메뉴 건너뛰기




Volumn 101, Issue 6, 2003, Pages 2253-2260

Cellular response to hypoxia involves signaling via Smad proteins

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 0037443517     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-02-0629     Document Type: Article
Times cited : (132)

References (70)
  • 2
    • 0028171579 scopus 로고
    • Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
    • McAllister KA, Grogg KM, Johnson DW, et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet. 1994;8:345-351.
    • (1994) Nat Genet , vol.8 , pp. 345-351
    • McAllister, K.A.1    Grogg, K.M.2    Johnson, D.W.3
  • 4
    • 0030579203 scopus 로고    scopus 로고
    • TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • Oshima M, Oshima H, Taketo MM. TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol. 1996;179:297-302.
    • (1996) Dev Biol , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.M.3
  • 5
    • 2642601112 scopus 로고    scopus 로고
    • Biomechanical activation: An emerging paradigm in endothelial adhesion biology
    • Gimbrone MA Jr, Nagel T, Topper JN. Biomechanical activation: an emerging paradigm in endothelial adhesion biology. J Clin Invest. 1997;100:S61-S65.
    • (1997) J Clin Invest , vol.100
    • Gimbrone M.A., Jr.1    Nagel, T.2    Topper, J.N.3
  • 6
    • 12644260471 scopus 로고    scopus 로고
    • Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium
    • Topper JN, Cai J, Qiu Y, et al. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A. 1997;94:9314-9319.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9314-9319
    • Topper, J.N.1    Cai, J.2    Qiu, Y.3
  • 7
    • 0030609894 scopus 로고    scopus 로고
    • TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes
    • Sanford LP, Ormsby I, Gittenberger-de Groot AC, et al. TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes. Development. 1997;124:2659-2670.
    • (1997) Development , vol.124 , pp. 2659-2670
    • Sanford, L.P.1    Ormsby, I.2    Gittenberger-de Groot, A.C.3
  • 8
    • 0034605095 scopus 로고    scopus 로고
    • Inhibition of E-selectin gene expression by transforming growth factor β in endothelial cells involves coactivator integration of Smad and nuclear factor κB-mediated signals
    • DiChiara MR, Kiely JM, Gimbrone MA Jr, Lee ME, Perrella MA, Topper JN. Inhibition of E-selectin gene expression by transforming growth factor β in endothelial cells involves coactivator integration of Smad and nuclear factor κB-mediated signals. J Exp Med. 2000;192:695-704.
    • (2000) J Exp Med , vol.192 , pp. 695-704
    • DiChiara, M.R.1    Kiely, J.M.2    Gimbrone M.A., Jr.3    Lee, M.E.4    Perrella, M.A.5    Topper, J.N.6
  • 9
    • 0035761416 scopus 로고    scopus 로고
    • Response to hypoxia involves transforming growth factor-β2 and Smad proteins in human endothelial cells
    • Akman HO, Zhang H, Siddiqui MA, Solomon W, Smith ELP, Batuman OA. Response to hypoxia involves transforming growth factor-β2 and Smad proteins in human endothelial cells. Blood. 2001; 98:3324-3331.
    • (2001) Blood , vol.98 , pp. 3324-3331
    • Akman, H.O.1    Zhang, H.2    Siddiqui, M.A.3    Solomon, W.4    Smith, E.L.P.5    Batuman, O.A.6
  • 10
    • 17744397294 scopus 로고    scopus 로고
    • Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice
    • Larsson J, Goumans MJ, Sjöstrand LJ, et al. Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice. EMBO J. 2001;20:1663-1673.
    • (2001) EMBO J , vol.20 , pp. 1663-1673
    • Larsson, J.1    Goumans, M.J.2    Sjöstrand, L.J.3
  • 11
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • Yang X, Li C, Xu X, Deng C. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998;95:3667-3672.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 12
    • 0032960886 scopus 로고    scopus 로고
    • Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
    • Yang X, Castilla LH, Xu X, et al. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development. 1999;126:1571-1580.
    • (1999) Development , vol.126 , pp. 1571-1580
    • Yang, X.1    Castilla, L.H.2    Xu, X.3
  • 13
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 1993; 122:923-932.
    • (1993) J Cell Biol , vol.122 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 14
    • 0028902002 scopus 로고
    • Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1
    • Schultz-Cherry S, Chen H, Mosher DF, et al. Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1. J Biol Chem. 1995;270:7304-7310.
    • (1995) J Biol Chem , vol.270 , pp. 7304-7310
    • Schultz-Cherry, S.1    Chen, H.2    Mosher, D.F.3
  • 15
    • 0033532054 scopus 로고    scopus 로고
    • The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-β
    • Ribeiro SM, Poczatek M, Schultz-Cherry S, Villain M, Murphy-Ullrich JE. The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-β. J Biol Chem. 1999;274:13586-13593.
    • (1999) J Biol Chem , vol.274 , pp. 13586-13593
    • Ribeiro, S.M.1    Poczatek, M.2    Schultz-Cherry, S.3    Villain, M.4    Murphy-Ullrich, J.E.5
  • 16
    • 0033818794 scopus 로고    scopus 로고
    • The functions of thrombospondin-1 and -2
    • Lawler J. The functions of thrombospondin-1 and -2. Curr Opin Cell Biol. 2000;12:634-640.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 634-640
    • Lawler, J.1
  • 18
    • 0032030891 scopus 로고    scopus 로고
    • Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia
    • Lawler J, Sunday M, Thibert V, et al. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia. J Clin Invest. 1998;101:982-992.
    • (1998) J Clin Invest , vol.101 , pp. 982-992
    • Lawler, J.1    Sunday, M.2    Thibert, V.3
  • 19
    • 0031685620 scopus 로고    scopus 로고
    • TGF-β signal transduction
    • Massagué J. TGF-β signal transduction. Annu Rev Biochem. 1998;67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massagué, J.1
  • 20
    • 0035914297 scopus 로고    scopus 로고
    • Synergistic cooperation between hypoxia and transforming growth factor-β pathways on human vascular endothelial growth factor gene expression
    • Sanchéz-Elsner T, Botella LM, Velasco B, Corbi A, Attisano L, Bernabéu C. Synergistic cooperation between hypoxia and transforming growth factor-β pathways on human vascular endothelial growth factor gene expression. J Biol Chem. 2001;276:38527-38535.
    • (2001) J Biol Chem , vol.276 , pp. 38527-38535
    • Sanchéz-Elsner, T.1    Botella, L.M.2    Velasco, B.3    Corbi, A.4    Attisano, L.5    Bernabéu, C.6
  • 21
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev. 2000;14:1983-1991.
    • (2000) Genes Dev , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 22
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 1995;270:1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 24
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J. Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem. 1997;272:22642-22647.
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 26
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway
    • Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L. Regulation of the hypoxia-inducible transcription factor 1α by the ubiquitin-proteasome pathway. J Biol Chem. 1999;274:6519-6525.
    • (1999) J Biol Chem , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 27
    • 0034712939 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
    • Sutter CH, Laughner E, Semenza GL. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci U S A. 2000;97:4748-4753.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4748-4753
    • Sutter, C.H.1    Laughner, E.2    Semenza, G.L.3
  • 28
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 31
    • 18444368709 scopus 로고    scopus 로고
    • Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
    • Hon WC, Wilson MI, Harlos K, et al. Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL. Nature. 2002;417:975-978.
    • (2002) Nature , vol.417 , pp. 975-978
    • Hon, W.C.1    Wilson, M.I.2    Harlos, K.3
  • 32
    • 0036391915 scopus 로고    scopus 로고
    • Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
    • Oehme F, Ellinghaus P, Kolkhof P, et al. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. Biochem Biophys Res Commun. 2002;296:343-349.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 343-349
    • Oehme, F.1    Ellinghaus, P.2    Kolkhof, P.3
  • 33
    • 0015822275 scopus 로고
    • Culture of human endothelial cells derived from umbilical veins; identification by morphologic and immunologic criteria
    • Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins; identification by morphologic and immunologic criteria. J Clin Invest. 1973;52:2745-2756.
    • (1973) J Clin Invest , vol.52 , pp. 2745-2756
    • Jaffe, E.A.1    Nachman, R.L.2    Becker, C.G.3    Minick, C.R.4
  • 34
    • 0016906538 scopus 로고
    • Culture of vascular endothelium
    • Gimbrone MA Jr. Culture of vascular endothelium. Prog Hemost Thromb. 1976;3:1-28.
    • (1976) Prog Hemost Thromb , vol.3 , pp. 1-28
    • Gimbrone M.A., Jr.1
  • 36
    • 0033649291 scopus 로고    scopus 로고
    • Measurement of active TGF-beta generated by cultured cells
    • Mazzieri R, Munger JS, Rifkin DB. Measurement of active TGF-beta generated by cultured cells. Methods Mol Biol. 2000;142:13-27.
    • (2000) Methods Mol Biol , vol.142 , pp. 13-27
    • Mazzieri, R.1    Munger, J.S.2    Rifkin, D.B.3
  • 37
    • 0028328817 scopus 로고
    • An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
    • Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB. An assay for transforming growth factor-β using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem. 1994;216:276-284.
    • (1994) Anal Biochem , vol.216 , pp. 276-284
    • Abe, M.1    Harpel, J.G.2    Metz, C.N.3    Nunes, I.4    Loskutoff, D.J.5    Rifkin, D.B.6
  • 38
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 39
    • 0020657715 scopus 로고
    • Macromolecular insoluble cold globulin (MICG): A marker for pluripotential hemopoietic stem cells
    • Batuman OA, Caro J, Schmidt RR, Hauptman SP. Macromolecular insoluble cold globulin (MICG): a marker for pluripotential hemopoietic stem cells. J Immunol. 1983;130:1051-1055.
    • (1983) J Immunol , vol.130 , pp. 1051-1055
    • Batuman, O.A.1    Caro, J.2    Schmidt, R.R.3    Hauptman, S.P.4
  • 40
    • 0026726489 scopus 로고
    • Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter
    • O'Reilly MA, Geiser AG, Kim SJ, et al. Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter. J Biol Chem. 1992;267:19938-19943.
    • (1992) J Biol Chem , vol.267 , pp. 19938-19943
    • O'Reilly, M.A.1    Geiser, A.G.2    Kim, S.J.3
  • 41
    • 0032442852 scopus 로고    scopus 로고
    • Smads: Transcriptional activators of TGF-βresponses
    • Derynck R, Zhang Y, Feng XH. Smads: transcriptional activators of TGF-βresponses. Cell. 1998; 95:737-740.
    • (1998) Cell , vol.95 , pp. 737-740
    • Derynck, R.1    Zhang, Y.2    Feng, X.H.3
  • 42
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-β signaling
    • Massagué J, Chen YG. Controlling TGF-β signaling. Genes Dev. 2000;14:627-644.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massagué, J.1    Chen, Y.G.2
  • 43
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian H, McKnight SL, Russell DW. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 1997;11:72-82.
    • (1997) Genes Dev , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.L.2    Russell, D.W.3
  • 44
    • 0026049416 scopus 로고
    • Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene
    • Beck I, Ramirez S, Weinmann R, Caro J. Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J Biol Chem. 1991;266:15563-15566.
    • (1991) J Biol Chem , vol.266 , pp. 15563-15566
    • Beck, I.1    Ramirez, S.2    Weinmann, R.3    Caro, J.4
  • 45
    • 0028834086 scopus 로고
    • Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization
    • Livak KJ, Flood SJ, Marmaro J, Giusti W, Deetz K. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods Appl. 1995;4:357-362.
    • (1995) PCR Methods Appl , vol.4 , pp. 357-362
    • Livak, K.J.1    Flood, S.J.2    Marmaro, J.3    Giusti, W.4    Deetz, K.5
  • 46
    • 0032387693 scopus 로고    scopus 로고
    • Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
    • Phelan MW, Forman LW, Perrine SP, Faller DV. Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells. J Lab Clin Med. 1998;132:519-529.
    • (1998) J Lab Clin Med , vol.132 , pp. 519-529
    • Phelan, M.W.1    Forman, L.W.2    Perrine, S.P.3    Faller, D.V.4
  • 47
    • 0033524949 scopus 로고    scopus 로고
    • The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosis
    • Munger JS, Huang X, Kawakatsu H, et al. The integrin αvβ6 binds and activates latent TGFβ1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999;96:319-328.
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.S.1    Huang, X.2    Kawakatsu, H.3
  • 48
    • 0030908028 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta: Structural features and mechanisms of activation
    • Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I, Rifkin DB. Latent transforming growth factor-beta: structural features and mechanisms of activation. Kidney Int. 1997;51:1376-1382.
    • (1997) Kidney Int , vol.51 , pp. 1376-1382
    • Munger, J.S.1    Harpel, J.G.2    Gleizes, P.E.3    Mazzieri, R.4    Nunes, I.5    Rifkin, D.B.6
  • 50
    • 0033452546 scopus 로고    scopus 로고
    • Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors
    • Iruela-Arispe ML, Vazquez F, Ortega MA. Antiangiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors. Ann N Y Acad Sci. 1999;886:58-66.
    • (1999) Ann N Y Acad Sci , vol.886 , pp. 58-66
    • Iruela-Arispe, M.L.1    Vazquez, F.2    Ortega, M.A.3
  • 51
    • 0034610729 scopus 로고    scopus 로고
    • Transforming growth factor beta2 inhibition of hepatocyte growth factor-induced endothelial proliferation and migration
    • Manganini M, Maier JA. Transforming growth factor beta2 inhibition of hepatocyte growth factor-induced endothelial proliferation and migration. Oncogene. 2000;19:124-133.
    • (2000) Oncogene , vol.19 , pp. 124-133
    • Manganini, M.1    Maier, J.A.2
  • 52
    • 0025316140 scopus 로고
    • Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane
    • Yang EY, Moses HL. Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol. 1990;111:731-741.
    • (1990) J Cell Biol , vol.111 , pp. 731-741
    • Yang, E.Y.1    Moses, H.L.2
  • 53
    • 0036086409 scopus 로고    scopus 로고
    • Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
    • Muraoka RS, Dumont N, Ritter CA, et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest. 2002;109:1551-1559.
    • (2002) J Clin Invest , vol.109 , pp. 1551-1559
    • Muraoka, R.S.1    Dumont, N.2    Ritter, C.A.3
  • 54
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-βantagonist protects mice against metastasis without adverse side effects
    • Yang YA, Dukhanina O, Tang B, et al. Lifetime exposure to a soluble TGF-βantagonist protects mice against metastasis without adverse side effects. J Clin Invest. 2002;109:1607-1615.
    • (2002) J Clin Invest , vol.109 , pp. 1607-1615
    • Yang, Y.A.1    Dukhanina, O.2    Tang, B.3
  • 55
    • 0033612364 scopus 로고    scopus 로고
    • Soluble transforming growth factor-β type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth
    • Smith JD, Bryant SR, Couper LL, et al. Soluble transforming growth factor-β type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. Circ Res. 1999;84:1212-1222.
    • (1999) Circ Res , vol.84 , pp. 1212-1222
    • Smith, J.D.1    Bryant, S.R.2    Couper, L.L.3
  • 56
    • 0031106404 scopus 로고    scopus 로고
    • Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
    • Pepper MS. Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity. Cytokine Growth Factor Rev. 1997;8:21-43.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 21-43
    • Pepper, M.S.1
  • 57
    • 0033621804 scopus 로고    scopus 로고
    • Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
    • Arthur HM, Ure J, Smith AJ, et al. Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol. 2000;217:42-53.
    • (2000) Dev Biol , vol.217 , pp. 42-53
    • Arthur, H.M.1    Ure, J.2    Smith, A.J.3
  • 58
    • 0032720393 scopus 로고    scopus 로고
    • A murine model of hereditary hemorrhagic telangiectasia
    • Bourdeau A, Dumont DJ, Letarte M. A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest. 1999;104:1343-1351.
    • (1999) J Clin Invest , vol.104 , pp. 1343-1351
    • Bourdeau, A.1    Dumont, D.J.2    Letarte, M.3
  • 59
    • 0033612141 scopus 로고    scopus 로고
    • Defective angiogenesis in mice lacking endoglin
    • Li DY, Sorensen LK, Brooke BS, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-1537.
    • (1999) Science , vol.284 , pp. 1534-1537
    • Li, D.Y.1    Sorensen, L.K.2    Brooke, B.S.3
  • 60
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998; 394:485-490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 61
    • 0033605559 scopus 로고    scopus 로고
    • MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2mediated transcriptional activation in endothelial cells
    • Brown JD, DiChiara MR, Anderson KR, Gimbrone MA, Topper JN. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2mediated transcriptional activation in endothelial cells. J Biol Chem. 1999;274:8797-8805.
    • (1999) J Biol Chem , vol.274 , pp. 8797-8805
    • Brown, J.D.1    DiChiara, M.R.2    Anderson, K.R.3    Gimbrone, M.A.4    Topper, J.N.5
  • 62
    • 0034043736 scopus 로고    scopus 로고
    • Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair
    • Scheid A, Wenger RH, Christina H, et al. Hypoxia-regulated gene expression in fetal wound regeneration and adult wound repair. Pediatr Surg Int. 2000;16:232-236.
    • (2000) Pediatr Surg Int , vol.16 , pp. 232-236
    • Scheid, A.1    Wenger, R.H.2    Christina, H.3
  • 64
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-β-induced transcriptional activation
    • Feng XH, Zhang Y, Wu RY, Derynck R. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-β-induced transcriptional activation. Genes Dev. 1998;12:2153-2163.
    • (1998) Genes Dev , vol.12 , pp. 2153-2163
    • Feng, X.H.1    Zhang, Y.2    Wu, R.Y.3    Derynck, R.4
  • 65
    • 0032483493 scopus 로고    scopus 로고
    • Physical and functional interaction of SMADs and p300/CBP
    • Pouponnot C, Jayaraman L, Massagué J. Physical and functional interaction of SMADs and p300/CBP. J Biol Chem. 1998;273:22865-22868.
    • (1998) J Biol Chem , vol.273 , pp. 22865-22868
    • Pouponnot, C.1    Jayaraman, L.2    Massagué, J.3
  • 67
    • 0031835957 scopus 로고    scopus 로고
    • Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein
    • Ebert BL, Bunn HF. Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein. Mol Cell Biol. 1998;18:4089-4096.
    • (1998) Mol Cell Biol , vol.18 , pp. 4089-4096
    • Ebert, B.L.1    Bunn, H.F.2
  • 68
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-β-activated Smad2
    • Lo RS, Massagué J. Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nat Cell Biol. 1999;1:472-478.
    • (1999) Nat Cell Biol , vol.1 , pp. 472-478
    • Lo, R.S.1    Massagué, J.2
  • 69
    • 0030768644 scopus 로고    scopus 로고
    • TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4
    • Nakao A, Imamura T, Souchelnytskyi S, et al. TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 1997;17:5353-5362.
    • (1997) EMBO J , vol.17 , pp. 5353-5362
    • Nakao, A.1    Imamura, T.2    Souchelnytskyi, S.3
  • 70
    • 0034924216 scopus 로고    scopus 로고
    • Angiogenesis research: Guidelines for translation to clinical application
    • Folkman J, Browder T, Palmblad J. Angiogenesis research: guidelines for translation to clinical application. Thromb Haemost. 2001;86:23-33.
    • (2001) Thromb Haemost , vol.86 , pp. 23-33
    • Folkman, J.1    Browder, T.2    Palmblad, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.