Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability

Lipids

Volumn 47, Issue 5, 2012, Pages 461-469

  Abuasal, Bilal S ^a   Lucas, Courtney ^a   Peyton, Breanne ^a   Alayoubi, Alaadin ^a   Nazzal, Sami ^a   Sylvester, Paul W ^a   Kaddoumi, Amal ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Tocotrienol; In situ intestinal perfusion; Intestinal permeability; NPC1L1; Oral absorption; Oral bioavailability; Solid lipid nanoparticles; Vitamin E

Indexed keywords

CELL PROTEIN; GAMMA TOCOTRIENOL; NEIMANN PICK C1 LIKE 1 PROTEIN; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG PENETRATION; DRUG UPTAKE; ENDOCYTOSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; INTESTINE PERFUSION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MICELLE; MOLECULAR DYNAMICS; NANOENCAPSULATION; NONHUMAN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMANS; INTESTINAL MUCOSA; LIPIDS; MALE; NANOPARTICLES; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

RATTUS;

EID: 84863445857     PISSN: 00244201     EISSN: 15589307     Source Type: Journal    
DOI: 10.1007/s11745-012-3655-4     Document Type: Article

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