Solid lipid nanoparticles for hydrophilic biotech drugs: Optimization and cell viability studies (Caco-2 & HEPG-2 cell lines)

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 28-34

  Severino, Patrícia ^a,b   Andreani, Tatiana ^b,c,d   Jäger, Alessandro ^e   Chaud, Marco V ^f   Santana, Maria Helena A ^a   Silva, Amélia M ^c,d   Souto, Eliana B ^b,c  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^d UNIVERSITY OF TRÁS OS MONTES AND ALTO DOURO   (Portugal)

^e INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^f UNIVERSITY OF SOROCABA   (Brazil)

Author keywords

Caco 2 cell lines; Double emulsion; HEPG 2 cell lines; Hydrophilic biotech drugs; insulin; Lipid nanoparticles

Indexed keywords

LIPOID S75; POLYMER; POLYSORBATE 80; SOLID LIPID NANOPARTICLE; SORBITAN OLEATE; UNCLASSIFIED DRUG; BIOMATERIAL; LIPID; NANOPARTICLE; SERUM ALBUMIN; SOFTISAN 100;

ARTICLE; BIOAVAILABILITY; CACO 2 CELL LINE; CELL VIABILITY; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; EMULSION; ENCAPSULATION; FACTORIAL DESIGN; HEP 2 CELL LINE; HUMAN; HYDROPHILICITY; IN VITRO STUDY; MEDICINAL CHEMISTRY; PARTICLE SIZE; PROCESS OPTIMIZATION; PROTEIN POLYMORPHISM; THERMODYNAMICS; THERMOSTABILITY; WIDE ANGLE X RAY DIFFRACTION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; ZETA POTENTIAL; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; HEPG2 CELL LINE; SURFACE PROPERTY;

BIOCOMPATIBLE MATERIALS; CACO-2 CELLS; CELL SURVIVAL; HEP G2 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIPIDS; NANOPARTICLES; PARTICLE SIZE; SERUM ALBUMIN; SURFACE PROPERTIES; THERMODYNAMICS;

EID: 84900395929     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.084     Document Type: Article

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