Formulation and evaluation of Nimodipine-loaded solid lipid nanoparticles delivered via lymphatic transport system

Colloids and Surfaces B: Biointerfaces

Volumn 97, Issue , 2012, Pages 109-116

  Chalikwar, Shailesh S ^a   Belgamwar, Veena S ^a   Talele, Vivek R ^a   Surana, Sanjay J ^a   Patil, Mrunal U ^a  

^a R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

High pressure homogenisation; Intestinal lymphatic targeting; Oral bioavailability; Palmitic acid; Pharmacokinetic evaluation

Indexed keywords

ANTIHYPERTENSIVE DRUGS; CHEMICAL INTERACTIONS; CO-SURFACTANTS; DRUG ENTRAPMENT; DRUG RELEASE; DRUG-LOADING EFFICIENCY; FACTORIAL DESIGN; HIGH PRESSURE HOMOGENISER; HOMOGENISATION; IN-VITRO; INTESTINAL LYMPHATIC TARGETING; LYMPHATIC TRANSPORT; MEAN PARTICLE SIZE; NIMODIPINE; NON-SPHERICAL; ORAL BIOAVAILABILITY; ORAL DELIVERY; PHARMACOKINETIC EVALUATION; PHARMACOKINETIC STUDIES; POLOXAMER; POLYDISPERSITY INDICES; RELATIVE BIOAVAILABILITY; SEM STUDY; SOLID LIPID NANOPARTICLE (SLN); STABILITY STUDY; WISTAR RAT;

CARBOXYLIC ACIDS; DIFFERENTIAL SCANNING CALORIMETRY; NANOPARTICLES; PALMITIC ACID; PARTICLE SIZE; PHARMACOKINETICS; PHOSPHOLIPIDS; POLYDISPERSITY; PYRIDINE; SATURATED FATTY ACIDS; SURFACE ACTIVE AGENTS; ZETA POTENTIAL;

BIOCHEMISTRY;

COSURFACTANT; LIPID; NIMODIPINE; PALMITIC ACID; PHOSPHATIDYLCHOLINE; POLOXAMER; SOLID LIPID NANOPARTICLE; SURFACTANT;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CHEMICAL INTERACTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ENTRAPMENT EFFICIENCY; DRUG FORMULATION; DRUG LOADING EFFICIENCY; DRUG RELEASE; DRUG SCREENING; DRUG STORAGE; DRUG SYNTHESIS; DRUG TARGETING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE LYMPH; LYMPHATIC SYSTEM; MALE; NONHUMAN; PARTICLE SIZE; POLYDISPERSITY INDEX; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; WISTAR RAT; ZETA POTENTIAL;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; LIPIDS; MALE; NANOPARTICLES; NIMODIPINE; RATS; RATS, WISTAR;

RATTUS NORVEGICUS;

EID: 84860997891     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2012.04.027     Document Type: Article

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