Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 4, 2006, Pages

  Sturrock, Anne ^a   Cahill, Barbara ^a   Norman, Kimberly ^a   Huecksteadt, Thomas P ^a   Hill, Kenneth ^a   Sanders, Karl ^a   Karwande, S V ^a   Stringham, James C ^a   Bull, David A ^a   Gleich, Martin ^a   Kennedy, Thomas P ^a   Hoidal, John R ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

ERK 1 2; Hypertrophy; Phosphatases; Pulmonary arterial hypertension; Rac 1; Smad 2 3; Superoxide anion

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ARACHIDONIC ACID; CONTRACTILE PROTEIN; CYCLOHEXIMIDE; DIPHENYLIODONIUM SALT; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN NOX4; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TIRON; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; NOX4 PROTEIN, HUMAN; SMAD PROTEIN; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION; CELL CULTURE; CYTOLOGY; METABOLISM; PHYSIOLOGY;

CELL PROLIFERATION; CELLS, CULTURED; CONTRACTILE PROTEINS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, SMOOTH MUSCLE; NADPH OXIDASE; PULMONARY ARTERY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33646593852     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00269.2005     Document Type: Article

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