Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

Science Translational Medicine

Volumn 6, Issue 231, 2014, Pages

  Hecker, Louise ^a,b   Logsdon, Naomi J ^a   Kurundkar, Deepali ^a   Kurundkar, Ashish ^a   Bernard, Karen ^a   Hock, Thomas ^a   Meldrum, Eric ^c   Sanders, Yan Y ^a   Thannickal, Victor J ^a  

^a University of Alabama at Birmingham   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

^c GENKYOTEX SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBROTIC AGENT; GKT 137831; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; NOX4 PROTEIN, HUMAN; NOX4 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG TARGETING; FIBROSING ALVEOLITIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROSIS; MOUSE; MYOFIBROBLAST; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SCAR FORMATION; WOUND HEALING; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; FEMALE; FIBROBLAST; LUNG INJURY; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PHENOTYPE;

AGING; ANIMALS; ANTIOXIDANTS; APOPTOSIS; FEMALE; FIBROBLASTS; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; LUNG INJURY; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NADPH OXIDASE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHENOTYPE;

EID: 84899103689     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3008182     Document Type: Article

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