Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model

Free Radical Biology and Medicine

Volumn 53, Issue 3, 2012, Pages 554-563

  Liu, Rui Ming ^a   Vayalil, Praveen Kumar ^a   Ballinger, Carol ^a   Dickinson, Dale A ^a   Huang, Wen Tan ^a   Wang, Suqing ^a   Kavanagh, Terrance J ^b   Matthews, Qiana L ^c   Postlethwait, Edward M ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

Free radicals; Glutamate cysteine ligase; GSH depletion; Lung fibrosis; Oxidative stress; Transforming growth factor 1

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; GLUTAMATE CYSTEINE LIGASE; PROTEIN TYROSINE KINASE; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ACTIVATING TRANSCRIPTION FACTOR 3; ANIMALS; APOPTOSIS; ASCORBIC ACID; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE DISULFIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; LUNG; MICE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PULMONARY FIBROSIS; RESPIRATORY MUCOSA; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1; TYROSINE;

ADENOVIRIDAE;

EID: 84863430288     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.016     Document Type: Article

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