Production & stability of stavudine solid lipid nanoparticles - From lab to industrial scale

International Journal of Pharmaceutics

Volumn 416, Issue 2, 2011, Pages 461-470

  Shegokar, R ^a,b   Singh, K K ^a   Muller R H ^b  

^a SNDT WOMEN S UNIVERSITY   (India)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

High pressure homogenization; HIV AIDS; Large scale production; Solid lipid nanoparticles; Stability

Indexed keywords

SOLID LIPID NANOPARTICLE; STAVUDINE; SURFACTANT;

ARTICLE; BATCH PROCESS; CIRCULATION TIME; DRUG STABILITY; MICROSCOPY; NANOEMULSION; NEUTRON DIFFRACTION; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; ROOM TEMPERATURE;

DRUG STABILITY; DRUG STORAGE; EMULSIONS; INJECTIONS, INTRAVENOUS; LIPIDS; NANOPARTICLES; PARTICLE SIZE; REFRIGERATION; REVERSE TRANSCRIPTASE INHIBITORS; STAVUDINE; SURFACE-ACTIVE AGENTS; SUSPENSIONS; TEMPERATURE;

EID: 79960457786     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.08.014     Document Type: Article

References (37)

1. G. Abdelbary, and R.H. Fahmy Diazepam-loaded solid lipid nanoparticles: design and characterization AAPS PharmSciTech 10 2009 211 219
2. A.J. Almeida, and E.B. Souto Solid lipid nanoparticles as a drug delivery system for peptides and proteins Adv. Drug Deliv. Rev. 59 2007 478 490 (Pubitemid 47260710)
3. R. Asasutjarit, S.I. Lorenzen, S. Sirivichayakul, K. Ruxrungtham, U. Ruktanonchai, and G.C. Ritthidej Effect of solid lipid nanoparticles formulation compositions on their size, zeta potential and potential for in vitro pHIS-HIV-hugag transfection Pharm. Res. 24 2007 1098 1107 (Pubitemid 46798889)
4. L. Baert, G. van't Klooster, W. Dries, M. Francois, A. Wouters, E. Basstanie, K. Iterbeke, F. Stappers, P. Stevens, L. Schueller, P. Van Remoortere, G. Kraus, P. Wigerinck, and J. Rosier Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment Eur. J. Pharm. Biopharm. 72 2009 502 508
5. E. Basaran, M. Demirel, B. Sirmagul, and Y. Yazan Cyclosporine-A incorporated cationic solid lipid nanoparticles for ocular delivery J. Microencapsul. 27 2010 37 47
6. A. Bender, V. Schfer, A.M. Steffan, C. Royer, J. Kreuter, H. Rubsamen-Waigmann, and H. von Briesen Inhibition of HIV in vitro by antiviral drug-targeting using nanoparticles Res. Virol. 145 1994 215 220 (Pubitemid 24244521)
7. C.C. Berry Intracellular delivery of nanoparticles via the HIV-1 tat peptide Nanomedicine (Lond.) 3 2008 357 365 (Pubitemid 351827312)
8. M.R. Bhalekar, V. Pokharkar, A. Madgulkar, and N. Patil Preparation and evaluation of miconazole nitrate-loaded solid lipid nanoparticles for topical delivery AAPS PharmSciTech 10 2009 289 296
9. M.L. Bondi, E.F. Craparo, G. Giammona, and F. Drago Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution Nanomedicine (Lond.) 5 2009 25 32
10. L. Bullock, J.F. Fitzgerald, and W.V. Walter Emulsion stability in total nutrient admixtures containing a pediatric amino acid formulation J. Parenter. Enteral Nutr. 16 1992 64 68
11. N. Chattopadhyay, J. Zastre, H.L. Wong, X.Y. Wu, and R. Bendayan Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line Pharm. Res. 25 2008 2262 2271
12. G.C. Deshpande, K. Simmer, T. Mori, and K. Croft Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial J. Pediatr. Gastroenterol. Nutr. 49 2009 619 625
13. Dingler, A., 1998. Fest Lipid-Nanopartikel als kolloidale Wirkstoffträgersysteme zur dermalen Applikation. Ph.D. Thesis, Freie Universität Berlin, Berlin, Germany.
14. C. Freitas, and R.H. Müller Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase Eur. J. Pharm. Biopharm. 47 1999 125 132 (Pubitemid 29185115)
15. T. Govender, E. Ojewole, P. Naidoo, and I. Mackraj Polymeric nanoparticles for enhancing antiretroviral drug therapy Drug Deliv. 15 2008 493 501
16. D. Hou, C. Xie, K. Huang, and C. Zhu The production and characteristics of solid lipid nanoparticles (SLNs) Biomaterials 24 2003 1781 1785 (Pubitemid 36184733)
17. M. Jarchau Hochdruckhomogenisieren im Umlaufbetrieb-Verfahrensweisen und Konsequenzen 1997 ZFL pp. 20-24
18. K. Krohn, and B. Koletzko Parenteral lipid emulsions in paediatrics Curr. Opin. Clin. Nutr. Metab. Care 9 2006 319 323 (Pubitemid 44097847)
19. K. Manjunath, J.S. Reddy, and V. Venkateswarlu Solid lipid nanoparticles as drug delivery systems Methods Find. Exp. Clin. Pharmacol. 27 2005 127 144
20. M. Muchow, P. Maincent, and R.H. Müller Lipid nanoparticles with a solid matrix (SLN, NLC, LDC) for oral drug delivery Drug Dev. Ind. Pharm. 34 2008 1394 1405
21. R.H. Müller, S. Gohla, A. Dingler, and T. Schneppe Large scale production of solid lipid nanoparticles (SLN™) and nanosuspensions (DissoCubes™) D.L. Wise, Handbook of Pharmaceutical Controlled Release Technology 2000 359 376
22. Müller, R.H., Mäder, K., Lippacher, A., Jenning, V., 2000. Solid-liquid (semi-solid) liquid particles and method of producing highly concentrated lipid particle dispersions. PCT/EP00/04565.
23. R.H. Müller, W. Mehnert, J.S. Lucks, C. Schwarz, A. zur Mühlen, H. Weyhers, C. Freitas, and D. Ruhl Solid lipid nanoparticles (SLN) - an alternative colloidal carrier system for controlled drug-delivery Eur. J. Pharm. Biopharm. 41 1995 62 69
24. R.H. Müller, M. Radtke, and S.A. Wissing Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations Adv. Drug Deliv. Rev. 54 2002 S131 S155
25. R. Radomska, R. Dobrucki, and R.H. Müller Chemical stability of the lipid matrices of solid lipid nanoparticles (SLN) - development of the analytical method and determination of long-term stability Die Pharmazie 54 1999 903 909
26. L.C. Rohan, and A.B. Sassi Vaginal drug delivery systems for HIV prevention AAPS J. 11 2009 78 87
27. Schneppe, T., 1998. Entwicklung und Qualifizierung einer Pilotanlage zur GMP- und QM-gerechten Herstellung von festen Lipid-Nanopartikeln. Ph.D. Thesis, Freie Universität Berlin.
28. Schwarz, C., 1995. Feste Lipidnanopartikel: Herstellung, Charakterisierung, Arzneistoffinkorporation und-freisetzung, Sterilisation und Lyophilisation. Ph.D. Thesis, Freie Universität, Berlin.
29. L.K. Shah, and M.M. Amiji Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS Pharm. Res. 23 2006 2638 2645 (Pubitemid 44691610)
30. Shegokar, R., 2010. Development and evaluation of novel drug delivery systems for an anti-HIV drugs. Ph.D. Thesis, S.N.D.T. Women's University, Mumbai, India.
31. R. Shegokar, K.K. Singh, and R.H. Müller Lipid nanoparticles of stavudine: from lab scale to industrial production scale 9th International Symposium of Controlled Release Society-Indian Local Chapter, Mumbai, India 2009 P-60
32. R. Shegokar, and K.K. Singh Nanodepot: nanostructured lipid carriers to target latent HIV reservoirs 8th International Symposium of CRS-Indian Local Chapter, Ahmedabad, India 2008
33. R. Shegokar, K.K. Singh, and R.H. Müller Surface modified stavudine lipid nanoparticles for targeting - scale up 69th International Congress of FIP Turkey, IPS-P-042 2009
34. E.B. Souto, C. Anselmi, M. Centini, and R.H. Müller Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN) Int. J. Pharm. 295 2005 261 268 (Pubitemid 40558808)
35. K. Westesen, H. Bunjes, and M.H.J. Koch Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential J. Contr. Rel. 48 1997 223 236 (Pubitemid 27401980)
36. H. Weyhers, S. Ehlers, H. Hahn, E.B. Souto, and R.H. Müller Solid lipid nanoparticles (SLN)-effects of lipid composition on in vitro degradation and in vivo toxicity Die Pharmazie 61 2006 539 544 (Pubitemid 43989132)
37. S.A. Wissing, O. Kayser, and R.H. Müller Solid lipid nanoparticles for parenteral drug delivery Adv. Drug Deliv. Rev. 56 2004 1257 1272 (Pubitemid 38510473)