Improved transport and absorption through gastrointestinal tract by pegylated solid lipid nanoparticles

Molecular Pharmaceutics

Volumn 10, Issue 5, 2013, Pages 1865-1873

  Yuan, Hong ^a   Chen, Chun Yan ^a   Chai, Gui Hong ^a   Du, Yong Zhong ^a   Hu, Fu Qiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Caco 2 cells; HT29 cells; oral drug delivery; polyethylene glycol; solid lipid nanoparticles

Indexed keywords

DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE; MACROGOL 2000; OCTADECYLAMINE; SOLID LIPID NANOPARTICLE; STEARIC ACID; DRUG CARRIER; LIPID; MACROGOL DERIVATIVE; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CELL TRANSPORT; COCULTURE; CONTROLLED STUDY; CYTOTOXICITY; DIFFUSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG STABILITY; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HYDROPHILICITY; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE FLUID; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MONOLAYER CULTURE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SURFACE PROPERTY; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; CACO 2 CELL LINE; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; HT 29 CELL LINE; INTESTINE MUCOSA; METABOLISM; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; COCULTURE TECHNIQUES; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; HT29 CELLS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; LIPIDS; MALE; NANOPARTICLES; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84877267457     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300649z     Document Type: Article

References (33)

1. Chalikwar, S. S.; Belgamwar, V. S.; Talele, V. R.; Surana, S. J.; Patil, M. U. Formulation and evaluation of Nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system Colloids Surf., B 2012, 97, 109-116
2. Wissing, S. A.; Kayser, O.; Müller, R. H. Solid lipid nanoparticles for parenteral drug delivery Adv. Drug Delivery Rev. 2004, 56, 1257-1272
3. Muchow, M.; Maincent, P.; Müller, R. H. Lipid Nanoparticles with a Solid Matrix (SLN, NLC, LDC) for Oral Drug Delivery Drug Dev. Ind. Pharm. 2008, 34, 1394-1405
4. Müller, R. H.; Runge, S.; Ravelli, V.; Mehnert, W.; Thünemann, A. F.; Souto, E. B. Oral bioavailability of cyclosporine: Solid lipid nanoparticles (SLN®) versus drug nanocrystals Int. J. Pharm. 2006, 317, 82-89
5. Ensign, L. M.; Cone, R.; Hanes, J. Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers Adv. Drug Delivery Rev. 2012, 64, 557-570
6. Morishita, M.; Peppas, N. A. Is the oral route possible for peptide and protein drug delivery? Drug Discovery Today 2006, 11, 905-910
7. Cone, R. A. Barrier properties of mucus Adv. Drug Delivery Rev. 2009, 61, 75-85
8. Lai, S. K.; Wang, Y.-Y.; Hanes, J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Delivery Rev. 2009, 61, 158-171
9. Tao, S. L.; Desai, T. A. Gastrointestinal patch systems for oral drug delivery Drug Discovery Today 2005, 10, 909-915
10. Ahmed, A.; Bonner, C.; Desai, T. A. Bioadhesive microdevices with multiple reservoirs: a new platform for oral drug delivery J. Controlled Release 2002, 81, 291-306
11. Colombo, P.; Sonvico, F.; Colombo, G.; Bettini, R. Novel Platforms for Oral Drug Delivery Pharm. Res. 2009, 26, 601-611
12. Kouchakzadeh, H.; Shojaosadati, S.; Maghsoudi, A.; Vasheghani Farahani, E. Optimization of PEGylation Conditions for BSA Nanoparticles Using Response Surface Methodology AAPS PharmSciTech 2010, 11, 1206-1211
13. Uskoković, V.; Lee, P. P.; Walsh, L. A.; Fischer, K. E.; Desai, T. A. PEGylated silicon nanowire coated silica microparticles for drug delivery across intestinal epithelium Biomaterials 2012, 33, 1663-1672
14. Zhang, Z.; Tan, S.; Feng, S.-S. Vitamin E TPGS as a molecular biomaterial for drug delivery Biomaterials 2012, 33, 4889-4906
15. Fishburn, C. S. The pharmacology of PEGylation: Balancing PD with PK to generate novel therapeutics J. Pharm. Sci. 2008, 97, 4167-4183
16. Wang, Y.-Y.; Lai, S. K.; Suk, J. S.; Pace, A.; Cone, R.; Hanes, J. Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that "Slip" through the Human Mucus Barrier Angew. Chem., Int. Ed. 2008, 47, 9726-9729
17. Mahler, G. J.; Shuler, M. L.; Glahn, R. P. Characterization of Caco-2 and HT29-MTX cocultures in an in vitro digestion/cell culture model used to predict iron bioavailability J. Nutr. Biochem. 2009, 20, 494-502
18. Woitiski, C. B.; Sarmento, B.; Carvalho, R. A.; Neufeld, R. J.; Veiga, F. Facilitated nanoscale delivery of insulin across intestinal membrane models Int. J. Pharm. 2011, 412, 123-131
19. Chula, S.; Hang, L.; Yinying, B.; Jianning, S.; Shi, R. The effects of notoginsenoside R1 on the intestinal absorption of geniposide by the everted rat gut sac model J. Ethnopharmacol. 2012, 142, 136-143
20. Yuan, H.; Miao, J.; Du, Y.-Z.; You, J.; Hu, F.-Q.; Zeng, S. Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells Int. J. Pharm. 2008, 348, 137-145
21. Huang, M.; Ma, Z.; Khor, E.; Lim, L.-Y. Uptake of FITC-Chitosan Nanoparticles by A549 Cells Pharm. Res. 2002, 19, 1488-1494
22. Wan, F.; You, J.; Sun, Y.; Zhang, X.-G.; Cui, F.-D.; Du, Y.-Z.; Yuan, H.; Hu, F.-Q. Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): Preparation and evaluation in vitro Int. J. Pharm. 2008, 359, 104-110
23. Cu, Y.; Saltzman, W. M. Controlled Surface Modification with Poly(ethylene)glycol Enhances Diffusion of PLGA Nanoparticles in Human Cervical Mucus Mol. Pharmaceutics 2008, 6, 173-181
24. You, J.; Wan, F.; de Cui, F.; Sun, Y.; Du, Y.-Z.; Hu, F. q. Preparation and characteristic of vinorelbine bitartrate-loaded solid lipid nanoparticles Int. J. Pharm. 2007, 343, 270-276
25. Duizer, E.; Gilde, A. J.; Versantvoort, C. H. M.; Groten, J. P. Effects of Cadmium Chloride on the Paracellular Barrier Function of Intestinal Epithelial Cell Lines Toxicol. Appl. Pharmacol. 1999, 155, 117-126
26. Cavalli, R.; Caputo, O.; Gasco, M. R. Preparation and characterization of solid lipid nanospheres containing paclitaxel Eur. J. Pharm. Sci. 2000, 10, 305-309
27. Wikman-Larhed, A.; Artursson, P. Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption Eur. J. Pharm. Sci. 1995, 3, 171-183
28. Rocha, R. A.; Vélez, D.; Devesa, V. In vitro evaluation of intestinal fluoride absorption using different cell models Toxicol. Lett. 2012, 210, 311-317
29. Perumal, O. P.; Inapagolla, R.; Kannan, S.; Kannan, R. M. The effect of surface functionality on cellular trafficking of dendrimers Biomaterials 2008, 29, 3469-3476
30. Gref, R.; Minamitake, Y.; Peracchia, M. T.; Trubetskoy, V.; Torchilin, V.; Langer, R. Biodegradable Long-Circulating Polymeric Nanospheres Science 1994, 263, 1600-1603
31. Galindo-Rodriguez, S. A.; Allemann, E.; Fessi, H.; Doelker, E. Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies Crit. Rev. Ther. Drug Carrier Syst. 2005, 22, 419-464
32. Tang, B. C.; Dawson, M.; Lai, S. K.; Wang, Y.-Y.; Suk, J. S.; Yang, M.; Zeitlin, P.; Boyle, M. P.; Fu, J.; Hanes, J. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier Proc. Natl. Acad. Sci. 2009, 106, 19268-19273
33. Lai, S. K.; Wang, Y.-Y.; Cone, R.; Wirtz, D.; Hanes, J. Altering Mucus Rheology to "Solidify" Human Mucus at the Nanoscale PLoS One 2009, 4, e4294