Lack of inducible nitric oxide synthase leads to increased hepatic apoptosis and decreased fibrosis in mice after chronic carbon tetrachloride administration

Hepatology

Volumn 47, Issue 6, 2008, Pages 2051-2058

  Aram, Ghazaleh ^a   Potter, James J ^a   Liu, Xiaopu ^a   Torbenson, Michael S ^a   Mezey, Esteban ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; CARBON TETRACHLORIDE; GELATINASE A; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; OLIVE OIL; TISSUE INHIBITOR OF METALLOPROTEINASE 1; COLLAGEN; MALONALDEHYDE; MESSENGER RNA; PEROXYNITROUS ACID; REACTIVE OXYGEN METABOLITE;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; ENZYME DEFICIENCY; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER INJURY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; STELLATE CELL; WESTERN BLOTTING; WILD TYPE; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; GENETICS; LIVER; LIVER CIRRHOSIS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; CARBON TETRACHLORIDE; COLLAGEN; LIVER; LIVER CIRRHOSIS; MALE; MALONDIALDEHYDE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE II; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSAMINASES;

EID: 46249128924     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22278     Document Type: Article

References (24)

1. Taylor BS, Alarcon LH, Billiar TR. Inducible nitric oxide synthase in the liver: regulation and function. Biochemistry (Mosc) 1998;63:766-781.
2. Ou J, Carlos TM, Watkins SC, Saavedra JE, Keefer LK, Kim YM, et al. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia. Nitric Oxide 1997;1:404-416.
3. Trachtman H, Futterweit S, Garg P, Reddy K, Singhal PC. Nitric oxide stimulates the activity of a 72-kDa neutral matrix metalloproteinase in cultured rat mesangial cells. Biochem Biophys Res Commun 1996;218: 704-708.
4. Chatziantoniou C, Boffa JJ, Ardaillou R, Dussaule JC. Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice: role of endothelin. J Clin Invest 1998;101:2780-2789.
5. Casini A, Ceni E, Salzano R, Biondi P, Parola M, Galli A, et al. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. HEPATOLOGY 1997;25:361-367.
6. 4 in mice. J Appl Toxicol 2006;26:326-332.
7. Novitskiy G, Potter JJ, Wang L, Mezey E. Influences of reactive oxygen species and nitric oxide on hepatic fibrogenesis. Liver Int 2006;26:1248-1257.
8. Potter JJ, Rennie-Tankersley L, Mezey E. Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol 2003; 38:281-288.
9. Bergmeyer HU, Scheibe P, Wahlefeld AW. Optimization of methods for aspartate aminotransferase and alanine aminotransferase. Clin Chem 1978; 24:58-73.
10. Uchiyama M, Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978;86:271-278.
11. Frankfurt OS, Krishan A. Identification of apoptotic cells by formamide-induced DNA denaturation in condensed chromatin. J Histochem Cytochem 2001;49:369-378.
12. 4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in fats. HEPATOLOGY 2001;34:677-687.
13. Zhou X, Hovell CJ, Pawley S, Hutchings MI, Arthur MJP, Iredale JP, et al. Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Into 2004;24:492-501.
14. Mezey E, Potter, JJ, Slusser RJ, Abdi, W. Changes in hepatic collagen metabolism in rats produced by chronic ethanol feeding. Lab Invest 1977: 36:206-214.
15. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, et al. Mechanisms of spontaneous resolution of rat liver fibrosis: hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998;102:538-549.
16. Galle PR, Hofmann WJ, Walczak, H, Schaller, H, Otto G, Stremmel W, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J Exp Med 1995;182:1223-1230.
17. Cheng J, Zhou T, Liu, C, Shapiro JP, Brauer MJ, Kiefer MC, et al. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 1994;263:1759-1762.
18. Krams SM, Fox, CK, Beatty PR, Cao S, Villanueva JC, Esquivel CO, et al. Human hepatocytes produce an isoform of Fas that inhibits apoptosis. Transplantation 1998;65:713-721.
19. Knipping E, Debatin KM, Stricker K, Heilig B, Eder A, Krammer PH. Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias. Blood 1995; 85:1562-1569.
20. Kim PKM, Kwon YG, Chung HT, Kim YM. Regulation of caspases by nitric oxide. Ann NY Acad Sci 2002;962:45-52.
21. Nieto N, Friedman SL, Greenwel P, Cederbaum AI. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. HEPATOLOGY 1999;30:987-996.
22. Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblast. A role of lipid peroxidation? J Biol Chem 1989;264:16957-16962.
23. Maher JJ, Tzagarakis C, Gimenez A. Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture. Alcohol Alcohol 1994;29:605-610.
24. Koruk M, Aksoy H, Akcay F, Drya Onuk MD. Antioxidant capacity of nitric oxide in patients with hepatic cirrhosis. Ann Clin Lab Sci 2002;32: 252-256.