Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

Journal of Clinical Investigation

Volumn 117, Issue 12, 2007, Pages 3810-3820

  Higgins, Debra F ^a   Kimura, Kuniko ^b   Bernhardt, Wanja M ^c   Shrimanker, Nikita ^a   Akai, Yasuhiro ^a,b   Hohenstein, Bernd ^c   Saito, Yoshihiko ^b   Johnson, Randall S ^d   Kretzler, Matthias ^e   Cohen, Clemens D ^f   Eckardt, Kai Uwe ^c   Iwano, Masayuki ^b   Haase, Volker H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALVASCULIN; CRE RECOMBINASE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN LYSINE 6 OXIDASE;

ANIMAL CELL; ARTICLE; CELL INFILTRATION; CELL MIGRATION; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; EPITHELIUM CELL; FIBROGENESIS; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN TISSUE; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY CELL; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; LOXP SITE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; URETER OBSTRUCTION;

ANIMALS; ANOXIA; CALCIUM-BINDING PROTEINS; CELL HYPOXIA; CELL MOVEMENT; CHRONIC DISEASE; COLLAGEN; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FIBROSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY TUBULES, PROXIMAL; MICE; MICE, KNOCKOUT; PROTEIN-LYSINE 6-OXIDASE; SIGNAL TRANSDUCTION; UP-REGULATION; URETERAL OBSTRUCTION;

EID: 36849021771     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI30487     Document Type: Article

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