Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies

Materials Science and Engineering C

Volumn 68, Issue , 2016, Pages 982-994

  Geszke Moritz, Małgorzata ^a   Moritz, Michał ^b  

^a ADAM MICKIEWICZ UNIVERSITY   (Poland)

^b POZNAN UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Drug delivery systems; Lipids; Nanocolloidal carriers; Pharmacokinetics; Solid lipid nanoparticles; Therapeutic agents

Indexed keywords

CHEMICAL MODIFICATION; LIPIDS; PHARMACOKINETICS; SURFACE TREATMENT;

DRUG DELIVERY SYSTEM; NANOCOLLOIDAL SYSTEMS; PHARMACOKINETIC PROPERTIES; SOLID LIPID NANOPARTICLE (SLN); SOLID LIPID NANOPARTICLES; STIMULI RESPONSIVENESS; THERAPEUTIC AGENTS; UBIQUITOUS APPLICATION;

NANOPARTICLES;

DRUG CARRIER; LIPID; NANOPARTICLE;

BACTERIAL INFECTIONS; BRAIN DISEASES; CHEMISTRY; EYE DISEASES; NEOPLASMS; SKIN DISEASES;

BACTERIAL INFECTIONS; BRAIN DISEASES; DRUG CARRIERS; EYE DISEASES; LIPIDS; NANOPARTICLES; NEOPLASMS; SKIN DISEASES;

EID: 84971597385     PISSN: 09284931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.msec.2016.05.119     Document Type: Review

References (143)

1. [1] Geszke-Moritz, M., Moritz, M., Quantum dots as versatile probes in medical sciences: synthesis, modification and properties. Mater. Sci. Eng. C 33 (2013), 1008–1021.
2. [2] Mehra, N.K., Jain, K., Jain, N.K., Pharmaceutical and biomedical applications of surface engineered carbon nanotubes. Drug Discov. Today 20 (2015), 750–759.
3. [3] Nanda, S.S., Papaefthymiou, G.C., Yi, D.K., Functionalization of graphene oxide and its biomedical applications. Crit. Rev. Solid State Mater. Sci. 40 (2015), 291–315.
4. [4] Moritz, M., Geszke-Moritz, M., Recent developments in the application of polymeric nanoparticles as drug carriers. Adv. Clin. Exp. Med. 24 (2015), 749–758.
5. [5] Labieniec-Watala, M., Watala, C., PAMAM dendrimers: destined for success or doomed to fail? Plain and modified PAMAM dedrimers in the context of biomedical applications. J. Pharm. Sci. 104 (2015), 2–14.
6. [6] Moritz, M., Geszke-Moritz, M., The newest achievements in synthesis, immobilization and practical applications of antibacterial nanoparticles. Chem. Eng. J. 228 (2013), 596–613.
7. [7] Garg, T., Goyal, A.K., Liposomes: targeted and controlled delivery systems. Drug Deliv. Lett. 4 (2014), 62–71.
8. [8] Moritz, M., Geszke-Moritz, M., Mesoporous materials as multifunctional tools in biosciences: principles and applications. Mater. Sci. Eng. C 49 (2015), 114–151.
9. [9] Schwarz, C., Mehnert, M., Lucks, J.S., Müller, R.H., Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization. J. Control. Release 30 (1994), 83–96.
10. [10] Freitas, C., Lucks, J.S., Müller, R.H., P238 effect on storage conditions on long-term stability of “solid lipid nanoparticles” (SLN) in aqueous dispersion. Eur. J. Pharm. Sci., 2, 1994, 178.
11. [11] Morel, S., Ugazio, E., Cavalli, R., Gasco, M.R., Thymopentin in solid lipid nanoparticles. Int. J. Pharm. 132 (1996), 259–261.
12. [12] Cavalli, R., Caputo, O., Carlotti, M.E., Trotta, M., Scarnecchia, C., Gasco, M.R., Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles. Int. J. Pharm. 148 (1997), 47–54.
13. [13] Siekmann, B., Westesen, K., P234 solid lipid nanoparticles stabilized by tyloxapol. Eur. J. Pharm. Sci., 2, 1994, 177.
14. [14] Kumar, M., Kakkar, V., Mishra, A.K., Chuttani, K., Kaur, I.P., Intranasal delivery of streptomycin sulfate (STRS) loaded solid lipid nanoparticles to brain and blood. Int. J. Pharm. 461 (2014), 223–233.
15. [15] Mehnert, W., Mäder, K., Solid lipid nanoparticles. production, characterization and applications. Adv. Drug Deliv. Rev. 47 (2001), 165–196.
16. [16] Gastaldi, L., Battaglia, L., Peira, E., Chirio, D., Muntoni, E., Solazzi, I., Gallarate, M., Dosio, F., Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art. Eur. J. Pharm. Biopharm. 87 (2014), 433–444.
17. [17] Weber, S., Zimmer, A., Pardeike, J., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art. Eur. J. Pharm. Biopharm. 86 (2014), 7–22.
18. [18] Pardeike, J., Hommoss, A., Müller, T.H., Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int. J. Pharm. 366 (2009), 170–184.
19. [19] Patel, M.R., Martin-Gonzalez, M.F.S., Characterization of ergocalciferol loaded solid lipid nanoparticles. J. Food Sci. 71 (2012), N8–N13.
20. [20] Kumar, S., Randhawa, J.K., High melting lipid based approach for drug delivery: solid lipid nanoparticles. Mater. Sci. Eng. C 33 (2013), 1842–1852.
21. [21] Benita, S., Microencapsulation: Methods and industrial applications. second ed., 2006, Taylor & Francis Group, New York London.
22. [22] Wissing, S.A., Kayser, O., Müller, R.H., Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug Deliv. Rev. 56 (2004), 1257–1272.
23. [23] Torchilin, V.P., Nanoparticulates as drug carriers. 2006, Imperial College Press, London.
24. [24] Venishetty, V.K., Komuravelli, R., Kuncha, M., Sistla, R., Diwan, P.V., Increased brain uptake of docetaxel and ketoconazole loaded folate-grafted solid lipid nanoparticles. Nanomedicine 9 (2013), 111–121.
25. [25] Yuan, H., Chen, C.-Y., Chai, G.-H., Du, Y.-Z., Hu, F.-Q., Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles. Mol. Pharm. 10 (2013), 1865–1873.
26. [26] Kuo, Y.-C., Wang, C.-C., Cationic solid lipid nanoparticles with primary and quaternary amines for release of saquinavir and biocompatibility with endothelia. Colloids Surf., B 101 (2013), 101–105.
27. [27] Zariwala, M.G., Elsaid, N., Jackson, T.L., López, F.C., Farnaud, S., Somavarapu, S., Renshaw, D., A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles. Int. J. Pharm. 456 (2013), 400–407.
28. [28] Soares, S., Fonte, P., Costa, A., Andrade, J., Seabra, V., Ferreira, D., Reis, S., Sarmento, B., Effect of freeze-drying, cryoprotectants and storage conditions on the stability of secondary structure of insulin-loaded solid lipid nanoparticles. Int. J. Pharm. 456 (2013), 370–381.
29. [29] Chen, G., Zeng, S., Jia, H., He, X., Fang, Y., Jing, Z., Cai, X., Adjuvant effect enhancement of porcine interleukin-2 packaged into solid lipid nanoparticles. Res. Vet. Sci. 96 (2014), 62–68.
30. [30] Xie, S., Zhu, L., Dong, Z., Wang, X., Wang, Y., Li, X., Zhou, W., Preparation, characterization and pharmacokinetics of enrofloxacin-loaded solid lipid nanoparticles: influences of fatty acids. Colloids Surf., B 83 (2011), 382–387.
31. [31] Alex, M.R.A., Chacko, A.J., Jose, S., Souto, E.B., Lopinavir loaded solid lipid nanoparticles (SLN) for intestinal lymphatic targeting. Eur. J. Pharm. Sci. 42 (2011), 11–18.
32. [32] Sun, J., Bi, C., Chan, H.M., Sun, S., Zhang, Q., Zheng, Y., Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability. Colloids Surf., B 111 (2013), 367–375.
33. [33] Raza, K., Singh, B., Singal, P., Wadhwa, S., Katare, O.P., Systematically optimized biocompatible isotretinoin-loaded solid lipid nanoparticles (SLNs) for topical treatment of acne. Colloids Surf., B 105 (2013), 67–74.
34. [34] Silva, A.C., González-Mira, E., García, M.L., Egea, M.A., Fonseca, J., Silva, R., Santos, D., Souto, E.B., Ferreira, D., Preparation, characterization and biocompatibility studies on risperidone-loaded solid lipid nanoparticles (SLN): high pressure homogenization versus ultrasound. Colloids Surf., B 86 (2011), 158–165.
35. [35] Hao, J., Wang, X., Bi, Y., Teng, Y., Wang, J., Li, F., Li, Q., Zhang, J., Guo, F., Liu, J., Fabrication of a composite system combining solid lipid nanoparticles and thermosensitive hydrogel for challenging opththalmic drug delivery. Colloids Surf., B 114 (2014), 111–120.
36. [36] Severino, P., Andreani, T., Jäger, A., Chaud, M.V., Santana, M.H.A., Silva, A.M., Souto, E.B., Solid lipid nanoparticles for hydrophilic biotech drugs: optimization and cell viability studies (Caco-2 & HEPG-2 cell lines). Eur. J. Med. Chem. 81 (2014), 28–34.
37. [37] R. Shah, D. Eldridge, E. Palombo, I. Harding, Lipid nanoparticles: Production, characterization and stability, Springer Chem Heidelberg New York Dordrecht London (2015).
38. [38] Wang, J., Wang, H., Zhu, R., Liu, Q., Fei, J., Wang, S., Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-β transgenic mice subjected to the lipopolysaccharide-induced sepsis. Biomaterials 53 (2015), 475–483.
39. [39] Kheradmandnia, S., Vasheghani-Farahani, E., Nosrati, M., Atyabi, F., Preparation and characterization of ketoprofen-loaded solid lipid nanoparticles made from beeswax and carnauba wax. Nanomedicine 6 (2010), 753–759.
40. [40] Arana, L., Salado, C., Vega, S., Aizpurua-Olaizola, O., de la Arada, I., Suarez, T., Usobiaga, A., Arrondo, J.L.R., Alonso, A., Goñi, F.M., Solid lipid nanoparticles for delivery of Calendula officinalis extract. Colloids Surf., B 135 (2015), 18–26.
41. [41] Shah, B., Khunt, D., Bhatt, H., Misra, M., Padh, H., Application of quality by design approach for intranasal delivery of rivastigmine loaded solid lipid nanoparticles: effect on formulation and characterization parameters. Eur. J. Pharm. Sci. 78 (2015), 54–66.
42. [42] Gaur, P.K., Mishra, S., Verma, A., Verma, N., Ceramide-palmitic acid complex based curcumin solid lipid nanoparticles for transdermal delivery: pharmacokinetic and pharmacodynamic study. J. Exp. Nanosci. 11 (2016), 38–53.
43. [43] Huang, X., Chen, Y.-J., Peng, D.-Y., Li, Q.-L., Wang, X.-S., Wang, D.-L., Chen, W.-D., Solid lipid nanoparticles as delivery systems for gambogenic acid. Colloids Surf., B 102 (2013), 391–397.
44. [44] Teskač, K., Kristl, J., The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int. J. Pharm. 390 (2010), 61–69.
45. [45] Rostami, E., Kashanian, S., Azandaryani, A.H., Preparation of solid lipid nanoparticles as drug carriers for levothyroxine sodium with in vitro drug delivery kinetic characterization. Mol. Biol. Rep. 41 (2014), 3521–3527.
46. [46] Shegokar, R., Singh, K.K., Müller, R.H., Production & stability of stavudine solid lipid nanoparticles - from lab scale to industrial scale. Int. J. Pharm. 416 (2011), 461–470.
47. [47] Madureira, A.R., Campos, D.A., Fonte, P., Nunes, S., Reis, F., Gomes, A.M., Sarmento, B., Pintado, M.M., Characterization of solid lipid nanoparticles produced with carnauba wax for rosmarinic acid oral delivery. RSC Adv. 5 (2015), 22665–22673.
48. [48] Kelidari, H.R., Saeedi, M., Akbari, J., Morteza-Semnani, K., Gill, P., Valizadeh, H., Nokhodchi, A., Formulation optimization and in vivo skin penetration of spironolactone loaded solid lipid nanoparticles. Colloids Surf., B 128 (2015), 473–479.
49. [49] Severino, P., Chaud, M.V., Shimojo, A., Antonini, D., Lancelloti, M., Santana, M.H.A., Souto, E.B., Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies. Colloids Surf., B 129 (2015), 191–197.
50. [50] Kuo, Y.-C., Wang, C.-C., Carmustine-loaded catanionic solid lipid nanoparticles with serotonergic 1B receptor subtype antagonist for in vitro targeted delivery to inhibit brain cancer growth. J. Taiwan Inst. Chem. Eng. 46 (2015), 1–14.
51. [51] Kuo, Y.-C., Chung, J.-F., Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers. Colloids Surf., B 83 (2011), 299–306.
52. [52] Das, S., Ng, W.K., Kanaujia, P., Kim, S., Tan, R.B.H., Formulation design, preparation and physicochemical characterizations of solid lipid nanoparticles containing a hydrophobic drug: effects of process variables. Colloids Surf., B 88 (2011), 483–489.
53. [53] Akanda, M.H., Rai, R., Slipper, I.J., Chowdhry, B.Z., Lamprou, D., Getti, G., Douroumis, D., Delivery of retinoic acid to LNCap human prostate cancer cells using solid lipid nanoparticles. Int. J. Pharm. 493 (2015), 161–171.
54. [54] Laserra, S., Basit, A., Sozio, P., Marinelli, L., Fornasari, E., Cacciatore, I., Ciulla, M., Türkez, H., Geyikoglu, F., di Stefano, A., Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization. Int. J. Pharm. 485 (2015), 183–191.
55. [55] Dwivedi, P., Khatik, R., Khandelwal, K., Taneja, I., Raju, K.S.R., Wahajuddin, Paliwal, S.K., Dwivedi, A.K., Mishra, P.R., Pharmacokinetics study of arteether loaded solid lipid nanoparticles: an improved oral bioavailability in rats. Int. J. Pharm. 466 (2014), 321–327.
56. [56] Negi, J.S., Chattopadhyay, P., Sharma, A.K., Ram, V., Development and evaluation of glyceryl behenate based solid lipid nanoparticles (SLNs) using hot self-nanoemulsification (SNE) technique. Arch. Pharm. Res. 37 (2014), 361–370.
57. [57] Shah, R.M., Malherbe, F., Eldridge, D., Palombo, E.A., Harding, I.H., Physicochemical characterization of solid lipid nanoparticles (SLNs) prepared by a novel microemulsion technique. J. Colloid Interface Sci. 428 (2014), 286–294.
58. [58] Venishetty, V.K., Chede, R., Komuravelli, R., Adepu, L., Sistla, R., Diwan, P.V., Design and evaluation of polymer coated carvedilol loaded solid lipid nanoparticles to improve the oral bioavailability: A novel strategy to avoid intraduodenal administration. Colloids Surf., B 95 (2012), 1–9.
59. [59] Wang, P., Zhang, L., Peng, H., Li, Y., Xiong, J., Xu, Z., The formulation and delivery of curcumin with solid lipid nanoparticles for the treatment of non-small cell lung cancer both in vitro and in vivo. Mater. Sci. Eng. C 33 (2013), 4802–4808.
60. [60] Rahman, Z., Zidan, A.S., Khan, M.A., Non-destructive methods of characterization of risperidone solid lipid nanoparticles. Eur. J. Pharm. Biopharm. 76 (2010), 127–137.
61. [61] Lee, M.-Y., Kong, W.H., Jung, H.S., Hahn, S.K., Hyaluronic acid-siRNA conjugates complexed with cationic solid lipid nanoparticles for target specific gene silencing. RSC Adv. 4 (2014), 19338–19344.
62. [62] Jain, A.K., Jain, A., Garg, N.K., Agarwal, A., Jain, A., Jain, S.A., Tyagi, R.K., Jain, R.K., Agrawal, H., Agrawal, G.P., Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment. Colloids Surf., B 121 (2014), 222–229.
63. [63] Jain, V., Gupta, A., Pawar, V.K., Asthana, S., Jaiswal, A.K., Dube, A., Chourasia, M.K., Chitosan-assisted immunotherapy for intervention of experimental leishmaniasis via amphotericin B-loaded solid lipid nanoparticles. Appl. Biochem. Biotechnol. 174 (2014), 1309–1330.
64. [64] Cai, S., Yang, Q., Bagby, T.R., Forrest, M.L., Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles. Adv. Drug Deliv. Rev. 63 (2011), 901–908.
65. [65] Müller, R.H., Radtke, M., Wissing, S.A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev. 54 (2002), S131–S155.
66. [66] Yu, Y.H., Kim, E., Park, D.E., Shim, G., Lee, S., Kim, Y.B., Kim, C.-W., Oh, Y.-K., Cationic solid lipid nanoparticles for co-delivery of paclitaxel and siRNA. Eur. J. Pharm. Biopharm. 80 (2012), 268–273.
67. [67] Doktorovová, S., Santos, D.L., Costa, I., Andreani, T., Souto, E.S., Silva, A.M., Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells. Int. J. Pharm. 471 (2014), 18–27.
68. [68] Lv, H., Zhang, S., Wang, B., Cui, S., Yan, J., Toxicity of cationic lipids and cationic polymers in gene delivery. J. Control. Release 114 (2006), 100–109.
69. [69] Hwang, T.-L., Aljuffali, I.A., Hung, C.-F., Chen, C.-H., Fang, J.-Y., The impact of cationic solid lipid nanoparticles on human neutrophil extracellular traps (NETs). Chem. Biol. Interact. 235 (2015), 108–114.
70. [70] Rao, M.P., Manjunath, K., Bhagawati, S.T., Thippeswami, B.S., Bixin loaded solid lipid nanoparticles for enhanced hepatoprotection - preparation, characterisation and in vivo evaluation. Int. J. Pharm. 473 (2014), 485–492.
71. [71] Nafee, N., Husari, A., Maurer, C.K., Lu, C., de Rossi, C., Steinbach, A., Hartmann, R.W., Lehr, C.-M., Schneider, M., Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors. J. Control. Release 192 (2014), 131–140.
72. [72] Shi, S., Han, L., Deng, L., Zhang, Y., Shen, H., Gong, T., Zhang, Z., Sun, X., Dual drugs (microRNA-34a and paclitaxel)-loaded functional solid lipid nanoparticles for synergistic cancer cell suppression. J. Control. Release 194 (2014), 228–237.
73. [73] Fadda, P., Monduzzi, M., Caboi, F., Piras, S., Lazzari, P., Solid lipid nanoparticle preparation by a warm microemulsion based process: influence of microemulsion microstructure. Int. J. Pharm. 446 (2013), 166–175.
74. [74] Jin, J., Bae, K.H., Yang, H., Lee, S.J., Kim, H., Kim, Y., Joo, K.M., Seo, S.W., Park, T.G., Nam, D.-H., In vivo specific delivery of c-Met siRNA to glioblastoma using cationic solid lipid nanoparticles. Bioconjug. Chem. 22 (2011), 2568–2572.
75. [75] Mulik, R.S., Mönkkönen, J., Juvonen, R.O., Mahadik, K.R., Paradkar, A.R., Transferrin mediated solid lipid nanoparticles containing curcumin: enhanced in vitro anticancer activity by induction of apoptosis. Int. J. Pharm. 398 (2010), 190–203.
76. [76] ud Din, F., Mustapha, O., Kim, D.W., Rashid, R., Park, J.H., Choi, J.Y., Ku, S.K., Yong, C.S., Kim, J.O., Choi, H.-G., Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect. Eur. J. Pharm. Biopharm. 94 (2015), 64–72.
77. [77] Wang, L., Li, H., Wang, S., Liu, R., Wu, Z., Wang, C., Wang, Y., Chen, M., Enhancing the antitumor activity of berberine hydrochloride by solid lipid nanoparticle encapsulation. AAPS PharmSciTech 15 (2014), 834–844.
78. [78] Zhang, Z., Gao, F., Bu, H., Xiao, J., Li, Y., Solid lipid nanoparticles loading candesartan cilexetil enhance oral bioavailability: in vitro characteristics and absorption mechanism in rats. Nanomedicine 8 (2012), 740–747.
79. [79] Jensen, L.B., Magnusson, E., Gunnarsson, L., Vermehren, C., Nielsen, H.M., Petersson, K., Corticosteroid solubility and lipid polarity control release from solid lipid nanoparticles. Int. J. Pharm. 390 (2010), 53–60.
80. [80] Kalhapure, R.S., Mocktar, C., Sikwal, D.R., Sonawane, S.J., Kathiravan, M.K., Skelton, A., Govender, T., Ion pairing with linoleic acid simultaneously enhances encapsulation efficiency and antibacterial activity of vancomycin in solid lipid nanoparticles. Colloids Surf., B 117 (2014), 303–311.
81. [81] Choi, K.-O., Aditya, N.P., Ko, S., Effect of aqueous pH and electrolyte concentration on structure, stability and flow behavior of non-ionic surfactant based solid lipid nanoparticles. Food Chem. 147 (2014), 239–244.
82. [82] Kuo, Y.-C., Liang, C.-T., Inhibition of human brain malignant glioblastoma cells using carmustine-loaded catanionic solid lipid nanoparticles with surface anti-epithelial growth factor receptor. Biomaterials 32 (2011), 3340–3350.
83. [83] Montenegro, L., Sinico, C., Castangia, I., Carbone, C., Puglisi, G., Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. Int. J. Pharm. 434 (2012), 169–174.
84. [84] Martins, S., Costa-Lima, S., Carneiro, T., Cordeiro-da-Silva, A., Souto, E.B., Ferreira, D.C., Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway. Int. J. Pharm. 430 (2012), 216–227.
85. [85] de Souza, A.L.R., Andreani, T., Oliveira, R.N.d., Kiill, C.P., dos Santos, F.K., Allegretti, S.M., Chaud, M.V., Souto, E.B., Silva, A.M., Gremião, M.P.D., In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment. Int. J. Pharm. 463 (2014), 31–37.
86. [86] Ravi, P.R., Vats, R., Dalal, V., Murthy, A.N., A hybrid design to optimize preparation of lopinavir loaded solid lipid nanoparticles and comparative pharmacokinetic evaluation with marketed lopinavir/ritonavir coformulation. J. Pharm. Pharmacol. 66 (2014), 912–926.
87. [87] Kakkar, V., Singh, S., Singla, D., Kaur, I.P., Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol. Nutr. Food Res. 55 (2011), 495–503.
88. [88] Tsai, M.-J., Huang, Y.-B., Wu, P.-C., Fu, Y.-S., Kao, Y.-R., Fang, J.-Y., Tsai, Y.-H., Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations. J. Pharm. Sci. 100 (2011), 547–557.
89. [89] Mohamed, R.A., Abass, H.A., Attia, M.A., Heikal, O.A., Formulation and evaluation of metoclopramid solid lipid nanoparticles for rectal suppository. J. Pharm. Pharmacol. 65 (2013), 1607–1621.
90. [90] Dhawan, S., Kapil, R., Singh, B., Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery. J. Pharm. Pharmacol. 63 (2010), 342–351.
91. [91] Ying, X.-Y., Cui, D., Yu, L., Du, Y.-Z., Solid lipid nanoparticles modified with chitosan oligosaccharides for the controlled release of doxorubicin. Carbohydr. Polym. 84 (2011), 1357–1364.
92. [92] Madan, J., Pandey, R.S., Jain, V., Katare, O.P., Chandra, R., Katyal, A., Poly (ethylene)-glycol conjugated solid lipid nanoparticles of noscapine improve biological half-life, brain delivery and efficacy in glioblastoma cells. Nanomedicine 9 (2013), 492–503.
93. [93] Wang, S., Chen, T., Chen, R., Hu, Y., Chen, M., Wang, Y., Emodin loaded solid lipid nanoparticles: preparation, characterization and antitumor activity studies. Int. J. Pharm. 430 (2012), 238–246.
94. [94] Jenning, V., Gysler, A., Schäfer-Korting, M., Gohla, S.H., Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur. J. Pharm. Biopharm. 49 (2000), 211–218.
95. [95] Almeida, A.J., Souto, E., Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv. Drug Deliv. Rev. 59 (2007), 478–490.
96. [96] Hao, J., Wang, F., Wang, X., Zhang, D., Bi, Y., Gao, Y., Zhao, X., Zhang, Q., Development and optimization of baicalin-loaded solid lipid nanoparticles prepared by coacervation method using central composite design. Eur. J. Pharm. Sci. 47 (2012), 497–505.
97. [97] Labovkina, T., Jacobson, G.B., Gonzalez-Gonzalez, E., Hickerson, R.P., Leake, D., Kaspar, R.L., Contag, C.H., Zare, R.N., In vivo sustained release of siRNA from solid lipid nanoparticles. ACS Nano 5 (2011), 9977–9983.
98. [98] Apaolaza, P.S., Delgado, D., del Pozo-Rodríguez, A., Gascón, A.R., Solinís, M.Á., A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases. Int. J. Pharm. 465 (2014), 413–426.
99. 3) and its pharmacokinetic applicability in rats. J. Pharm. Biomed. Anal. 91 (2014), 73–80.
100. [100] Yi, J., Lam, T.I., Yokoyama, W., Cheng, L.W., Zhong, F., Cellular uptake of β-carotene from protein stabilized solid lipid nanoparticles prepared by homogenization-evaporation method. J. Agric. Food Chem. 62 (2014), 1096–1104.
101. [101] Abbasalipourkabir, R., Salehzadeh, A., Abdullah, R., Tamoxifen-loaded solid lipid nanoparticles-induced apoptosis in breast cancer cell lines. J. Exp. Nanosci. 11 (2016), 161–174.
102. [102] Shi, L.-L., Cao, Y., Zhu, X.-Y., Cui, J.-H., Cao, Q.-R., Optimization of process variables of zanamivir-loaded solid lipid nanoparticles and the prediction of their cellular transport in Caco-2 cell model. Int. J. Pharm. 478 (2015), 60–69.
103. [103] Kuo, Y.-C., Ko, H.-F., Targeting delivery of saquinavir to the brain using 83-14 monoclonal antibody-grafted solid lipid nanoparticles. Biomaterials 34 (2013), 4818–4830.
104. [104] Hamishehkar, H., Ghanbarzadeh, S., Sepehran, S., Javadzadeh, Y., Adib, Z.M., Kouhsoltani, M., Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia. Drug Dev. Ind. Pharm. 8 (2015), 1–8.
105. [105] Hansraj, G.P., Singh, S.K., Kumar, P., Sumatriptan succinate loaded chitosan solid lipid nanoparticles for enhanced anti-migraine potential. Int. J. Biol. Macromol. 81 (2015), 467–476.
106. [106] Salminen, H., Gömmel, C., Leuenberger, B.H., Weiss, J., Influence of encapsulated functional lipids on crystal structure and chemical stability in solid lipid nanoparticles: towards bioactive-based design of delivery systems. Food Chem. 190 (2016), 928–937.
107. [107] Navarro, F.P., Creusat, G., Frochot, C., Moussaron, A., Verhille, M., Vanderesse, R., Thomann, J.-S., Boisseau, P., Texier, I., Couffin, A.-C., Barberi-Heyob, M., Preparation and characterization of mTHPC-loaded solid lipid nanoparticles for photodynamic therapy. J. Photochem. Photobiol. B 130 (2014), 161–169.
108. [108] Cengiz, M., Kutlu, H.M., Burukoglu, D.D., Ayhanci, A., A comparative study on the therapeutic effects of silymarin and silymarin-loaded solid lipid nanoparticles on D-GaIN/TNF-α-induced liver damage in Balb/c mice. Food Chem. Toxicol. 77 (2015), 93–100.
109. [109] Liu, Z., Zhang, L., He, Q., Liu, X., Okeke, C.I., Tong, L., Guo, L., Yang, H., Zhang, Q., Zhao, H., Gu, X., Effect of baicalin-loaded PEGylated cationic solid lipid nanoparticles modified by OX26 antibody on regulating the levels of baicalin and amino acids during cerebral ischemia-reperfusion in rats. Int. J. Pharm. 489 (2015), 131–138.
110. [110] Li, M., Zahi, M.R., Yuan, Q., Tian, F., Liang, H., Preparation and stability of astaxanthin solid lipid nanoparticles based on stearic acid. Eur. J. Lipid Sci. Technol., 117, 2015.
111. [111] Aditya, N.P., Ko, S., Solid lipid nanoparticles (SLNs): delivery vehicles for food bioactives. RSC Adv. 5 (2015), 30902–30911.
112. [112] Luo, C.-F., Yuan, M., Chen, M.-S., Liu, S.-M., Zhu, L., Huang, B.-Y., Liu, X.-W., Xiong, W., Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. Int. J. Pharm. 410 (2011), 138–144.
113. [113] Hu, L.D., Xing, Q., Meng, J., Shang, C., Preparation and enhanced oral bioavailability of cryptotanshinone-loaded solid lipid nanoparticles. AAPS PharmSciTech 11 (2010), 582–587.
114. [114] Hu, L.D., Jia, Y., Ding, W., Preparation and characterization of solid lipid nanoparticles loaded with epirubicin for pulmonary delivery. Pharmazie 65 (2010), 585–587.
115. [115] del Pozo-Rodríguez, A., Delgado, D., Solinís, M.Á., Pedraz, J.L., Echevarría, E., Rodríguez, J.M., Gascón, A.R., Solid lipid nanoparticles as potential tools for gene therapy: in vivo protein expression after intravenous administration. Int. J. Pharm. 385 (2010), 157–162.
116. [116] Chalikwar, S., Belgamwar, V.S., Talele, V.R., Surana, S.J., Patil, M.U., Formulation and evaluation of nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system. Colloids Surf., B 97 (2012), 109–116.
117. [117] Rawat, M.K., Jain, A., Singh, S., Studies on binary lipid matrix based solid lipid nanoparticles of repaglinide: in vitro and in vivo evaluation. J. Pharm. Sci. 100 (2011), 2366–2378.
118. [118] Abuasal, B.S., Lucas, C., Peyton, B., Alayoubi, A., Nazzal, S., Sylvester, P.W., Kaddoumi, A., Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability. Lipids 47 (2012), 461–469.
119. [119] Paliwal, R., Paliwal, S.R., Agrawal, G.P., Vyas, S.P., Biomimetic solid lipid nanoparticles for oral bioavailability enhancement of low molecular weight heparin and its lipid conjugates: In vitro and in vivo evaluation. Mol. Pharm. 8 (2011), 1314–1321.
120. [120] Li, Y.-Z., Sun, X., Gong, T., Liu, J., Zuo, J., Zhang, Z.-R., Inhalable microparticles as carriers for pulmonary delivery of thymopentin-loaded solid lipid nanoparticles. Pharm. Res. 27 (2010), 1977–1986.
121. [121] Fan, T., Chen, C., Guo, H., Xu, J., Zhang, J., Zhu, X., Yang, Y., Zhou, Z., Li, L., Huang, Y., Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs. Eur. J. Pharm. Biopharm. 88 (2014), 518–528.
122. [122] Kuo, Y.-C., Hong, T.-Y., Delivering etoposide to the brain using catanionic solid lipid nanoparticles with surface 5-HT-moduline. Int. J. Pharm. 465 (2014), 132–142.
123. [123] Zhang, N., Ping, Q., Huang, G., Xu, W., Cheng, Y., Han, X., Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm. 327 (2006), 153–159.
124. [124] Delgado, D., Gascón, A.R., del Pozo-Rodríguez, A., Echevarría, E., de Garibay, A.P.R., Rodríguez, J.M., Solinís, M.A., Dextran-protamine-solid lipid nanoparticles as a non-viral vector for gene therapy: In vitro characterization and in vivo transfection after intravenous administration to mice. Int. J. Pharm. 425 (2012), 35–43.
125. [125] Ramalingam, P., Ko, Y.T., Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles. Colloids Surf., B 139 (2016), 52–61.
126. [126] Alukda, D., Sturgis, T., Youan, B.-B.C., Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention. J. Pharm. Sci. 100 (2011), 3345–3356.
127. [127] Zhang, Z.-H., Zhang, Y.-L., Zhou, J.-P., Lv, H.-X., Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. Int. J. Nanomedicine 7 (2012), 3333–3339.
128. [128] Kuo, Y.-C., Lee, C.-H., Dual targeting of solid lipid nanoparticles grafted with 83-14 MAb and anti-EGF receptor for malignant brain tumor therapy. Life Sci. 146 (2016), 222–231.
129. [129] Kuo, Y.-C., Lee, I.-H., Delivery of doxorubicin to glioblastoma multiforme in vitro using solid lipid nanoparticles with surface aprotinin and melanotransferrin antibody for enhanced chemotherapy. J. Taiwan Inst. Chem. Eng. 1 (2016), 1–14.
130. [130] Tran, T.H., Choi, J.Y., Ramasamy, T., Truong, D.H., Nguyen, C.N., Choi, H.-G., Yong, C.S., Kim, J.O., Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells. Carbohydr. Polym. 114 (2014), 407–415.
131. [131] Kuo, Y.-C., Wang, L.-J., Transferrin-grafted catanionic solid lipid nanoparticles for targeting delivery of saquinavir to the brain. J. Taiwan Inst. Chem. Eng. 45 (2014), 755–763.
132. [132] Venishetty, V.K., Samala, R., Komuravelli, R., Kuncha, M., Sistla, R., Diwan, P.V., β-Hydroxybutyric acid grafted solid lipid nanoparticles: a novel strategy to improve drug delivery to brain. Nanomedicine 9 (2013), 388–397.
133. [133] Luo, Y., Teng, Z., Li, Y., Wang, Q., Solid lipid nanoparticles for oral drug delivery: chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake. Carbohydr. Polym. 122 (2015), 221–229.
134. [134] Sarmento, B., Mazzaglia, D., Bonferoni, M.C., Neto, A.P., do Céu Monteiro, M., Seabra, V., Effect of chitosan coating in overcoming the phagocytosis of insulin loaded solid lipid nanoparticles by mononuclear phagocyte system. Carbohydr. Polym. 84 (2011), 919–925.
135. [135] Fonte, P., Nogueira, T., Gehm, C., Ferreira, D., Sarmento, B., Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Deliv. Transl. Res. 1 (2011), 299–308.
136. [136] Fang, G., Tang, B., Chao, Y., Xu, H., Gou, J., Zhang, Y., Xu, H., Tang, X., Cysteine-functionalized nanostructured lipid carriers for oral delivery of docetaxel: a permeability and pharmacokinetic study. Mol. Pharm. 12 (2015), 2384–2395.
137. [137] Jain, A., Agarwal, A., Majumder, S., Lariya, N., Khaya, A., Agrawal, H., Majumdar, S., Agrawal, G.P., Mannosylated solid lipid nanoparticles as vectors for site-specific delivery of an anti-cancer drug. J. Control. Release 148 (2010), 359–367.
138. [138] Yu, W., Liu, C., Liu, Y., Zhang, N., Xu, W., Mannan-modified solid lipid nanoparticles for targeted gene delivery to alveolar macrophages. Pharm. Res. 27 (2010), 1584–1596.
139. [139] Ying, B., Campbell, R.B., Delivery of kinesin spindle protein targeting siRNA in solid lipid nanoparticles to cellular models of tumor vasculature. Biochem. Biophys. Res. Commun. 446 (2014), 441–447.
140. [140] Baek, J.-S., Cho, C.-W., Controlled release and reversal of multidrug resistance by co-encapsulation of paclitaxel and verapamil in solid lipid nanoparticles. Int. J. Pharm. 478 (2015), 617–624.
141. [141] Pardeshi, C.V., Rajput, P.V., Belgamwar, V.S., Tekade, A.R., Surana, S.J., Novel surface modified solid lipid nanoparticles as intranasal carriers for ropinirole hydrochloride: application of factorial design approach. Drug Deliv. 20 (2013), 47–56.
142. [142] Kim, S., Stébé, M.-J., Blin, J.-L., Pasc, A., pH-controlled delivery of curcumin from compartmentalized solid lipid nanoparticles@mesostructured silica matrix. J. Mater. Chem. B 2 (2014), 7910–7917.
143. [143] Saljoughian, N., Zahedifard, F., Doroud, D., Doustdari, F., Vasel, M., Papadopoulou, B., Rafati, S., Cationic solid-lipid nanoparticles are as efficient as electroporation in DNA vaccination against visceral leishmaniasis in mice. Parasite Immunol. 35 (2013), 397–408.