Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations

Advanced Drug Delivery Reviews

Volumn 54, Issue SUPPL., 2002, Pages

  Muller R H ^a   Radtke, M ^b   Wissing, S A ^b  

^a PharmaSol GmbH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Film formation; Large scale production; Loading capacity; Occlusivity; Stability; Sunscreens; Supersaturation; Topical drug targeting; Triggered release

Indexed keywords

DRUG PRODUCTS; EMULSIONS; LIPIDS; NANOSTRUCTURED MATERIALS;

OCCLUSIVITY;

DERMATOLOGY;

COSMETIC; LIPOSOME; RETINOL; SOLID LIPID NANOPARTICLE; SURFACTANT;

CONFERENCE PAPER; CONTROLLED DRUG RELEASE; DERMATOLOGY; DRUG FORMULATION; EMULSION; FILM; HUMAN; IN VIVO STUDY; PRIORITY JOURNAL; SKIN;

ADMINISTRATION, TOPICAL; COSMETICS; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; LIPIDS; NANOTECHNOLOGY; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; SKIN ABSORPTION; TECHNOLOGY, PHARMACEUTICAL;

EID: 2242472082     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00118-7     Document Type: Conference Paper

References (51)

1. R.H. Müller, J.S. Lucks, Arzneistoffträger aus festen Lipidteilchen, Feste Lipidnanosphären (SLN), European Patent No. 0605497 (1996).
2. M.R. Gasco, Method for producing solid lipid microspheres having a narrow size distrivution, US Patent 5 250 236 (1993).
3. Siekmann B., Westesen K. Sub-micron sized parenteral carrier systems based on solid lipid. Pharm. Pharmacol. Lett. 1:1992;123-126.
4. Müller R.H., Mehnert W., Lucks J.S., Schwarz C., zur Mühlen A., Weyhers H., Freitas C., Rühl D. Solid lipid nanoparticles (SLN) - an alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm. 41:1995;62-69.
5. Müller R.H., Mäder K., Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur. J. Pharm. Biopharm. 50:2000;161-177.
6. Mehnert W., Mäder K. Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev. 47:2001;165-196.
7. Code of Federal Regulations. Food and Drugs. 21:(3):2001;170.
8. H. Weyhers, Feste Lipid-Nanopartikel (SLN) für die Gewebsspezifische Arzneistoffapplikation, PhD thesis, Free University of Berlin (1995).
9. S.A. Wissing, SLN als Innovatives Formulierungskonzept für Pflegende und Protektive Dermale Zubereitungen, PhD thesis, Free University of Berlin (2002).
10. Hildebrand G.E., Dingler A., Runge S.A., Müller R.H. Medium scale production of solid lipid nanoparticles (SLN). Int. Symp. Control. Release Bioact. Mater. 25:1998;968-969.
11. Müller R.H., Dingler A., Schneppe T., Gohla S. Large scale production of solid lipid nanoparticles (SLN™) and nanosuspensions (DissoCubes™). Wise D. Handbook of Pharmaceutical Controlled Release Technology. 2000;359-376 Marcel Dekker, New York.
12. T. Schneppe, Entwicklung und Qualifizierung einer Pilotanlage zur GMP- und QM-gerechten Herstellung von festen Lipid-Nanopartikeln, PhD thesis, Free University of Berlin (1998).
13. Müller R.H., Dingler A. Feste Lipid-Nanopartikel (Lipopearls™) als neuartiger Carrier für kosmetische und dermatologische Wirkstoffe. PZ Wiss. 49:1998;11-15.
14. A. Dingler, Feste Lipid-Nanopartikel als Kolloidale Wirkstoffträgersysteme zur Dermalen Applikation, PhD thesis, Free University of Berlin (1998).
15. Jenning V., Schäfer-Korting M., Gohla S. Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J. Control. Release. 66:2000;115-126.
16. Jenning V., Gysler A., Schäfer-Korting M., Gohla S. Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur. J. Pharm. Biopharm. 49:2000;211-218.
17. Jenning V., Gohla S. Encapsulation of retinoids in solid lipid nanoparticles (SLN). J. Microencapsul. 18:2001;149-158.
18. V. Jenning, Feste Lipid-Nanopartikel (SLN) als Trägersystem für die dermale Applikation von Retinol: Wirkstoffinkorporation,-freisetzung und Struktur, PhD thesis, Free University of Berlin (1999).
19. Mehnert W., zur Mühlen A., Dingler A., Weyhers H., Müller R.H. Solid lipid nanoparticles (SLN) - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika. II. Wirkstoffinkorporation. Freisetzung und Sterilisierbarkeit. Pharm. Ind. 59:(6):1997;511-514.
20. zur Mühlen A., Mehnert W. Drug release and release mechanism of prednisolone loaded solid lipid nanoparticles. Pharmazie. 53:1998;552.
21. zur Mühlen A., Schwarz C., Mehnert W. Solid lipid nanoparticles (SLN) for controlled drug delivery: drug release and release mechanism. Eur. J. Pharm. Biopharm. 45:1998;149-155.
22. A. zur Mühlen, Feste Lipid Nanopartikel mit Prolongierter Wirkstoffliberation, Herstellung, Langzeitstabilität, Charakterisierung, Freisetzungsverhalten und -Mechanismen, PhD thesis, Free University of Berlin (1996).
23. Müller R.H., Schwarz C., zur Mühlen A., Mehnert W. Incorporation of lipophilic drugs and drug release profiles of solid lipid nanoparticles (SLN). Int. Symp. Control. Release Bioact. Mater. 21:1994;146-147.
24. Müller R.H., Mehnert W., Dingler A., Runge S.A., zur Mühlen A., Freitas C. Solid lipid nanoparticles (SLN, Lipopearls) - present state of development. Int. Symp. Control. Release Bioact. Mater. 24:1997;923-924.
25. zur Mühlen A., Schwarz C., Mehnert W., Müller R.H. Produktion von 'solid lipid nanoparticles' (SLN) für die kontrollierte Arzneistoffapplikation. Arch. Pharm. 326:1993;752.
26. Stiess M. Mechanische Verfahrenstechnik 1. 1995;Springer, Berlin. pp. 59-62.
27. T. de Vringer, Topical preparation containing a suspension of solid lipid particles, European Patent Application EP 0 506 197 A1 (1992).
28. Wissing S.A., Lippacher A., Müller R.H. Investigations on the occlusive properties of solid lipid nanoparticles (SLN™). J. Cosmet. Sci. 52:2001;313-323.
29. Müller R.H., Dingler A. The next generation after the liposomes: solid lipid nanoparticles (SLN. Lipopearls) as dermal carrier in cosmetics, Eurocosmetics. 7-8:1998;19-26.
30. Wissing S.A., Müller R.H. Solid lipid nanoparticles (SLN™) - a novel carrier for UV blockers. Pharmazie. 56:2001;783-786.
31. S.A. Wissing, R.H. Müller, The influence of solid lipid nanoparticles (SLN) on skin hydration and viscoelasticity: In vivo study, Eur. J. Pharm. Biopharm. (2002) submitted for publication.
32. Dingler A., Blum R.P., Niehus H., Gohla S., Müller R.H. Solid lipid nanoparticles (SLN™/Lipiopearls™) - A pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. J. Microencapsul. 16:(6):1999;751-767.
33. Santos Maia C., Mehnert W., Schäfer-Korting M. Solid lipid nanoparticles as drug carriers for topical glucocorticoids. Int. J. Pharm. 196:2000;165-167.
34. Wissing S.A., Mäder K., Müller R.H. Solid lipid nanoparticles (SLN™) as a novel carrier system offering prolonged release of the perfume Allure (Chanel). Int. Symp. Control. Release Bioact. Mater. 27:2000;311-312.
35. Yaziksiz-Iscan Y., Hekimoglu S., Sargon M.F., Kas S., Hincal A.A. In vitro release and skin permeation of DEET incorporated solid lipid particles in various vehicles. Proceedings of the 4th World Meeting, ADRITELF/APGI/APV. 2002;1183-1184.
36. Yaziksiz-Iscan Y., Wissing S.A., Müller R.H., Hekimoglu S. Different production methods for solid lipid nanoparticles (SLN) containing the insect repellent DEET. Proceedings of the 4th World Meeting, ADRITELF/APGI/APV. 2002;789-790.
37. Hagedorn-Leweke U., Lippold B.C. Accumulation of sunscreens and other compounds in keratinous substrates. Eur. J. Pharm. Biopharm. 46:1998;215-221.
38. S.A. Wissing, R.H. Müller, Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration, J. Control. Release (2002) in press.
39. Radtke M., Müller R.H. NLC™. Nanostructured lipid carriers: the new generation of lipid drug carriers. New Drugs. 2:2001;48-52.
40. Westesen K., Bunjes H., Koch M.H.J. Physicochemical characterisation of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential. J. Control. Release. 48:1997;223-236.
41. Jenning V., Thünemann A.F., Gohla S.H. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int. J. Pharm. 199:2000;167-177.
42. 1H NMR study. Int. J. Pharm. 205:2000;15-21.
43. 1H NMR, Eur. J. Pharm. Biopharm. (2002) in press.
44. Zimmermann E., Müller R.K., Mäder H. ESR investigations on SLN™ structure and drug incorporation. Millenium World Congress of Pharmaceutical Sciences. 2000;63-64.
45. Zimmermann E., Müller R.H., Mäder K. ESR investigations on drug incorporation in SLN™ and the influence of gastrointestinal media. Int. Symp. Control. Release Bioact. Mater. 27:2000;289-290.
46. Müller B.W. Mikroemulsionen als neue Wirkstoff-Trägersysteme. Müller R.H., Hildebrand G.E. Pharmazeutische Technologie: Moderne Arzneiformen. 1997;109-116 Wissenschaftliche, Stuttgart.
47. R.H. Müller, K. Mäder, A. Lippacher, V. Jenning, Fest-flüssige (halbfeste) Lipidpartikel und Verfahren zur Herstellung Hochkonzentrierter Lipidpartikeldispersionen, PCT application PCT/EP00/04565 (2000).
48. A. Lippacher, Pharmazeutisch-technologische Charakterisierung von flüssigen und halbfesten SLN Dispersionen für die topische Applikation, PhD thesis, Free University of Berlin (2001).
49. Wissing S.A., Lippacher A., Müller-Goymann C.C., Müller R.H. Highly concentrated solid lipid nanoparticles (SLN): production and transmission electron microscopy (TEM) investigations. Proceedings of the 4th World Meeting, ADRITELF/APGI/APV. 2002;811-812.
50. Ghyczy M. Arzneimittel mit Phosphatidylcholin und Liposomen: Entwicklung, Bewertung, Perspektiven. Müller R.H., Hildebrand G.E. Pharmazeutische Technologie: Moderne Arzneiformen. 1997;155-166 Wissenschaftliche, Stuttgart.
51. Bunjes H., Westesen K. Stabilizers may decrease the amount of supercooling in Lipid Nanoparticle dispersions. Proceedings of the 4th World Meeting, ADRITELF/APGI/APV. 2002;671-672.