fabregat, I.7
  • 93
    • 34748835852 scopus 로고    scopus 로고
    • Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells
    • Hu R, Wang YL, Edderkaoui M, Lugea A, Apte MV, and Pandol SJ. Ethanol augments PDGF-induced NADPH oxidase activity and proliferation in rat pancreatic stellate cells. Pancreatology 7: 332-340, 2007
    • (2007) Pancreatology , vol.7 , pp. 332-340
    • Hu, R.1    Wang, Y.L.2    Edderkaoui, M.3    Lugea, A.4    Apte, M.V.5    Pandol, S.J.6
  • 95
    • 0028310765 scopus 로고
    • The renin-Angiotensin system
    • Inagami T. The renin-Angiotensin system. Essays Biochem 28: 147-164, 1994
    • (1994) Essays Biochem , vol.28 , pp. 147-164
    • Inagami, T.1
  • 96
    • 67651156448 scopus 로고    scopus 로고
    • Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets
    • Jaquet V, Scapozza L, Clark RA, Krause KH, and Lambeth JD. Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal 11: 2535-2552, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 2535-2552
    • Jaquet, V.1    Scapozza, L.2    Clark, R.A.3    Krause, K.H.4    Lambeth, J.D.5
  • 100
    • 0041347547 scopus 로고    scopus 로고
    • AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4
    • Kanno K, Tazuma S, and Chayama K. AT1A-deficient mice show less severe progression of liver fibrosis induced by CCl(4). Biochem Biophys Res Commun 308: 177-183, 2003
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 177-183
    • Kanno, K.1    Tazuma, S.2    Chayama, K.3
  • 102
    • 14844334642 scopus 로고    scopus 로고
    • Essential role of ATF-1 in induction of NOX1, a catalytic subunit of NADPH oxidase: Involvement of mitochondrial respiratory chain
    • Katsuyama M, Fan C, Arakawa N, Nishinaka T, Miyagishi M, Taira K, and Yabe-Nishimura C. Essential role of ATF-1 in induction of NOX1, a catalytic subunit of NADPH oxidase: Involvement of mitochondrial respiratory chain. Biochem J 386: 255-261, 2005
    • (2005) Biochem J , vol.386 , pp. 255-261
    • Katsuyama, M.1    Fan, C.2    Arakawa, N.3    Nishinaka, T.4    Miyagishi, M.5    Taira, K.6    Yabe-Nishimura, C.7
  • 103
    • 84864674993 scopus 로고    scopus 로고
    • Primary involvement of NADPH oxidase 4 in hypoxiainduced generation of reactive oxygen species in adiposederived stem cells
    • Kim JH, Song SY, Park SG, Song SU, Xia Y, and Sung JH. Primary involvement of NADPH oxidase 4 in hypoxiainduced generation of reactive oxygen species in adiposederived stem cells. Stem Cells Dev 21: 2212-2221, 2012
    • (2012) Stem Cells Dev , vol.21 , pp. 2212-2221
    • Kim, J.H.1    Song, S.Y.2    Park, S.G.3    Song, S.U.4    Xia, Y.5    Sung, J.H.6
  • 104
    • 77953555446 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta and betacatenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages
    • Kim JS, Yeo S, Shin DG, Bae YS, Lee JJ, Chin BR, Lee CH, and Baek SH. Glycogen synthase kinase 3beta and betacatenin pathway is involved in toll-like receptor 4-mediated NADPH oxidase 1 expression in macrophages. FEBS J 277: 2830-2837, 2010
    • (2010) FEBS J , vol.277 , pp. 2830-2837
    • Kim, J.S.1    Yeo, S.2    Shin, D.G.3    Bae, Y.S.4    Lee, J.J.5    Chin, B.R.6    Lee, C.H.7    Baek, S.H.8
  • 110
    • 0036645337 scopus 로고    scopus 로고
    • Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats
    • Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, and Imaizumi T. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation 106: 130-135, 2002
    • (2002) Circulation , vol.106 , pp. 130-135
    • Kuwahara, F.1    Kai, H.2    Tokuda, K.3    Kai, M.4    Takeshita, A.5    Egashira, K.6    Imaizumi, T.7
  • 113
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4: 181-189, 2004
    • (2004) Nat Rev Immunol , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 115
    • 0035844030 scopus 로고    scopus 로고
    • Novel gp91(phox) homologues in vascular smooth muscle cells: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways
    • Lassegue B, Sorescu D, Szocs K, Yin Q, Akers M, Zhang Y, Grant SL, Lambeth JD, and Griendling KK. Novel gp91(phox) homologues in vascular smooth muscle cells: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res 88: 888-894, 2001
    • (2001) Circ Res , vol.88 , pp. 888-894
    • Lassegue, B.1    Sorescu, D.2    Szocs, K.3    Yin, Q.4    Akers, M.5    Zhang, Y.6    Grant, S.L.7    Lambeth, J.D.8    Griendling, K.K.9
  • 116
    • 67650501166 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
    • Latella G, Vetuschi A, Sferra R, Catitti V, D'Angelo A, Zanninelli G, Flanders KC, and Gaudio E. Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice. Liver Int 29: 997-1009, 2009
    • (2009) Liver Int , vol.29 , pp. 997-1009
    • Latella, G.1    Vetuschi, A.2    Sferra, R.3    Catitti, V.4    D'Angelo, A.5    Zanninelli, G.6    Flanders, K.C.7    Gaudio, E.8
  • 117
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee KS, Buck M, Houglum K, and Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96: 2461-2468, 1995
    • (1995) J Clin Invest , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 120
    • 42449127029 scopus 로고    scopus 로고
    • Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury
    • Li Q, Zhang Y, Marden JJ, Banfi B, and Engelhardt JF. Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury. Biochem J 411: 531-541, 2008
    • (2008) Biochem J , vol.411 , pp. 531-541
    • Li, Q.1    Zhang, Y.2    Marden, J.J.3    Banfi, B.4    Engelhardt, J.F.5
  • 121
    • 0345256577 scopus 로고    scopus 로고
    • Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease
    • Lieber CS, Weiss DG, Groszmann R, Paronetto F, and Schenker S. II. Veterans Affairs Cooperative Study of polyenylphosphatidylcholine in alcoholic liver disease. Alcohol Clin Exp Res 27: 1765-1772, 2003
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 1765-1772
    • Lieber, C.S.1    Weiss, D.G.2    Groszmann, R.3    Paronetto, F.4    Schenker II, S.5
  • 124
    • 0028101281 scopus 로고
    • Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture
    • Maher JJ, Tzagarakis C, and Gimenez A. Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture. Alcohol Alcohol 29: 605-610, 1994
    • (1994) Alcohol Alcohol , vol.29 , pp. 605-610
    • Maher, J.J.1    Tzagarakis, C.2    Gimenez, A.3
  • 127
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • Martinon F, Chen X, Lee AH, and Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11: 411-418, 2010
    • (2010) Nat Immunol , vol.11 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.H.3    Glimcher, L.H.4
  • 128
    • 26244444476 scopus 로고    scopus 로고
    • Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases
    • Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, and Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18: 69-82, 2006
    • (2006) Cell Signal , vol.18 , pp. 69-82
    • Martyn, K.D.1    Frederick, L.M.2    Von Loehneysen, K.3    Dinauer, M.C.4    Knaus, U.G.5
  • 131
    • 34848885825 scopus 로고    scopus 로고
    • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3
    • Miller FJ Jr., Filali M, Huss GJ, Stanic B, Chamseddine A, Barna TJ, and Lamb FS. Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. Circ Res 101: 663-671, 2007
    • (2007) Circ Res , vol.101 , pp. 663-671
    • Miller Jr., F.J.1    Filali, M.2    Huss, G.J.3    Stanic, B.4    Chamseddine, A.5    Barna, T.J.6    Lamb, F.S.7
  • 135
    • 47749151450 scopus 로고    scopus 로고
    • Biological roles for the NOX family NADPH oxidases
    • Nauseef WM. Biological roles for the NOX family NADPH oxidases. J Biol Chem 283: 16961-16965, 2008
    • (2008) J Biol Chem , vol.283 , pp. 16961-16965
    • Nauseef, W.M.1
  • 136
    • 0034733746 scopus 로고    scopus 로고
    • Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2
    • Nieto N, Greenwel P, Friedman SL, Zhang F, Dannenberg AJ, and Cederbaum AI. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. J Biol Chem 275: 20136-20145, 2000
    • (2000) J Biol Chem , vol.275 , pp. 20136-20145
    • Nieto, N.1    Greenwel, P.2    Friedman, S.L.3    Zhang, F.4    Dannenberg, A.J.5    Cederbaum, A.I.6
  • 137
  • 138
    • 65349113056 scopus 로고    scopus 로고
    • Signaling components of redox active endosomes: The redoxosomes
    • Oakley FD, Abbott D, Li Q, and Engelhardt JF. Signaling components of redox active endosomes: The redoxosomes. Antioxid Redox Signal 11: 1313-1333, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1313-1333
    • Oakley, F.D.1    Abbott, D.2    Li, Q.3    Engelhardt, J.F.4
  • 139
    • 70450267433 scopus 로고    scopus 로고
    • Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane
    • Oakley FD, Smith RL, and Engelhardt JF. Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane. J Biol Chem 284: 33255-33264, 2009
    • (2009) J Biol Chem , vol.284 , pp. 33255-33264
    • Oakley, F.D.1    Smith, R.L.2    Engelhardt, J.F.3
  • 141
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, and Weinman SA. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122: 366-375, 2002
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3    Showalter, L.A.4    Scholle, F.5    Lemon, S.M.6    Weinman, S.A.7
  • 143
    • 79955091590 scopus 로고    scopus 로고
    • The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice
    • Paik YH, Iwaisako K, Seki E, Inokuchi S, Schnabl B, Osterreicher CH, Kisseleva T, and Brenner DA. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Hepatology 53: 1730-1741, 2011
    • (2011) Hepatology , vol.53 , pp. 1730-1741
    • Paik, Y.H.1    Iwaisako, K.2    Seki, E.3    Inokuchi, S.4    Schnabl, B.5    Osterreicher, C.H.6    Kisseleva, T.7    Brenner, D.A.8
  • 145
    • 0038185316 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells
    • Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, and Brenner DA. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology 37: 1043-1055, 2003
    • (2003) Hepatology , vol.37 , pp. 1043-1055
    • Paik, Y.H.1    Schwabe, R.F.2    Bataller, R.3    Russo, M.P.4    Jobin, C.5    Brenner, D.A.6
  • 146
  • 148
    • 33750519444 scopus 로고    scopus 로고
    • Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells
    • Park HS, Chun JN, Jung HY, Choi C, and Bae YS. Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells. Cardiovasc Res 72: 447-455, 2006
    • (2006) Cardiovasc Res , vol.72 , pp. 447-455
    • Park, H.S.1    Chun, J.N.2    Jung, H.Y.3    Choi, C.4    Bae, Y.S.5
  • 149
    • 4644350365 scopus 로고    scopus 로고
    • Cutting edge: Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen
    • Park HS, Jung HY, Park EY, Kim J, Lee WJ, and Bae YS. Cutting edge: Direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol 173: 3589-3593, 2004
    • (2004) J Immunol , vol.173 , pp. 3589-3593
    • Park, H.S.1    Jung, H.Y.2    Park, E.Y.3    Kim, J.4    Lee, W.J.5    Bae, Y.S.6
  • 150
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M and Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 35: 297-306, 2001
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 153
    • 0024840085 scopus 로고
    • Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
    • Pinzani M, Gesualdo L, Sabbah GM, and Abboud HE. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest 84: 1786-1793, 1989
    • (1989) J Clin Invest , vol.84 , pp. 1786-1793
    • Pinzani, M.1    Gesualdo, L.2    Sabbah, G.M.3    Abboud, H.E.4
  • 154
    • 0029859861 scopus 로고    scopus 로고
    • Oxidative damage and fibrogenesis
    • Poli G and Parola M. Oxidative damage and fibrogenesis. Free Radic Biol Med 22: 287-305, 1997
    • (1997) Free Radic Biol Med , vol.22 , pp. 287-305
    • Poli, G.1    Parola, M.2
  • 155
    • 1542504567 scopus 로고    scopus 로고
    • Portal tract fibrogenesis in the liver
    • Ramadori G and Saile B. Portal tract fibrogenesis in the liver. Lab Invest 84: 153-159, 2004
    • (2004) Lab Invest , vol.84 , pp. 153-159
    • Ramadori, G.1    Saile, B.2
  • 156
    • 33847067437 scopus 로고    scopus 로고
    • Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis
    • Ramjaun AR, Tomlinson S, Eddaoudi A, and Downward J. Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis. Oncogene 26: 970-981, 2007
    • (2007) Oncogene , vol.26 , pp. 970-981
    • Ramjaun, A.R.1    Tomlinson, S.2    Eddaoudi, A.3    Downward, J.4
  • 157
    • 22844440003 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
    • Reinehr R, Becker S, Eberle A, Grether-Beck S, and Haussinger D. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem 280: 27179-27194, 2005
    • (2005) J Biol Chem , vol.280 , pp. 27179-27194
    • Reinehr, R.1    Becker, S.2    Eberle, A.3    Grether-Beck, S.4    Haussinger, D.5
  • 159
    • 0036911138 scopus 로고    scopus 로고
    • Hydrogen peroxide as second messenger in lymphocyte activation
    • Reth M. Hydrogen peroxide as second messenger in lymphocyte activation. Nat Immunol 3: 1129-1134, 2002
    • (2002) Nat Immunol , vol.3 , pp. 1129-1134
    • Reth, M.1
  • 161
    • 0026846805 scopus 로고
    • Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture
    • Rockey DC, Boyles JK, Gabbiani G, and Friedman SL. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol 24: 193-203, 1992
    • (1992) J Submicrosc Cytol Pathol , vol.24 , pp. 193-203
    • Rockey, D.C.1    Boyles, J.K.2    Gabbiani, G.3    Friedman, S.L.4
  • 162
    • 0026613011 scopus 로고
    • Cytochrome b558: The flavin-binding component of the phagocyte NADPH oxidase
    • Rotrosen D, Yeung CL, Leto TL, Malech HL, and Kwong CH. Cytochrome b558: The flavin-binding component of the phagocyte NADPH oxidase. Science 256: 1459-1462, 1992
    • (1992) Science , vol.256 , pp. 1459-1462
    • Rotrosen, D.1    Yeung, C.L.2    Leto, T.L.3    Malech, H.L.4    Kwong, C.H.5
  • 164
    • 84891790166 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: Potential role in hypertension
    • Santos CXC, Nabeebaccus AA, Shah AM, Camargo LL, Filho SV, and Lopes LR. Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: Potential role in hypertension. Antioxid Redox Signal. 20: 121-134, 2014
    • (2014) Antioxid Redox Signal. , vol.20 , pp. 121-134
    • Santos, C.X.C.1    Nabeebaccus, A.A.2    Shah, A.M.3    Camargo, L.L.4    Filho, S.V.5    Lopes, L.R.6
  • 171
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki E and Brenner DA. Toll-like receptors and adaptor molecules in liver disease: Update. Hepatology 48: 322-335, 2008
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 175
    • 33745808765 scopus 로고    scopus 로고
    • Transforming growth factor beta: A central modulator of pulmonary and airway inflammation and fibrosis
    • Sheppard D. Transforming growth factor beta: A central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 3: 413-417, 2006
    • (2006) Proc Am Thorac Soc , vol.3 , pp. 413-417
    • Sheppard, D.1
  • 177
    • 69249141789 scopus 로고    scopus 로고
    • Bile acidinduced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis
    • Sommerfeld A, Reinehr R, and Haussinger D. Bile acidinduced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J Biol Chem 284: 22173-22183, 2009
    • (2009) J Biol Chem , vol.284 , pp. 22173-22183
    • Sommerfeld, A.1    Reinehr, R.2    Haussinger, D.3
  • 178
    • 31644451945 scopus 로고    scopus 로고
    • Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: A pilot study
    • Sookoian S, Fernandez MA, and Castano G. Effects of six months losartan administration on liver fibrosis in chronic hepatitis C patients: A pilot study. World J Gastroenterol 11: 7560-7563, 2005
    • (2005) World J Gastroenterol , vol.11 , pp. 7560-7563
    • Sookoian, S.1    Fernandez, M.A.2    Castano, G.3
  • 181
    • 18644369234 scopus 로고    scopus 로고
    • Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C
    • Terui Y, Saito T, Watanabe H, Togashi H, Kawata S, Kamada Y, and Sakuta S. Effect of angiotensin receptor antagonist on liver fibrosis in early stages of chronic hepatitis C. Hepatology 36: 1022, 2002
    • (2002) Hepatology , vol.36 , pp. 1022
    • Terui, Y.1    Saito, T.2    Watanabe, H.3    Togashi, H.4    Kawata, S.5    Kamada, Y.6    Sakuta, S.7
  • 182
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R, Oldach D, Chang KM, Steiger C, Ray SC, and Chisari FV. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J Exp Med 194: 1395-1406, 2001
    • (2001) J Exp Med , vol.194 , pp. 1395-1406
    • Thimme, R.1    Oldach, D.2    Chang, K.M.3    Steiger, C.4    Ray, S.C.5    Chisari, F.V.6
  • 183
    • 10044270011 scopus 로고    scopus 로고
    • A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: Role of NADPH oxidase-derived oxygen radicals
    • Thoren F, Romero A, Lindh M, Dahlgren C, and Hellstrand K. A hepatitis C virus-encoded, nonstructural protein (NS3) triggers dysfunction and apoptosis in lymphocytes: Role of NADPH oxidase-derived oxygen radicals. J Leukoc Biol 76: 1180-1186, 2004
    • (2004) J Leukoc Biol , vol.76 , pp. 1180-1186
    • Thoren, F.1    Romero, A.2    Lindh, M.3    Dahlgren, C.4    Hellstrand, K.5
  • 184
    • 0037076798 scopus 로고    scopus 로고
    • Expression of a functionally active gp91phox-containing neutrophil-Type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin I.I
    • Touyz RM, Chen X, Tabet F, Yao G, He G, Quinn MT, Pagano PJ, and Schiffrin EL. Expression of a functionally active gp91phox-containing neutrophil-Type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II. Circ Res 90: 1205-1213, 2002
    • (2002) Circ Res , vol.90 , pp. 1205-1213
    • Touyz, R.M.1    Chen, X.2    Tabet, F.3    Yao, G.4    He, G.5    Quinn, M.T.6    Pagano, P.J.7    Schiffrin, E.L.8
  • 185
    • 0038374866 scopus 로고    scopus 로고
    • Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis
    • Ueberham E, Low R, Ueberham U, Schonig K, Bujard H, and Gebhardt R. Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology 37: 1067-1078, 2003
    • (2003) Hepatology , vol.37 , pp. 1067-1078
    • Ueberham, E.1    Low, R.2    Ueberham, U.3    Schonig, K.4    Bujard, H.5    Gebhardt, R.6
  • 186
    • 65349157681 scopus 로고    scopus 로고
    • Compartmentalization of redox signaling through NADPH oxidase-derived ROS
    • Ushio-Fukai M. Compartmentalization of redox signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal 11: 1289-1299, 2009
    • (2009) Antioxid Redox Signal , vol.11 , pp. 1289-1299
    • Ushio-Fukai, M.1
  • 187
    • 33745217132 scopus 로고    scopus 로고
    • Redox signaling in angiogenesis: Role of NADPH oxidase
    • Ushio-Fukai M. Redox signaling in angiogenesis: Role of NADPH oxidase. Cardiovasc Res 71: 226-235, 2006
    • (2006) Cardiovasc Res , vol.71 , pp. 226-235
    • Ushio-Fukai, M.1
  • 188
    • 58049200120 scopus 로고    scopus 로고
    • Mutational analysis reveals distinct features of the Nox4-p22 phox complex
    • von Lohneysen K, Noack D, Jesaitis AJ, Dinauer MC, and Knaus UG. Mutational analysis reveals distinct features of the Nox4-p22 phox complex. J Biol Chem 283: 35273-35282, 2008
    • (2008) J Biol Chem , vol.283 , pp. 35273-35282
    • Von Lohneysen, K.1    Noack, D.2    Jesaitis, A.J.3    Dinauer, M.C.4    Knaus, U.G.5
  • 189
    • 75749118290 scopus 로고    scopus 로고
    • Structural insights into Nox4 and Nox2: Motifs involved in function and cellular localization
    • von Lohneysen K, Noack D, Wood MR, Friedman JS, and Knaus UG. Structural insights into Nox4 and Nox2: Motifs involved in function and cellular localization. Mol Cell Biol 30: 961-975, 2010
    • (2010) Mol Cell Biol , vol.30 , pp. 961-975
    • Von Lohneysen, K.1    Noack, D.2    Wood, M.R.3    Friedman, J.S.4    Knaus, U.G.5
  • 190
    • 71549122264 scopus 로고    scopus 로고
    • Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication
    • Wang B, Trippler M, Pei R, Lu M, Broering R, Gerken G, and Schlaak JF. Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication. J Hepatol 51: 1037-1045, 2009
    • (2009) J Hepatol , vol.51 , pp. 1037-1045
    • Wang, B.1    Trippler, M.2    Pei, R.3    Lu, M.4    Broering, R.5    Gerken, G.6    Schlaak, J.F.7
  • 193
    • 0032865515 scopus 로고    scopus 로고
    • Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide
    • Winterbourn CC and Metodiewa D. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. Free Radic Biol Med 27: 322-328, 1999
    • (1999) Free Radic Biol Med , vol.27 , pp. 322-328
    • Winterbourn, C.C.1    Metodiewa, D.2
  • 194
    • 0141703529 scopus 로고    scopus 로고
    • Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1
    • Wu RF, Gu Y, Xu YC, Nwariaku FE, and Terada LS. Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1. J Biol Chem 278: 36830-36840, 2003
    • (2003) J Biol Chem , vol.278 , pp. 36830-36840
    • Wu, R.F.1    Gu, Y.2    Xu, Y.C.3    Nwariaku, F.E.4    Terada, L.S.5
  • 195
    • 77954382142 scopus 로고    scopus 로고
    • Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation
    • Wu RF, Ma Z, Liu Z, and Terada LS. Nox4-derived H2O2 mediates endoplasmic reticulum signaling through local Ras activation. Mol Cell Biol 30: 3553-3568, 2010
    • (2010) Mol Cell Biol , vol.30 , pp. 3553-3568
    • Wu, R.F.1    Ma, Z.2    Liu, Z.3    Terada, L.S.4
  • 197
    • 71049139747 scopus 로고    scopus 로고
    • Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling
    • Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, and Chen YG. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol Chem 284: 30097-30104, 2009
    • (2009) J Biol Chem , vol.284 , pp. 30097-30104
    • Yan, X.1    Lin, Z.2    Chen, F.3    Zhao, X.4    Chen, H.5    Ning, Y.6    Chen, Y.G.7
  • 198
    • 84866432939 scopus 로고    scopus 로고
    • Toll-like receptors in liver fibrosis: Cellular crosstalk and mechanisms
    • Yang L and Seki E. Toll-like receptors in liver fibrosis: Cellular crosstalk and mechanisms. Front Physiol 3: 138, 2012
    • (2012) Front Physiol , vol.3 , pp. 138
    • Yang, L.1    Seki, E.2
  • 199
    • 21844457440 scopus 로고    scopus 로고
    • Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice
    • Yang L, Bataller R, Dulyx J, Coffman TM, Gines P, Rippe RA, and Brenner DA. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol 43: 317-323, 2005
    • (2005) J Hepatol , vol.43 , pp. 317-323
    • Yang, L.1    Bataller, R.2    Dulyx, J.3    Coffman, T.M.4    Gines, P.5    Rippe, R.A.6    Brenner, D.A.7
  • 203
    • 33645243410 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
    • Zhan SS, Jiang JX, Wu J, Halsted C, Friedman SL, Zern MA, and Torok NJ. Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology 43: 435-443, 2006
    • (2006) Hepatology , vol.43 , pp. 435-443
    • Zhan, S.S.1    Jiang, J.X.2    Wu, J.3    Halsted, C.4    Friedman, S.L.5    Zern, M.A.6    Torok, N.J.7
  • 204
    • 84864346121 scopus 로고    scopus 로고
    • Fibrosis-dependent mechanisms of hepatocarcinogenesis
    • Zhang DY and Friedman SL. Fibrosis-dependent mechanisms of hepatocarcinogenesis. Hepatology 56: 769-775, 2012
    • (2012) Hepatology , vol.56 , pp. 769-775
    • Zhang, D.Y.1    Friedman, S.L.2
  • 206
    • 24144471786 scopus 로고    scopus 로고
    • Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: Role in redox signaling and vascular hypertrophy
    • Zuo L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, and Alexander RW. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: Role in redox signaling and vascular hypertrophy. Arterioscler Thromb Vasc Biol 25: 1824-1830, 2005
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1824-1830
    • Zuo, L.1    Ushio-Fukai, M.2    Ikeda, S.3    Hilenski, L.4    Patrushev, N.5    Alexander, R.W.6


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